Cited by 339Pain Management and Placebo EffectStatistical Methods in Clinical TrialsHistorical Medical Research and Treatments

The DOI matches its Crossref record; 42 of the 44 references it cites were found in a registry or an index.

‘Powerful Placebo: The Dark Side of the Randomised Controlled Trial’

Kaptchuk, Ted J·1998·The Lancet

DOI 10.1016/s0140-6736(97)10111-8

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(97)10111-8

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A history and theory of informed consent
Kapp, M. B. (1986) · Journal of Legal Medicine · doi:10.1080/01947648609513478 · Cited by 2,328
THE POWERFUL PLACEBO
Beecher, H. K. (1955) · JAMA · doi:10.1001/jama.1955.02960340022006 · Cited by 1,850
A history and theory of informed consent
Spiro, H. M. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90657-3 · Cited by 1,417
Harry M. Marks. The Progress of Experiment: Science and Therapeutic Reform in the United States, 1900–1990. (Cambridge History of Medicine.) New York: Cambridge University Press. 1997. Pp. xi, 258. $59.95
Parascandola, J., & Marks, H. M. (1999) · The American Historical Review · doi:10.2307/2650255 · Cited by 417
Concept of true and perceived placebo effects
Ernst, E., & Resch, K. (1995) · BMJ · doi:10.1136/bmj.311.7004.551 · Cited by 407
Guide to clinical trials
Spilker, B. (1991) · Cited by 322
Intentional Ignorance: A History of Blind Assessment and Placebo Controls in Medicine
Kaptchuk, T. J. (1998) · Bulletin of the history of medicine · doi:10.1353/bhm.1998.0159 · Cited by 315
Self-citation
The Clinical Trial
Hill, A. B. (1952) · New England Journal of Medicine · doi:10.1056/nejm195207242470401 · Cited by 256
EFFECTS OF SUGGESTION AND CONDITIONING ON THE ACTION OF CHEMICAL AGENTS IN HUMAN SUBJECTS—THE PHARMACOLOGY OF PLACEBOS 12
Wolf, S. (1950) · Journal of Clinical Investigation · doi:10.1172/jci102225 · Cited by 253
The power of nonspecific effects in healing: Implications for psychosocial and biological treatments
Roberts, A. H., Kewman, D., Mercier, L., & Hovell, M. (1993) · Clinical Psychology Review · doi:10.1016/0272-7358(93)90010-j · Cited by 190

Show all 44 references

Research works printed but not linked: 7

Anon, 1885, Placebos, Med Record, 27, 576
Pepper, 1945, A note on the placebo, Am J Pharm, 117, 409
Anon, 1954, The humble humbug, Lancet, ii, 321
Liberman, 1967, The elusive placebo reactor, Neuropsychopharm, 5, 557
Beecher, 1953, The effectiveness of placebo “reactors” and “non-reactors”, J Pharmacol Exp Ther, 109, 393
Evans, 1974, The placebo response in pain reduction, Adv Neurology, 4, 289
Kaptchuk, 1997, Legitimate evidence: randomized or otherwise, Advances, 13, 48

