The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Primary insomnia: a risk factor to develop depression?
Abstract
Background Chronic insomnia afflicts approximately 5-10% of the adult population in Western industrialized countries. Insomnia may be secondary, i.e. triggered and/or maintained by psychiatric/organic illnesses, the intake of prescribed/illicit drugs or alcohol, or by a combination of these factors. Insomnia can also occur as primary insomnia, caused by a psychophysiological hyperarousal process. In the present review a literature search was undertaken to identify longitudinal epidemiological studies which investigate the question whether primary insomnia at baseline predicts the development of depression at follow-up measurements.Methods MEDLINE search for the medical subject headings insomnia and depression; identification of longitudinal epidemiological studies with at least two measurement points 1 year apart measuring insomnia and depression and indicating explicit criteria for both disorders.Results Eight relevant epidemiological studies were identified. Almost unambiguously insomnia at baseline significantly predicted an increased depression risk at follow-up 1-3 years later.Conclusion As insomniac symptoms alone seem to be of predictive value for the development of depression in the succeeding years, it would be worthwhile to investigate if early adequate treatment is able to prevent psychiatric sequelae of primary insomnia.
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“Insomnia is not only a symptom of depression, but is a common precursor, with high-quality longitudinal data having established insomnia as an independent risk factor for depression onset.5–7”
From Pilot evaluation of the Sleep Ninja: A smartphone application for adolescent insomnia symptoms (2019) · cites this paper as [7]
In the citing paper
“and especially depression [6]”
From Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (2010) · cites this paper as [6]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668
Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?
Ford, D. E. (1989) · JAMA · doi:10.1001/jama.262.11.1479 · Cited by 2,440
Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders: An Opportunity for Prevention?
Ford, D. E. (1989) · JAMA · doi:10.1001/jama.1989.03430110069030 · Cited by 2,252
Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young Adults
Breslau, N., Roth, T., Rosenthal, L., & Andreski, P. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00188-3 · Cited by 1,831
Psychophysiological insomnia: the behavioural model and a neurocognitive perspective
PERLIS, M. L., GILES, D. E., MENDELSON, W. B., BOOTZIN, R. R., & WYATT, J. K. (1997) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1997.00045.x · Cited by 795
Sleep Loss Results in an Elevation of Cortisol Levels the Next Evening
(1997) · Sleep · doi:10.1093/sleep/20.10.865 · Cited by 745
Insomnia in Young Men and Subsequent Depression: The Johns Hopkins Precursors Study
Chang, P. P., Ford, D. E., Mead, L. A., Cooper, L. A., & Klag, M. J. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009241 · Cited by 674
Sleep and depression--results from psychobiological studies: an overview
Riemann, D., Berger, M., & Voderholzer, U. (2001) · Biological Psychology · doi:10.1016/s0301-0511(01)00090-4 · Cited by 653
Self-citationStress, hypercortisolism and corticosteroid receptors in depression: implicatons for therapy
Holsboer, F. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00352-9 · Cited by 575
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Mustarichie, R., Megantara, S., Saptarini, N. M., & HAYATI, S. H. (2022) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2022.v14s5.15
Early-warning signals derived from actigraphy and electrocardiogram time series data
Kunkels, Y. K. (2023) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.667033090
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Chopra, A., Weilburg, J. B., & Winkelman, J. W. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-11844-9.00022-9
Gehrman, P., Grant, S. F. A., & Keene, A. C. (2024) · Springer eBooks · doi:10.1007/978-3-031-62723-1_1
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Verduga, M. D. F. N., Vélez, K. E. C., Guaman, J. D. R., Mendoza, H. N. G., Sánchez, L. M. C., Guajala, R. G. Y., & Vera, A. G. M. (2024) · doi:10.56470/978-9942-660-78-7
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Manber, R., Dietch, J. R., Gumport, N. B., & Simpson, N. S. (2025) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197602751.013.28
