CoChat
Sign Up
Cited by 140Hepatitis C virus researchTryptophan and brain disordersTreatment of Major Depression

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Incidence and clinical course of major depression in patients with chronic hepatitis type C undergoing interferon-alpha therapy: a prospective study

Horikawa, Naoshi, Yamazaki, Tomoko, Izumi, Namiki, Uchihara, Masakatsu·2003·General Hospital Psychiatry
DOI 10.1016/s0163-8343(02)00239-6
Open this paper in CoChat — free account

Abstract

This study examined the incidence, clinical course and its risk factors for major depression in patients with chronic hepatitis type C undergoing interferon-alpha therapy. Ninety-nine subjects underwent the psychiatric interviews for diagnosis of major depressive episode according to the DSM-IV criteria before the start of interferon therapy, and once every 4 weeks during both the 24-week treatment period and 12 weeks after the end of therapy. Depressive symptoms were also evaluated using the Hamilton Rating Scale for Depression. Major depression occurred during interferon therapy in 23 patients (23.2%). In 73.9% of them depression occurred within 8 weeks after the start of therapy. Twenty-two patients with depression completed the therapy and 59.1% of them achieved remission by the end of therapy with a mean duration of 11.6 weeks. Although the other 40.9% were not in remission at the end of therapy, they achieved remission within 12 weeks thereafter. The only risk factor for depression was advanced age. Depression occurs frequently among patients with hepatitis type C undergoing interferon-alpha therapy. Such patients require careful observation, and psychiatrists should be sufficiently aware of this significant psychiatric complication of interferon therapy.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0163-8343(02)00239-6

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 42 references

Research works printed but not linked: 2

  1. Malek-Ahmadi, 2001, Mood disorders associated with interferon treatment, Ann Pharmacother, 35, 489, 10.1345/aph.10172 · DOI · Paper page
  2. Horikawa, 1999, A case of akathisia during interferon-alpha therapy for chronic hepatitis type C, Gen Hosp Psychiatry, 21, 134

Cited by

Sorted by citations

See all 140

Related

Metadata

Authors
Horikawa, N., Yamazaki, T., Izumi, N., & Uchihara, M.
Affiliations
  • Tokyo Women's Medical University (JP)
  • Musashino Red Cross Hospital (JP)
Corresponding author
Horikawa, Naoshi
ORCID
Izumi, Namiki
Venue
General Hospital Psychiatry
Publisher
Elsevier BV
Published
2003-01
Volume
25
Issue
1
Pages
34-38
ISSN
0163-8343 (ISSN-L)
DOI
10.1016/s0163-8343(02)00239-6
OpenAlex
W2130844638
Cited by
140
References
42
Citations by year
2026: 1 · 2024: 1 · 2023: 4 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 14
FWCI
7.86
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • General Hospital Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
major depressive disorder, chronic hepatitis C, interferon-alpha therapy, antidepressant side effects, depression incidence, clinical course, remission, risk factors, old age
MeSH terms
Antiviral Agents, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Prospective Studies, Incidence, Interferon-alpha, Hepatitis C, Chronic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review