In vitro hydrolysis of blends from enantiomeric poly(lactide)s. Part 4: well-homo-crystallized blend and nonblended films
Abstract
Well-homocrystallized enantiomeric blend and nonblended films were prepared from poly(L-lactide), i.e., poly(L-lactic acid) (PLLA) and poly(D-lactide), i.e., poly(D-lactic acid) (PDLA) by crystallization from the melt. The effects of enantiomeric blending on the in vitro autocatalytic hydrolysis of the homo-crystallized polylactide, i.e., poly(lactic acid) (PLA) films were investigated in phosphate-buffered solution (pH 7.4) at 37 degrees C for up to 24 months. In the period of 0-12 months, the effects of enantiomeric polymer blending on the autocatalytic hydrolysis were very small. This finding reflects that in the PLLA/PDLA blend film separate homo-crystallization of PLLA and PDLA into the respective crystallites reduced the peculiar strong interaction between PLLA and PDLA chains in the amorphous region between the homo-crystalline regions. In the period of 12-24 months, enantiomeric polymer blending significantly retarded the autocatalytic hydrolysis of the PLLA/PDLA blend film compared with that of the nonblended PLLA and PDLA films. This is attributable to the increased chain mobility and the reduced entanglement effects due to the chain cleavage to a great extent, resulting in the enhanced interaction between PLLA and PDLA chains. It was also revealed that the hydrolyzabilities of the PLA films can be widely varied by enantiomeric polymer blending, crystalline species and their amounts, and molecular weight.
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Pure PLLA displayed a small amount of degradation after 30 days, with a degradation rate comparable with previous works.
“Pure PLLA displayed a small amount of degradation, with a degradation rate comparable with previous works [36, 37]”
From Tuning structural relaxations, mechanical properties, and degradation timescale of PLLA during hydrolytic degradation by blending with PLCL-PEG (2019) · cites this paper as [36]
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- Authors
- Tsuji, H.
- Affiliations
- Toyohashi University of Technology (JP)
- Corresponding author
- Tsuji, Hideto
- ORCID
- Tsuji, Hideto
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 24
- Issue
- 4
- Pages
- 537-547
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2084749443
- Cited by
- 145
- References
- 39
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 10 · 2015: 7 · 2014: 7 · 2013: 11 · 2012: 7
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer crystallization and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- poly(L-lactic acid), poly(D-lactide), in vitro hydrolysis, autocatalytic hydrolysis, biodegradation, chain mobility, entanglement, molecular weight effects, polylactide films
- MeSH terms
- Biocompatible Materials, Calorimetry, Differential Scanning, Crystallization, Hydrolysis, Molecular Weight, Polyesters, Polymers, Lactic Acid, In Vitro Techniques
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