Sorted by citations

External validity of randomised controlled trials: “To whom do the results of this trial apply?”
Rothwell, P. M. (2005) · The Lancet · doi:10.1016/s0140-6736(04)17670-8 · Cited by 2,544
Influence of context effects on health outcomes: a systematic review
Blasi, Z. D., Harkness, E. F., Ernst, E., Georgiou, A., & Kleijnen, J. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04169-6 · Cited by 1,405
Biological, clinical, and ethical advances of placebo effects
Finniss, D. G., Kaptchuk, T. J., Miller, F. G., & Benedetti, F. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61706-2 · Cited by 1,309
Self-citation
Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome
Kaptchuk, T. J., Kelley, J. M., Conboy, L. A., Davis, R. B., Kerr, C. E., Jacobson, E. E., Kirsch, I., Schyner, R. N., Nam, B. H., Nguyen, L. T., et al. (2008) · BMJ · doi:10.1136/bmj.39524.439618.25 · Cited by 1,196
Self-citation
Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease
de la Fuente‐Fernández, R., Ruth, T. J., Sossi, V., Schulzer, M., Calne, D. B., & Stoessl, A. J. (2001) · Science · doi:10.1126/science.1060937 · Cited by 991
The Placebo Effect in Alternative Medicine: Can the Performance of a Healing Ritual Have Clinical Significance?
Kaptchuk, T. J. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-11-200206040-00011 · Cited by 619
Self-citation
The double-blind, randomized, placebo-controlled trial
Kaptchuk, T. J. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00347-4 · Cited by 595
Self-citation
Sham device v inert pill: randomised controlled trial of two placebo treatments
Kaptchuk, T. J., Stason, W. B., Davis, R. B., Legedza, A., Schnyer, R. N., Kerr, C. E., Stone, D. A., Nam, B. H., Kirsch, I., & Goldman, R. H. (2006) · BMJ · doi:10.1136/bmj.38726.603310.55 · Cited by 535
Self-citation
The Marfan Syndrome
Pyeritz, R. E. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.481 · Cited by 512
Set and setting, psychedelics and the placebo response: an extra-pharmacological perspective on psychopharmacology
Hartogsohn, I. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116677852 · Cited by 483
Placebos and painkillers: is mind as real as matter?
Colloca, L., & Benedetti, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1705 · Cited by 465
Do medical devices have enhanced placebo effects?
Kaptchuk, T. J., Goldman, P., Stone, D. A., & Stason, W. B. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00206-7 · Cited by 463
Self-citation
Effectiveness of manual therapies: the UK evidence report
Bronfort, G., Haas, M., Evans, R., Leininger, B., & Triano, J. (2010) · Chiropractic & Osteopathy · doi:10.1186/1746-1340-18-3 · Cited by 434
An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis
Sköldstam, L., Hagfors, L., & Johansson, G. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.3.208 · Cited by 409
Re: Should meta-analyses of interventions include observational studies in addition to randomized controlled trials? A critical examination of underlying principles.
Pereira, C., & Castilho, E. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwp016 · Cited by 365
Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma
Wechsler, M. E., Kelley, J. M., Boyd, I. O. E., Dutile, S., Marigowda, G., Kirsch, I., Israel, E., & Kaptchuk, T. J. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103319 · Cited by 341
Self-citation
Blinding and expectancy confounds in psychedelic randomized controlled trials
Muthukumaraswamy, S. D., Forsyth, A., & Lumley, T. (2021) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2021.1933434 · Cited by 324
Paradoxes in Acupuncture Research: Strategies for Moving Forward
Langevin, H. M., Wayne, P. M., MacPherson, H., Schnyer, R. N., Milley, R. J., Napadow, V., Lao, L., Park, J., Harris, R. E., Cohen, M. R., et al. (2010) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2011/180805 · Cited by 288
Use of placebo controls in the evaluation of surgery: systematic review
