Sleep deprivation in depression: what do we know, where do we go?

Wirz-Justice, Anna; Van den Hoofdakker, Rutger H

doi:10.1016/s0006-3223(99)00125-0

Cited by 429Sleep and related disordersCircadian rhythm and melatoninSleep and Wakefulness Research

Sleep deprivation in depression: what do we know, where do we go?

Wirz-Justice, Anna, Van den Hoofdakker, Rutger H·1999·Biological Psychiatry

DOI 10.1016/s0006-3223(99)00125-0

Open this paper in CoChat — free account

Abstract

Manipulations of the sleep-wake cycle, whether of duration (total or partial sleep deprivation [SD]) or timing (partial SD, phase advance), have profound and rapid effects on depressed mood in 60% of all diagnostic subgroups of affective disorders. Relapse after recovery sleep is less when patients are receiving medication; it may be prevented by co-administration of lithium, pindolol, serotonergic antidepressants, bright light, or a subsequent phase advance procedure. Diurnal and day-to-day mood variability predict both short-term response to SD and long-term response to antidepressant drug treatment. These mood patterns can be understood in terms of a "two-process model of mood regulation" based on the model well established for sleep regulation: the interaction of circadian and homeostatic processes. The therapeutic effect of SD is postulated to be linked to changes in disturbed circadian- and sleep-wake-dependent phase relationships and concomitant increase of slow-wave-sleep pressure; additionally, SD-induced sleepiness may counteract the hyperarousal state in depression. This model has the advantage of providing a comprehensive theoretical framework and stringent protocols ("constant routine," "forced desynchrony") to dissect out specific disturbances. Many aspects tie in with current serotonergic receptor hypotheses of SD action. A treatment inducing euthymia in severely depressed patients within hours is an important therapeutic option that has come of age for clinical use.

Integrity signals

Registry

Crossref · 10.1016/s0006-3223(99)00125-0

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Antidepressant medications typically require 2 to 8 weeks to have an effect.
“in contrast to antidepressant medications that typically require 2 to 8 weeks to have an effect.52,53”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [53]
Acute sleep deprivation is effective in 40% to 60% of depressed subjects in improving mood within 24 to 48 hours.
“Moreover, acute sleep deprivation is effective in 40% to 60% of depressed subjects in improving mood within 24 to 48 hours, in contrast to antidepressant medications that typically require 2 to 8 weeks to have an effect.52,53”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [53]

Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985 · see citing works
Neuropsychopharmacology
Bunney, W. E., Hippius, H., Laakmann, G., & Schmauß, M. (1990) · Springer eBooks · doi:10.1007/978-3-642-74034-3 · Cited by 1,523 · see citing works
Timing of human sleep: recovery process gated by a circadian pacemaker
Daan, S., Beersma, D. G. M., & Borbély, A. A. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.2.r161 · Cited by 1,424 · see citing works
The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis
Wu, J. C., & Bunney, W. E. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.1.14 · Cited by 614 · see citing works
Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine
Smeraldi, E., Zanardi, R., Benedetti, F., Bella, D. D., Pérez, J., & Catalano, M. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000425 · Cited by 614 · see citing works
Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance
Dijk, D., Duffy, J. F., & Czeisler, C. A. (1992) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1992.tb00021.x · Cited by 602 · see citing works
Phase Advance of the Circadian Sleep-Wake Cycle as an Antidepressant
Wehr, T. A., Wirz-Justice, A., Goodwin, F. K., Duncan, W., & Gillin, J. C. (1979) · Science · doi:10.1126/science.227056 · Cited by 528 · see citing works
Self-citation
Improvement of Depression by REM Sleep Deprivation
Vogel, G. W. (1980) · Archives of General Psychiatry · doi:10.1001/archpsyc.1980.01780160017001 · Cited by 432 · see citing works
Complex Interaction of the Sleep-Wake Cycle and Circadian Phase Modulates Mood in Healthy Subjects
Boivin, D. B. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830140055010 · Cited by 378 · see citing works
Prediction of Antidepressant Effects of Sleep Deprivation by Metabolic Rates in the Ventral Anterior Cingulate and Medial Prefrontal Cortex
Wu, J. C., Buchsbaum, M. S., Gillin, J. C., Tang, C. Y., Cadwell, S., Wiegand, M. H., Najafi, A., Klein, E., Hazen, K., & Bunney, W. E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1149 · Cited by 327 · see citing works
Sleep, sleep deprivation and depression. A hypothesis derived from a model of sleep regulation.
Borbély, A. A., & Wirz‐Justice, A. (1982) · PubMed · Cited by 323 · see citing works
Self-citation
Efficacy of Paroxetine in Depression Is Influenced by a Functional Polymorphism Within the Promoter of the Serotonin Transporter Gene
Zanardi, R., Benedetti, F., Bella, D. D., Catalano, M., & Smeraldi, E. (2000) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200002000-00021 · Cited by 309 · see citing works
Effect of sleep deprivation on brain metabolism of depressed patients
Wu, J. C., Gillin, J. C., Buchsbaum, M. S., Hershey, T. G., Johnson, J., & Bunney, W. E. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.4.538 · Cited by 290 · see citing works
Sleep, sleepiness and performance.
(1993) · Accident Analysis & Prevention · doi:10.1016/0001-4575(93)90105-6 · Cited by 280 · see citing works
Rate of switch from depression into mania after therapeutic sleep deprivation in bipolar depression
Colombo, C., Benedetti, F., Barbini, B., Campori, E., & Smeraldi, E. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00036-0 · Cited by 268 · see citing works
Sleep deprivation and human immune function
Dinges, D. F., Douglas, S. D., Hamarman, S., Zaugg, L., & Kapoor, S. C. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(95)00002-j · Cited by 234 · see citing works
Sleep, sleepiness and performance
(1992) · Choice Reviews Online · doi:10.5860/choice.30-0966 · Cited by 230 · see citing works
Effects of sleep deprivation on the limbic system and the frontal lobes in affective disorders: A study with Tc-99m-HMPAO SPECT
Ebert, D., Feistel, H., & Barocka, A. (1991) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(91)90016-j · Cited by 192 · see citing works
