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Cited by 112Glaucoma and retinal disordersHeat shock proteins researchOcular Diseases and Behçet’s Syndrome

Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United States

Wax, M·2001·Ophthalmology
DOI 10.1016/s0161-6420(00)00525-x
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Abstract

Objective To study serum titers of antibodies against heat shock proteins in glaucoma patients from two different ethnic populations and to examine the relationship between serum antibody titers and glaucomatous damage.Study design Comparative, cross-sectional study.Participants Twenty-seven age-matched patients with primary open-angle glaucoma, 28 patients with normal pressure glaucoma, and a control group of 26 healthy subjects from Japan; and 21 age-matched patients with primary open-angle glaucoma, 40 patients with normal pressure glaucoma, and a control group of 20 healthy subjects from the United States.Main outcome measures Measurement of serum antibody titers and examination of optic disc and visual field parameters.Methods Serum immunoreactivity against heat shock proteins, including hsp27, alphaB-crystallin, and human and bacterial hsp60, was studied by enzyme-linked immunosorbent assay (ELISA). The relationship of serum antibody titers to glaucoma parameters, including mean deviation, neural rim area-to-disc area ratio, and peripapillary atrophy area-to-disc area ratio was examined.Results The serum ELISA titers of antibodies, including hsp27, alphaB-crystallin, human hsp60, and bacterial hsp60 antibodies, were higher in glaucoma patients compared with control subjects in both the Japanese and American groups (P: < 0.05). There was no association between the serum antibody titers and optic disc parameters in either group from Japan or the United States (P: > 0.05).Conclusions These findings suggest that increased titers of circulating antibodies against heat shock proteins occur in both Japanese and American patients with glaucoma. The lack of a relationship between the level of serum antibody titers and the degree of glaucomatous damage in either ethnic group suggests that increased antibodies to heat shock proteins do not occur as an epiphenomenon of the glaucomatous neurodegeneration process.

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Authors
Wax, M.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Wax, M
Venue
Ophthalmology
Publisher
Elsevier BV
Published
2001-02
Volume
108
Issue
2
Pages
296-302
ISSN
0161-6420 (ISSN-L)
DOI
10.1016/s0161-6420(00)00525-x
OpenAlex
W2114126399
Cited by
112
References
32
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 5
FWCI
2.96
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Eye Institute (R01EY012314, EY 12314)
Topics
  • Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
glaucoma, heat shock proteins, autoantibodies, primary open-angle glaucoma, normal-tension glaucoma, HSP27, alphaB-crystallin, HSP60, optic disc damage, peripapillary atrophy, glaucomatous neurodegeneration, ethnic differences, Japanese patients, United States patients
MeSH terms
Aged, Autoantibodies, Cross-Sectional Studies, Crystallins, Enzyme-Linked Immunosorbent Assay, Female, Glaucoma, Open-Angle, Heat-Shock Proteins, Humans, Intraocular Pressure, Japan, Male, Middle Aged, Optic Disk, United States, Visual Fields, Chaperonin 60

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