Cited by 1,229Atherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular HealthAcute Myocardial Infarction Research

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Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

Ridker, Paul M, Hennekens, Charles H, Roitman-Johnson, Beatrice, Stampfer, Meir J, Allen, Jean·1998·The Lancet

DOI 10.1016/s0140-6736(97)09032-6

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Abstract

Background The intercellular adhesion molecule ICAM-1 mediates adhesion and transmigration of leucocytes to the vascular endothelial wall, a step proposed to be critical in the initiation and progression of atherosclerosis. Whether concentrations of soluble ICAM-1 (sICAM-1) are raised in apparently healthy individuals who later suffer acute myocardial infarction is unknown.Methods We obtained baseline plasma samples from a prospective cohort of 14,916 healthy men enrolled in the Physicians' Health Study. With a nested case-control design, we measured sICAM-1 concentrations for 474 participants who developed a first myocardial infarction, and 474 controls (participants who remained healthy throughout the 9-year follow-up). Cases were matched to controls according to age and smoking status at the time of myocardial infarction.Findings We found a significant association between increasing concentration of sICAM-1 and risk of future myocardial infarction (p = 0.003), especially among participants with baseline sICAM-1 concentrations in the highest quartile (> 260 ng/mL; relative risk 1.6 [95% Cl 1.1-2.4], p = 0.02). This association was present overall as well as among non-smokers, and persisted after control for lipid and non-lipid risk factors. In multivariate analyses, the risk of future myocardial infarction was 80% higher for participants with baseline sICAM-1 concentrations in the highest quartile (relative risk 1.8 [1.1-2.8], p = 0.02). Similar risk estimates were seen among non-smokers. We found slight but significant correlations between sICAM-1 and fibrinogen, high-density-lipoprotein cholesterol, homocysteine, triglycerides, tissue-type plasminogen-activator antigen, and C-relative protein, but adjustment for these altered the risk little. The risk of myocardial infarction associated with raised concentrations of sICAM-1 seemed to increase with length of follow-up.Interpretation Our data support the hypothesis that cellular mediators of inflammation have a role in atherogenesis and provide a clinical basis to consider antiadhesion therapies as a novel means of cardiovascular disease prevention.

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The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
Dustin, M. L., Rothlein, R., Bhan, A. K., Dinarello, C. A., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.1.245 · Cited by 2,450
Final Report on the Aspirin Component of the Ongoing Physicians' Health Study
Steering Committee of the Physicians' Health Study Research Group (1989) · New England Journal of Medicine · doi:10.1056/nejm198907203210301 · Cited by 2,267
Molecular Bases of the Acute Coronary Syndromes
Libby, P. (1995) · Circulation · doi:10.1161/01.cir.91.11.2844 · Cited by 2,029
Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis
Cybulsky, M. I., & Gimbrone, M. A. (1991) · Science · doi:10.1126/science.1990440 · Cited by 1,710
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
Pober, J. S., Gimbrone, M. A., Lapierre, L. A., Mendrick, D. L., Fiers, W., Rothlein, R., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.6.1893 · Cited by 1,413
The expression of the adhesion molecules ICAM‐1, VCAM‐1, PECAM, and E‐selectin in human atherosclerosis
Davies, M. J., Gordon, J. L., Gearing, A. J. H., Pigott, R., Woolf, N., Katz, D. R., & Kyriakopoulos, A. (1993) · The Journal of Pathology · doi:10.1002/path.1711710311 · Cited by 777
Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells
Pigott, R., Dillon, L. P., Hemingway, I., & Gearing, A. J. H. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91234-h · Cited by 650

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Oliveira, G. H. (2005) · Current Atherosclerosis Reports · doi:10.1007/s11883-005-0038-9 · Cited by 21
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Cotter, B. R. (2006) · Current HIV/AIDS Reports · doi:10.1007/bf02696656 · Cited by 21
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Liang, K., Lee, W., Lee, W.-L., Chen, Y., Ting, C.-T., & Sheu, W. H. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.10.003 · Cited by 20
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Pulawski, E., Mellwig, K., Brinkmann, T., Kleesiek, K., & Horstkotte, D. (2002) · Therapeutic Apheresis and Dialysis · doi:10.1046/j.1526-0968.2002.00405.x · Cited by 20
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Background
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Ariyo, A., Hennekens, C. H., Stampfer, M. J., & Ridker, P. M. (1998) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182679800500410 · Cited by 19
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Blum, A., & Cannon, R. O. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb04016.x · Cited by 19
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Vita, J. A., & Mitchell, G. F. (2003) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.09.020 · Cited by 19
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Background
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Background
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Temu, T. M., Zifodya, J. S., Polyak, S. J., Wagoner, J., Wanjalla, C. N., Masyuko, S. J., Nyabiage, J., Kinuthia, J., Bloomfield, G. S., Page, S. T., et al. (2020) · AIDS · doi:10.1097/qad.0000000000002729 · Cited by 18
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Background
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Lowenstein, C. J., & Matsushita, K. (2004) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2004.08.001 · Cited by 18
[Role of inflammation in atherogenesis].
Rodríguez, G., Mago, N., & Rosa, F. (2009) · PubMed · Cited by 26
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Nuraeni, A. (2016) · Jurnal Keperawatan Padjadjaran · doi:10.24198/jkp.v4n2.1 · Cited by 18
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Leitner, J. M., Pernerstorfer-Schön, H., Weiss, A., Schindler, K., Rieger, A., & Jilma, B. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.09.001 · Cited by 17
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Zhang, W.-J., Stocker, R., McCall, M. R., Forte, T. M., & Frei, B. B. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00247-2 · Cited by 18
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Background
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Newby, L. K. (2004) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2003.12.006 · Cited by 18
Pizza and Vegetables Don’t Stick to the Endothelium
Giugliano, D., Nappo, F., & Coppola, L. (2001) · Circulation · doi:10.1161/01.cir.104.7.e34 · Cited by 18
Cell adhesion molecules and inflammation in acute coronary syndromes: markers and emerging risk factors
Best, P. J. M. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2661 · Cited by 18
“In a nested case-control study from the Physicians’ Health Study in healthy men, soluble ICAM-1 predicted future myocardial infarctions([1]).”
Background
Laboratory surrogates for anti-atherosclerotic drug development
Stein, E. A. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01421-7 · Cited by 18
Inflammation in acute coronary syndromes.
Robbins, M. A., & Topol, E. J. (2002) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.69.suppl_2.sii130 · Cited by 18
Quality of sleep in people living with HIV in the era of highly active antiretroviral treatment
Petrakis, V., Steiropoulos, P., Παπάνας, Ν., Trypsianis, G. A., Papazoglou, D., & Panagopoulos, P. (2022) · International Journal of STD & AIDS · doi:10.1177/09564624221146608 · Cited by 17
“Chronic sleep disturbances, common in an aging population, could have an inflammatory component leading to cardiovascular morbidity and mortality.(6,7) Sleep disturbances in people living with human immunodeficiency virus (PLWHIV) have been documented since the early stage of the HIV epidemic.”
Background
Is There Any Relationship between Joint Destruction and Carotid Intima-media Thickness in Patients with Rheumatoid Arthritis?
Tutoğlu, A., Boyacı, A., Boyacı, N., Kaya, Z., Aridici, R., & Koca, İ. (2014) · Journal of Physical Therapy Science · doi:10.1589/jpts.26.1093 · Cited by 17
Endotoxin-induced and vaccine-induced systemic inflammation both impair endothelium-dependent vasodilation, but not pulse wave reflection
Lind, L., Johansson, A., Hedner, E., & Hulthe, J. (2012) · Vascular Health and Risk Management · doi:10.2147/vhrm.s19161 · Cited by 17
Intercellular Adhesion Molecule-1 K469E and Angiotensinogen T207M Polymorphisms in Coronary Slow Flow
Gazı, E., Barutçu, A., Altun, B., Temız, A., Bekler, A., Urfalı, M., Sılan, F., Çölkesen, Y., & Özdemir, Ö. (2014) · Medical Principles and Practice · doi:10.1159/000363451 · Cited by 15
Comparison Between Serum hsCRP and LDL Cholesterol for Search of a Better Predictor for Ischemic Heart Disease
Datta, S., Iqbal, Z., & Prasad, R. K. (2011) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-010-0100-4 · Cited by 17
“interleukin (IL-6) [20, 21], serum amyloid A (SAA) [ 22 ], Tumour necrosis factor-a (TNF-a )[ 23], CD40 ligand [24].”
SOLUBLE CELL ADHESION MOLECULES S-VCAM-1 AND S-ICAM-1 IN SUBJECTS WITH FAMILIAL COMBINED HYPERLIPIDEMIA
Karásek, D., Vaverková, H., Halenka, M., Budı́ková, M., & Novotný, D. (2005) · Biomedical Papers · doi:10.5507/bp.2005.012 · Cited by 17
Antibodies against HDL Components in Ischaemic Stroke and Coronary Artery Disease
Batuca, J. R., Amaral, M., Favas, C., Justino, G. C., Papoila, A. L., Ames, P. R. J., & Alves, J. D. (2018) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1645857 · Cited by 16
Relationship Between Plasma Homocysteine and the Morphological and Immunohistochemical Study of Carotid Plaques in Patients With Carotid Stenosis Over 70%
Álvarez, B., Yugueros, X., Fernández, E., Luccini, F., Gené, A., & Matas, M. (2012) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2011.05.047 · Cited by 17
Pioglitazone has anti-inflammatory effects in patients with Type 2 diabetes
Heliövaara, M. K., Herz, M., Teppo, A.-M., Leinonen, E. S., & Ebeling, P. R. (2007) · Journal of Endocrinological Investigation · doi:10.1007/bf03346296 · Cited by 17
Expanded Network of Inflammatory Markers of Atherogenesis: Where Are We Now?~!2009-11-07~!2009-12-10~!2010-02-22~!
Abbasi, S. H., & Boroumand, M. A. (2010) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192401004020038 · Cited by 17
“Besides, it was shown that soluble ICAM-1 is correlated with the severity of atherosclerosis, that its inhibition can retard atherogenesis [106-108] and that ICAM-1 can serve as a predictor of vascular events [109].”
Background
Controlling Inflammation in Peritoneal Dialysis: The Role of PD-Related Factors as Potential Intervention Targets
Fortes, P. C. N., Versari, P. H., Stinghen, A. E. M., & Pecoits‐Filho, R. (2007) · Peritoneal Dialysis International · doi:10.1177/089686080702702s14 · Cited by 17
“Also notable are the strong associations between surrogate markers of inflammation and plasma levels of adhesion molecules (11).”
Background
Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model
Kemény, Á., Csekő, K., Szitter, I., Varga, Z. V., Bencsik, P., Kiss, K., Halmosi, R., Deres, L., Erős, K., Perkecz, A., et al. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.04.098 · Cited by 17
“: increased risk of myocardial infarction (Ridker et al., 1998), in addition chronic smokers have elevated levels of sICAM-1 (Rohde et al.”
Background
The release of soluble VAP-1/SSAO by 3T3-L1 adipocytes is stimulated by isoproterenol and low concentrations of TNFα
García‐Vicente, S., Abella, A., Viguerie, N., Ros-Baró, A., Camps, M., Testar, X., Palacı́n, M., Zorzano, A., & Marti, L. (2005) · Journal of Physiology and Biochemistry · doi:10.1007/bf03167057 · Cited by 17
Increased Endothelial Injury in Septic Patients With Coronary Artery Disease
Kern, H., Wittich, R., Rohr, U., Kox, W. J., & Spies, C. (2001) · CHEST Journal · doi:10.1378/chest.119.3.874 · Cited by 17
Atherosclerosis and plaque rupture
Welt, F. G. P., & Simon, D. I. (2001) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.1130 · Cited by 17
“Human studies have demonstrated that plasma levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin correlate with clinical manifestations of coronary atherosclerosis [5].”
Background
Do novel risk factors differ between men and women aged 18 to 39 years with a high risk of coronary heart disease?
Tonstad, S., Thorsrud, H., Torjesen, P. A., & Seljeflot, I. (2007) · Metabolism · doi:10.1016/j.metabol.2006.10.006 · Cited by 17
Preanalytical Factors (Biological Variation) and the Measurement of Serum Soluble Intercellular Adhesion Molecule-1 in Humans: Influence of the Time of Day, Food Intake, and Physical and Psychological Stress
Dugué, B., Leppänen, E., & Gräsbeck, R. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.9.1543 · Cited by 17
“Soluble adhesion proteins such as sICAM-1 may become important markers for early atherosclerosis ( 1 ) and some other diseases [e.g., see Refs.”
Background
Vascular Function and Mild Renal Impairment in Stable Coronary Artery Disease
van der Harst, P., Smilde, T. D. J., Buikema, H., Voors, A. A., Navis, G. J., van Veldhuisen, D. J., & van Gilst, W. H. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000197844.06411.22 · Cited by 17
Coronary risk factors: new perspectives
Niccoli, G., Iacoviello, L., Cianflone, D., & Crea, F. (2001) · International Journal of Epidemiology · doi:10.1093/ije/30.suppl_1.s41 · Cited by 17
Cytomegalovirus Infection and Coronary Heart Disease
Nieto, F. J., Szklo, M., & Sorlie, P. D. (1999) · Circulation · doi:10.1161/01.cir.100.25.e139 · Cited by 17
Evaluation of Blood Intercellular Adhesion Molecule-1 (ICAM-1) Level in Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis
Imani, M. M., Sadeghi, M., Gholamipour, M. A., Brühl, A. B., Bahmani, D. S., & Brand, S. (2022) · Medicina · doi:10.3390/medicina58101499 · Cited by 16
“Given this, ICAM-1 level can be considered a reliable predictor of CAD, similar to C-reactive protein (CRP) [66].”
Result
Association of Blood Pressure and Fitness With Levels of Atherosclerotic Risk Markers Pre-Exercise and Post-exercise
von Känel, R., Hong, S. J., Pung, M. A., & MILLS, P. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2007.01.005 · Cited by 16
“The risk of first-time myocardial infarction was previously increased with increasing quartiles of IL-6 and sICAM-1 concentrations.(12,13) In our group of individuals, secondto-third and third-to-fourth quartile transitions in sICAM-1 levels corresponded with MAP increases of 15 and 18 mm Hg, respectively.”
Background
A role for innate immunity in the development of hypertension
Gomolak, J. R., & Didion, S. P. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2013.12.027 · Cited by 16
Circulating Transforming Growth Factor-β1, Lipoprotein(a) and Cellular Adhesion Molecules in Angiographically Assessed Coronary Artery Disease
Bogavac‐Stanojević, N., Djurovic, S., Jelić‐Ivanović, Z., Spasojević‐Kalimanovska, V., & Kalimanovska‐Oštrić, D. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.135 · Cited by 16
“Other authors reported that elevated ICAM-1 concentration was associated with the increased risk for acute coronary events (18, 31) or adverse events in patients with peripheral arterial disease (32).”
Background
High cardiovascular risk in young Saudi males: Cardiovascular risk factors, diet and inflammatory markers
Alissa, E. M., Bahjri, S. M., Alama, N., Ahmed, W. H., & Ferns, G. A. (2005) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.09.007 · Cited by 16
Dietary Antioxidants Decrease Serum Soluble Adhesion Molecule (sVCAM‐1, sICAM‐1) but not Chemokine (JE/MCP‐1, KC) Concentrations, and Reduce Atherosclerosis in C57BL but Not ApoE*3 Leiden Mice Fed an Atherogenic Diet
Murphy, N., Grimsditch, D. C., Vidgeon-Hart, M., Groot, P. H. E., Overend, P., Benson, G. M., & Graham, A. (2005) · Disease Markers · doi:10.1155/2005/394152 · Cited by 16
“Significantly, emerging data suggest that elevated levels of sICAM-1 may be predictive of future risk of coronary artery disease [6,13], while sVCAM-1 levels are strongly prognostic of the extent and severity of existing atherosclerosis [9–11], reviewed in [13].”
Background
Association between ABO Genotype and Risk of Hepatocellular Carcinoma in Koreans
Shim, H.-J., Lee, R., Shin, M., Kim, H. N., Cho, D., Ahn, H.-R., & Kweon, S. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.7.2771 · Cited by 16
“…an SNP at the ABO locus was found to be statistically significantly associated with plasma levels of soluble intercellular adhesion molecule 1, which is a marker of inflammation associated with the risk of incident diabetes (Meigs et al., 2004) and myocardial infarction (Ridker et al., 1998).”
Background
Soluble Intercellular Adhesion Molecule-1: A Potential Biomarker for Pain Intensity in Chronic Pain Patients
Luchting, B., Hinske, L. C., Rachinger-Adam, B., Celi, L. A., Kreth, S., & Azad, S. C. (2017) · Biomarkers in Medicine · doi:10.2217/bmm-2016-0246 · Cited by 16
Effect of preexisting statin use on expression of C-reactive protein, adhesion molecules, interleukin-6, and antioxidized low-density lipoprotein antibody in patients with unstable angina undergoing coronary stenting
Doo, Y., Han, S.-J., Han, S.-W., Park, W.-J., Choi, S., Cho, G., Hong, K.-S., Han, K., Lee, N., Oh, D., et al. (2005) · Clinical Cardiology · doi:10.1002/clc.4960280206 · Cited by 16
Long Term Angiotensin Converting Enzyme-inhibition in Patients after Coronary Artery Bypass Grafting Reduces Levels of Soluble Intercellular Cell Adhesion Molecule-1
van Haelst, P. L., Tervaert, J. W. C., van Geel, P. P., Veeger, N. J. G. M., Gurné, O., Gans, R. O. B., & van Gilst, W. H. (2003) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/s1078-5884(03)00084-4 · Cited by 16
Homocysteine, malondialdehyde and endothelial markers in dialysis patients during low‐dose folinic acid therapy
Apeland, T., Mansoor, M. A., Seljeflot, I., Brønstad, I., Gøransson, L. G., & Strandjord, R. E. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.01056.x · Cited by 16
Reciprocal activation of leukocyte–endothelial adhesion molecules in acute coronary syndromes
Murphy, R. T., Foley, J. B., Crean, P., & Walsh, M. J. (2003) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00557-0 · Cited by 16
Chlamydia pneumoniae Seropositivity Is Associated With Increased Plasma Levels of Soluble Cellular Adhesion Molecules in Community-Dwelling Subjects
Kohara, K., Tabara, Y., Yamamoto, Y., Igase, M., & Miki, T. (2002) · Stroke · doi:10.1161/01.str.0000018974.05768.fb · Cited by 16
Are statins anti-inflammatory? Issues in the design and conduct of the pravastatin inflammation C-reactive protein evaluation
Ridker, P. M. (2000) · Current Cardiology Reports · doi:10.1007/s11886-000-0080-8 · Cited by 16
“Together with basic laboratory data, these clinical studies and those focusing on interleukin-6 [19,21,22], cellular adhesion molecules [23, 24 ], and tumor necrosis factor [25] underscore the importance of inflammation in the atherogenic process.”
Method

Authors: Ridker, P. M., Hennekens, C. H., Roitman-Johnson, B., Stampfer, M. J., & Allen, J.
Affiliations: Brigham and Women's Hospital (US)
R&D Systems (United States) (US)
Corresponding author: Ridker, Paul M
ORCID: Ridker, Paul M
Hennekens, Charles H
Stampfer, Meir J
Venue: The Lancet
Publisher: Elsevier BV
Published: 1998-01
Volume: 351
Issue: 9096
Pages: 88-92
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(97)09032-6
OpenAlex: W2138809584
Cited by: 1,229
References: 35
Citations by year: 2026: 7 · 2025: 10 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 16 · 2020: 17 · 2019: 23 · 2018: 14 · 2017: 28 · 2016: 27 · 2015: 25 · 2014: 38 · 2013: 27 · 2012: 36
FWCI: 26.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Keywords: soluble intercellular adhesion molecule-1, sICAM-1, myocardial infarction, atherosclerosis, inflammation, endothelial cell adhesion, anti-adhesion therapy, cardiovascular risk, fibrinogen, homocysteine, tissue plasminogen activator, C-reactive protein, healthy men, Physicians' Health Study
MeSH terms: Antioxidants, Arteriosclerosis, Aspirin, Double-Blind Method, Humans, Male, Middle Aged, Myocardial Infarction, Platelet Aggregation Inhibitors, Prospective Studies, Risk Factors, Multivariate Analysis, Case-Control Studies, Intercellular Adhesion Molecule-1, beta Carotene

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Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

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