Effect of partial sleep deprivation on sleep stages and EEG power spectra: evidence for non-REM and REM sleep homeostasis
Brunner, D. P., Dijk, D., Tobler, I., & Borbély, A. A. (1990) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(90)90136-8 · Cited by 182 · see citing works
Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression
Benedetti, F., Serretti, A., Colombo, C., Campori, E., Barbini, B., di Bella, D., & Smeraldi, E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1450 · Cited by 167 · see citing works
Bright light therapy stabilizes the antidepressant effect of partial sleep deprivation
Neumeister, A., Gößler, R., Lucht, M. J., Kapitany, T., Bamas, C., & Kasper, S. F. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00086-0 · Cited by 158 · see citing works
Is sleep deprivation useful in the treatment of depression?
Leibenluft, E., & Wehr, T. A. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.2.159 · Cited by 150 · see citing works
Circadian rhythms in mammalian neurotransmitter receptors
Wirz‐Justice, A. (1987) · Progress in Neurobiology · doi:10.1016/0301-0082(87)90022-0 · Cited by 141 · see citing works
Self-citation
REM sleep deprivation during 5 hours leads to an immediate REM sleep rebound and to suppression of non-REM sleep intensity
Beersma, D. G. M., Dijk, D., Blok, G., & Everhardus, I. (1990) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(90)90209-3 · Cited by 129 · see citing works
Sleep deprivation therapy
Kuhs, H., & Tölle, R. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90255-k · Cited by 124 · see citing works
[Therapy of endogenous depressions using sleep deprivation. Practical and theoretical consequences].
Pflug, B., & Tölle, R. (1971) · PubMed · Cited by 122 · see citing works
Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial
Smeraldi, E. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00129-8 · Cited by 116 · see citing works
The unipolar–bipolar dichotomy and the response to sleep deprivation
Barbini, B., Colombo, C., Benedetti, F., Campori, E., Bellodi, L., & Smeraldi, E. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00020-1 · Cited by 115 · see citing works
Sleep deprivation combined with consecutive sleep phase advance as a fast-acting therapy in depression: an open pilot trial in medicated and unmedicated patients
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.870 · Cited by 114 · see citing works
Endogenous and exogenous components in the circadian variation of core body temperature in humans
Hiddinga, A. E., BEERSMA, & van den Hoofdakker, R. H. (1997) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1997.00047.x · Cited by 105 · see citing works
How to preserve the antidepressive effect of sleep deprivation: a comparison of sleep phase advance and sleep phase delay
Riemann, D., König, A., Hohagen, F., Kiemen, A., Voderholzer, U., Backhaus, J., Bunz, J., Wesiack, B., Hermle, L., & Berger, M. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050092 · Cited by 99 · see citing works
Neurobiological similarities in antidepressant sleep deprivation and psychostimulant use: a psychostimulant theory of antidepressant sleep deprivation
Ebert, D., & Berger, T. (1998) · Psychopharmacology · doi:10.1007/s002130050732 · Cited by 99 · see citing works
Ongoing Lithium Treatment Prevents Relapse After Total Sleep Deprivation
Benedetti, F., Colombo, C., Barbini, B., Campori, E., & Smeraldi, E. (1999) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199906000-00007 · Cited by 95 · see citing works
Prediction of the antidepressant response to total sleep deprivation by diurnal variation of mood
Reinink, E., Bouhuys, N., Wirz‐Justice, A., & van den Hoofdakker, R. (1990) · Psychiatry Research · doi:10.1016/0165-1781(90)90077-i · Cited by 92 · see citing works
Self-citation
