Cited by 369Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchDevelopmental Biology and Gene Regulation

Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

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Spitzer, Sonia Olivia, Sitnikov, Sergey, Kamen, Yasmine, Evans, Kimberley Anne, Kronenberg-Versteeg, Deborah, Dietmann, Sabine, de Faria, Omar, Agathou, Sylvia +1 more·2019·Neuron

Abstract

Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during CNS development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and, likewise, differentiation failure with age.

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Crossref · 10.1016/j.neuron.2018.12.020

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  • The previously reported aging-related decline of OPC, NRP and ImmN was observed.

    “Nonetheless, we did observe the previously reported aging-related decline of OPC 49 , NRP 35,36 and ImmN 36,50 .”

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Authors
Spitzer, S. O., Sitnikov, S., Kamen, Y., Evans, K. A., Kronenberg-Versteeg, D., Dietmann, S., de Faria, O., Agathou, S., & Káradóttir, R. T.
Affiliations
Wellcome/MRC Cambridge Stem Cell Institute (GB)
Corresponding author
Káradóttir, Ragnhildur Thóra
Venue
Neuron
Publisher
Elsevier BV
Published
2019-02
Volume
101
Issue
3
Pages
459-471.e5
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2909833689
Cited by
364
References
53
Citations by year
2026: 32 · 2025: 48 · 2024: 53 · 2023: 47 · 2022: 66 · 2021: 52 · 2020: 41 · 2019: 23
FWCI
17.13
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Opin vísindi (Opin vísindi) (submittedVersion, cc-by-nc-sa)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Opin vísindi (Opin vísindi) (submittedVersion, other-oa)
  • Apollo (cc-by)
Funders
  • European Research Council
  • European Union Horizon 2020 Research and Innovation Program (771411)
  • Wellcome Trust (091543/Z/10/Z, 102160/Z/13/Z)
  • Paul G. Allen Frontiers Group (12076)
  • Medical Research Council
  • Gates Cambridge Trust
  • Biotechnology and Biological Sciences Research Council
  • Homerton College Cambridge
  • UK MS Society (50)
  • Fonds de Recherche du Québec - Santé
  • Cambridge Commonwealth, European and International Trust
  • Lister Institute
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
oligodendrocyte precursor cells, functional heterogeneity, regional heterogeneity, aging, myelination, oligodendrocyte differentiation, single-cell electrophysiology, adult brain
MeSH terms
Action Potentials, Animals, Brain, Cells, Cultured, Female, Ion Channels, Male, Mice, Inbred C57BL, Oligodendroglia, Receptors, N-Methyl-D-Aspartate, Mice, Neural Stem Cells

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