A quantitative study of the progress of myelination in the rat central nervous system, using the immunohistochemical method for proteolipid protein
Abstract
The temporal changes in intensity of myelination of the nervous pathways in 0 to 42-day-old Wistar rats were quantitatively analyzed by immunohistochemistry with anti-proteolipid protein and compared with that obtained by immunohistochemistry with anti-myelin basic protein. Immunohistochemistry was performed on paraffin-embedded tissue according to the standard ABC technique. Intensity of myelination was examined by an image analyzing system. We analyzed nine nervous pathways: corpus callosum, optic tract, internal capsule, spinal tract of the trigeminal nerve, inferior cerebellar peduncle, cerebellar white matter, pyramidal tract, medial longitudinal fasciculus, and cuneate fasciculus. The presence of immunoreactive fibers for proteolipid protein (PLP) in the spinal tract of the trigeminal nerve, medial longitudinal fasciculus and cuneate fasciculus was noted on postnatal day 0. Those of the corpus callosum, inferior cerebellar peduncle, cerebellar white matter, pyramidal tract and internal capsule were noted on day 7, and that of optic tract on day 14. The time required to reach the intensity of myelination of day 42 was day 14 for the cuneate fasciculus, day 21 for the spinal tract of the trigeminal nerve, inferior cerebellar peduncle and medial longitudinal fasciculus, day 28 for the optic and pyramidal tracts, day 35 for the corpus callosum and day 42 for the internal capsule and cerebellar white matter. The appearance of immunoreactive fibers for PLP was usually earlier than that for myelin basic protein (MBP) and the pattern of difference between PLP and MBP can be classified into three groups: (1) their time of appearance and progress are almost the same, as in the optic tract; (2) the appearance and progress of PLP occurs earlier than those of MBP, as in the pyramidal tract; (3) the appearance of PLP occurs earlier than that of MBP, but their progress is the same. Our findings revealed that the time of appearance and progress of myelination as measured by PLP are different among the nervous pathways, and that there is also a difference between PLP and MBP. This difference between PLP and MBP may indicate a functional difference between them.
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Tamoxifen administration between the ages of 4 and 8 weeks, after the majority of developmental myelination has taken place, avoids developmental and early postnatal effects of BACE1 knockout on myelin.
“To avoid developmental and early postnatal effects of BACE1 knockout on myelin [34], we used tamoxifen inducible Cre lines, with tamoxifen administered between the ages of 4 and 8 weeks (after the majority of developmental myelination has taken place [35]), according to standard protocols [36].”
From Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease (2024) · cites this paper as [35]
The distribution of ITPR2+ oligodendrocytes correlates with active and prolonged differentiation in the juvenile rat corpus callosum.
“This distribution of ITPR2+ oligodendrocytes correlates with active and prolonged differentiation in the juvenile rat corpus callosum (19).”
From Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system (2016) · cites this paper as [19]
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- Authors
- Hamano, K., Takeya, T., Iwasaki, N., Nakayama, J., Ohto, T., & Okada, Y.
- Affiliations
- University of Tsukuba (JP)
- Corresponding author
- Hamano, Kenzo
- Venue
- Developmental Brain Research
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 108
- Issue
- 1-2
- Pages
- 287-293
- ISSN
- 0165-3806 (ISSN-L)
- OpenAlex
- W2084354203
- Cited by
- 64
- References
- 22
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- myelination, proteolipid protein, myelin basic protein, central nervous system development, postnatal development, rats, corpus callosum, optic tract, corticospinal tract, medial longitudinal fasciculus, inferior cerebellar peduncle, cerebellar white matter, internal capsule
- MeSH terms
- Age Factors, Animals, Brain, Brain Chemistry, Cerebellum, Corpus Callosum, Immunohistochemistry, Male, Myelin Sheath, Nerve Fibers, Pyramidal Tracts, Trigeminal Nerve, Rats, Wistar, Myelin Proteolipid Protein, Rats
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