Prolongation of the antidepressant response to partial sleep deprivation by lithium
Baxter, L. R., Liston, E. H., Schwartz, J. M., Altshuler, L. L., WILKINS, J. N., Richeimer, S. H., & Guzé, B. H. (1986) · Psychiatry Research · doi:10.1016/0165-1781(86)90088-0 · Cited by 86 · see citing works
Refractory depression : current strategies and future directions
Nolen, W. A. (1994) · Medical Entomology and Zoology · Cited by 85 · see citing works
Sleep deprivation hastens the antidepressant action of fluoxetine
Benedetti, F., Barbini, B., Lucca, A., Campori, E., Colombo, C., & Smeraldi, E. (1997) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02900200 · Cited by 85 · see citing works
Effects of partial sleep deprivation on the diurnal variation of mood and motor activity in major depression
Szuba, M. P., Baxter, L. R., Fairbanks, L. A., Guzé, B. H., & Schwartz, J. M. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90237-g · Cited by 81 · see citing works
Effect of morning and afternoon naps on mood after total sleep deprivation in patients with major depression
Wiegand, M. H., Riemann, D. W., Schreiber, W., Lauer, C. J., & Berger, T. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90175-d · Cited by 79 · see citing works
A longitudinal study of diurnal mood variation in depression; characteristics and significance
Gordijn, M. C. M., Beersma, D. G. M., Bouhuys, A. L., Reinink, E., & van den Hoofdakker, R. H. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90102-3 · Cited by 74 · see citing works
Neuroendocrinological investigations during sleep deprivation in depression I. Early morning levels of thyrotropin, TH, cortisol, prolactin, LH, FSH, estradiol, and testosterone
Baumgartner, A., Gräf, K.-J., Kürten, I., MEINHOLD, H., & Scholz, P. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90394-h · Cited by 70 · see citing works
Lithium sustains the acute antidepressant effects of sleep deprivation: Preliminary findings from a controlled study
Szuba, M. P., Baxter, L. R., Altshuler, L. L., Allen, E. M., Guzé, B. H., Schwartz, J. M., & Liston, E. H. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90015-9 · Cited by 69 · see citing works
Effects of Tryptophan Depletion in Drug-Free Depressed Patients Who Responded to Total Sleep Deprivation
Neumeister, A., Praschak-Rieder, N., Heßelmann, B., Vitouch, O., Rauh, M., Barocka, A., Tauscher, J. T., & Kasper, S. F. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.2.167 · Cited by 66 · see citing works
On the contribution of sleep wake physiology to the explanation and the treatment of depression
van den Hoofdakker, R. H., & Beersma, D. G. M. (1988) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1988.tb08555.x · Cited by 65 · see citing works
Can non-REM sleep be depressogenic?
Beersma, D. G. M., & van den Hoofdakker, R. H. (1992) · Journal of Affective Disorders · doi:10.1016/0165-0327(92)90024-z · Cited by 62 · see citing works
Effects of wakefulness and sleep on depression and mania.
Wehr, T. A. (1990) · Cited by 61 · see citing works
Prediction of sleep deprivation outcome by diurnal variation of mood
Haug, H. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90050-a · Cited by 54 · see citing works
Microsleep during partial sleep deprivation in depression
Hemmeter, U., Bischof, R., Hatzinger, M., Seifritz, E., & Holsboer-Trachsler, E. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00297-7 · Cited by 54 · see citing works
Dopamine agonist amineptine prevents the antidepressant effect of sleep deprivation
Benedetti, F., Barbini, B., Campori, E., Colombo, C., & Smeraldi, E. (1996) · Psychiatry Research · doi:10.1016/s0165-1781(96)03000-4 · Cited by 48 · see citing works
Sleep and biological rhythms; basic mechanisms and applications to psychiatry
(1992) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(92)90036-j · Cited by 45 · see citing works
