Cited by 115Stress Responses and CortisolInflammatory Bowel DiseaseAdrenal Hormones and Disorders

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Uncoupling of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis in inflammatory bowel disease?

Straub, Rainer H., Herfarth, Hans, Falk, Werner, Andus, Tilo, Schölmerich, Jürgen·2002·Journal of Neuroimmunology

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Abstract

In inflammatory diseases such as Crohn's disease (CD) and ulcerative colitis (UC), one would expect that TNF or IL-6 stimulates the hypothalamus, which activates the hypothalamus-autonomic nervous system (HANS) axis and the hypothalamic-pituitary-adrenal (HPA) axis in a parallel fashion. The study was initiated in order to investigate the parallelism of the HANS and HPA axes. We measured a typical marker of the HANS axis (neuropeptide Y, NPY) and of the HPA axis (serum cortisol). Plasma NPY was positively correlated with serum cortisol in control subjects (R(Rank)=0.259, p=0.026), which is a sign for the parallel activation of the two axes in healthy subjects. However, serum cortisol was not correlated with plasma NPY in CD or UC patients. In the active CD or UC, inclusion of patients with and without prior prednisolone therapy revealed a negative correlation between the serum cortisol and plasma NPY (CD: R(Rank)=-0.285, p<0.05; UC: R(Rank)=-0.510, p<0.01). This study demonstrates that the two stress axes seem to act in a parallel fashion in control subjects but are uncoupled in IBD patients. Uncoupling of these two axes may be partly due to prior corticosteroid therapy, whereas inverse coupling is a result of simultaneous corticosteroid therapy. It is discussed how the uncoupling of the two anti-inflammatory stress axes can appear.

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Authors: Straub, R. H., Herfarth, H., Falk, W., Andus, T., & Schölmerich, J.
Affiliations: University Hospital Regensburg (DE)
ORCID: Straub, Rainer H.
Herfarth, Hans
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2002-05
Volume: 126
Issue: 1-2
Pages: 116-125
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/s0165-5728(02)00047-4
OpenAlex: W2082901516
Semantic Scholar: d6ff2f63c6820d719fdf42dcd5f9a8dcb63589cb
Cited by: 115
References: 59
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 10 · 2013: 4 · 2012: 6
FWCI: 3.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, hypothalamic-pituitary-adrenal axis, neuropeptide Y, cortisol, corticosteroid therapy, prednisolone, cytokines, TNF-α, interleukin-6
MeSH terms: Adult, Anti-Inflammatory Agents, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Neuropeptide Y, Pituitary-Adrenal System, Prednisolone, Sex Factors, Sympathetic Nervous System, Tumor Necrosis Factor-alpha, Inflammatory Bowel Diseases, Neuroimmunomodulation, Interleukin-6

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Uncoupling of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis in inflammatory bowel disease?

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