Cited by 1,229Atherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular HealthAcute Myocardial Infarction Research

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Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

Ridker, Paul M, Hennekens, Charles H, Roitman-Johnson, Beatrice, Stampfer, Meir J, Allen, Jean·1998·The Lancet

DOI 10.1016/s0140-6736(97)09032-6

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Abstract

Background The intercellular adhesion molecule ICAM-1 mediates adhesion and transmigration of leucocytes to the vascular endothelial wall, a step proposed to be critical in the initiation and progression of atherosclerosis. Whether concentrations of soluble ICAM-1 (sICAM-1) are raised in apparently healthy individuals who later suffer acute myocardial infarction is unknown.Methods We obtained baseline plasma samples from a prospective cohort of 14,916 healthy men enrolled in the Physicians' Health Study. With a nested case-control design, we measured sICAM-1 concentrations for 474 participants who developed a first myocardial infarction, and 474 controls (participants who remained healthy throughout the 9-year follow-up). Cases were matched to controls according to age and smoking status at the time of myocardial infarction.Findings We found a significant association between increasing concentration of sICAM-1 and risk of future myocardial infarction (p = 0.003), especially among participants with baseline sICAM-1 concentrations in the highest quartile (> 260 ng/mL; relative risk 1.6 [95% Cl 1.1-2.4], p = 0.02). This association was present overall as well as among non-smokers, and persisted after control for lipid and non-lipid risk factors. In multivariate analyses, the risk of future myocardial infarction was 80% higher for participants with baseline sICAM-1 concentrations in the highest quartile (relative risk 1.8 [1.1-2.8], p = 0.02). Similar risk estimates were seen among non-smokers. We found slight but significant correlations between sICAM-1 and fibrinogen, high-density-lipoprotein cholesterol, homocysteine, triglycerides, tissue-type plasminogen-activator antigen, and C-relative protein, but adjustment for these altered the risk little. The risk of myocardial infarction associated with raised concentrations of sICAM-1 seemed to increase with length of follow-up.Interpretation Our data support the hypothesis that cellular mediators of inflammation have a role in atherogenesis and provide a clinical basis to consider antiadhesion therapies as a novel means of cardiovascular disease prevention.

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“have provided strong evidence for the association between elevated levels of soluble ICAM-1 and future coronary events [55].”
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The Effects of Raloxifene and Simvastatin on Plasma Lipids and Endothelium
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“[ 22 ]. Estrogen therapy reduces the levels of soluble adhesion molecules in both healthy [23] and coronary postmenopausal women [24‐26] whereas statins do not [27,28].”
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“Moreover, those with the highest levels of sICAM-1 are at the highest risk([30]); this observation raises the possibility that antiadhesion therapies may play a role in the prevention and treatment of coronary disease([31]).”
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Changes in biomarkers of cardiovascular risk after a switch to abacavir in HIV‐1‐infected individuals receiving combination antiretroviral therapy
Kristoffersen, U. S., Kofoed, K. F., Kronborg, G., Benfield, T., Kjær, A., & Lebech, A. (2009) · HIV Medicine · doi:10.1111/j.1468-1293.2009.00733.x · Cited by 34
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“In prospective studies, however, elevated sVCAM-1 levels were not related to cardiovascular risk events.19,28 This finding is in contrast to the results of other studies of CAMs, such as ICAM-1 and E-selectin.19,20 These differences may be because of the small sample sizes or the absence of information on complication…”
BackgroundResultInfluential
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“A large clinical study showed that baseline levels of soluble ICAM-1 were higher among patients who had suffered myocardial infarction than among those who had not.(38) The Atherosclerosis Risk in Communities study revealed that the relative risk of coronary artery disease among women and men in the highest quartile o…”
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“Systemic inflammation has been identified as one of the major pathophysiological mechanisms underlying life-threatening human diseases such as coronary heart disease and stroke (e.g., Danesh et al., 2000; Hansson, 2005; Pradhan et al., 2001; Ridker et al., 1998).”
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Thompson, J. E. S., Smith, W. T., Ware, L. J., Mels, C. M. C., van Rooyen, J. M., Huisman, H. W., Malan, L., Malan, N. T., Lammertyn, L., & Schutte, A. E. (2015) · Hypertension Research · doi:10.1038/hr.2015.123 · Cited by 31
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BackgroundResultInfluential

Authors: Ridker, P. M., Hennekens, C. H., Roitman-Johnson, B., Stampfer, M. J., & Allen, J.
Affiliations: Brigham and Women's Hospital (US)
R&D Systems (United States) (US)
Corresponding author: Ridker, Paul M
ORCID: Ridker, Paul M
Hennekens, Charles H
Stampfer, Meir J
Venue: The Lancet
Publisher: Elsevier BV
Published: 1998-01
Volume: 351
Issue: 9096
Pages: 88-92
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(97)09032-6
OpenAlex: W2138809584
Cited by: 1,229
References: 35
Citations by year: 2026: 7 · 2025: 10 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 16 · 2020: 17 · 2019: 23 · 2018: 14 · 2017: 28 · 2016: 27 · 2015: 25 · 2014: 38 · 2013: 27 · 2012: 36
FWCI: 26.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Keywords: soluble intercellular adhesion molecule-1, sICAM-1, myocardial infarction, atherosclerosis, inflammation, endothelial cell adhesion, anti-adhesion therapy, cardiovascular risk, fibrinogen, homocysteine, tissue plasminogen activator, C-reactive protein, healthy men, Physicians' Health Study
MeSH terms: Antioxidants, Arteriosclerosis, Aspirin, Double-Blind Method, Humans, Male, Middle Aged, Myocardial Infarction, Platelet Aggregation Inhibitors, Prospective Studies, Risk Factors, Multivariate Analysis, Case-Control Studies, Intercellular Adhesion Molecule-1, beta Carotene

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Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

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