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Cited by 140Hepatitis C virus researchTryptophan and brain disordersTreatment of Major Depression

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Incidence and clinical course of major depression in patients with chronic hepatitis type C undergoing interferon-alpha therapy: a prospective study

Horikawa, Naoshi, Yamazaki, Tomoko, Izumi, Namiki, Uchihara, Masakatsu·2003·General Hospital Psychiatry
DOI 10.1016/s0163-8343(02)00239-6
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Abstract

This study examined the incidence, clinical course and its risk factors for major depression in patients with chronic hepatitis type C undergoing interferon-alpha therapy. Ninety-nine subjects underwent the psychiatric interviews for diagnosis of major depressive episode according to the DSM-IV criteria before the start of interferon therapy, and once every 4 weeks during both the 24-week treatment period and 12 weeks after the end of therapy. Depressive symptoms were also evaluated using the Hamilton Rating Scale for Depression. Major depression occurred during interferon therapy in 23 patients (23.2%). In 73.9% of them depression occurred within 8 weeks after the start of therapy. Twenty-two patients with depression completed the therapy and 59.1% of them achieved remission by the end of therapy with a mean duration of 11.6 weeks. Although the other 40.9% were not in remission at the end of therapy, they achieved remission within 12 weeks thereafter. The only risk factor for depression was advanced age. Depression occurs frequently among patients with hepatitis type C undergoing interferon-alpha therapy. Such patients require careful observation, and psychiatrists should be sufficiently aware of this significant psychiatric complication of interferon therapy.

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Research works printed but not linked: 2

  1. Malek-Ahmadi, 2001, Mood disorders associated with interferon treatment, Ann Pharmacother, 35, 489, 10.1345/aph.10172 · DOI · Paper page
  2. Horikawa, 1999, A case of akathisia during interferon-alpha therapy for chronic hepatitis type C, Gen Hosp Psychiatry, 21, 134

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Metadata

Authors
Horikawa, N., Yamazaki, T., Izumi, N., & Uchihara, M.
Affiliations
  • Tokyo Women's Medical University (JP)
  • Musashino Red Cross Hospital (JP)
Corresponding author
Horikawa, Naoshi
ORCID
Izumi, Namiki
Venue
General Hospital Psychiatry
Publisher
Elsevier BV
Published
2003-01
Volume
25
Issue
1
Pages
34-38
ISSN
0163-8343 (ISSN-L)
DOI
10.1016/s0163-8343(02)00239-6
OpenAlex
W2130844638
Cited by
140
References
42
Citations by year
2026: 1 · 2024: 1 · 2023: 4 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 14
FWCI
7.86
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • General Hospital Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
major depressive disorder, chronic hepatitis C, interferon-alpha therapy, antidepressant side effects, depression incidence, clinical course, remission, risk factors, old age
MeSH terms
Antiviral Agents, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Prospective Studies, Incidence, Interferon-alpha, Hepatitis C, Chronic

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