CoChat
Sign Up
Cited by 115Stress Responses and CortisolInflammatory Bowel DiseaseAdrenal Hormones and Disorders

The DOI matches its Crossref record; 55 of the 59 references it cites were found in a registry or an index.

Uncoupling of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis in inflammatory bowel disease?

Straub, Rainer H., Herfarth, Hans, Falk, Werner, Andus, Tilo, Schölmerich, Jürgen·2002·Journal of Neuroimmunology
DOI 10.1016/s0165-5728(02)00047-4
Open this paper in CoChat — free account

Abstract

In inflammatory diseases such as Crohn's disease (CD) and ulcerative colitis (UC), one would expect that TNF or IL-6 stimulates the hypothalamus, which activates the hypothalamus-autonomic nervous system (HANS) axis and the hypothalamic-pituitary-adrenal (HPA) axis in a parallel fashion. The study was initiated in order to investigate the parallelism of the HANS and HPA axes. We measured a typical marker of the HANS axis (neuropeptide Y, NPY) and of the HPA axis (serum cortisol). Plasma NPY was positively correlated with serum cortisol in control subjects (R(Rank)=0.259, p=0.026), which is a sign for the parallel activation of the two axes in healthy subjects. However, serum cortisol was not correlated with plasma NPY in CD or UC patients. In the active CD or UC, inclusion of patients with and without prior prednisolone therapy revealed a negative correlation between the serum cortisol and plasma NPY (CD: R(Rank)=-0.285, p<0.05; UC: R(Rank)=-0.510, p<0.01). This study demonstrates that the two stress axes seem to act in a parallel fashion in control subjects but are uncoupled in IBD patients. Uncoupling of these two axes may be partly due to prior corticosteroid therapy, whereas inverse coupling is a result of simultaneous corticosteroid therapy. It is discussed how the uncoupling of the two anti-inflammatory stress axes can appear.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0165-5728(02)00047-4

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 59 references

Cited by

Sorted by citations

Items 101–114 of 114

Related

See all

Metadata

Authors
Straub, R. H., Herfarth, H., Falk, W., Andus, T., & Schölmerich, J.
Affiliations
University Hospital Regensburg (DE)
ORCID
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2002-05
Volume
126
Issue
1-2
Pages
116-125
ISSN
0165-5728 (ISSN-L)
DOI
10.1016/s0165-5728(02)00047-4
OpenAlex
W2082901516
Semantic Scholar
d6ff2f63c6820d719fdf42dcd5f9a8dcb63589cb
Cited by
115
References
59
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 10 · 2013: 4 · 2012: 6
FWCI
3.58
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
inflammatory bowel disease, Crohn's disease, ulcerative colitis, hypothalamic-pituitary-adrenal axis, neuropeptide Y, cortisol, corticosteroid therapy, prednisolone, cytokines, TNF-α, interleukin-6
MeSH terms
Adult, Anti-Inflammatory Agents, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Neuropeptide Y, Pituitary-Adrenal System, Prednisolone, Sex Factors, Sympathetic Nervous System, Tumor Necrosis Factor-alpha, Inflammatory Bowel Diseases, Neuroimmunomodulation, Interleukin-6

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review