Cited by 1,229Atherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular HealthAcute Myocardial Infarction Research

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Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

Ridker, Paul M, Hennekens, Charles H, Roitman-Johnson, Beatrice, Stampfer, Meir J, Allen, Jean·1998·The Lancet

DOI 10.1016/s0140-6736(97)09032-6

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Abstract

Background The intercellular adhesion molecule ICAM-1 mediates adhesion and transmigration of leucocytes to the vascular endothelial wall, a step proposed to be critical in the initiation and progression of atherosclerosis. Whether concentrations of soluble ICAM-1 (sICAM-1) are raised in apparently healthy individuals who later suffer acute myocardial infarction is unknown.Methods We obtained baseline plasma samples from a prospective cohort of 14,916 healthy men enrolled in the Physicians' Health Study. With a nested case-control design, we measured sICAM-1 concentrations for 474 participants who developed a first myocardial infarction, and 474 controls (participants who remained healthy throughout the 9-year follow-up). Cases were matched to controls according to age and smoking status at the time of myocardial infarction.Findings We found a significant association between increasing concentration of sICAM-1 and risk of future myocardial infarction (p = 0.003), especially among participants with baseline sICAM-1 concentrations in the highest quartile (> 260 ng/mL; relative risk 1.6 [95% Cl 1.1-2.4], p = 0.02). This association was present overall as well as among non-smokers, and persisted after control for lipid and non-lipid risk factors. In multivariate analyses, the risk of future myocardial infarction was 80% higher for participants with baseline sICAM-1 concentrations in the highest quartile (relative risk 1.8 [1.1-2.8], p = 0.02). Similar risk estimates were seen among non-smokers. We found slight but significant correlations between sICAM-1 and fibrinogen, high-density-lipoprotein cholesterol, homocysteine, triglycerides, tissue-type plasminogen-activator antigen, and C-relative protein, but adjustment for these altered the risk little. The risk of myocardial infarction associated with raised concentrations of sICAM-1 seemed to increase with length of follow-up.Interpretation Our data support the hypothesis that cellular mediators of inflammation have a role in atherogenesis and provide a clinical basis to consider antiadhesion therapies as a novel means of cardiovascular disease prevention.

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The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
Dustin, M. L., Rothlein, R., Bhan, A. K., Dinarello, C. A., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.1.245 · Cited by 2,450
Final Report on the Aspirin Component of the Ongoing Physicians' Health Study
Steering Committee of the Physicians' Health Study Research Group (1989) · New England Journal of Medicine · doi:10.1056/nejm198907203210301 · Cited by 2,267
Molecular Bases of the Acute Coronary Syndromes
Libby, P. (1995) · Circulation · doi:10.1161/01.cir.91.11.2844 · Cited by 2,029
Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis
Cybulsky, M. I., & Gimbrone, M. A. (1991) · Science · doi:10.1126/science.1990440 · Cited by 1,710
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
Pober, J. S., Gimbrone, M. A., Lapierre, L. A., Mendrick, D. L., Fiers, W., Rothlein, R., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.6.1893 · Cited by 1,413
The expression of the adhesion molecules ICAM‐1, VCAM‐1, PECAM, and E‐selectin in human atherosclerosis
Davies, M. J., Gordon, J. L., Gearing, A. J. H., Pigott, R., Woolf, N., Katz, D. R., & Kyriakopoulos, A. (1993) · The Journal of Pathology · doi:10.1002/path.1711710311 · Cited by 777
Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells
Pigott, R., Dillon, L. P., Hemingway, I., & Gearing, A. J. H. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91234-h · Cited by 650