Wartolowska, K. A., Judge, A., Hopewell, S., Collins, P. G. S., Dean, B. J. F., Rombach, I., Brindley, D. A., Savulescu, J., Beard, D. J., & Carr, A. J. (2014) · BMJ · doi:10.1136/bmj.g3253 · Cited by 288
A prospective study of EUS-guided celiac plexus neurolysis for pancreatic cancer pain
Gunaratnam, N. T., Sarma, A. V., Norton, I. D., & Wiersema, M. J. (2001) · Gastrointestinal Endoscopy · doi:10.1067/mge.2001.117515 · Cited by 277
Can words hurt? Patient–provider interactions during invasive procedures
Lang, E. V., Hatsiopoulou, O., Koch, T., Berbaum, K. S., Lutgendorf, S. K., Kettenmann, E., Logan, H. L., & Kaptchuk, T. J. (2005) · Pain · doi:10.1016/j.pain.2004.12.028 · Cited by 280
Self-citation
The therapeutic misconception: problems and solutions.
Lidz, C. W., & Appelbaum, P. S. (2002) · PubMed · doi:10.1097/01.mlr.0000023956.25813.18 · Cited by 268
Genetics and the placebo effect: the placebome
Hall, K. T., Loscalzo, J., & Kaptchuk, T. J. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.02.009 · Cited by 281
Self-citation
Prescribing "placebo treatments": results of national survey of US internists and rheumatologists
Tilburt, J. C., Emanuel, E. J., Kaptchuk, T. J., Curlin, F. A., & Miller, F. G. (2008) · BMJ · doi:10.1136/bmj.a1938 · Cited by 265
Self-citation
The Placebo Effect: Illness and Interpersonal Healing
Miller, F. G., Colloca, L., & Kaptchuk, T. J. (2009) · Perspectives in biology and medicine · doi:10.1353/pbm.0.0115 · Cited by 254
Self-citation
Circular instead of hierarchical: methodological principles for the evaluation of complex interventions
Walach, H., Falkenberg, T., Fønnebø, V. M., Lewith, G. T., & Jonas, W. B. (2006) · BMC Medical Research Methodology · doi:10.1186/1471-2288-6-29 · Cited by 253
The Persuasive Appeal of Alternative Medicine
Kaptchuk, T. J., & Eisenberg, D. M. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-12-199812150-00011 · Cited by 248
Self-citation
Randomised controlled trial of a short course of traditional acupuncture compared with usual care for persistent non-specific low back pain
Thomas, K. J., MacPherson, H., Thorpe, L., Brazier, J. E., FITTER, M. J., Campbell, M. J., Roman, M., Walters, S. J., & Nicholl, J. P. (2006) · BMJ · doi:10.1136/bmj.38878.907361.7c · Cited by 240
Placebo effects: clinical aspects and neurobiology
Oken, B. S. (2008) · Brain · doi:10.1093/brain/awn116 · Cited by 237
Open versus hidden medical treatments: The patient's knowledge about a therapy affects the therapy outcome.
Benedetti, F., Maggi, G., Lopiano, L., Lanotte, M., Rainero, I., Vighetti, S., & Pollo, A. (2003) · Prevention & Treatment · doi:10.1037/1522-3736.6.1.61a · Cited by 221
Placebos and placebo effects in medicine: historical overview
de Craen, A. J. M., Kaptchuk, T. J., Tijssen, J. G. P., & Kleijnen, J. (1999) · Journal of the Royal Society of Medicine · doi:10.1177/014107689909201005 · Cited by 219
Self-citation
Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice
Kaptchuk, T. J., Hemond, C. C., & Miller, F. G. (2020) · BMJ · doi:10.1136/bmj.m1668 · Cited by 224
Self-citation
The placebo effect in neurological disorders
de la Fuente-Fernández, R., Schulzer, M., & Stoessl, A. J. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00038-8 · Cited by 187
The Therapeutic Misconception
Lidz, C. W., & Appelbaum, P. S. (2002) · Medical Care · doi:10.1097/00005650-200209001-00008 · Cited by 190
Psychophysical outcomes from a randomized pilot study of manual, electro, and sham acupuncture treatment on experimentally induced thermal pain
Kong, J., Fufa, D. T., Gerber, A. J., Rosman, I. S., Vangel, M. G., Gracely, R. H., & Gollub, R. L. (2004) · Journal of Pain · doi:10.1016/j.jpain.2004.10.005 · Cited by 180
Placebo studies and ritual theory: a comparative analysis of Navajo, acupuncture and biomedical healing
Kaptchuk, T. J. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0385 · Cited by 185
Self-citation
Acupuncture for musculoskeletal pain: A meta-analysis and meta-regression of sham-controlled randomized clinical trials
