The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Greatly increased luminal nitric oxide in ulcerative colitis
Abstract
A role for nitric oxide (NO) in ulcerative colitis has been suggested because mucosal NO synthase activity, measured by indirect assays, is increased in this disorder. We directly measured luminal NO in the colons of twelve controls and six patients with active ulcerative colitis. During colonoscopy, gas was aspirated from different parts of the colon and immediately analysed by a chemiluminescence technique. NO concentrations were more than 100 times higher in the patients than in the controls. Luminal NO is rapidly and easily measurable and may be used to monitor inflammatory bowel disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This shift is particularly notable in the context of inflammatory bowel disease, where massive blooms of pathogenic, nitrate-reducing Salmonella and Escherichia coli are seen in response to inflammation[333,334,338,339].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [339]
In the citing paper
“which is then reduced to nitrite by commensal anaerobic bacteria on the tongue [22].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [22]
In the citing paper
“However, chronic inflammation, including inflammatory bowel disease and Helicobacter pylori-induced gastritis induce inducible NOS (iNOS) and generate large quantities of NO [22,146,147], forming nitrosating and oxidant species such as N2O3 and peroxynitrite, which might cause mutagenesis through deamination, nitration of DNA, or inhibition of the DNA repair system [148,149].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [22]
In the citing paper
“Acidic disproportionation of nitrite can lead to increased levels of NO [84–86].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [86]
Citations
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Increased amount of nitric oxide in exhaled air of asthmatics
Alving, K., Weitzberg, E., & Lundberg, J. (1993) · European Respiratory Journal · doi:10.1183/09031936.93.06091368 · Cited by 1,232
Self-citationIntragastric nitric oxide production in humans: measurements in expelled air.
Lundberg, J. O., Weitzberg, E., Lundberg, J. M., & Alving, K. (1994) · Gut · doi:10.1136/gut.35.11.1543 · Cited by 661
Self-citationNitric oxide synthase activity in ulcerative colitis and Crohn's disease
Boughton-Smith, N. K., Evans, S., Whittle, B. J. R., Moncada, S., Hawkey, C. J., COLE, A. T., & Balsitis, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)91476-3 · Cited by 459
Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome
Lundberg, J., Weitzberg, E., Nordvall, S. L., Kuylenstierna, R., Jm, L., & Alving, K. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07081501 · Cited by 408
Self-citationIncreased nitric oxide synthesis in ulcerative colitis
Middleton, S. J., Shorthouse, M., & Hunter, J. O. (1993) · The Lancet · doi:10.1016/0140-6736(93)90211-x · Cited by 343
Nitric oxide synthase induction and intestinal epithelial cell viability in rats
Tepperman, B. L., Brown, J. F., & Whittle, B. J. R. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.265.2.g214 · Cited by 194
The rectal mucosa-associated microflora in patients with ulcerative colitis
Hartley, M. G., HUDSON, M. J., Swarbrick, E. T., Hill, M. J., Gent, A. E., Hellier, M. D., & Grace, R. H. (1992) · Journal of Medical Microbiology · doi:10.1099/00222615-36-2-96 · Cited by 80
Research works printed but not linked: 1
- Ji, 1989, Nitrate reductase of Escherichia coli as a NO-producing nitrite reductase, Biochem Arch, 5, 61
Cited by
Sorted by citations
Items 201–266 of 266
The effects of aminosalicylic acid derivatives on nitric oxide in a cell‐free system
Reynolds, P., Middleton, S. J., Shorthouse, M., & HUNTER, J. O. (1995) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1995.tb00411.x · Cited by 9
Miki, T., Kurihara, S., Uemura, T., Ami, Y., Ito, M., Haneda, T., Furuchi, T., Okada, N., Minamino, T., & Kim, Y. (2025) · mBio · doi:10.1128/mbio.01786-25 · Cited by 8
Stimulation of voltage-dependent Ca2+channels by NO at rat myenteric neurons
Sitmo, M., Rehn, M., & Diener, M. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00124.2007 · Cited by 8
Mu, H., Lin, C., Huang, L., Yang, D., Lü, A., Han, Q., & Bian, Z. (2016) · Chinese Medicine · doi:10.1186/s13020-016-0077-x · Cited by 8
Szabó, C. (2008) · Springer eBooks · doi:10.1007/0-387-36005-0_16 · Cited by 8
Vardareli, E., Dündar, E., Angin, K., Sarıçam, T., & İnal, M. (2003) · Experimental and Toxicologic Pathology · doi:10.1078/0940-2993-00324 · Cited by 8
Dacquay, L. C., Tsang, D., Chan, D., Parkinson, J., Philpott, D. J., & McMillen, D. R. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1994832 · Cited by 7
A Nitric Oxide-Sensing T1 Contrast Agent for In Vivo Molecular MR Imaging of Inflammatory Disease
Hong, A., Vollett, K. D. W., & Cheng, H. M. (2024) · ACS Sensors · doi:10.1021/acssensors.4c01604 · Cited by 7
NOS inhibitors in colitis: a suitable case for treatment?