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Filho, W. S., Filho, E. E. M., Horta, P. E., Lemos, P. A., Migueletto, B. C., Junior, C. V. S., Ramires, J. A. F., & Martinez, T. L. D. R. (2005) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2005001600006 · Cited by 5
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Silvestro, A. (2002) · European Heart Journal Supplements · doi:10.1016/s1520-765x(02)90015-5 · Cited by 5
Higher Plasma Levels of von Willebrand Factor and C-Reactive Protein during a Peritoneal Dialysis Regimen with Less Glucose and Glucose Degradation Products
le Poole, C. Y., Schalkwijk, C. G., Teerlink, T., Valentijn, R. M., ter Wee, P. M., & van Ittersum, F. J. (2013) · Peritoneal Dialysis International · doi:10.3747/pdi.2012.00097 · Cited by 5
“nonrenal patient groups, high levels of hsCRP and markers of endothelial activation were associated with a significantly higher risk for cardiovascular morbidity and mortality (10,11).”
Background
ICAM-1: Contribution to Vascular Inflammation and Early Atherosclerosis
Sabine, I., & Lawso, C. (2012) · InTech eBooks · doi:10.5772/29608 · Cited by 6
Time course of plasma adhesion molecules in acute coronary syndromes
Hope, S. A., Meredith, I. T., Farouque, H. M. O., Worthley, S. G., Plunkett, J. C., & Balazs, N. D. H. (2002) · Coronary Artery Disease · doi:10.1097/00019501-200206000-00003 · Cited by 5
Effects of Caloric Intake and Aerobic Activity in Individuals with Prehypertension and Hypertension on Levels of Inflammatory, Adhesion and Prothrombotic Biomarkers—Secondary Analysis of a Randomized Controlled Trial
Wagner, E.-Y. N., Hong, S., Wilson, K. L., Calfas, K. J., Rock, C. L., Redwine, L. S., von Känel, R., & Mills, P. J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030655 · Cited by 5
“The reason for that is mainly seen in endothelial activation [12], which explains the tight linkage between elevated BP, chronic inflammatory processes including atherosclerosis and adverse health related outcomes [7,16].”
Background
Soluble adhesion molecules and coronary heart disease
Ballantyne, C. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07644-4 · Cited by 5
Correction: Evidence for the Role of Epstein Barr Virus Infections in the Pathogenesis of Acute Coronary Events
Binkley, P. F., Cooke, G. E., Lesinski, A., Taylor, M. B., Chen, M., Laskowski, B. F., Waldman, W. J., Ariza, M. E., Williams, M. V., Knight, D. A., et al. (2013) · PLoS ONE · doi:10.1371/annotation/834e21b0-6acb-40ae-8735-f7ad120c989a · Cited by 5
Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide
Sattar, N., Linetzky, B., Ruotolo, G., Verma, S., Sourij, H., Wang, H., Vanderman, K., Wilson, J. M., Griffin, R. M., Stefanski, A., et al. (2026) · JACC · doi:10.1016/j.jacc.2026.04.044 · Cited by 5
The relationship and diagnostic value of C-reactive protein (CRP) and high-sensitivity- reactive protein (hsCRP) for myocardial infarction
Honarm, H., Mirzajani, E., Rahbar Taromsari, M., Saadat, F., Mirblock, F., & Mashayekhi, F. (2011) · African Journal of Microbiology Research · doi:10.5897/ajmr11.244 · Cited by 4
“…in serum is normal, other indicators such as serum amyloid A, ICAM1, VCAM-1, homocystein, preinflamatory cytokins such as IL-1 and Il-6, and acute phase proteins especially CRP can be regarded as indicators for MI (Hwang et al., 1997; Ridker et al., 1997; 2000; 1998; 1999; Harris et al., 1999).”
Background
Effects of marine-derived n–3 PUFA supplementation on soluble adhesion molecules: A systematic review and dose-response meta-analysis of randomized controlled trials
Shirani, M., Talebi, S., Sadeghi, O., Hassanizadeh, S., Askari, G., Bagherniya, M., & Sahebkar, A. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106963 · Cited by 4
Novel plasma biomarkers of coronary artery calcium incidence or progression: Insights from the prospective multi-ethnic Dallas Heart Study cohort
Grinberg, T., Eisen, A., Talmor‐Barkan, Y., Kornowski, R., Hamdan, A., Witberg, G., Ayers, C. R., Joshi, P. H., Rohatgi, A. K., Khera, A., et al. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.117469 · Cited by 4
Periodontal diseases and carotid intima‐media thickness in Bangladesh
Wu, F., Chen, Y., Demmer, R. T., Parvez, F., Paul, R. R., Shaheen, I., Sarwar, G., Ahmed, A., Eunus, M., Ahsan, N., et al. (2016) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12597 · Cited by 4
“Both markers are positively associated with CVD risk (Ridker et al., 1998, Hansson et al., 2011).”
Background
Managing Cardiovascular Complications in Diabetes
Betteridge, J. D., & Nicholls, S. J. (2014) · Wiley eBooks · doi:10.1002/9781118337967 · Cited by 5
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Raghavan, V. A., & Garber, A. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-043-4_7 · Cited by 4
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Berardi, C., Wassel, C. L., Decker, P. A., Larson, N. B., Kirsch, P. S., de Andrade, M., Tsai, M. Y., Pankow, J. S., Sale, M. M., Sicotte, H., et al. (2016) · Angiology · doi:10.1177/0003319716659178 · Cited by 4