Yuan, Q., Wang, P., Liu, L., Sun, F., Cai, Y., Wu, W., Ye, M.-L., Ma, J., Xu, B.-B., & Zhang, Y. (2016) · Scientific Reports · doi:10.1038/srep30675 · Cited by 185
Expectations and associations that heal: Immunomodulatory placebo effects and its neurobiology
Pacheco‐López, G., Engler, H., Niemi, M., & Schedlowski, M. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.05.003 · Cited by 165
Expectancy and treatment interactions: A dissociation between acupuncture analgesia and expectancy evoked placebo analgesia
Kong, J., Kaptchuk, T. J., Polich, G. R., Kirsch, I., Vangel, M. G., Zyloney, C. E., Rosen, B. R., & Gollub, R. L. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.025 · Cited by 161
Self-citation
“Maybe I Made Up the Whole Thing”: Placebos and Patients’ Experiences in a Randomized Controlled Trial
Kaptchuk, T. J., Shaw, J. E., Kerr, C. E., Conboy, L. A., Kelley, J. M., Csordas, T. J., Lembo, A. J., & Jacobson, E. (2009) · Culture Medicine and Psychiatry · doi:10.1007/s11013-009-9141-7 · Cited by 165
Self-citation
Placebo effect studies are susceptible to response bias and to other types of biases
Hróbjartsson, A., Kaptchuk, T. J., & Miller, F. G. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.01.008 · Cited by 150
“Beecher saw placebo effects as a major source of bias in the assessment of treatment efficacy and his chief purpose in publicizing such a potential threat was to advocate for placebo-controlled trials [2].”
BackgroundSelf-citation
Do “placebo responders” exist?
Kaptchuk, T. J., Kelley, J. M., Deykin, A., Wayne, P. M., Lasagna, L. C., Epstein, I. O., Kirsch, I., & Wechsler, M. E. (2008) · Contemporary Clinical Trials · doi:10.1016/j.cct.2008.02.002 · Cited by 150
Self-citation
The Efficacy Paradox in Randomized Controlled Trials of CAM and Elsewhere: Beware of the Placebo Trap
Walach, H. (2001) · The Journal of Alternative and Complementary Medicine · doi:10.1089/107555301300328070 · Cited by 147
Pain, placebo, and test of treatment efficacy: a narrative review
Vase, L., & Wartolowska, K. A. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.01.040 · Cited by 151
The Placebo Effect of Artificial Intelligence in Human–Computer Interaction
Kosch, T., Welsch, R., Chuang, L., & Schmidt, A. (2022) · ACM Transactions on Computer-Human Interaction · doi:10.1145/3529225 · Cited by 137
Placebo Effects in Oncology
Chvetzoff, G., & Tannock, I. F. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.1.19 · Cited by 130
Challenges and Recommendations for Placebo Controls in Randomized Trials in Physical and Rehabilitation Medicine
Fregni, F., Imamura, M., Chien, H. F., Lew, H. L., Boggio, P. S., Kaptchuk, T. J., Riberto, M., Hsing, W. T., Battistella, L. R., & Furlan, A. D. (2010) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0b013e3181bc0bbd · Cited by 118
Self-citation
The “placebo” response in osteoarthritis and its implications for clinical practice
Doherty, M., & Dieppe, P. A. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.03.023 · Cited by 120
A meta‐analysis of the placebo response in complementary and alternative medicine trials of irritable bowel syndrome
Dorn, S. D., Kaptchuk, T. J., Park, J. B., Nguyen, L. T., Canenguez, K., Nam, B. H., Woods, K. B., Conboy, L. A., Stason, W. B., & Lembo, A. J. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00937.x · Cited by 119
Self-citation
Distinct neural representations of placebo and nocebo effects
Freeman, S., Yu, R., Egorova, N., Chen, X., Kirsch, I., Claggett, B., Kaptchuk, T. J., Gollub, R. L., & Kong, J. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.03.015 · Cited by 116
“There is an increasing body of literature suggesting that placebo effects can enhance the therapeutic benefits of care through the context in which the treatment is administered (Brody and Miller, 2011; Cleophas, 1995; de la Fuente-fernandex et al., 2002; Di Blasi et al., 2001; Finniss et al., 2010; Kaptchuk, 1998; Pr…”
BackgroundSelf-citation
