Cited by 140Hepatitis C virus researchTryptophan and brain disordersTreatment of Major Depression

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Incidence and clinical course of major depression in patients with chronic hepatitis type C undergoing interferon-alpha therapy: a prospective study

Horikawa, Naoshi, Yamazaki, Tomoko, Izumi, Namiki, Uchihara, Masakatsu·2003·General Hospital Psychiatry

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Abstract

This study examined the incidence, clinical course and its risk factors for major depression in patients with chronic hepatitis type C undergoing interferon-alpha therapy. Ninety-nine subjects underwent the psychiatric interviews for diagnosis of major depressive episode according to the DSM-IV criteria before the start of interferon therapy, and once every 4 weeks during both the 24-week treatment period and 12 weeks after the end of therapy. Depressive symptoms were also evaluated using the Hamilton Rating Scale for Depression. Major depression occurred during interferon therapy in 23 patients (23.2%). In 73.9% of them depression occurred within 8 weeks after the start of therapy. Twenty-two patients with depression completed the therapy and 59.1% of them achieved remission by the end of therapy with a mean duration of 11.6 weeks. Although the other 40.9% were not in remission at the end of therapy, they achieved remission within 12 weeks thereafter. The only risk factor for depression was advanced age. Depression occurs frequently among patients with hepatitis type C undergoing interferon-alpha therapy. Such patients require careful observation, and psychiatrists should be sufficiently aware of this significant psychiatric complication of interferon therapy.

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Authors: Horikawa, N., Yamazaki, T., Izumi, N., & Uchihara, M.
Affiliations: Tokyo Women's Medical University (JP)
Musashino Red Cross Hospital (JP)
Corresponding author: Horikawa, Naoshi
ORCID: Izumi, Namiki
Venue: General Hospital Psychiatry
Publisher: Elsevier BV
Published: 2003-01
Volume: 25
Issue: 1
Pages: 34-38
ISSN: 0163-8343 (ISSN-L)
DOI: 10.1016/s0163-8343(02)00239-6
OpenAlex: W2130844638
Cited by: 140
References: 42
Citations by year: 2026: 1 · 2024: 1 · 2023: 4 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 14
FWCI: 7.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: General Hospital Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: major depressive disorder, chronic hepatitis C, interferon-alpha therapy, antidepressant side effects, depression incidence, clinical course, remission, risk factors, old age
MeSH terms: Antiviral Agents, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Prospective Studies, Incidence, Interferon-alpha, Hepatitis C, Chronic

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Incidence and clinical course of major depression in patients with chronic hepatitis type C undergoing interferon-alpha therapy: a prospective study

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