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Vargas, I., Walker, J. L., Campbell, R. L., & Veilleux, J. C. (2025) · CBT: science into practice · doi:10.1007/978-3-031-92265-7_4
Effects of Shallow Needling for Chronic Primary Insomnia: Protocol for a Randomized Controlled Trial
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Vargas, I., Garland, S. N., Kloss, J. D., & Perlis, M. L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13954-3.00044-9
Guan, J., Liu, T., Gao, G., Yang, K., & Liang, H. (2024) · Figshare · doi:10.6084/m9.figshare.26461875
Guan, J., Liu, T., Gao, G., Yang, K., & Liang, H. (2024) · Figshare · doi:10.6084/m9.figshare.26461823
Blomqvist, S., Westerlund, H., Alexanderson, K. A. E., & Magnusson Hanson, L. L. (2020) · Figshare · doi:10.6084/m9.figshare.12257750
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CD4+ T cell dysregulation in major depressive disorder is associated with sleep disturbance
Gao, Y., Lei, Z., Ren, Y., Zhan, X., Chen, Z., Guo, Z., Zhou, Z., Ma, X., & Li, P. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1763750
Liu, S. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1685297
Itzhacki, J. (2018) · doi:10.70675/28866788z07e5z4fadza9b2zd5b51f5b8cc9
Hatfield, S., & Tamm, J. (2026) · Theoretical and Applied Ergonomics · doi:10.3390/tae2030017
A Pragmatic Algorithm for Selecting Psychopharmacology Treatment for Secondary Insomnia
Chen, A. C. N., Taj, F., Fonseka, L. N., & Osser, D. N. (2026) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000002219
Singh, J. I., Sangha, S. S., Datt, B., Kumar, S., Batta, G., Akal, R. S., Ghosh, I., Srivastava, S., Dogra, P. M., & Pannu, K. K. (2026) · Journal of the Association of Physicians of India · doi:10.59556/japi.74.1518
Lee, E., & Heinze, J. E. (2026) · Journal of Community Psychology · doi:10.1002/jcop.70121
Jin, Q., Zhao, S., Wang, M., Wang, Z., Qi, T., Zhong, S., Li, A., Liu, Y., & Wei, Y. (2026) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2026.06.014
Insomnia beyond emotion regulation in adolescent anxiety and depression: A severity-based analysis
Sánchez-Moreno, V., Cavas, M., & Rey, L. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.07.019
Sleep, anxiety, and depression: The bidirectional brain-behavior axis
Rao, J. K., Emani, L. S., Padhi, S., Sharafkhaneh, A., Nami, M., & Rao, K. S. J. (2026) · Progress in brain research · doi:10.1016/bs.pbr.2026.07.007
Galling, B., Wu, J., Oberstadt, A., Dück, A., Xiao, L., Prehn‐Kristensen, A., & Lehr, D. (2026) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-026-03146-9
鷹見, 将., KADOTANI, H., 西川, 公., 角幸頼, Nakabayashi, T., 藤井, 勇., MATSUO, M., Yamada, H., Takami, M., Nishikawa, K., et al. (2018) · Institutional Repositories DataBase (IRDB)
Cai, L., Yan, J., & Zeng, L. (2026) · Acta Psychologica · doi:10.1016/j.actpsy.2026.107771
Hamilton, J. M., Pain, É., Riise, J., & Zhang, Z. (2026) · Interactive Journal of Medical Research · doi:10.2196/93231
Nomeikaitė, A., Orobosa, G. O., Hadjistavropoulos, H. D., Titov, N., Dear, B. F., & Scott, A. J. (2026) · Internet Interventions · doi:10.1016/j.invent.2026.101018
Assessment and differential diagnosis of sleep disorders in the elderly
Cooke, J. R., & Ancoli‐Israel, S. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511770661.014
El sueño en los trastornos psiquiátricos
Franzen, P. L., & Buysse, D. J. (2011) · Elsevier eBooks · doi:10.1016/b978-84-8086-733-7.00032-2
Pharmacological Treatment of Insomnia.
(2015) · PubMed Central · Cited by 109
Metadata
- Authors
- Riemann, D.
- Affiliations
- University Medical Center Freiburg (DE)
- Corresponding author
- Riemann, D
- ORCID
- Riemann, D
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 76
- Issue
- 1-3
- Pages
- 255-259
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2154516720
- Semantic Scholar
- b8c0f4f8624614a33be6ebf15f3d53fc3d809e0d
- Cited by
- 641
- References
- 28
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 40 · 2023: 27 · 2022: 35 · 2021: 18 · 2020: 25 · 2019: 32 · 2018: 26 · 2017: 32 · 2016: 32 · 2015: 26 · 2014: 32 · 2013: 44 · 2012: 38
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- primary insomnia, depression, depression risk prediction, longitudinal epidemiology, insomnia treatment, psychiatric comorbidity
- MeSH terms
- Adult, Aged, Chronic Disease, Depressive Disorder, Female, Humans, Sleep Initiation and Maintenance Disorders, Longitudinal Studies, Male, Middle Aged, Risk Factors, Epidemiologic Studies
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