Massage Therapy for Osteoarthritis of the Knee: A Randomized Dose-Finding Trial
Perlman, A. I., Ali, A., Njike, V. Y., Hom, D. L., Davidi, A., Gould-Fogerite, S., Milak, C., & Katz, D. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030248 · Cited by 120
Acupuncture for Chronic Low Back Pain
Cho, Y.-J., Song, Y.-K., Cha, Y.-Y., Shin, B., Shin, I.-H., Park, H., Lee, H., Kim, K., Cho, J., Chung, W., et al. (2012) · Spine · doi:10.1097/brs.0b013e318275e601 · Cited by 110
Placebo and Nocebo in Interventional Pain Management: A Friend or a Foe – Or Simply Foes?
Manchikanti, L. (2011) · Pain Physician · doi:10.36076/ppj.2011/14/e157 · Cited by 96
The ethics of the placebo in clinical practice
Lichtenberg, P., Heresco‐Levy, U., & Nitzan, U. (2004) · Journal of Medical Ethics · doi:10.1136/jme.2002.002832 · Cited by 104
Reconsidering the Placebo Response from a Broad Anthropological Perspective
Thompson, J. J., Ritenbaugh, C., & Nichter, M. (2009) · Culture, Medicine, and Psychiatry · doi:10.1007/s11013-008-9122-2 · Cited by 159
Treatment utilization for endometriosis symptoms: a cross-sectional survey study of lifetime experience
Sinaii, N., Cleary, S. D., Younes, N., Ballweg, M. L., & Stratton, P. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.051 · Cited by 96
Placebo in clinical trials
Gupta, U., & Verma, M. (2013) · Perspectives in Clinical Research · doi:10.4103/2229-3485.106383 · Cited by 112
Expectancy effect: Impact of pill administration on cognitive performance in healthy seniors
Oken, B., Flegal, K. E., Zajdel, D. P., Kishiyama, S. S., Haas, M., & Peters, D. (2007) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390701775428 · Cited by 89
On the problems of mixing RCTs with qualitative research: the case of the MRC framework for the evaluation of complex healthcare interventions
Blackwood, B., O’Halloran, P. D., & Porter, S. (2010) · Journal of research in nursing · doi:10.1177/1744987110373860 · Cited by 91
Evidence for placebo effects on physical but not on biochemical outcome parameters: a review of clinical trials
Meißner, K., Distel, H., & Mitzdorf, U. (2007) · BMC Medicine · doi:10.1186/1741-7015-5-3 · Cited by 86
Complementary Therapies in Pediatrics: A Legal Perspective
Cohen, M. H., & Kemper, K. J. (2005) · PEDIATRICS · doi:10.1542/peds.2004-1093 · Cited by 83
Placebos, Placebo Effect, and the Response to the Healing Situation: The Evolution of a Concept
Papakostas, Y. G., & Daras, M. D. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.41601.x · Cited by 78
Placebo Research: The Evidence Base for Harnessing Self-Healing Capacities
Walach, H., & Jonas, W. B. (2004) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2004.10.s-103 · Cited by 75
Patient expectations in placebo‐controlled randomized clinical trials
Stone, D. A., Kerr, C. E., Jacobson, E., Conboy, L. A., & Kaptchuk, T. J. (2005) · Journal of Evaluation in Clinical Practice · doi:10.1111/j.1365-2753.2004.00512.x · Cited by 77
Self-citation
Clinical Use of Placebo Effects in Patients With Pain Disorders
Klinger, R., Stuhlreyer, J., Schwartz, M., Schmitz, J., & Colloca, L. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.015 · Cited by 79
Context Effects
Blasi, Z. D., & Kleijnen, J. (2003) · Evaluation & the Health Professions · doi:10.1177/0163278703026002003 · Cited by 71
Comparative Efficacy of Eletriptan and Zolmitriptan in the Acute Treatment of Migraine
Steiner, T., Diener, H., MacGregor, E. A., Schoenen, J. E., Muirhead, N., & Sikes, C. R. (2003) · Cephalalgia · doi:10.1046/j.1468-2982.2003.00617.x · Cited by 71
Users' guide to the surgical literature. How to assess a randomized controlled trial in surgery.
Thoma, A., Farrokhyar, F., Bhandari, M., & Tandan, V. (2004) · PubMed Central · Cited by 70
Holistic Pediatrics: A Research Agenda
Kemper, K. J., Cassileth, B. R., & Ferris, T. G. G. (1999) · PEDIATRICS · doi:10.1542/peds.103.s1.902 · Cited by 70
Placebos: A Review of The Placebo Response
