Cited by 229Head and Neck Cancer StudiesCancer, Hypoxia, and MetabolismRadiation Therapy and Dosimetry

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RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER

Henk, J.M., Kunkler, P.B., Smith, C.W.·1977·The Lancet

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Abstract

We report the results of a prospective controlled trial of the effect of hyperbaric oxygen as an adjuvant in radiotherapy of head and neck cancer. Patients were allocated randomly to treatment in oxygen or air. The radiotherapy in both groups was identical in planning, dose, and fractionation--i.e., 3500 rads in 10 fractions in 3 weeks. There was no difference in the survival rate between the two groups. However, significantly better local tumour control was seen in the hyperbaric-oxygen group, particularly in smaller lesions; there was significantly greater need for salvage surgery in the air group. Radiation effects on normal tissue appeared somewhat greater in the oxygen series, especially on laryngeal cartilage.

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Authors: Henk, J. M., Kunkler, P. B., & Smith, C. W.
Affiliations: Velindre Cancer Centre (GB)
Venue: The Lancet
Publisher: Elsevier BV
Published: 1977-07
Volume: 310
Issue: 8029
Pages: 101-103
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(77)90116-7
OpenAlex: W2013729607
Cited by: 229
References: 20
Citations by year: 2026: 4 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 7
FWCI: 17.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Keywords: hyperbaric oxygen therapy, head and neck cancer, radiotherapy, adjuvant therapy, local tumor control, salvage surgery, laryngeal cartilages, survival
MeSH terms: Carcinoma, Squamous Cell, Clinical Trials as Topic, Female, Follow-Up Studies, Head and Neck Neoplasms, Humans, Hyperbaric Oxygenation, Laryngeal Neoplasms, Male, Mouth Neoplasms, Neoplasm Recurrence, Local, Nose Neoplasms, Pharyngeal Neoplasms, Prospective Studies, Radiotherapy Dosage

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RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER

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