The effect of weight change over a 2-year period on inflammatory status in postmenopausal women
Cronin, B. E., Allsopp, P. J., Slevin, M. M., Magee, P. J., McCaffrey, T. A., Livingstone, M. B. E., Strain, J., & McSorley, E. M. (2017) · European Journal of Clinical Nutrition · doi:10.1038/s41430-017-0014-9 · Cited by 4
“A similar percentage of weight or FM gain yields significant increases in the pro-inflammatory markers TNF-α, leptin and ICAM-1, the latter of which is associated with an increased risk of heart disease [32, 33].”
Background
ICAM‐1 and MKL‐1 polymorphisms impose considerable impacts on coronary heart disease occurrence
Wu, C., & Huang, C. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15645 · Cited by 4
Effects of A379V variant of the Lp-PLA 2 gene on Lp-PLA2 activity and markers of oxidative stress and endothelial function in Koreans
Chae, J. S., Kwak, J. H., Kim, M., Shin, K. H., Lee, S., Jeong, T., & Lee, J. H. (2014) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-014-1074-5 · Cited by 4
“ICAM-1, but not VCAM-1, has consistently been associated with the incidence of coronary artery disease in healthy populations [19–21].”
Background
Measuring Soluble ICAM-1 in African Populations
Abdi, A. I., Muthui, M. K., Kiragu, E. W., & Bull, P. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108956 · Cited by 4
“Soluble levels of ICAM-1 (sICAM-1) in plasma have been associated with coronary heart disease and other vascular diseases [2].”
Background
Comparison of biochemical, functional and structural aspects of arterial wall properties in elderly men
Trøseid, M., Hjerkinn, E. M., Seljeflot, I., Klemsdal, T. O., Bergengen, L., Breivik, L., & Arnesen, H. (2006) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510500474462 · Cited by 4
“Increased levels of ICAM-1 are related to increased risk of future myocardial infarction [5] as well as to increased prevalence of coronary heart disease and carotid atherosclerosis [29].”
Background
Occult fungal infection is the underlying pathogenic cause of atherogenesis
Sastry, P. S. R. K. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.050 · Cited by 4
Effect of Atorvastatin and Pioglitazone on Plasma Levels of Adhesion Molecules in Non-Diabetic Patients With Hypertension or Stable Angina or Both
Pattan, V., Jehangir, W., Seth, S., Bhargava, B., & Maulik, S. K. (2015) · Journal of Clinical Medicine Research · doi:10.14740/jocmr2178e · Cited by 4
“On the other hand, sVCAM-1 has failed to show such consistent association in studies [5, 26].”
BackgroundInfluential
The Role of IL-33 in the Inflammation Process of Asthma and Atherosclerosis.
Fulgheri, G., & Malinowski, B. (2011) · PubMed Central · Cited by 4
Adhesion Molecules and Alcohol Consumption Supported by grant PI/020611 from Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, Spain.
Sacanella, E., Estruch, R., Nicolás, J., & Fernández-Solá, J. (2005) · Elsevier eBooks · doi:10.1016/b978-012564370-2/50088-x · Cited by 4
Microvascular Changes in the Diabetic Foot
Dinh, T., & Veves, A. (2006) · Humana Press eBooks · doi:10.1007/978-1-59745-075-1_7 · Cited by 4
HMG-CoA Reductase Inhibition in the Treatment of Atherosclerosis: Effects Beyond Lipid Lowering
März, W., & Br, W. (2002) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 4
Cell Adhesion Molecules in Cardiovascular Pathology – A Glance into the Future?
Goudev, A., Georgiev, D. B., Atar, D., Kehayov, I. R., & Kyurkchiev, S. (2001) · Heart Drug · doi:10.1159/000048964 · Cited by 4
ATVB In Focus
Cohen, R. A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000137187.16206.79 · Cited by 4
Adiponectin. Spectator or Player?
Clark, W. M. (2005) · Stroke · doi:10.1161/01.str.0000177885.74606.d1 · Cited by 4
The Effects of Hormone Therapy on Inflammatory, Hemostatic, and Fibrinolytic Markers in Postmenopausal Women
Koh, K. K., Yoon, B.-K., Merz, C. N. B., Sakuma, I., & Rebar, R. W. (2007) · Elsevier eBooks · doi:10.1016/b978-012369443-0/50042-9 · Cited by 4
ADAM proteases in cytokine biology: Modulators of immune signaling, inflammation and cancer
Khattab, H., Solujic, J., & Saad, M. I. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2026.120137 · Cited by 4
Evaluation of Circulating Levels of ICAM-1 in Obstructive Sleep Apnea (OSA) Adults: Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Link Between OSA and Cardiovascular Disease
Imani, M. M., Imani, A., Sadeghi, M., Brühl, A. B., & Brand, S. (2025) · Life · doi:10.3390/life15081278 · Cited by 3
C‐R eactive protein and soluble intracellular adhesion molecule‐1 are related to pulse wave reflection in type 1 diabetes 在1型糖尿病中 C ‐反应蛋白以及可溶性细胞间黏附分子在1与脉冲波反射有关
Rogowicz‐Frontczak, A., Piłaciński, S., Araszkiewicz, A., Zozulińska‐Ziółkiewicz, D., Wykrętowicz, A., & Wierusz‐Wysocka, B. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12129 · Cited by 3
Untitled work
Komuro (2001) · doi:10.1002/1529-0131(200112)44:12

