Dopamine agonist amineptine prevents the antidepressant effect of sleep deprivation
Abstract
In a double-blind study, the effects of the interaction between the administration of amineptine versus placebo and repeated cycles of total sleep deprivation (TSD), which is thought to act through an enhancement in dopaminergic transmission, were analyzed. Twenty-two consecutively admitted patients with bipolar depression formed the study group. Repeated administrations of TSD significantly enhanced perceived mood levels in placebo-treated patients, while amineptine administration blocked the antidepressant action of TSD. Hypothesized changes in brain dopaminergic transmission attributable to amineptine pretreatment are discussed.
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Pretreatment with the dopamine agonist amineptine prevents the antidepressant effects of total sleep deprivation.
“In contrast, pretreatment with the dopamine agonist, amineptine, prevents the antidepressant effects of TSD (Benedetti et al., 1996).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 1996
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- Authors
- Benedetti, F., Barbini, B., Campori, E., Colombo, C., & Smeraldi, E.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Campori, Euridice
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 65
- Issue
- 3
- Pages
- 179-184
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2087342491
- Cited by
- 48
- References
- 29
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2016: 3 · 2014: 3 · 2013: 1
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- amineptine, total sleep deprivation, antidepressant effects, dopamine agonists, bipolar depression, dopamine signaling, mood improvement, drug interactions
- MeSH terms
- Adult, Aged, Antidepressive Agents, Tricyclic, Bipolar Disorder, Brain, Depressive Disorder, Dibenzocycloheptenes, Dopamine, Double-Blind Method, Female, Humans, Male, Middle Aged, Synaptic Transmission, Sleep Deprivation, Dopamine Agonists
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