Cited by 265Estrogen and related hormone effectsNF-κB Signaling PathwaysAdrenal Hormones and Disorders

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Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors

De Bosscher, K·2000·Journal of Neuroimmunology

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Abstract

Glucocorticoids are the most widely used anti-inflammatory and immunomodulatory agents, whose mechanism of action is based mainly on interference with the activity of transcription factors, such as nuclear factor kappaB (NF-kappaB) and activator protein-1 (AP-1). The precise molecular mechanisms of gene repression by glucocorticoids are a controversial matter, due to the existence of many conflicting hypotheses. We discuss the three main paradigms reported in the literature, namely the inhibitor kappaB-alpha (IkappaB-alpha) upregulatory model, the protein-protein interaction model and the competition model.

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See all 265

Authors: De Bosscher, K.
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2000-09-01
Volume: 109
Issue: 1
Pages: 16-22
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/s0165-5728(00)00297-6
OpenAlex: W2148930555
Cited by: 264
References: 52
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 10 · 2020: 8 · 2019: 5 · 2018: 12 · 2017: 12 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 7 · 2012: 9
FWCI: 10.49
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: glucocorticoids, anti-inflammatory activity, immunosuppression, glucocorticoid receptor, transcription factors, NF-κB, AP-1, gene repression, IκBα, protein-protein interaction, competition model
MeSH terms: NF-KappaB Inhibitor alpha, Animals, Anti-Inflammatory Agents, DNA-Binding Proteins, Glucocorticoids, Humans, Immunosuppressive Agents, Receptors, Glucocorticoid, Transcription Factors, NF-kappa B, Cyclic AMP Response Element-Binding Protein, I-kappa B Proteins

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Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors

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