The timing of partial sleep deprivation in depression
Giedke, H., Geilenkirchen, R., & Hauser, M. (1992) · Journal of Affective Disorders · doi:10.1016/0165-0327(92)90074-g · Cited by 44 · see citing works
Placebo run-in period in studies of depressive disorders
Quitkin, F. M., McGrath, P. J., Stewart, J. W., Ocepek‐Welikson, K., Taylor, B. P., Nunes, E. V., Delivannides, D., Agosti, V., Donovan, S., Ross, D. C., et al. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.173.3.242 · Cited by 37 · see citing works
Sleep deprivation reduces the citalopram –induced inhibition of serotoninergic neuronal firing in the nucleus raphe dorsalis of the rat
Prevot, E., Maudhuit, C., Poul, E. L., Hamon, M., & ADRIEN, J. (1996) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1996.00238.x · Cited by 36 · see citing works
Dimensions to sleepiness.
Horne, J. A. (1991) · Cited by 36 · see citing works
The relationship between tiredness prior to sleep deprivation and the antidepressant response to sleep deprivation in depression
Bouhuys, A. L., van den Burg, W., & van den Hoofdakker, R. H. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00175-3 · Cited by 35 · see citing works
Prediction of the antidepressant response to total sleep deprivation of depressed patients: Longitudinal versus single day assessment of diurnal mood variation
Reinink, E., Bouhuys, A. L., Gordijn, M. C. M., & van den Hoofdakker, R. H. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90238-9 · Cited by 34 · see citing works
Advanced vs. normal sleep timing: effects on depressed mood after response to sleep deprivation in patients with a major depressive disorder
Riemann, D. W., Hohagen, F., König, A., Schwarz, B., Gomille, J., Voderholzer, U., & Berger, T. (1996) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00082-8 · Cited by 30 · see citing works
Observed behavior as a predictor of the response to sleep deprivation in depressed patients
Bouhuys, A. L., Beersma, D. G. M., & van den Hoofdakker, R. H. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90197-2 · Cited by 28 · see citing works
Sleep and biological rhythms; basic mechanisms and applications to psychiatry
Moldofsky, H. (1992) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(92)90572-8 · Cited by 25 · see citing works
Maintenance of antidepressant effect of sleep deprivation with the help of lithium
Grube, M., & Hartwich, P. (1990) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02190095 · Cited by 23 · see citing works
Self‐rated arousal concurrent with the antidepressant response to total sleep deprivation of patients with a major depressive disorder: a disinhibition hypothesis
van den Burg, W., Beersma, D. G. M., Bouhuys, A. L., & van den Hoofdakker, R. H. (1992) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1992.tb00042.x · Cited by 23 · see citing works
Sleep deprivation and depression
Elsenga, S. (1992) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 19 · see citing works
Antidepressant response to sleep deprivation as a function of time into depressive episode in rapidly cycling bipolar patients
Gill, D. S., Ketter, T. A., & Post, R. M. (1993) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1993.tb03338.x · Cited by 18 · see citing works
A longitudinal study of sleep deprivation responses in depression; The variability is highly related to diurnal mood variability
Gordijn, M. C. M., Beersma, D. G. M., Bouhuys, A. L., et al. (1995) · Acta Neuropsychiatrica · doi:10.1017/s0924270800037583 · Cited by 12 · see citing works
Antidepressant Medication and Total Sleep Deprivation in Depressives
Elsenga, S., & van den Hoofdakker, R. H. (1990) · Neuropsychopharmacology · doi:10.1007/978-3-642-74034-3_63 · Cited by 10 · see citing works
Timing of human sleep
Daan, S., Beersma, D. G. M., & Borbély, A. A. (1984) · Cited by 8 · see citing works

