The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER
Abstract
We report the results of a prospective controlled trial of the effect of hyperbaric oxygen as an adjuvant in radiotherapy of head and neck cancer. Patients were allocated randomly to treatment in oxygen or air. The radiotherapy in both groups was identical in planning, dose, and fractionation--i.e., 3500 rads in 10 fractions in 3 weeks. There was no difference in the survival rate between the two groups. However, significantly better local tumour control was seen in the hyperbaric-oxygen group, particularly in smaller lesions; there was significantly greater need for salvage surgery in the air group. Radiation effects on normal tissue appeared somewhat greater in the oxygen series, especially on laryngeal cartilage.
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“Results from earlier clinical studies confirmed the importance of oxygen content in the biological effects of radiation therapy.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [339]
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RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER
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Metadata
- Authors
- Henk, J. M., Kunkler, P. B., & Smith, C. W.
- Affiliations
- Velindre Cancer Centre (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1977-07
- Volume
- 310
- Issue
- 8029
- Pages
- 101-103
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2013729607
- Cited by
- 229
- References
- 20
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 7
- FWCI
- 17.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Keywords
- hyperbaric oxygen therapy, head and neck cancer, radiotherapy, adjuvant therapy, local tumor control, salvage surgery, laryngeal cartilages, survival
- MeSH terms
- Carcinoma, Squamous Cell, Clinical Trials as Topic, Female, Follow-Up Studies, Head and Neck Neoplasms, Humans, Hyperbaric Oxygenation, Laryngeal Neoplasms, Male, Mouth Neoplasms, Neoplasm Recurrence, Local, Nose Neoplasms, Pharyngeal Neoplasms, Prospective Studies, Radiotherapy Dosage
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