Warner, T. D., & McCartney, S. A. (1998) · Gut · doi:10.1136/gut.42.2.152 · Cited by 7
Endothelin and nitric oxide in inflammation
m, R. E. M., & Weitzberg, E. (2003) · Journal of Hypertension · doi:10.1097/00004872-200401000-00006 · Cited by 7
Respiratory Involvement in Children with Inflammatory Bowel Disease
Gut, G., & Sivan, Y. (2011) · Pediatric Allergy Immunology and Pulmonology · doi:10.1089/ped.2011.0086 · Cited by 6
Shichijo, K., Ihara, M., Razzaque, M. S., Matsuu‐Matsuyama, M., Nakayama, T., Nakashima, M., & Sekine, I. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0160-3 · Cited by 6
Arthur, S., Palaniappan, B., Afroz, S., & Sundaram, U. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab093 · Cited by 6
Intestinal Hydrogen and Nitric Oxide Gases in Preterm Infants – Effects of Antibiotic Therapy
Sobko, T., Elfström, K., Navér, L., Lundberg, J. O., & Norman, M. (2008) · Neonatology · doi:10.1159/000151757 · Cited by 6
Self-citationBörjesson, L., & Delbro, D. S. (2003) · Autonomic Neuroscience · doi:10.1016/s1566-0702(03)00130-9 · Cited by 6
Nitric Oxide and Epithelial Host Defense
Benjamin, N., & Dykhuizen, R. S. (2002) · Springer eBooks · doi:10.1007/0-306-46816-6_11 · Cited by 5
Schmidt, P. T., Bozkurt, A., & Hellström, P. M. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00369-x · Cited by 5
Self-citationKhajah, M. A., Hawai, S., Barakat, A., Albaloushi, A., Alkharji, M., & Masocha, W. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1252174 · Cited by 4
Ragnoli, B., Cena, T., Pochetti, P., Pignatti, P., & Malerba, M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020354 · Cited by 4
Nitric Oxide Inhibition of Glycyl Radical Enzymes and Their Activases
Cáceres, J. C., Michellys, N. G., & Greene, B. L. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.4c14786 · Cited by 4
Farrow, S., & Farrow, A. (1999) · Medical Hypotheses · doi:10.1054/mehy.1998.0750 · Cited by 4
Depressing acid, deconjugating bile
Murphy, G. M. (1998) · Gut · doi:10.1136/gut.42.2.154 · Cited by 4
Ye, M., Liu, X. Q., Peng, Z., Li, S., Jia, X., Yang, X., Jiang, S., Wang, F., Yang, X., Yu, J., et al. (2026) · Nature Microbiology · doi:10.1038/s41564-026-02378-4 · Cited by 4
Anti-inflammatory effects of Cheongilppong on DSS-induced ulcerative colitis in mice
Choi, I.-Y., Lee, K.-T., Kim, M., Kim, S., Kim, D., Jeon, Y., Park, Y., Kim, H. S., Lee, D. W., Um, J., et al. (2011) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-011-0009-3 · Cited by 3
Kolaja, K. L., Bell, R. R., Janssen, D., Manning, P. T., Schlosser, M. J., & Khan, K. N. M. (2004) · Inflammopharmacology · doi:10.1163/156856004773121356 · Cited by 3
Antibacterial effects of nitrite in urine
Carlsson, S. (2005) · Figshare · Cited by 3
Sobko, T. (2006) · Figshare · Cited by 3
Overproduction of Nitric Oxide in Physiology and Pathophysiology: EPR Detection
Henry, Y. A. (1997) · Springer eBooks · doi:10.1007/978-1-4613-1185-0_12 · Cited by 3
E. coli and gut health—For the loser now will be later to win
Lundberg, J. O. (2025) · FEBS Journal · doi:10.1111/febs.70326 · Cited by 3
Self-citationCheng, S., Wang, H., He, X., Shao, Y., Ma, F., Huang, J., Hu, B., & Liu, Z. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114574 · Cited by 2
Increased Rectal Nitric Oxide in Coeliac Disease after Local Challenge with Gluten
Herulf, L. B. M. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520118744 · Cited by 2
Nitric Oxide in the Painful Bladder/Interstitial Cystitis
Renström Koskela, L., & Wiklund, N. P. (2007) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 2
Inflammatory bowel diseases: a new wave of therapy
Murthy, S., Flanigan, A., Osborne, B., & Murthy, N. S. (1998) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.8.7.785 · Cited by 2
Quenching of Nitric Oxide by an Oral Carbonaceous Adsorbent
Iwamoto, N., Ito, K., Kakuchi, J., & Yoshioka, T. (1997) · The Japanese Journal of Pharmacology · doi:10.1016/s0021-5198(19)31412-x · Cited by 2
Oishi, P. E., Hoffman, J. I. E., Fuhrman, B. P., & Fineman, J. R. (2006) · Elsevier eBooks · doi:10.1016/b978-032301808-1.50021-3 · Cited by 2
Sasse, R., & Mejias-Beck, J. (2026) · Digestive Diseases and Sciences · doi:10.1007/s10620-026-09986-4 · Cited by 1
Measurement of luminal nitric oxide in the uterine cavity using a silicon balloon catheter
Sioutas, A., Gemzell‐Danielsson, K., Lundberg, J. O., & Ehrén, I. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.04.007 · Cited by 1
Self-citationAmbulatory manometry in dyspepsia: walking a thin line
Valori, R. (1998) · Gut · doi:10.1136/gut.42.2.153 · Cited by 1
Lundberg, S. (2006) · Figshare · Cited by 1
Protein kinase C in the Regulation of Inflammatory Genes iNOS and TTP
Leppänen, T. (2010) · Tampere University Institutional Repository (Tampere University) · Cited by 1
Inflammatory markers for evaluation of inflammatory bowel disease therapy
Lönnkvist, M. H. (2011) · Figshare · Cited by 1
On the role of nitric oxide in lower urinary tract disease
Koskela, L. R. (2011) · Open Archive (Karolinska Institutet) · Cited by 1
Nutrition, Inflammation, and Infectious Disease
Oz, H. S., & Yeh, S. (2012) · Mediators of Inflammation · doi:10.1155/2012/172480 · Cited by 1
Rectal NO and fecal calprotectin in IBD
Lundberg, J. O. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802647939 · Cited by 1
Self-citationForte, P. (2001) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.2001.tb07288.x · Cited by 1
Seibert, D. G. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-314-9_16 · Cited by 1
A widespread gut bacterial lineage distinguished by redox metabolism and phage defensePreprint
Noecker, C. A., Guo, L., Daté, C., Rai, N., Daramy, F., Hernandez, L. A. R., Kyaw, T. S., Trepka, K. R., Gupta, C. L., Ha, C. W. Y., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.31.715625 · Cited by 1
STUDIES ON FEMALE GENITAL TRACT INFECTIONS AND THE ROLE OF NITRIC OXIDE IN DIAGNOSIS
Sioutas, A. (2010) · Figshare
On the role of the inducible enzymes iNOS and COX-2 in colitis
Kankuri, E. M. (2002) · Työväentutkimus Vuosikirja
Modulators of Inducible Nitric Oxide Synthase: Potential Drugs for the Therapy of Gut Inflammation?
Whittle, B. J. R., Cavicchi, M., & Lamarque, D. (2002) · KARGER eBooks · doi:10.1159/000060959
Inducible nitric oxide synthase in intestinal inflammation
Dijkstra, G. D. H. (2004) · University of Groningen research database (University of Groningen / Centre for Information Technology)
Airborne Nitric Oxide in Health and Disease
Weitzberg, E., & Lundberg, J. O. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50058-7
Self-citationThe role of nitric oxide in the gastrointestinal tract
Gillberg, L. (2012) · Figshare
Mori Folium regulates DSS-induced ulcerative colitis in mice and cytokine production in mast cells
Choi, I.-Y., Kim, Y.-J., Kee, J., Kim, M.-C., Lee, D., Cho, S.-O., Ko, J.-H., Kim, D., Jeon, Y., Yoon, C.-H., et al. (2012) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-012-0055-5
EVALUATION OF BLOOD AND BIOCHEMICAL PARAMETERS IN EXPERIMENTAL COLITIS TREATED WITH LYCOPENE
Altuner, Y., Şahin, İ. K., Özkorkmaz, E. G., Özden, H., Bayramoğlu, G., & Şentürk, H. (2011)
Exhaled nitrogen oxides and carbon monoxide in asthma and cystic fibrosis : Markers of Inflammation?
Zetterquist, W. (2008) · Figshare
Plasma nitrate concentration ininfective gastroenteritis andinflammatory boweldisease
SDykhuizen, R., Mowat, A. N. G., Smith, C. C., & Benjamin, N. (1996)
Roles of keratins in intestinal health and disease
Asghar, M. N. (2015) · Doria (University of Helsinki)
Luminal Nitric Oxide in the Upper Airways: Implications for Local and Distal Sites of Action
Alving, K., Lundberg, J. O., Rinder, J., & Weitzberg, E. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8474-7_10
Self-citationGas profiling in quasi-closed pressure regulated anaerobic fermentation systems
Rotbart, A. (2017) · RMIT Research Repository (RMIT University Library) · doi:10.25439/rmt.27580128
Oishi, P. E., Hoffman, J. I. E., Fuhrman, B. P., & Fineman, J. R. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-07307-3.10020-5
MOIR, J. W. B. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717977367.793470837
Biomedical Applications of Biosensors
Chaurasiya, N., Mumtaz, I., & Altaf, A. (2024) · Springer eBooks · doi:10.1007/978-981-97-3144-2_5
Engineering inflammation-responsive proteins through nitric oxide-caged amino acids
Cai, W., Cui, J., Zeng, Z., Xiang, Z., Xie, Y., Su, Y., Zuo, Y., Liu, Y., Wang, H., Chang, L., et al. (2026) · Nature Biomedical Engineering · doi:10.1038/s41551-026-01782-9
Antisense Inhibition of Inducible Nitric Oxide Synthase Expression - Does it make Sense?
Hemmrich, K. (2005) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver
Metadata
- Authors
- Lundberg, J. O. N., Lundberg, J. M., Alving, K., & Hellström, P. M.
- Affiliations
- Karolinska Institutet (SE)
- Karolinska University Hospital (SE)
- Corresponding author
- Lundberg, J.O.N.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 344
- Issue
- 8938
- Pages
- 1673-1674
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2054157046
- Cited by
- 266
- References
- 8
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 8 · 2014: 2 · 2013: 6 · 2012: 10
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- nitric oxide, ulcerative colitis, nitric oxide synthase, inflammatory bowel disease, chemiluminescence measurement, colon, disease surveillance
- MeSH terms
- Adult, Aged, Colitis, Ulcerative, Colon, Colonoscopy, Humans, Luminescent Measurements, Middle Aged, Nitric Oxide
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review