Thompson, G. W. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02179.x · Cited by 69
Chronic pediatric asthma and chiropractic spinal manipulation: A prospective clinical series and randomized clinical pilot study
Brønfort, G., Evans, R., Kubic, P., & Filkin, P. (2001) · Journal of Manipulative and Physiological Therapeutics · doi:10.1067/mmt.2001.116417 · Cited by 66
An index of patient reported outcomes (PRO-Index) discriminates effectively between active and control treatment in 4 clinical trials of adalimumab in rheumatoid arthritis.
Pincus, T., Chung, C. P., Segurado, O. G., Amara, I. A., & Koch, G. G. (2006) · PubMed · Cited by 63
Acupuncture outcomes, expectations, patient-provider relationship, and the placebo effect: implications for health promotion.
So, D. W. (2002) · American Journal of Public Health · doi:10.2105/ajph.92.10.1662 · Cited by 62
Response to placebo in clinical epilepsy trials—Old ideas and new insights
Goldenholz, D. M., & Goldenholz, S. R. (2016) · Epilepsy Research · doi:10.1016/j.eplepsyres.2016.02.002 · Cited by 63
A Randomized Trial Investigating a Chiropractic Manual Placebo: A Novel Design Using Standardized Forces in the Delivery of Active and Control Treatments
Hawk, C., Long, C. R., Rowell, R. M., Gudavalli, M. R., & Jedlicka, J. (2005) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2005.11.109 · Cited by 62
The Association Between Psychopathology and Placebo Analgesia in Patients with Discogenic Low Back Pain
Wasan, A. D., Kaptchuk, T. J., Davar, G., & Jamison, R. N. (2006) · Pain Medicine · doi:10.1111/j.1526-4637.2006.00154.x · Cited by 61
Self-citation
Go open: A plea for transparency in psychotherapy.
Gaab, J., Blease, C. R., Locher, C., & Gerger, H. (2015) · Psychology of Consciousness Theory Research and Practice · doi:10.1037/cns0000063 · Cited by 63
The effect of a biscuit with red palm oil as a source of β-carotene on the vitamin A status of primary school children: a comparison with β-carotene from a synthetic source in a randomised controlled trial
van Stuijvenberg, M., Dhansay, M., Lombard, C. J., Faber, M., & Benadé, A. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601196 · Cited by 60
Evaluating preference effects in partially unblinded, randomized clinical trials
Halpern, S. D. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00598-x · Cited by 59
Placebo controls: historical, methodological and general aspects
Walach, H. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0401 · Cited by 58
American Acupuncture and Efficacy: Meanings and Their Points of Insertion
Barnes, L. L. (2005) · Medical Anthropology Quarterly · doi:10.1525/maq.2005.19.3.239 · Cited by 57
Open-label versus double-blind placebo treatment in irritable bowel syndrome: study protocol for a randomized controlled trial
Ballou, S., Kaptchuk, T. J., Hirsch, W., Nee, J. W., Iturrino, J., Hall, K. T., Kelley, J. M., Cheng, V., Kirsch, I., Jacobson, E., et al. (2017) · Trials · doi:10.1186/s13063-017-1964-x · Cited by 56
Self-citation
Issues in Planning a Placebo-Controlled Trial of Manual Methods: Results of a Pilot Study
Hawk, C., Long, C., Reiter, R., Davis, C. S., Cambron, J., & Evans, R. (2002) · Journal of Alternative and Complementary Medicine · doi:10.1089/107555302753507159 · Cited by 61
Method as Argument: Boundary Work in Evidence‐Based Medicine
Derkatch, C. (2008) · Social Epistemology · doi:10.1080/02691720802559412 · Cited by 53
A randomised-controlled trial in Sweden of acupuncture and care interventions for the relief of inflammatory symptoms of the breast during lactation
Kvist, L. J., Hall‐Lord, M., Rydhstroem, H., & Wilde‐Larsson, B. (2006) · Midwifery · doi:10.1016/j.midw.2006.02.003 · Cited by 53
Which patients improve: Characteristics increasing sensitivity to a supportive patient–practitioner relationship
Conboy, L. A., Macklin, E. A., Kelley, J. M., Kokkotou, E. G., Lembo, A. J., & Kaptchuk, T. J. (2009) · Social Science & Medicine · doi:10.1016/j.socscimed.2009.10.024 · Cited by 53
Self-citation
