Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation
Abstract
An experimental investigation was undertaken to measure the intrinsic elastic properties of several of the microstructural components of human vertebral trabecular bone and tibial cortical bone by the nanoindentation method. Specimens from two thoracic vertebrae (T-12) and two tibiae were obtained from frozen, unembalmed human male cadavers aged 57 and 61 years. After drying and mounting in epoxy resin nanoindentation tests were conducted to measure Young's modulus and the hardness of individual trabeculae in the vertebrae and single osteons, and interstitial lamellae in the tibiae. Measurements on the vertebral trabeculae were made in the transverse direction, and the average Young's modulus was found to be 13.5 +/- 2.0 GPa. The tibial specimens were tested in the longitudinal direction, yielding moduli of 22.5 +/- 1.3 GPa for the osteons and 25.8 +/- 0.7 GPa for the interstitial lamellae. Analysis of variance showed that the differences in the measured moduli are statistically significant. Hardness differences among the various microstructural components were also observed.
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Elastic moduli measured by nanoindentation are on the order of 23 GPa and 26 GPa for osteonal and interstitial lamellae, respectively, in the longitudinal direction.
“Elastic moduli measured by nanoindentation are on the order of 23 GPa and 26 GPa for osteonal and interstitial lamellae, respectively, in the longitudinal direction (36, 37)”
From Bone Mechanical Properties in Healthy and Diseased States (2018) · cites this paper as [36]
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“Elastic moduli measured by nanoindentation are on the order of 23 GPa and 26 GPa for osteonal and interstitial lamellae, respectively, in the longitudinal direction (36, 37), and are approximately 45% lower in the transverse direction (37).”
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- Authors
- Rho, J.-Y., Tsui, T. Y., & Pharr, G. M.
- Affiliations
- University of Memphis (US)
- Rice University (US)
- Corresponding author
- Rho, Jae-Young
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 18
- Issue
- 20
- Pages
- 1325-1330
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2016256338
- Cited by
- 924
- References
- 28
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 22 · 2023: 25 · 2022: 33 · 2021: 31 · 2020: 46 · 2019: 46 · 2018: 45 · 2017: 49 · 2016: 38 · 2015: 48 · 2014: 55 · 2013: 34 · 2012: 56
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Physical Sciences › Engineering › Mechanics of Materials › Metal and Thin Film Mechanics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- trabecular bone, cortical bone, lamellar bone, Young's modulus, hardness, nanoindentation, osteons, human bone, bone microarchitecture, tibia, thoracic vertebrae
- MeSH terms
- Elasticity, Humans, Male, Microchemistry, Middle Aged, Spine, Tibia
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