The DOI matches its Crossref record; 110 of the 111 references it cites were found in a registry or an index.
Puberty and the maturation of the male brain and sexual behavior: recasting a behavioral potential
Abstract
The pubertal transition from the juvenile to adult state requires significant changes in behavior to meet the demands for success and survival in adulthood. These behavioral changes during puberty must be mediated by changes in the structure and/or function of the central nervous system. Despite the profound consequences of puberty on an animal's behavioral repertoire, the mechanisms underlying pubertal maturation of the nervous system remain largely unknown. In this review, we provide a synthesis of neural development during puberty as it relates to maturation of male reproductive behavior. We first outline neuroendocrine events associated with puberty and review work from our laboratory that identifies pubertal changes in the neural substrate controlling male reproduction by comparing the neural responses of prepubertal and adult males to steroids and female chemosensory cues. We then raise the question of whether puberty is a sensitive period in which gonadal hormones influence the structural and functional organization of neural circuits underlying male reproductive behavior. The central thesis of this review is that the development of the nervous system during puberty alters the way in which the male responds to social stimuli, involving the restructuring of neural circuits that integrate steroidal and sensory information and ultimately mediate steroid-dependent social behaviors in adulthood.
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“For instance, in male Syrian hamsters, it is well-established how pubertal hormones influence the structure and function of neural circuits that integrate steroidal and sensory information, and how these changing neural circuits alter the way males respond to social stimuli and engage in mating behaviors (Romeo et al., 2002).”
From Becoming a sexual being: The “elephant in the room” of adolescent brain development (2017) · cites this paper as Romeo et al., 2002
Citations
Cites
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Research works printed but not linked: 10
- Plant, 1994, Puberty in primates, vol. 2, 453
- Foster, 1994, Puberty in the sheep, vol. 2, 411
- Ojeda, 1994, Puberty in the rat, vol. 2, 363
- Richardson, 2001, Puberty and steroid regulation of gonadotropin releasing hormone (GnRH) mRNA, Soc Neurosci Abstr, 27
- Romeo, 2001, The role of progesterone in the pubertal maturation of male sexual behavior, Soc Neurosci Abstr, 27
- Parfitt, 1999, Differential neuroendocrine responses to female pheromones in juvenile and adult male Syrian hamsters, Soc Neurosci Abstr, 25, 1453
- Schulz, 2001, Female pheromones elicit a dopaminergic response in the medial preoptic area (MPOA) in adult but not prepubertal male Syrian hamsters, Soc Neurosci Abstr, 27
- Richardson, 2000, Dopaminergic regulation of reproductive behavior in male Syrian hamsters, Soc Neurosci Abstr, 26, 210
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Cited by
Sorted by citations
The neural basis of puberty and adolescence
Sisk, C. L., & Foster, D. L. (2004) · Nature Neuroscience · doi:10.1038/nn1326 · Cited by 1,085
Pubertal hormones organize the adolescent brain and behavior
Sisk, C. L., & Zehr, J. L. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.003 · Cited by 1,082
“The scientiWc literature on adolescent behavior in animals and humans has been reviewed from a number of diVerent perspectives, and the reader is referred to these papers for comprehensive treatment and analysis of this topic [1,3,19,23,26,67,96, 99,111,120,121].”
BackgroundSelf-citationNELSON, E. E., LEIBENLUFT, E., McCLURE, E. B., & PINE, D. S. (2005) · Psychological Medicine · doi:10.1017/s0033291704003915 · Cited by 1,075
“The regions that make up the affective node are densely innervated by gonadal steroid receptors and undergo both functional and anatomical reorganization during puberty (Geidd et al. 1997; McEwen, 2001; Osterlund & Hurd, 2001; Romeo et al. 2002; Stevens, 2002).”
BackgroundSomerville, L. H., Jones, R. M., & Casey, B. J. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.07.003 · Cited by 1,025
Strategies and Methods for Research on Sex Differences in Brain and Behavior
Becker, J. B., Arnold, A. P., Berkley, K. J., Blaustein, J. D., Eckel, L. A., Hampson, E., Herman, J. P., Marts, S. A., Sadée, W., Steiner, M. S., et al. (2004) · Endocrinology · doi:10.1210/en.2004-1142 · Cited by 833
“In some cases, for example, steroids acting during puberty may have persistent effects on traits measured later in life (45, 46).”
Background
Metadata
- Authors
- Romeo, R. D., Richardson, H. N., & Sisk, C. L.
- Affiliations
- Michigan State University (US)
- Corresponding author
- Sisk, Cheryl L.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 26
- Issue
- 3
- Pages
- 381-391
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2095232389
- Cited by
- 152
- References
- 111
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 12 · 2015: 9 · 2014: 10 · 2013: 13 · 2012: 4
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-26483, R01HD026483)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- puberty, male reproductive behavior, brain maturation, neuroendocrine regulation, sex steroids, neural circuits, sensitive period, social behavior, prepubertal males
- MeSH terms
- Androgens, Animals, Brain, Hormones, Humans, Male, Puberty, Sexual Behavior, Sexual Behavior, Animal
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