The sweetest pill to swallow: How patient neurobiology can be harnessed to maximise placebo effects
Jubb, J., & Bensing, J. M. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.09.006 · Cited by 52
Open-label placebos—a systematic review and meta-analysis of experimental studies with non-clinical samples
Spille, L., Fendel, J. C., Seuling, P. D., Göritz, A. S., & Schmidt, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-30362-z · Cited by 51
Treating Individuals 1 - External validity of randomised controlled trials: "To whom do the results of this trial apply?"'
Rothwell, P. M. (2005) · The Lancet · Cited by 50
Sex and Gender in Adverse Drug Events, Addiction, and Placebo
Franconi, F., Campesi, I., Occhioni, S., Antonini, P., & Murphy, M. F. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3_6 · Cited by 49
Informed Consent in Cross-cultural Perspective: Clinical Research in the Tibetan Autonomous Region, PRC
Adams, V., Miller, S., Craig, S. R., Sonam, S., Nyima, Droyoung, Le, P. V., & Varner, M. W. (2007) · Culture Medicine and Psychiatry · doi:10.1007/s11013-007-9070-2 · Cited by 48
Study design considerations for irritable bowel syndrome clinical trials.
Miller, L. E. (2014) · Europe PMC (PubMed Central) · Cited by 48
When and Why Placebo-Prescribing Is Acceptable and Unacceptable: A Focus Group Study of Patients' Views
Bishop, F. L., Aizlewood, L., & Adams, A. E. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101822 · Cited by 47
The powerful placebo effect in osteoarthritis.
Zhang, W. (2019) · PubMed · Cited by 47
Self-help advice as a process integral to traditional acupuncture care: Implications for trial design
MacPherson, H., & Thomas, K. J. (2008) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2008.02.010 · Cited by 45
The Many Meanings of the Placebo Effect: Where They Came From, Why They Matter
Harrington, A. (2006) · BioSocieties · doi:10.1017/s1745855206050216 · Cited by 47
Placebo Effects in Acupuncture
Kaptchuk, T. J. (2020) · Medical Acupuncture · doi:10.1089/acu.2020.1483 · Cited by 44
Self-citation
Placebo response in binge eating disorder
Jacobs-Pilipski, M. J., Wilfley, D. E., Crow, S. J., Walsh, B. T., Lilenfeld, L., West, D. S., Berkowitz, R. I., Hudson, J. I., & Fairburn, C. G. (2006) · International Journal of Eating Disorders · doi:10.1002/eat.20287 · Cited by 44
The placebo effect of human augmentation: Anticipating cognitive augmentation increases risk-taking behavior
Villa, S., Kosch, T., Grelka, F., Schmidt, A., & Welsch, R. (2023) · Computers in Human Behavior · doi:10.1016/j.chb.2023.107787 · Cited by 49
Why Not Call Modern Medicine "Alternative"?
Bates, D. G. (2000) · Perspectives in biology and medicine · doi:10.1353/pbm.2000.0032 · Cited by 42

Authors: Kaptchuk, T. J.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Kaptchuk, Ted J
ORCID: Kaptchuk, Ted J
Venue: The Lancet
Publisher: Elsevier BV
Published: 1998-06
Volume: 351
Issue: 9117
Pages: 1722-1725
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(97)10111-8
OpenAlex: W2146129917
Cited by: 339
References: 44
Citations by year: 2026: 4 · 2025: 6 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 5 · 2020: 12 · 2019: 8 · 2018: 11 · 2017: 12 · 2016: 8 · 2015: 17 · 2014: 15 · 2013: 16 · 2012: 18
FWCI: 5.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
DigitalGeorgetown (Georgetown University Library) (submittedVersion)
Funders: Fetzer Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (U24 AR3441)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
Keywords: placebo, placebo effect, placebo ethics, efficacy evaluation
MeSH terms: Double-Blind Method, Ethics, Medical, Humans, Placebos, Placebo Effect, Randomized Controlled Trials as Topic, Risk Assessment, Paternalism, Control Groups, Research Subjects, Biomedical Research, History, 20th Century

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

‘Powerful Placebo: The Dark Side of the Randomised Controlled Trial’

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks