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Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors
Abstract
Glucocorticoids are the most widely used anti-inflammatory and immunomodulatory agents, whose mechanism of action is based mainly on interference with the activity of transcription factors, such as nuclear factor kappaB (NF-kappaB) and activator protein-1 (AP-1). The precise molecular mechanisms of gene repression by glucocorticoids are a controversial matter, due to the existence of many conflicting hypotheses. We discuss the three main paradigms reported in the literature, namely the inhibitor kappaB-alpha (IkappaB-alpha) upregulatory model, the protein-protein interaction model and the competition model.
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“For example, one of the mechanisms underlying the anti-inflammatory effects of GCs is the inhibition of nuclear factor-κB (NF-κB), a major transcription factor for the inflammatory-response genes (De Bosscher et al, 2000).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as De Bosscher et al, 2000
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Laethem, F. V., Liang, X., Andris, F., Urbain, J., Vandenbranden, M., Ruysschaert, J., Resh, M. D., Stulnig, T. M., & Léo, O. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.2932 · Cited by 44
The HPA Axis and the Immune System
Dunn, A. J. (2007) · Neuroimmune biology · doi:10.1016/s1567-7443(07)00201-3 · Cited by 45
Geng, C.-D., & Vedeckis, W. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508245200 · Cited by 43
Metadata
- Authors
- De Bosscher, K.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2000-09-01
- Volume
- 109
- Issue
- 1
- Pages
- 16-22
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2148930555
- Cited by
- 264
- References
- 52
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 10 · 2020: 8 · 2019: 5 · 2018: 12 · 2017: 12 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 7 · 2012: 9
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoids, anti-inflammatory activity, immunosuppression, glucocorticoid receptor, transcription factors, NF-κB, AP-1, gene repression, IκBα, protein-protein interaction, competition model
- MeSH terms
- NF-KappaB Inhibitor alpha, Animals, Anti-Inflammatory Agents, DNA-Binding Proteins, Glucocorticoids, Humans, Immunosuppressive Agents, Receptors, Glucocorticoid, Transcription Factors, NF-kappa B, Cyclic AMP Response Element-Binding Protein, I-kappa B Proteins
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