Cited by 1,229Atherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular HealthAcute Myocardial Infarction Research

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Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

Ridker, Paul M, Hennekens, Charles H, Roitman-Johnson, Beatrice, Stampfer, Meir J, Allen, Jean·1998·The Lancet

DOI 10.1016/s0140-6736(97)09032-6

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Abstract

Background The intercellular adhesion molecule ICAM-1 mediates adhesion and transmigration of leucocytes to the vascular endothelial wall, a step proposed to be critical in the initiation and progression of atherosclerosis. Whether concentrations of soluble ICAM-1 (sICAM-1) are raised in apparently healthy individuals who later suffer acute myocardial infarction is unknown.Methods We obtained baseline plasma samples from a prospective cohort of 14,916 healthy men enrolled in the Physicians' Health Study. With a nested case-control design, we measured sICAM-1 concentrations for 474 participants who developed a first myocardial infarction, and 474 controls (participants who remained healthy throughout the 9-year follow-up). Cases were matched to controls according to age and smoking status at the time of myocardial infarction.Findings We found a significant association between increasing concentration of sICAM-1 and risk of future myocardial infarction (p = 0.003), especially among participants with baseline sICAM-1 concentrations in the highest quartile (> 260 ng/mL; relative risk 1.6 [95% Cl 1.1-2.4], p = 0.02). This association was present overall as well as among non-smokers, and persisted after control for lipid and non-lipid risk factors. In multivariate analyses, the risk of future myocardial infarction was 80% higher for participants with baseline sICAM-1 concentrations in the highest quartile (relative risk 1.8 [1.1-2.8], p = 0.02). Similar risk estimates were seen among non-smokers. We found slight but significant correlations between sICAM-1 and fibrinogen, high-density-lipoprotein cholesterol, homocysteine, triglycerides, tissue-type plasminogen-activator antigen, and C-relative protein, but adjustment for these altered the risk little. The risk of myocardial infarction associated with raised concentrations of sICAM-1 seemed to increase with length of follow-up.Interpretation Our data support the hypothesis that cellular mediators of inflammation have a role in atherogenesis and provide a clinical basis to consider antiadhesion therapies as a novel means of cardiovascular disease prevention.

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Authors: Ridker, P. M., Hennekens, C. H., Roitman-Johnson, B., Stampfer, M. J., & Allen, J.
Affiliations: Brigham and Women's Hospital (US)
R&D Systems (United States) (US)
Corresponding author: Ridker, Paul M
ORCID: Ridker, Paul M
Hennekens, Charles H
Stampfer, Meir J
Venue: The Lancet
Publisher: Elsevier BV
Published: 1998-01
Volume: 351
Issue: 9096
Pages: 88-92
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(97)09032-6
OpenAlex: W2138809584
Cited by: 1,229
References: 35
Citations by year: 2026: 7 · 2025: 10 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 16 · 2020: 17 · 2019: 23 · 2018: 14 · 2017: 28 · 2016: 27 · 2015: 25 · 2014: 38 · 2013: 27 · 2012: 36
FWCI: 26.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Keywords: soluble intercellular adhesion molecule-1, sICAM-1, myocardial infarction, atherosclerosis, inflammation, endothelial cell adhesion, anti-adhesion therapy, cardiovascular risk, fibrinogen, homocysteine, tissue plasminogen activator, C-reactive protein, healthy men, Physicians' Health Study
MeSH terms: Antioxidants, Arteriosclerosis, Aspirin, Double-Blind Method, Humans, Male, Middle Aged, Myocardial Infarction, Platelet Aggregation Inhibitors, Prospective Studies, Risk Factors, Multivariate Analysis, Case-Control Studies, Intercellular Adhesion Molecule-1, beta Carotene

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Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

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