Puberty: a period of both organizational and activational effects of steroid hormones on neurobehavioural development

Romeo, R. D.

doi:10.1111/j.1365-2826.2003.01106.x

Cited by 233Hypothalamic control of reproductive hormonesSexual Differentiation and DisordersNeuroendocrine regulation and behavior

Puberty: a period of both organizational and activational effects of steroid hormones on neurobehavioural development

Romeo, R. D.·2003·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2003.01106.x

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Abstract

During perinatal development, steroid hormones act on the central nervous system (CNS) to organize neural circuits. These circuits remain relatively dormant until hormonal stimulation received in adulthood acts on the CNS to activate adult reproductive physiology and behaviour. In this review, the proposal is put forward that, in addition to perinatal development, puberty serves as another period of neural maturation mediated by both steroid-dependent and -independent events that further organize and shape the behavioural potential of the adult organism. In support of this thesis, data are summarized that clearly show the organizational effects of the pubertal rise in gonadal hormones on mating behaviour and other steroid-mediated behaviours exhibited in adulthood, and on the neural pathways that mediate these behaviours. The importance of determining whether this sensitive period of neural development during puberty is a 'critical period' is also discussed, as well as whether perturbations of the nervous system during pubertal development may result in negative behavioural and physiological outcomes in adulthood. It is concluded that puberty is not merely a time when increasing levels of gonadal steroids activate the neural circuits organized during perinatal development, but also a time of further organization of the CNS, which allows for appropriate behaviours to emerge in adulthood.

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Increases in estradiol and progesterone contribute to remodeling and activation of neural circuitry for both males and females during puberty.
“In addition to testosterone, increases in estradiol and progesterone contribute to remodeling and activation of neural circuitry for both males and females during puberty.”
From Becoming a sexual being: The “elephant in the room” of adolescent brain development (2017) · cites this paper as Romeo, 2003
Both estradiol and progesterone play important roles in sexual, social, and risk-taking behavior.
“Both estradiol and progesterone have been found to play important roles in sexual, social, and risk-taking behavior”
From Becoming a sexual being: The “elephant in the room” of adolescent brain development (2017) · cites this paper as Romeo, 2003

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Authors: Romeo, R. D.
Affiliations: Rockefeller University (US)
Corresponding author: Romeo, R. D.
ORCID: Romeo, R. D.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2003-11-25
Volume: 15
Issue: 12
Pages: 1185-1192
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2003.01106.x
OpenAlex: W2058104566
Cited by: 233
References: 62
Citations by year: 2026: 5 · 2025: 2 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 13 · 2020: 7 · 2019: 9 · 2018: 5 · 2017: 16 · 2016: 12 · 2015: 9 · 2014: 13 · 2013: 24 · 2012: 7
FWCI: 1.28
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: puberty, steroid hormones, organizational effects, activational effects, gonadal hormones, mating behavior, neural circuit maturation, critical period, perinatal development, reproductive behavior, neural pathways
MeSH terms: Animals, Critical Period, Psychological, Sexual Behavior, Animal, Gonadal Steroid Hormones, Sexual Maturation

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Puberty: a period of both organizational and activational effects of steroid hormones on neurobehavioural development

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