Heat shock proteins, immunity and glaucoma

Tezel, Gülgün; Yang, Junjie; Wax, Martin B.

doi:10.1016/s0361-9230(03)00074-1

Cited by 66Glaucoma and retinal disordersHeat shock proteins researchNeuroinflammation and Neurodegeneration Mechanisms

Heat shock proteins, immunity and glaucoma

Tezel, Gülgün, Yang, Junjie, Wax, Martin B.·2004·Brain Research Bulletin

DOI 10.1016/s0361-9230(03)00074-1

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Abstract

Glaucoma is no longer viewed simply as elevated intraocular pressure (IOP) that damages the optic nerve. In addition to high IOP, evidence is rapidly accumulating that suggests damage to the optic nerve may be initiated or sustained by any number of factors including ischemia, excitotoxicity, neurotrophin insufficiency, peroxynitrite damage or others not yet defined. These different harmful influences then likely act through common final pathways that eventually activate the cellular proteases that accompany neuronal programmed cell death. We believe aberrant immune signal processing may also result in retinal ganglion cell death. We hypothesized that one form of glaucoma may be an autoimmune neuropathy in which an individual's immune system is not only inappropriately regulated, but a cytotoxic effect is rendered by the very system which normally serves to protect it against stress. We propose that the family of proteins termed "heat shock proteins" are critical modulators of both the homeostatic/cytoprotective as well as pathogenic/neurodegenerative arms of the immune system in retinal ganglion cells or glial cells and are thus integral to glaucomatous neurodegeneration.

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The serum of glaucoma patients contains high levels of antibodies, including against HSPs.
“The serum of glaucoma patients has been found to contain high levels of antibodies (e.g., against HSPs; Maruyama et al., 2000; Wax et al., 2001; Tezel et al., 2004; Grus et al., 2008).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Tezel et al., 2004

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Role of Heat Shock Proteins in Glaucoma
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Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cell Neurons via Activated T-Cell-Derived Fas-Ligand
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Authors: Tezel, G., Yang, J., & Wax, M. B.
Affiliations: University of Louisville (US)
Washington University in St. Louis (US)
Corresponding author: Wax, Martin B.
ORCID: Tezel, Gülgün
Yang, Junjie
Venue: Brain Research Bulletin
Publisher: Elsevier BV
Published: 2004-02
Volume: 62
Issue: 6
Pages: 473-480
ISSN: 0361-9230 (ISSN-L)
DOI: 10.1016/s0361-9230(03)00074-1
OpenAlex: W2031002260
Cited by: 66
References: 58
Citations by year: 2025: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 2
FWCI: 1.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Research Bulletin (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute (EY012314, R01EY012314)
Topics: Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: heat shock proteins, glaucoma, retinal ganglion cell death, optic nerve degeneration, autoimmune neuropathy, neurodegeneration, immune regulation, glial cells, excitotoxicity, ischemia, peroxynitrite, neurotrophins, programmed cell death, intraocular pressure
MeSH terms: Animals, Glaucoma, Heat-Shock Proteins, Humans, Immunity

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