The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors
Abstract
Glucocorticoids are the most widely used anti-inflammatory and immunomodulatory agents, whose mechanism of action is based mainly on interference with the activity of transcription factors, such as nuclear factor kappaB (NF-kappaB) and activator protein-1 (AP-1). The precise molecular mechanisms of gene repression by glucocorticoids are a controversial matter, due to the existence of many conflicting hypotheses. We discuss the three main paradigms reported in the literature, namely the inhibitor kappaB-alpha (IkappaB-alpha) upregulatory model, the protein-protein interaction model and the competition model.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For example, one of the mechanisms underlying the anti-inflammatory effects of GCs is the inhibition of nuclear factor-κB (NF-κB), a major transcription factor for the inflammatory-response genes (De Bosscher et al, 2000).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as De Bosscher et al, 2000
Citations
Cites
1 retracted
Adcock, I. M., Nasuhara, Y., Stevens, D. A., & Barnes, P. J. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702613 · Cited by 118
RetractedNF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science · doi:10.1126/science.270.5234.286 · Cited by 2,390
Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R. A., Rose, D. W., Glass, C. K., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81118-6 · Cited by 2,150
Steroid hormone receptors: Many Actors in search of a plot
Beato, M., Herrlich, P. A., & Schütz, G. (1995) · Cell · doi:10.1016/0092-8674(95)90201-5 · Cited by 1,816
Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids
Scheinman, R. I., Cogswell, P. C., Lofquist, A. K., & Baldwin, A. S. (1995) · Science · doi:10.1126/science.270.5234.283 · Cited by 1,676
Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms
Barnes, P. J. (1998) · Clinical Science · doi:10.1042/cs0940557 · Cited by 1,591
Jonat, C., Rahmsdorf, H. J., Park, K.-K., Cato, A. C. B., Gebel, S., Ponta, H., & Herrlich, P. (1990) · Cell · doi:10.1016/0092-8674(90)90395-u · Cited by 1,544
Zhong, H., Voll, R. E., & Ghosh, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80066-0 · Cited by 1,210
Cited by
Sorted by citations
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898
NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
Roman‐Blas, J. A., & Jiménez, S. A. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.04.008 · Cited by 701
Reddy, T. E., Pauli, F., Sprouse, R. O., Neff, N. F., Newberry, K. M., Garabedian, M. J., & Myers, R. M. (2009) · Genome Research · doi:10.1101/gr.097022.109 · Cited by 543
NF-κB in inflammation and cancer
Mao, H., Zhao, X., & Sun, S. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01310-w · Cited by 601
Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
Silverman, M. N., Pearce, B. D., Biron, C. A., & Miller, A. H. (2005) · Viral Immunology · doi:10.1089/vim.2005.18.41 · Cited by 506
Metadata
- Authors
- De Bosscher, K.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2000-09-01
- Volume
- 109
- Issue
- 1
- Pages
- 16-22
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2148930555
- Cited by
- 264
- References
- 52
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 10 · 2020: 8 · 2019: 5 · 2018: 12 · 2017: 12 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 7 · 2012: 9
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoids, anti-inflammatory activity, immunosuppression, glucocorticoid receptor, transcription factors, NF-κB, AP-1, gene repression, IκBα, protein-protein interaction, competition model
- MeSH terms
- NF-KappaB Inhibitor alpha, Animals, Anti-Inflammatory Agents, DNA-Binding Proteins, Glucocorticoids, Humans, Immunosuppressive Agents, Receptors, Glucocorticoid, Transcription Factors, NF-kappa B, Cyclic AMP Response Element-Binding Protein, I-kappa B Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