Authors: Ridker, P. M., Hennekens, C. H., Roitman-Johnson, B., Stampfer, M. J., & Allen, J.
Affiliations: Brigham and Women's Hospital (US)
R&D Systems (United States) (US)
Corresponding author: Ridker, Paul M
ORCID: Ridker, Paul M
Hennekens, Charles H
Stampfer, Meir J
Venue: The Lancet
Publisher: Elsevier BV
Published: 1998-01
Volume: 351
Issue: 9096
Pages: 88-92
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(97)09032-6
OpenAlex: W2138809584
Cited by: 1,229
References: 35
Citations by year: 2026: 7 · 2025: 10 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 16 · 2020: 17 · 2019: 23 · 2018: 14 · 2017: 28 · 2016: 27 · 2015: 25 · 2014: 38 · 2013: 27 · 2012: 36
FWCI: 26.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Keywords: soluble intercellular adhesion molecule-1, sICAM-1, myocardial infarction, atherosclerosis, inflammation, endothelial cell adhesion, anti-adhesion therapy, cardiovascular risk, fibrinogen, homocysteine, tissue plasminogen activator, C-reactive protein, healthy men, Physicians' Health Study
MeSH terms: Antioxidants, Arteriosclerosis, Aspirin, Double-Blind Method, Humans, Male, Middle Aged, Myocardial Infarction, Platelet Aggregation Inhibitors, Prospective Studies, Risk Factors, Multivariate Analysis, Case-Control Studies, Intercellular Adhesion Molecule-1, beta Carotene

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Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

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