The DOI matches its Crossref record, with a small difference in title or year; 31 of the 31 references it cites were found in a registry or an index.
Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study
Abstract
Background The lignan enterolactone, produced by the intestinal microflora from dietary precursors, has been implicated in protection against cancer. We investigated the association of serum enterolactone concentration with the risk of acute coronary events in a prospective nested case-control study in middle-aged men from eastern Finland.Methods Enterolactone was measured by time-resolved fluoroimmunoassay in serum from 167 men who had an average 7.7 years of follow-up to an acute coronary event and from 167 control men. Both cases and controls were from a cohort of 2005 men who had no clinical coronary heart disease (CHD) at baseline. The controls were matched for age, examination year, and residence. Acute coronary events were registered prospectively.Findings The mean baseline serum enterolactone concentration was lower among the cases than the controls (18.2 [SD 21.1] vs 23.5 [18.2] nmol/L, p=0.001). The men in the highest quarter of the enterolactone distribution (>30.1 nmol/L) had a 58.8% (95% CI 24.1-77.6, p=0.005) lower risk of acute coronary events than men in the lowest quarter. After adjustment for the nine most strongly predictive risk factors, men in the highest enterolactone quarter had a 65.3% (11.9-86.3, p=0.03) lower risk than men in the lowest quarter.Interpretation Healthy men with high serum concentrations of enterolactone had a lower risk of acute coronary events than men with lower concentrations. These findings support the hypothesis that plant-dominated fibre-rich food lowers the risk of CHD.
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“Most studies18–25,27–35 used centralized adjudication processes or registry linkage rather than self-report alone in ascertaining events, reducing information bias.”
From ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies (2016) · cites this paper as [25]
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Self-citationPhyto-oestrogens and Western Diseases
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Self-citationCase-control study of phyto-oestrogens and breast cancer
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Self-citationDiet and 20-Year Mortality from Coronary Heart Disease
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Metadata
- Authors
- Vanharanta, M., Voutilainen, S., Lakka, T. A., van der Lee, M., Adlercreutz, H., & Salonen, J. T.
- Affiliations
- University of Eastern Finland (FI)
- University of Helsinki (FI)
- Corresponding author
- Salonen, Jukka T
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 354
- Issue
- 9196
- Pages
- 2112-2115
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2090905087
- Cited by
- 246
- References
- 31
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 8 · 2016: 7 · 2015: 3 · 2014: 7 · 2013: 6 · 2012: 12
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 44199)
- Academy of Finland (1041086, 41471, 2041022)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant-derived Lignans Synthesis and Bioactivity
- Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Lignin and Wood Chemistry
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- enterolactone, acute coronary events, coronary artery disease, serum biomarkers, lignans, dietary fiber, plant-based diet, gut microbiota, cardiovascular risk, middle-aged men
- MeSH terms
- Analysis of Variance, Blood Pressure, Cholesterol, Coronary Disease, Diet, Finland, Humans, Life Style, Male, Middle Aged, Prospective Studies, Risk Factors, Smoking, 4-Butyrolactone, Fluoroimmunoassay, Case-Control Studies, Lignans
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