Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Chou, T.-C., & Talalay, P. (1984) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(84)90007-4 · Cited by 7,178 · see citing works

Proposals for the Classification of the Acute Leukaemias F rench ‐A merican ‐B ritish (FAB) C o‐operative G roup

Bennett, J. M., Catovsky, D., Mt, D., Flandrin, G., Galton, D. A. G., Gralnick, H. R., & Sultan, C. (1976) · British Journal of Haematology · doi:10.1111/j.1365-2141.1976.tb03563.x · Cited by 5,595 · see citing works

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

Johnson, G. L., & Lapadat, R. (2002) · Science · doi:10.1126/science.1072682 · Cited by 4,295 · see citing works

Vitamin D

Norman, A. W. (1979) · Cited by 3,769 · see citing works

Cellular response to oxidative stress: Signaling for suicide and survival *

Martindale, J., & Holbrook, N. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10119 · Cited by 2,392 · see citing works

FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.003 · Cited by 1,562 · see citing works

Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

Deeb, K. K., Trump, D. L., & Johnson, C. S. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2196 · Cited by 1,419 · see citing works

The oxidative environment and protein damage

Davies, M. J. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.08.007 · Cited by 1,392 · see citing works

Acute promyelocytic leukemia: from highly fatal to highly curable

Wang, Z., & Chen, Z. (2008) · Blood · doi:10.1182/blood-2007-07-102798 · Cited by 1,283 · see citing works

Acute Myeloid Leukemia

Löwenberg, B., Downing, J. R., & Burnett, A. K. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411407 · Cited by 1,283 · see citing works

Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.

Abe, E., Miyaura, C., Sakagami, H., Takeda, M., Konno, K., Yamazaki, T., Yoshiki, S., & Suda, T. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.4990 · Cited by 1,020 · see citing works

High-Dose Daunorubicin in Older Patients with Acute Myeloid Leukemia

Löwenberg, B., Ossenkoppele, G. J., van Putten, W., Schouten, H. C., Graux, C., Ferrant, A., Sonneveld, P., Maertens, J. A., Jongen‐Lavrencic, M., von Lilienfeld‐Toal, M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901409 · Cited by 828 · see citing works

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

Owusu-Ansah, E., & Banerjee, U. (2009) · Nature · doi:10.1038/nature08313 · Cited by 742 · see citing works

The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer

Daniels‐Wells, T. R., Delgado, T., Rodríguez, J. A., Helguera, G. F., & Penichet, M. L. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.06.010 · Cited by 630 · see citing works

Transferrin receptors in human tissues: their distribution and possible clinical relevance.

Gatter, K. C., Brown, G., Trowbridge, I. S., Woolston, R.-E., & Mason, D. Y. (1983) · Journal of Clinical Pathology · doi:10.1136/jcp.36.5.539 · Cited by 530 · see citing works

G ENETICS OF M YELOID L EUKEMIAS

Kelly, L. M., & Gilliland, D. G. (2002) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.3.032802.115046 · Cited by 522 · see citing works

The transferrin receptor part II: Targeted delivery of therapeutic agents into cancer cells

Daniels‐Wells, T. R., Delgado, T., Helguera, G. F., & Penichet, M. L. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.06.006 · Cited by 519 · see citing works

A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics

Whitnall, M., Howard, J., Ponka, P., & Richardson, D. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604979103 · Cited by 510 · see citing works

Transcriptional control of granulocyte and monocyte development

Friedman, A. D. (2007) · Oncogene · doi:10.1038/sj.onc.1210764 · Cited by 427 · see citing works

Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint

Owusu-Ansah, E., Yavari, A., Mandal, S., & Banerjee, U. K. (2008) · Nature Genetics · doi:10.1038/ng.2007.50 · Cited by 364 · see citing works

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

Nasr, R., Guillemin, M.-C., Ferhi, O., Soilihi, H., Pérès, L., Berthier, C., Rousselot, P. H., Robledo-Sarmiento, M., Lallemand-Breitenbach, V., Gourmel, B., et al. (2008) · Nature Medicine · doi:10.1038/nm.1891 · Cited by 354 · see citing works

Genetics of Myeloid Malignancies: Pathogenetic and Clinical Implications

Fröhling, S., Scholl, C., Gilliland, D. G., & Levine, R. L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.010 · Cited by 352 · see citing works

Cooperating gene mutations in acute myeloid leukemia: a review of the literature

Renneville, A., Roumier, C., Biggio, V., Nibourel, O., Boissel, N., Fenaux, P., & Preudhomme, C. (2008) · Leukemia · doi:10.1038/leu.2008.19 · Cited by 351 · see citing works

Transcriptional regulation of granulocyte and monocyte development

Friedman, A. D. (2002) · Oncogene · doi:10.1038/sj.onc.1205324 · Cited by 325 · see citing works

Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation

Le, N. T. V., & Richardson, D. R. (2004) · Blood · doi:10.1182/blood-2004-05-1866 · Cited by 321 · see citing works

MafB Is an Interaction Partner and Repressor of Ets-1 That Inhibits Erythroid Differentiation

Sieweke, M. H., Tekotte, H., Frampton, J., & Graf, T. (1996) · Cell · doi:10.1016/s0092-8674(00)81081-8 · Cited by 302 · see citing works

Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy

Moura, I. C., Centelles, M. N., Arcos-Fajardo, M., Malheiros, D. M., Collawn, J. F., Cooper, M. D., & Monteiro, R. C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.417 · Cited by 293 · see citing works

Iron trafficking in the mitochondrion: novel pathways revealed by disease

Napier, I. A., Ponka, P., & Richardson, D. R. (2004) · Blood · doi:10.1182/blood-2004-10-3856 · Cited by 287 · see citing works

Rewired ERK-JNK Signaling Pathways in Melanoma

Lopez‐Bergami, P., Huang, C. C., Goydos, J. S., Yip, D., Bar‐Eli, M., Herlyn, M., Smalley, K. S. M., Mahale, A. M., Eroshkin, A. M., Aaronson, S. A., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.03.009 · Cited by 285 · see citing works

Transferrin and transferrin receptors in carcinoma of the breast

Page Faulk, W., Hsi, B.-L., & Stevens, P. J. (1980) · The Lancet · doi:10.1016/s0140-6736(80)90440-7 · Cited by 280 · see citing works

Anti-transferrin receptor monoclonal antibody and toxin–antibody conjugates affect growth of human tumour cells

Trowbridge, I. S., & Domingo, D. L. (1981) · Nature · doi:10.1038/294171a0 · Cited by 275 · see citing works

The Molecular Basis of Leukemia

Gilliland, D. G., Jordan, C. T., & Felix, C. A. (2004) · Hematology · doi:10.1182/asheducation-2004.1.80 · Cited by 274 · see citing works

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents

Richardson, D. R., Kalinowski, D. S., Lau, S. L., Jansson, P. J., & Lovejoy, D. B. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.04.003 · Cited by 260 · see citing works

Hematopoietic Growth Factors Signal Through the Formation of Reactive Oxygen Species

Sattler, M., Winkler, T., Verma, S., Byrne, C. H., Shrikhande, G., Salgia, R., & Griffin, J. D. (1999) · Blood · doi:10.1182/blood.v93.9.2928 · Cited by 254 · see citing works

Heterozygous PU.1 mutations are associated with acute myeloid leukemia

Mueller, B. U., Pabst, T., Osato, M., Asou, N., Johansen, L. M., Minden, M. D., Behre, G., Hiddemann, W., Ito, Y., & Tenen, D. G. (2002) · Blood · doi:10.1182/blood.v100.3.998 · Cited by 243 · see citing works

A Review of Fluorescence Methods for Assessing Labile Iron in Cells and Biological Fluids

Espósito, B. P., Epsztejn, S., Breuer, W. V., & Cabantchik, Z. I. (2002) · Analytical Biochemistry · doi:10.1006/abio.2002.5611 · Cited by 241 · see citing works

Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues.

Hp, K., AMATRUDA, T. T., IKEKAWA, N., Kobayashi, Y., & Hf, D. (1984) · PubMed · Cited by 230 · see citing works

Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation

Pullarkat, V. A., Blanchard, S., Tegtmeier, B., Dagis, A., Patané, K., Ito, J. I., & Forman, S. J. (2008) · Bone Marrow Transplantation · doi:10.1038/bmt.2008.262 · Cited by 207 · see citing works

Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans

Kansas, G., Muirhead, M., & Dailey, M. O. (1990) · Blood · doi:10.1182/blood.v76.12.2483.2483 · Cited by 204 · see citing works

1α,25-Dihydroxyvitamin D3–Induced Myeloid Cell Differentiation Is Regulated by a Vitamin D Receptor–Phosphatidylinositol 3-Kinase Signaling Complex

Hmama, Z., Nandan, D., Sly, L. M., Knutson, K. L., Herrera-Velit, P., & Reiner, N. E. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.11.1583 · Cited by 176 · see citing works

Proteomic and Genetic Approaches Identify Syk as an AML Target

Hahn, C. K., Berchuck, J. E., Ross, K. N., Kakoza, R. M., Clauser, K. R., Schinzel, A. C., Ross, L. S., Galinsky, I. A., Davis, T. N., Silver, S. J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.08.018 · Cited by 169 · see citing works

A transcription factor party during blood cell differentiation

Sieweke, M. H., & Graf, T. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80009-9 · Cited by 164 · see citing works

Pathways of retinoic acid- or arsenic trioxide-induced PML/RARα catabolism, role of oncogene degradation in disease remission

Zhu, J., Lallemand-Breitenbach, V., & de Thé, H. (2001) · Oncogene · doi:10.1038/sj.onc.1204852 · Cited by 151 · see citing works

The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell.

Richardson, D. R., Poňka, P., & Baker, E. (1994) · PubMed · Cited by 139 · see citing works

Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion

Fu, D., & Richardson, D. R. (2007) · Blood · doi:10.1182/blood-2007-03-076737 · Cited by 132 · see citing works

Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia

Ricciardi, M. R., McQueen, T. J., Chism, D. D., Milella, M., Estey, E. H., Kaldjian, E. P., Sebolt, J. S., Konopleva, M. Y., & Andreeff, M. (2005) · Leukemia · doi:10.1038/sj.leu.2403859 · Cited by 125 · see citing works

Potent Antitumor Activity of Novel Iron Chelators Derived from Di-2-Pyridylketone Isonicotinoyl Hydrazone Involves Fenton-Derived Free Radical Generation

Chaston, T. B., Watts, R., Yuan, J. J., & Richardson, D. R. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0865 · Cited by 120 · see citing works

The JNK Are Important for Development and Survival of Macrophages

Himes, S. R., Sester, D. P., Ravasi, T., Cronau, S. L., Sasmono, T., & Hume, D. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2219 · Cited by 117 · cited 1× · see citing works

A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients

Moura, I. C. (2004) · Blood · doi:10.1182/blood-2003-07-2440 · Cited by 114 · see citing works

Objectives of iron chelation therapy in myelodysplastic syndromes: more than meets the eye?

Pullarkat, V. A. (2009) · Blood · doi:10.1182/blood-2009-07-234062 · Cited by 108 · see citing works

Human vitamin D receptor phosphorylation by casein kinase II at Ser-208 potentiates transcriptional activation.

Jurutka, P. W., Hsieh, J., Nakajima, S., Haussler, C. A., Whitfield, G. K., & Haussler, M. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3519 · Cited by 104 · see citing works

Retinoblastoma Protein and CCAAT/Enhancer-Binding Protein β Are Required for 1,25-Dihydroxyvitamin D3-Induced Monocytic Differentiation of HL60 Cells

Ji, Y., & Studzinski, G. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3029 · Cited by 94 · see citing works

Progress in the treatment of acute myeloid leukemia

Ravandi, F., Burnett, A. K., Agura, E. D., & Kantarjian, H. M. (2007) · Cancer · doi:10.1002/cncr.23000 · Cited by 79 · see citing works

HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor

Taghon, T., Stolz, F., Smedt, M. D., Cnockaert, M., Verhasselt, B., Plum, J. R., & Leclercq, G. (2002) · Blood · doi:10.1182/blood.v99.4.1197 · Cited by 70 · see citing works

Vitamin D3-driven signals for myeloid cell differentiation—Implications for differentiation therapy

Hughes, P., Marcinkowska, E., Gocek, E., Studzinski, G. P., & Brown, G. (2009) · Leukemia Research · doi:10.1016/j.leukres.2009.09.010 · Cited by 66 · see citing works

Recent advances in adult T-cell leukemia therapy: focus on a new anti-transferrin receptor monoclonal antibody

Callens, C., Moura, I. C., Lepelletier, Y., Coulon, S., Renand, A., Dussiot, M., Ghez, D., Benhamou, M., Monteiro, R. C., Bazarbachi, A. A., et al. (2007) · Leukemia · doi:10.1038/sj.leu.2404958 · Cited by 62 · see citing works

The relationship of erythropoietin and iron metabolism to red blood cell production in humans.

Adamson, J. W. (1994) · PubMed · Cited by 59 · see citing works

Structure and function of transferrin receptors and their relationship to cell growth.

Trowbridge, I. S., & Shackelford, D. A. (1986) · PubMed · Cited by 58 · see citing works

Jun N‐terminal kinase pathway enhances signaling of monocytic differentiation of human leukemia cells induced by 1,25‐dihydroxyvitamin D3

Wang, Q., Wang, X., & Studzinski, G. P. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10595 · Cited by 54 · see citing works

Signal Transduction by MAP Kinases: Regulation by Phosphorylation-Dependent Switches

Whitmarsh, A. J., & Davis, R. J. (1999) · Science s STKE · doi:10.1126/stke.1999.1.pe1 · Cited by 52 · see citing works

Phospholipid Scramblase 1 Modulates a Selected Set of IgE Receptor-mediated Mast Cell Responses through LAT-dependent Pathway

Amir-Moazami, O., Alexia, C., Charles, N., Launay, P., Monteiro, R. C., & Benhamou, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705320200 · Cited by 45 · see citing works

1α,25-Dihydroxyvitamin D3Transrepresses Retinoic Acid Transcriptional Activity via Vitamin D Receptor in Myeloid Cells

Bastie, J.-N., Balitrand, N., Guidez, F., Guillemot, I., Larghero, J., Calabresse, C., Chomienne, C., & Delva, L. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0412 · Cited by 43 · see citing works

Prevention of Mantle Lymphoma Tumor Establishment by Routing Transferrin Receptor toward Lysosomal Compartments

Lepelletier, Y., Camara‐Clayette, V., Jin, H., Hermant, A., Coulon, S., Dussiot, M., Arcos‐Fajardo, M., Baude, C., Canionni, D., Delarue, R., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1962 · Cited by 39 · see citing works

Erlotinib and gefitinib for the treatment of myelodysplastic syndrome and acute myeloid leukemia: A preclinical comparison

Boehrer, S., Adès, L., Galluzzi, L., Tajeddine, N., Tailler, M., Gardin, C., de Botton, S., Fenaux, P., & Kroemer, G. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.05.024 · Cited by 36 · see citing works

Methods for Studying Signal‐Dependent Regulation of Translation Factor Activity

Wang, X., & Proud, C. G. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)31007-0 · Cited by 35 · see citing works

Vitamin D2 analog (Paricalcitol; Zemplar) for treatment of myelodysplastic syndrome

Koeffler, H. P., Aslanian, N., & O’Kelly, J. (2005) · Leukemia Research · doi:10.1016/j.leukres.2005.04.003 · Cited by 35 · see citing works

The Vitamin D3/Hox-A10 Pathway Supports MafB Function during the Monocyte Differentiation of Human CD34+ Hemopoietic Progenitors

Gemelli, C., Orlandi, C., Zanocco‐Marani, T., Martello, A., Vignudelli, T., Ferrari, F., Montanari, M., Parenti, S., Testa, A., Grande, A., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5660 · Cited by 30 · see citing works

Transferrin-receptor interaction and iron uptake by reticulocytes of vertebrate animals ? a comparative study

Lim, B., McArdle, H. J., & Morgan, E. H. (1987) · Journal of Comparative Physiology B · doi:10.1007/bf00693363 · Cited by 30 · see citing works

Differentiating agents + low-dose chemotherapy in the management of old/poor prognosis patients with acute myeloid leukemia or myelodysplastic syndrome.

Ferrero, D., Campa, E., Dellacasa, C. M., Campana, S., Foli, C., & Boccadoro, M. (2004) · PubMed · Cited by 29 · see citing works

Iron signaling and oxidant damage

Kalyanaraman, B. (2007) · Cardiovascular Toxicology · doi:10.1007/s12012-007-0025-1 · Cited by 22 · see citing works

Cooperation of activating Ras/rtk signal transduction pathway mutations and inactivating myeloid differentiation gene mutations in M0 AML: a study of 45 patients

Roumier, C., Lejeune‐Dumoulin, S., Renneville, A., Goethgeluck, A. S., Philippe, N., Fenaux, P., & Preudhomme, C. (2006) · Leukemia · doi:10.1038/sj.leu.2404097 · Cited by 19 · see citing works

Effect of 1,25(OH)2Vitamin D3Analogs on Differentiation Induction and Cytokine Modulation in Blasts from Acute Myeloid Leukemia Patients

Srivastava, M. D., & Ambrus, J. L. (2004) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/1042819032000159924 · Cited by 17 · see citing works

THE COMBINED USE OF MICROINCINERATION AND THE PRUSSIAN BLUE REACTION FOR A MORE SENSITIVE HISTOCHEMICAL DEMONSTRATION OF IRON

FENTON, R. H., Johnson, F. B., & Zimmerman, L. E. (1964) · Journal of Histochemistry & Cytochemistry · doi:10.1177/12.3.153 · Cited by 12 · see citing works

1α, 25‐Dihydroxy‐vitamin D3 alters syk activation through FcγRII in monocytic THP‐1 cells

Agramonte‐Hevia, J., Hallal, C., Garay-Canales, C. A., Guerra‐Araiza, C., Camacho‐Arroyo, I., & Ortega, E. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10575 · Cited by 6 · see citing works

Retinoic acid and acute promyelocytic leukemia: a model of targetting treatment for human cancer.

Chen, Z., Chen, S., & Wang, Z. (1994) · PubMed · Cited by 5 · see citing works

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Sasaki, M., Knobbe, C. B., Munger, J. C., Lind, E. F., Brenner, D., Brüstle, A., Harris, I. S., Holmes, R., Wakeham, A., Haight, J., et al. (2012) · Nature · doi:10.1038/nature11323 · Cited by 513 · see citing works

Differentiation therapy revisited

de Thé, H. (2018) · Nature reviews. Cancer · doi:10.1038/nrc.2017.103 · Cited by 462 · see citing works

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

Jeanne, M., Lallemand-Breitenbach, V., Ferhi, O., Koken, M. H. M., Bras, M. L., Duffort, S., Pérès, L., Berthier, C., Soilihi, H., Raught, B., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.06.003 · Cited by 332 · see citing works

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

Duarte, D., Hawkins, E., Akinduro, O., Ang, H., Filippo, K. D., Kong, I. Y., Haltalli, M., Ruivo, N., Straszkowski, L., Vervoort, S., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2017.11.006 · Cited by 292 · see citing works

IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+ cell subsets from Id2-dependent precursors

Satoh‐Takayama, N., Lesjean‐Pottier, S., Vieira, P., Sawa, S., Eberl, G., Vosshenrich, C. A. J., & Santo, J. P. D. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092029 · Cited by 307 · see citing works

Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia

Willems, L., Jacque, N., Jacquel, A., Neveux, N., Maciel, T. T., Lambert, M., Schmitt, A., Poulain, L., Green, A. S., Uzunov, M., et al. (2013) · Blood · doi:10.1182/blood-2013-03-493163 · Cited by 296 · see citing works

Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents

Candelaria, P. V., Leoh, L. S., Penichet, M. L., & Daniels‐Wells, T. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.607692 · Cited by 275 · see citing works

Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells

Liu, C., Yin, Q., Zhou, H., Wu, Y., Pu, J., Li, X., Liu, W., Huang, X. Y., Jiang, T., Wu, M., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.935 · Cited by 222 · see citing works

Transition metal chelators, pro-chelators, and ionophores as small molecule cancer chemotherapeutic agents

Steinbrueck, A., Sedgwick, A. C., Brewster, J. T., Yan, K., Shang, Y., Knoll, D. M., Vargas‐Zúñiga, G. I., He, X., Tian, H., & Sessler, J. L. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00373h · Cited by 215 · see citing works

Iron and Reactive Oxygen Species: Friends or Foes of Cancer Cells?

Bystrom, L. M., Guzman, M. L., & Rivella, S. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5014 · Cited by 212 · see citing works

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

Green, A. S., Chapuis, N., Trovati Maciel, T., Willems, L., Lambert, M., Arnoult, C., Boyer, O., Bardet, V., Park, S., Foretz, M., et al. (2010) · Blood · doi:10.1182/blood-2010-02-269837 · Cited by 199 · see citing works

Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications

Medrano, M., Carrillo‐Cruz, E., Montero, I., & Pérez‐Simón, J. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092663 · Cited by 193 · see citing works

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers

LaBelle, J. L., Katz, S. G., Bird, G. H., Gavathiotis, E., Stewart, M. L., Lawrence, C. E., Fisher, J. K., Godes, M., Pitter, K. L., Kung, A. L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci46231 · Cited by 176 · see citing works

Iron and leukemia: new insights for future treatments

Wang, F., Lv, H., Zhao, B., Zhou, L., Wang, S., Luo, J., Liu, J., & Shang, P. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1397-3 · Cited by 170 · see citing works

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation

Roth, M. E., Will, B., Simkin, G. O., Narayanagari, S., Barreyro, L., Bartholdy, B., Tamari, R., Mitsiades, C. S., Verma, A., & Steidl, U. G. (2012) · Blood · doi:10.1182/blood-2011-12-399667 · Cited by 165 · see citing works

Iron metabolism and its contribution to cancer (Review)

Chen, Y., Fan, Z., Yang, Y., & Gu, C. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4720 · Cited by 142 · see citing works

Surviving change: the metabolic journey of hematopoietic stem cells

Kohli, L., & Passegue, E. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.04.001 · Cited by 127 · see citing works

Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome

Shenoy, N. K., Vallumsetla, N., Rachmilewitz, E. A., Verma, A., & Ginzburg, Y. Z. (2014) · Blood · doi:10.1182/blood-2014-03-563221 · Cited by 123 · see citing works

Iron Deprivation in Cancer––Potential Therapeutic Implications

Heath, J. L., Weiss, J. M., Lavau, C., & Wechsler, D. S. (2013) · Nutrients · doi:10.3390/nu5082836 · Cited by 121 · see citing works

Found in translation: the human equivalent of mouse CD8+ dendritic cells

Villadangos, J. A., & Shortman, K. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100985 · Cited by 120 · see citing works

The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow

Zhang, D.-C., Gao, X., Li, H., Borger, D. K., Wei, Q.-Z., Yang, E., Xu, C.-L., Pinho, S., & Frenette, P. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2021.12.009 · Cited by 95 · see citing works

Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies

Minden, M. D., Hogge, D. E., Weir, S. J., Kasper, J., Webster, D. A., Patton, L., Jitkova, Y., Hurren, R., Gronda, M., Goard, C. A., et al. (2013) · American Journal of Hematology · doi:10.1002/ajh.23640 · Cited by 100 · see citing works

Vitamin D in combination cancer treatment

Ma, Y., Trump, D. L., & Johnson, C. S. (2010) · Journal of Cancer · doi:10.7150/jca.1.101 · Cited by 98 · see citing works

Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag -dependent immunodeficiency

Walter, J. E., Rucci, F., Patrizi, L., Recher, M., Regenass, S., Paganini, T., Keszei, M., Pessach, I. M., Lang, P. A., Poliani, P. L., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091927 · Cited by 96 · see citing works

Differential regulation of hepcidin in cancer and non-cancer tissues and its clinical implications

Vela, D., & Vela‐Gaxha, Z. (2018) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.273 · Cited by 94 · see citing works

Anemia, Ineffective Erythropoiesis, and Hepcidin: Interacting Factors in Abnormal Iron Metabolism Leading to Iron Overload in β-Thalassemia

Gardenghi, S., Grady, R. W., & Rivella, S. (2010) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2010.08.003 · Cited by 96 · see citing works

Cancer cells with irons in the fire

Bystrom, L. M., & Rivella, S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.04.035 · Cited by 89 · see citing works

The Clinical Significance of Iron Overload and Iron Metabolism in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Weber, S., Parmon, A., Kurrle, N., Schnütgen, F., & Serve, H. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.627662 · Cited by 86 · see citing works

Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies

Nyamao, R. M., Wu, J., Li, Y., Xiao, X., & Zhang, F. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.11.003 · Cited by 83 · see citing works

Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development

Yao, Y., Li, F., Huang, J., Jin, J., & Wang, H. (2021) · Experimental Hematology and Oncology · doi:10.1186/s40164-021-00233-2 · Cited by 86 · see citing works

Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1

Chaib, H., Nebbioso, A., Prébet, T., Castellano, R., Garbit, S., Restouin, A., Vey, N., Altucci, L., & Collette, Y. (2011) · Leukemia · doi:10.1038/leu.2011.271 · Cited by 78 · see citing works

Iron chelation therapy

Bruzzese, A., Martino, E. A., Mendicino, F., Lucia, E., Olivito, V., Bova, C., Filippelli, G., Capodanno, I., Neri, A., Morabito, F., et al. (2023) · European Journal Of Haematology · doi:10.1111/ejh.13935 · Cited by 76 · see citing works

Protein Carbonylation and Lipid Peroxidation in Hematological Malignancies

Rodríguez-García, A., García-Vicente, R., Morales, M. L., Ortiz-Ruiz, A., Martínez‐López, J., & Linares, M. (2020) · Antioxidants · doi:10.3390/antiox9121212 · Cited by 75 · see citing works

Iron overload in hematological disorders

Fibach, E., & Rachmilewitz, E. A. (2017) · La Presse Médicale · doi:10.1016/j.lpm.2017.10.007 · Cited by 76 · see citing works

Metabolism and the leukemic stem cell

Abdel-Wahab, O. I., & Levine, R. L. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100523 · Cited by 74 · see citing works

Genetic manipulation of AML1-ETO–induced expansion of hematopoietic precursors in a Drosophila model

Sinenko, S. A., Hung, T., Moroz, T. P., Tran, Q.-M., Sidhu, S., Cheney, M. D., Speck, N. A., & Banerjee, U. K. (2010) · Blood · doi:10.1182/blood-2010-03-276998 · Cited by 72 · see citing works

Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia

Coulon, S., Dussiot, M., Grapton, D., Maciel, T. T., Wang, P. H. M., Callens, C., Tiwari, M. K., Agarwal, S., Fricot, A., Vandekerckhove, J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2462 · Cited by 70 · see citing works

Iron regulatory protein (IRP)–mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow

Bonadonna, M., Altamura, S., Tybl, E., Palais, G., Qatato, M., Polycarpou‐Schwarz, M., Schneider, M., Kalk, C., Rüdiger, W., Ertl, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq4469 · Cited by 67 · see citing works

Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome

Cassani, B., Poliani, P. L., Marrella, V., Schena, F., Sauer, A. V., Ravanini, M., Strina, D., Busse, C. E., Regenass, S., Wardemann, H., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091928 · Cited by 68 · see citing works

A storm in the niche: Iron, oxidative stress and haemopoiesis

Pilo, F., & Angelucci, E. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.08.005 · Cited by 68 · see citing works

The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells

Bobilev, I., Novik, V., Levi, I., Shpilberg, O., Levy, J., Sharoni, Y., Studzinski, G. P., & Danilenko, M. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.3.14098 · Cited by 65 · see citing works

Targetting ferroptosis for blood cell-related diseases

Chen, Z., Jiang, J., Fu, N., & Chen, L. (2021) · Journal of drug targeting · doi:10.1080/1061186x.2021.1971237 · Cited by 63 · see citing works

Targeting ferroptosis contributes to ATPR-induced AML differentiation via ROS-autophagy-lysosomal pathway

Du, Y. Z., Bao, J., Zhang, M., Li, L., Xu, X.-L., Chen, H., Feng, Y., Peng, X., & Chen, F. (2020) · Gene · doi:10.1016/j.gene.2020.144889 · Cited by 61 · see citing works

Iron regulates myeloma cell/macrophage interaction and drives resistance to bortezomib

Camiolo, G., Barbato, A., Giallongo, C., Vicario, N., Romano, A., Parrinello, N. L., Parenti, R., Cantón-Sandoval, J., García‐Moreno, D., Lazzarino, G., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101611 · Cited by 60 · see citing works

Mechanistic Insights of Vitamin D Anticancer Effects.

Ma, Y.-Y., Johnson, C. S., & Trump, D. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2015.11.003 · Cited by 55 · see citing works

From Iron Chelation to Overload as a Therapeutic Strategy to Induce Ferroptosis in Leukemic Cells

Grignano, É., Birsen, R., Chapuis, N., & Bouscary, D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.586530 · Cited by 54 · see citing works

New insights into transfusion-related iron toxicity: Implications for the oncologist

Porter, J. B., de Witte, T., Cappellini, M. D., & Gattermann, N. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.11.017 · Cited by 53 · see citing works

Iron overload-induced oxidative stress in myelodysplastic syndromes and its cellular sequelae

Kim, C. H., & Leitch, H. A. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103367 · Cited by 54 · see citing works

Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow

Paubelle, É., Zylbersztejn, F., Maciel, T. T., Carvalho, C., Mupo, A., Cheok, M. H.-C., Lieben, L., Sujobert, P., Decroocq, J., Yokoyama, A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.055 · Cited by 50 · see citing works

Iron chelators induce autophagic cell death in multiple myeloma cells

Pullarkat, V. A., Meng, Z., Donohue, C., Yamamoto, V. N., Tomassetti, S., Bhatia, R., Krishnan, A. Y., Forman, S. J., & Synold, T. W. (2014) · Leukemia Research · doi:10.1016/j.leukres.2014.06.005 · Cited by 49 · see citing works

Evidence of Differentiation in Myeloid Malignancies Associated Neutrophilic Dermatosis: A Fluorescent In Situ Hybridization Study of 14 Patients

Sujobert, P., Cuccuini, W., Vignon-Pennamen, D., Martin‐Garcia, N., Albertini, A. F., Uzunov, M., Redjoul, R., Dombret, H., & Raffoux, E. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.408 · Cited by 47 · see citing works

Controversies surrounding iron chelation therapy for MDS

Leitch, H. A. (2010) · Blood Reviews · doi:10.1016/j.blre.2010.09.003 · Cited by 47 · see citing works

Retinoids in hematology: a timely revival?

Geoffroy, M., Esnault, C., & de Thé, H. (2021) · Blood · doi:10.1182/blood.2020010100 · Cited by 46 · see citing works

Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: Novel iron chelators with selective antiproliferative action

Macková, E., Hrušková, K., Bendová, P., Jirkovská, A., Jansová, H., Hašková, P., Kovařı́ková, P., Vávrová, K., & Šimůnek, T. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.03.010 · Cited by 45 · see citing works

Iron for proliferation of cell lines and hematopoietic progenitors: Nailing down the intracellular functional iron concentration

Pourcelot, E., Lénon, M., Mobilia, N., Cahn, J.-Y. Y., Arnaud, J., Fanchon, É., Moulis, J., & Mossuz, P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.03.009 · Cited by 44 · see citing works

Cafestol, a diterpene molecule found in coffee, induces leukemia cell death

Lima, C. S., Spíndola, D. G., Bechara, A., Garcia, D. M., Palmeira-dos-Santos, C., Peixoto-da-Silva, J., Erustes, A. G., Michelin, L. F. G., Pereira, G. J. S., Smaili, S. S., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.109 · Cited by 43 · see citing works

Increased CD34+CD38−CD123+ cells in myelodysplastic syndrome displaying malignant features similar to those in AML

Li, L. J., Tao, J., Fu, R., Wang, H. Q., Jiang, H. J., Lan, Y., Zhang, W., Liu, H., & Shao, Z. H. (2014) · International Journal of Hematology · doi:10.1007/s12185-014-1590-2 · Cited by 42 · see citing works

MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia

Jiang, W., Min, J., Sui, X., Qian, Y., Liu, Y., Liu, Z., Zhou, H., Li, X., & Gong, Y. (2014) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2014.924115 · Cited by 42 · see citing works

Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect

Ghio, A. J., Soukup, J. M., Dailey, L. A., Tong, H., Kesic, M. J., Budinger, G. R. S., & Mutlu, G. M. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00270 · Cited by 41 · see citing works

Improved survival with iron chelation therapy for red blood cell transfusion dependent lower IPSS risk MDS may be more significant in patients with a non-RARS diagnosis

Leitch, H. A., Chan, C. T., Leger, C. S., Foltz, L. M., Ramadan, K. M., & Vickars, L. M. (2012) · Leukemia Research · doi:10.1016/j.leukres.2012.08.001 · Cited by 40 · see citing works

Application of vitamin D and derivatives in hematological malignancies

Kim, M., Mirandola, L., Pandey, A. K., Nguyen, D. D. T., Jenkins, M., Turcel, M., Cobos, E., & Chiriva‐Internati, M. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.10.026 · Cited by 40 · see citing works

Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity

Sen, S., Hassane, D. C., Corbett, C. A., Becker, M. W., Jordan, C. T., & Guzmán, M. L. (2013) · Experimental Hematology · doi:10.1016/j.exphem.2013.04.012 · Cited by 40 · see citing works

Deferasirox and Vitamin D Improves Overall Survival in Elderly Patients with Acute Myeloid Leukemia after Demethylating Agents Failure

Paubelle, É., Zylbersztejn, F., Alkhaeir, S., Suárez, F., Callens, C., Dussiot, M., Isnard, F., Rubio, M., Damaj, G. L., Gorin, N. C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065998 · Cited by 40 · see citing works

Air pollutants disrupt iron homeostasis to impact oxidant generation, biological effects, and tissue injury

Ghio, A. J., Soukup, J. M., Dailey, L. A., & Madden, M. C. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.007 · Cited by 39 · see citing works

A review of select minerals influencing the haematopoietic process

de Oliveira, D. C., Nogueira‐Pedro, A., Santos, E. W., Hastreiter, A. A., da Silva, G. B., Borelli, P., & Fock, R. A. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422418000112 · Cited by 38 · see citing works

Sequestration of mitochondrial iron by silica particle initiates a biological effect

Ghio, A. J., Tong, H., Soukup, J. M., Dailey, L. A., Cheng, W.-Y., Samet, J. M., Kesic, M. J., Bromberg, P. A., Turi, J. L., Upadhyay, D., et al. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00099.2013 · Cited by 37 · see citing works

MUC1-C oncoprotein suppresses reactive oxygen species–induced terminal differentiation of acute myelogenous leukemia cells

Yin, L., Wu, Z., Avigan, D., Rosenblatt, J. M., Stone, R. M., Kharbanda, S. M., & Kufe, D. W. (2011) · Blood · doi:10.1182/blood-2010-10-296632 · Cited by 37 · see citing works

Tuning the Solid- and Solution-State Fluorescence of the Iron-Chelator Deferasirox

Hu, X., Sedgwick, A. C., Mangel, D. N., Shang, Y., Steinbrueck, A., Yan, K., Zhu, L., Snelson, D. W., Sen, S., Chau, C. V., et al. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c01155 · Cited by 37 · see citing works

Acquired Dependence of Acute Myeloid Leukemia on the DEAD-Box RNA Helicase DDX5

Mazurek, A., Park, Y., Miething, C., Wilkinson, J. E., Gillis, J. A., Lowe, S. W., Vakoc, C. R., & Stillman, B. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.019 · Cited by 37 · see citing works

Serum Iron Protects from Renal Postischemic Injury

Vaugier, C., Amano, M. T., Chemouny, J., Dussiot, M., Berrou, C., Matignon, M., Mkaddem, S. B., Wang, P. H. M., Fricot, A., Maciel, T. T., et al. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016080926 · Cited by 36 · see citing works

Advanced Techniques in Biology & Medicine

Arika, W. M., Ogola, P. E., Nyamai, D. W., Mawia, A. M., Wambua, F. K., Kiboi, N. G., Wambani, J. R., Njagi, S. M., Rachuonyo, H. O., Emmah, K. O., et al. (2018) · Advanced Techniques in Biology & Medicine · doi:10.4172/2379-1764 · Cited by 35 · see citing works

Article Commentary: Effects of Environmental Pollutants on Cellular Iron Homeostasis and Ultimate Links to Human Disease

Schreinemachers, D. M., & Ghio, A. J. (2016) · Environmental Health Insights · doi:10.4137/ehi.s36225 · Cited by 32 · see citing works

Hematologic improvement with iron chelation therapy in myelodysplastic syndromes: Clinical data, potential mechanisms, and outstanding questions

Leitch, H. A., & Gattermann, N. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.06.002 · Cited by 32 · see citing works

Iron chelation: an adjuvant therapy to target metabolism, growth and survival of murine PTEN-deficient T lymphoma and human T lymphoblastic leukemia/lymphoma

Benadiba, J., Rosilio, C., Nebout, M., Heimeroth, V., Neffati, Z., Popa, A., Mary, D. A. S. G., Griessinger, E., Imbert, V., Sirvent, N., et al. (2016) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2016.1239257 · Cited by 32 · see citing works

Reactive oxygen species in eradicating acute myeloid leukemic stem cells.

Zhang, H., Fang, H., & Wang, K. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2306-9759.2014.04.03 · Cited by 31 · see citing works

Reactive oxygen species activate differentiation gene transcription of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway

Lam, C. F., Yeung, H. T., Lam, Y. M., & Ng, R. K. (2018) · Leukemia Research · doi:10.1016/j.leukres.2018.03.012 · Cited by 30 · see citing works

Anti-Anemic Effect of Antioxidant-Rich Apple Vinegar against Phenylhydrazine-Induced Hemolytic Anemia in Rats

Ousaaid, D., Ghouizi, A. E., Laaroussi, H., Bakour, M., Mechchate, H., Es-safi, I., Kamaly, O. M. A., Saleh, A., Conte, R., Lyoussi, B., et al. (2022) · Life · doi:10.3390/life12020239 · Cited by 32 · see citing works

Neratinib inhibits proliferation and promotes apoptosis of acute myeloid leukemia cells by activating autophagy‐dependent ferroptosis

Ma, H., Liu, Y., Miao, Z., Cheng, S., Zhu, Y., Wu, Y., Fan, X., Yang, J., Li, X., & Guo, L. (2022) · Drug Development Research · doi:10.1002/ddr.21983 · Cited by 30 · see citing works

Deferasirox exposure induces reactive oxygen species and reduces growth and viability of myelodysplastic hematopoietic progenitors

Pullarkat, V. A., Sehgal, A., Li, L., Meng, Z., Lin, A., Forman, S. J., & Bhatia, R. (2012) · Leukemia Research · doi:10.1016/j.leukres.2012.03.018 · Cited by 30 · see citing works

Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells

Reed, M. A. C., Ludwig, C., Bunce, C. M., Khanim, F. L., & Günther, U. L. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0155-7 · Cited by 30 · see citing works

Too much iron: A masked foe for leukemias

Brissot, É., Bernard, D. G., Loréal, O., Brissot, P., & Troadec, M. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.100617 · Cited by 28 · see citing works

Vitamin D Control of Hematopoietic Cell Differentiation and Leukemia

Studzinski, G. P., Harrison, J. S., Wang, X., Sarkar, S., Kalia, V., & Danilenko, M. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25104 · Cited by 28 · see citing works

Targeting peroxiredoxins against leukemia

Liu, C., Zhou, H., Yin, Q., Wu, Y., & Chen, G. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.06.013 · Cited by 28 · see citing works

Patients with acute myeloid leukemia can be subclassified based on the constitutive cytokine release of the leukemic cells; the possible clinical relevance and the importance of cellular iron metabolism

Brenner, A. K., Tvedt, T. H. A., Nepstad, I., Rye, K. P., Hagen, K. M., Reikvam, H., & Bruserud, Ø. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1300255 · Cited by 28 · see citing works

Data-driven integration of epidemiological and toxicological data to select candidate interacting genes and environmental factors in association with disease

Patel, C. J., Chen, R., & Butte, A. J. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts229 · Cited by 27 · see citing works

Dipetidyl peptidase-4 and transferrin receptor serve as prognostic biomarkers for acute myeloid leukemia

Wei, J., Nai, G. Y., Dai, Y., Huang, X. J., Xiong, M. Y., Yao, X. Y., Huang, Z., Li, S. N., Zhou, W. J., Huang, Y., et al. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-3368 · Cited by 25 · see citing works

Elevated TIM3+ hematopoietic stem cells in untreated myelodysplastic syndrome displayed aberrant differentiation, overproliferation and decreased apoptosis

Tao, J., Li, L., Fu, R., Wang, H., Jiang, H., Yue, L., Zhang, W., Liu, H., Ruan, E.-B., Qü, W., et al. (2014) · Leukemia Research · doi:10.1016/j.leukres.2014.03.018 · Cited by 27 · see citing works

Air pollution particles and iron homeostasis

Ghio, A. J., Soukup, J. M., & Dailey, L. A. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.05.026 · Cited by 27 · see citing works

Iron overload in myelodysplastic syndromes: Evidence based guidelines from the Canadian consortium on MDS

Leitch, H. A., Buckstein, R. J., Zhu, N. Y., Nevill, T. J., Yee, K. W. L., Leber, B. F., Keating, M., St‐Hilaire, È., Kumar, R., Delage, R., et al. (2018) · Leukemia Research · doi:10.1016/j.leukres.2018.09.005 · Cited by 27 · see citing works

Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition

Lei, Y., Yf, W., Xiao, J., Shen, Q., Chi, S., Gao, Y., Lin, D., Ding, J., Fang, Y.-F., & Chen, Y. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01097-4 · Cited by 26 · see citing works

Antileukemic activity and cellular effects of the antimalarial agent artesunate in acute myeloid leukemia

Kumar, B., Kalvala, A., Chu, S., Rosen, S. T., Forman, S. J., Marcucci, G., Chen, C., & Pullarkat, V. A. (2017) · Leukemia Research · doi:10.1016/j.leukres.2017.05.007 · Cited by 26 · see citing works

Some hematopoietic stem cells are more equal than others

Hock, H. R. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100950 · Cited by 26 · see citing works

Iron‐chelating therapy with deferasirox in transfusion‐dependent, higher risk myelodysplastic syndromes: a retrospective, multicentre study

Musto, P., Maurillo, L., Simeon, V., Poloni, A., Finelli, C., Balleari, E., Ricco, A., Rivellini, F., Cortelezzi, A., Tarantini, G., et al. (2017) · British Journal of Haematology · doi:10.1111/bjh.14621 · Cited by 25 · see citing works

Effects of deferoxamine on the osteogenic differentiation of human periodontal ligament cells

Mu, S., Guo, S., Wang, X., Zhan, Y., Li, Y., Jiang, Y., Zhang, R., & Zhang, B. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7810 · Cited by 25 · see citing works

The Vitamin D Receptor, Inflammatory Bowel Diseases, and Colon Cancer

Lu, R., Wu, S., Xia, Y., & Sun, J. (2012) · Current Colorectal Cancer Reports · doi:10.1007/s11888-011-0114-1 · Cited by 23 · see citing works

Current and emerging molecular and epigenetic disease entities in acute myeloid leukemia and a critical assessment of their therapeutic modalities

Zhao, X., Liu, H., Wang, L., Yang, L., & Liu, X. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.010 · Cited by 23 · see citing works

Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure

Pambianchi, E., Ferrara, F., Pecorelli, A., Benedusi, M., Choudhary, H., Therrien, J., & Valacchi, G. (2021) · Antioxidants · doi:10.3390/antiox10121928 · Cited by 22 · see citing works

The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy

Gocek, E., & Studzinski, G. P. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4040504 · Cited by 22 · see citing works

MUC1-C Oncoprotein Blocks Terminal Differentiation of Chronic Myelogenous Leukemia Cells by a ROS-Mediated Mechanism

Yin, L., & Kufe, D. W. (2011) · Genes & Cancer · doi:10.1177/1947601911405044 · Cited by 22 · see citing works

Development of Synthetic Peptide-Modified Liposomes with LDL Receptor Targeting Capacity and Improved Anticancer Activity

Liu, M., Li, W., Larregieu, C. A., Cheng, M., Yan, B., Chu, T., Li, H., & Mao, S. (2014) · Molecular Pharmaceutics · doi:10.1021/mp400759d · Cited by 22 · see citing works

Differentiation Therapy of Acute Myeloid Leukemia

Gocek, E., & Marcinkowska, E. (2011) · Cancers · doi:10.3390/cancers3022402 · Cited by 47 · see citing works

Vitamin D Derivatives in Acute Myeloid Leukemia: The Matter of Selecting the Right Targets

Marcinkowska, E. (2022) · Nutrients · doi:10.3390/nu14142851 · Cited by 12 · see citing works

New Developments of Differentiation Therapy of Acute Myeloid Leukemia

Castelli, G., Pelosi, E., & Testa, U. (2017) · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · doi:10.2174/1875692115666170224094023

Targeting the pyrimidine synthesis pathway for differentiation therapy of acute myelogenous leukemia

Sun, Y., & Hes, J. L. (2017) · Translational Cancer Research · doi:10.21037/tcr.2017.01.28 · Cited by 1 · see citing works

Differentiation therapy of myeloid leukemia: four decades of development

Madan, V., & Koeffler, H. P. (2020) · Haematologica · doi:10.3324/haematol.2020.262121 · Cited by 70 · see citing works