Flagged first, then by citations

Sorted by citations

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works
The two‐process model of sleep regulation: a reappraisal
Borbély, A. A., Daan, S., Wirz‐Justice, A., & Deboer, T. (2016) · Journal of Sleep Research · doi:10.1111/jsr.12371 · Cited by 1,577 · see citing works
Self-citation
The ascent of mouse: advances in modelling human depression and anxiety
Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198 · see citing works
Overnight therapy? The role of sleep in emotional brain processing
Walker, M. P., & van der Helm, E. (2009) · Psychological Bulletin · doi:10.1037/a0016570 · Cited by 1,087 · see citing works
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055 · see citing works
Sleep disorders as core symptoms of depression
Nutt, D., Wilson, S., & Paterson, L. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.3/dnutt · Cited by 839 · see citing works
Circadian genes, rhythms and the biology of mood disorders
McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666 · see citing works
Sleep and depression--results from psychobiological studies: an overview
Riemann, D., Berger, M., & Voderholzer, U. (2001) · Biological Psychology · doi:10.1016/s0301-0511(01)00090-4 · Cited by 653 · see citing works
Circadian rhythm disturbances in depression
Germain, A., & Kupfer, D. J. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.964 · Cited by 644 · see citing works
A neural circuit for circadian regulation of arousal
Aston-Jones, G., Chen, S., Zhu, Y., & Oshinsky, M. L. (2001) · Nature Neuroscience · doi:10.1038/89522 · Cited by 632 · see citing works
Is mood chemistry?
Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563 · see citing works
Light Therapy for Seasonal and Nonseasonal Depression: Efficacy, Protocol, Safety, and Side Effects
Terman, M., & Terman, J. S. (2005) · CNS Spectrums · doi:10.1017/s1092852900019611 · Cited by 546 · see citing works
Effect of sleep deprivation on the human metabolome
Davies, S. K., Ang, J. E., Revell, V. L., Holmes, B., Mann, A., Robertson, F. P., Cui, N., Middleton, B., Ackermann, K., Kayser, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402663111 · Cited by 527 · see citing works
Circadian rhythms, sleep, and the menstrual cycle
Baker, F. C., & Driver, H. S. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.09.011 · Cited by 529 · see citing works
Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences
Gujar, N., Yoo, S.-S., Hu, P., & Walker, M. P. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3220-10.2011 · Cited by 491 · see citing works
Toward constructing an endophenotype strategy for bipolar disorders
Hasler, G., Drevets, W. C., Gould, T. D., Gottesman, I. I., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.006 · Cited by 423 · see citing works
Circadian Time of Morning Light Administration and Therapeutic Response in Winter Depression
Terman, J. S., Terman, M., Lo, E.-S., & Cooper, T. B. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.1.69 · Cited by 366 · see citing works
Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference
Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppä, T., Lichtermann, D., Praschak-Rieder, N., Neumeister, A., Nilsson, L.-G., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300121 · Cited by 341 · see citing works
Sleep Deprivation and Circadian Disruption
McEwen, B. S., & Karatsoreos, I. N. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2014.11.007 · Cited by 338 · see citing works
Long sleep and mortality: rationale for sleep restriction
Youngstedt, S. D., & Kripke, D. F. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2003.10.002 · Cited by 324 · see citing works
Chronotherapeutics (light and wake therapy) in affective disorders
WIRZ-JUSTICE, A., BENEDETTI, F., BERGER, M., LAM, R. W., MARTINY, K., TERMAN, M., & WU, J. C. (2005) · Psychological Medicine · doi:10.1017/s003329170500437x · Cited by 291 · see citing works
Self-citation
Genetic dissection of psychopathological symptoms: Insomnia in mood disorders and <i>CLOCK</i> gene polymorphism
Serretti, A., Benedetti, F., Mandelli, L., Lorenzi, C., Pirovano, A., Colombo, C., & Smeraldi, E. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20053 · Cited by 264 · see citing works
Endophenotypes in bipolar disorder
Lenox, R. H., Gould, T. D., & Manji, H. K. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10360 · Cited by 264 · see citing works
Sleep and circadian functioning: critical mechanisms in the mood disorders?
Harvey, A. G. (2011) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032210-104550 · Cited by 237 · see citing works
A randomised, controlled study on the effects of a short-term endurance training programme in patients with major depression.
Knubben, K., Reischies, F. M., Adli, M., Schlattmann, P., Bauer, M., & Dimeo, F. (2007) · British Journal of Sports Medicine · doi:10.1136/bjsm.2006.030130 · Cited by 226 · see citing works
The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology
Gottlieb, J. F., Benedetti, F., Geoffroy, P. A., Henriksen, T. E. G., Lam, R. W., Murray, G., Phelps, J., Sit, D., Swartz, H. A., Crowe, M., et al. (2019) · Bipolar Disorders · doi:10.1111/bdi.12847 · Cited by 196 · see citing works
Rapid Onset of Antidepressant Action: A New Paradigm in the Research and Treatment of Major Depressive Disorder
Machado-Vieira, R., Salvadore, G., Luckenbaugh, D. A., Manji, H. K., & Zarate, C. A. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0610 · Cited by 195 · see citing works
Adenosine, caffeine, and sleep–wake regulation: state of the science and perspectives
Reichert, C. F., Deboer, T., & Landolt, H. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13597 · Cited by 183 · see citing works
Agomelatine: Mechanism of action and pharmacological profile in relation to antidepressant properties
Guardiola‐Lemaitre, B., De Bodinat, C., Delagrange, P., Millan, M. J., Munoz, C., & Mocaër, E. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12720 · Cited by 182 · see citing works
Sleep EEG, depression and gender
Armitage, R., & Hoffmann, R. F. (2001) · Sleep Medicine Reviews · doi:10.1053/smrv.2000.0144 · Cited by 170 · see citing works
Morningness-eveningness and depression: Preliminary evidence for the role of the behavioral activation system and positive affect
Hasler, B. P., Allen, J. J. B., Sbarra, D. A., Bootzin, R. R., & Bernert, R. A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.06.006 · Cited by 168 · see citing works
Dark therapy for mania: a pilot study
Barbini, B., Benedetti, F., Colombo, C., Dotoli, D., Bernasconi, A., Cigala‐Fulgosi, M., Florita, M., & Smeraldi, E. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00166.x · Cited by 169 · see citing works
Perspectives for the development of animal models of bipolar disorder
Machado-Vieira, R., Kapczinski, F., & Soares, J. C. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.10.015 · Cited by 158 · see citing works
Sleep in Mood Disorders
Peterson, M. J., & Benca, R. M. (2006) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2006.09.003 · Cited by 164 · see citing works
Evolving applications of light therapy
Terman, M. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.06.003 · Cited by 152 · see citing works
Sleep phase advance and lithium to sustain the antidepressant effect of total sleep deprivation in bipolar depression: new findings supporting the internal coincidence model?
Benedetti, F., Barbini, B., Campori, E., Fulgosi, M. C., Pontiggia, A., & Colombo, C. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00034-6 · Cited by 110 · see citing works
Sleep deprivation as a model experimental antidepressant treatment: findings from functional brain imaging
Gillin, J. C., Buchsbaum, M., Wu, J., Clark, C., & Bunney, W. (2001) · Depression and Anxiety · doi:10.1002/da.1045 · Cited by 103 · see citing works
Phase advance is an actimetric correlate of antidepressant response to sleep deprivation and light therapy in bipolar depression
Benedetti, F., Dallaspezia, S., Fulgosi, M. C., Barbini, B., Colombo, C., & Smeraldi, E. (2007) · Chronobiology International · doi:10.1080/07420520701649455 · Cited by 97 · see citing works
Chronobiology and mood disorders
Wirz-Justice, A. (2003) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2003.5.4/awirzjustice · Cited by 91 · see citing works
Self-citation
Sleep deprivation facilitates extinction of implicit fear generalization and physiological response to fear
Kuriyama, K., Soshi, T., & Kim, Y. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.015 · Cited by 84 · see citing works
‘One night’ sleep deprivation stimulates hippocampal neurogenesis
Grassi Zucconi, G., Cipriani, S., Balgkouranidou, I., & Scattoni, R. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.01.009 · Cited by 86 · see citing works
REM sleep reduction, mood regulation and remission in untreated depression
Cartwright, R., Baehr, E., Kirkby, J., Pandi-Perumal, S. R., & Kabat, J. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(03)00236-1 · Cited by 82 · see citing works
Sleep and manipulations of the sleep–wake rhythm in depression
Berger, M., Van Calker, D., & Riemann, D. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.108.s418.17.x · Cited by 82 · see citing works
Ketamine-Induced Glutamatergic Mechanisms of Sleep and Wakefulness: Insights for Developing Novel Treatments for Disturbed Sleep and Mood
Duncan, W. C., Ballard, E. D., & Zarate, C. A. (2017) · Handbook of Experimental Pharmacology · doi:10.1007/164_2017_51 · Cited by 58 · see citing works
Role for the<i>Clock</i>Gene in Bipolar Disorder
McClung, C. A. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.031 · Cited by 57 · see citing works
Spectroscopic correlates of antidepressant response to sleep deprivation and light therapy: A 3.0 Tesla study of bipolar depression
Benedetti, F., Calabrese, G., Bernasconi, A., Cadioli, M., Colombo, C., Dallaspezia, S., Falini, A., Radaelli, D., Scotti, G., & Smeraldi, E. (2009) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2008.08.004 · Cited by 53 · see citing works
Extraocular light therapy in winter depression: a double-blind placebo-controlled study
Koorengevel, K. M., Gordijn, M. C. M., Beersma, D. G. M., Meesters, Y., den Boer, J. A., van den Hoofdakker, R. H., & Daan, S. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01182-9 · Cited by 47 · see citing works
Timing is everything: does the robust upregulation of noradrenergically regulated plasticity genes underlie the rapid antidepressant effects of sleep deprivation?
Payne, J. L., Quiroz, J. A., Zarate, C. A., & Manji, H. K. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01676-1 · Cited by 46 · see citing works
Chronotherapy for the rapid treatment of depression: a meta-analysis
Humpston, C., Benedetti, F., Serfaty, M., Markham, S., Hodsoll, J., Young, A. H., & Veale, D. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.09.078 · Cited by 45 · see citing works
Diurnal autonomic variations and emotional reactivity
Hot, P., Leconte, P., & Sequeira, H. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2004.08.005 · Cited by 44 · see citing works
Meta-analysis of sleep deprivation in the acute treatment of bipolar depression
Gottlieb, J. F., Goel, N., Chen, S., & Young, M. A. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13255 · Cited by 44 · see citing works
The day-to-day acute effect of wake therapy in patients with major depression using the HAM-D6 as primary outcome measure: results from a randomised controlled trial
Martiny, K., Refsgaard, E., Lund, V., Lunde, M., Sørensen, L., Thougaard, B., Lindberg, L., & Bech, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067264 · Cited by 43 · see citing works
Chronotherapeutics (light and wake therapy) as a class of interventions for affective disorders
(2012) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-52002-9.00042-5 · Cited by 42 · see citing works
Mood regulation in seasonal affective disorder patients and healthy controls studied in forced desynchrony
Koorengevel, K. M., Beersma, D. G. M., den Boer, J. A., & van den Hoofdakker, R. H. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(02)00305-0 · Cited by 42 · see citing works
Self-citation
Effectiveness of sleep deprivation in treating acute bipolar depression as augmentation strategy: a systematic review and meta-analysis
Ramirez-Mahaluf, J. P., Rozas-Serri, E., Ivanovic-Zuvic, F., Risco, L., & Vöhringer, P. A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00070 · Cited by 28 · see citing works
Delay in the Recovery of Normal Sleep-Wake Cycle after Disruption of the Light-Dark Cycle in Mice: A Bipolar Disorder-Prone Animal Model?
Jung, S. H., Park, J.-M., Moon, E., Chung, Y. I., Lee, B. D., Lee, Y. M., Kim, J. H., Kim, S. Y., & Jeong, H. J. (2014) · Psychiatry Investigation · doi:10.4306/pi.2014.11.4.487 · Cited by 22 · see citing works
Augmentation of pharmacotherapy by sleep deprivation with sleep phase advance in treatment-resistant depression
Kurczewska, E., Ferensztajn-Rochowiak, E., Jasińska-Mikołajczyk, A., Chłopocka-Woźniak, M., & Rybakowski, J. K. (2019) · Pharmacopsychiatry · doi:10.1055/a-0695-9138 · Cited by 17 · see citing works
Usage of therapeutic sleep deprivation: a survey in psychiatric hospitals in Austria, Germany, and Switzerland
Winkler, D., Spies, M., Al-Resheg, Y., Wu, J. C., Bunney, W. E., Bunney, B. G., Kasper, S., & Pjrek, E. (2019) · Behavioral Sleep Medicine · doi:10.1080/15402002.2018.1469494 · Cited by 12 · see citing works
Blunted prolactin response to fentanyl in depression. Normalizing effect of partial sleep deprivation
Frecska, E., Perenyi, A., & Arato, M. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(03)00072-6 · Cited by 3 · see citing works

Authors: Wirz-Justice, A., & Van den Hoofdakker, R. H.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1999-08
Volume: 46
Issue: 4
Pages: 445-453
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(99)00125-0
OpenAlex: W2076299279
Cited by: 429
References: 66
Citations by year: 2025: 8 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 15 · 2018: 11 · 2017: 12 · 2016: 14 · 2015: 18 · 2014: 24 · 2013: 33 · 2012: 9
FWCI: 6.83
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: sleep deprivation, depression, circadian rhythm, phase advance, slow-wave sleep, hyperarousal, mood variability, antidepressant response, lithium, pindolol, serotonergic antidepressants, bright light therapy, forced desynchrony, constant routine, sleep-wake cycle
MeSH terms: Antidepressive Agents, Brain Chemistry, Circadian Rhythm, Combined Modality Therapy, Depression, Humans, Models, Neurological, Sleep Deprivation, Sleep Stages, Mood Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sleep deprivation in depression: what do we know, where do we go?

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks