Uncoupling of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis in inflammatory bowel disease?

The Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System

Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252

Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones

Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519

Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial.

Rachmilewitz, D. (1989) · BMJ · doi:10.1136/bmj.298.6666.82 · Cited by 1,038

Admission criteria for immunogerontological studies in man: The senieur protocol

Ligthart, G. J., Corberand, J. X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B., Müller-Hermelink, H. K., & Steinmann, G. G. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90152-0 · Cited by 754 · cited 1×

Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats.

Sternberg, E. M., Hill, J. M., Chrousos, G. P., Kamilaris, T., Listwak, S. J., Gold, P. W., & Wilder, R. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2374 · Cited by 723

Intraadrenal interactions in the regulation of adrenocortical steroidogenesis.

Ehrhart-Bornstein, M., Hinson, J. P., Bornstein, S. R., Scherbaum, W. A., & Vinson, G. P. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.2.0326 · Cited by 600 · cited 1×

Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans.

Mastorakos, G., Chrousos, G. P., & Weber, J. S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263159 · Cited by 591

Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging

Poynter, M. E., & Daynes, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32833 · Cited by 556

Hypothalamic–pituitary–adrenal axis perturbations in patients with fibromyalgia

Crofford, L. J., Pillemer, S. R., Kalogeras, K. T., Cash, J. M., Michelson, D., Kling, M. A., Sternberg, E. M., Gold, P. W., Chrousos, G. P., & Wilder, R. L. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780371105 · Cited by 508

Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.

MURCH, S. H., Lamkin, V. A., Savage, M. O., Walker‐Smith, J. A., & MacDonald, T. T. (1991) · Gut · doi:10.1136/gut.32.8.913 · Cited by 482

Brain–Gut Interactions in Inflammatory Bowel Disease

Bonaz, B. L., & Bernstein, C. N. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.10.003 · Cited by 667

Psychological stress in IBD: new insights into pathogenic and therapeutic implications

Mawdsley, J. E., & Rampton, D. S. (2005) · Gut · doi:10.1136/gut.2005.064261 · Cited by 622

Neuropeptide, Y, peptide YY and pancreatic polypeptide in the gut-brain axis

Holzer, P., Reichmann, F., & Farzi, A. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.08.005 · Cited by 501

Neuropeptides and the Microbiota-Gut-Brain Axis

Holzer, P., & Farzi, A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_9 · Cited by 451

Autonomic Nervous System and Immune System Interactions

Kenney, M., & Ganta, C. K. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130051 · Cited by 441

A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation

Rosenkranz, M. A., Davidson, R. J., MacCoon, D. G., Sheridan, J. F., Kalin, N. H., & Lutz, A. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.013 · Cited by 307

The role of the sympathetic nervous system in intestinal inflammation

Straub, R. H., Wiest, R., Strauch, U. G., Härle, P., & Schölmerich, J. (2006) · Gut · doi:10.1136/gut.2006.091322 · Cited by 237

The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry

Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 236

Effects of Exercise Training on the Autonomic Nervous System with a Focus on Anti-Inflammatory and Antioxidants Effects

Daniela, M., Luca, C. M., Onu, I., Paula, M., Iordan, D. A., & Buculei, I. (2022) · Antioxidants · doi:10.3390/antiox11020350 · Cited by 264

Adrenal Insufficiency and Colonic Inflammation after a Novel Chronic Psycho-Social Stress Paradigm in Mice: Implications and Mechanisms

Reber, S. O., Birkeneder, L., Veenema, A. H., Obermeier, F., Falk, W., Straub, R. H., & Neumann, I. (2006) · Endocrinology · doi:10.1210/en.2006-0983 · Cited by 212

Stress and the Brain-Gut Axis in Functional and Chronic-Inflammatory Gastrointestinal Diseases: A Transdisciplinary Challenge

Labanski, A., Langhorst, J., Engler, H., & Elsenbruch, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104501 · Cited by 200

Neural immune pathways and their connection to inflammatory diseases.

Eskandari, F., Webster, J. I., & Sternberg, E. M. (2003) · Arthritis Research · doi:10.1186/ar1002 · Cited by 201

Altered neuro-endocrine–immune pathways in the irritable bowel syndrome: the top-down and the bottom-up model

Stasi, C., Rosselli, M., Bellini, M., Laffi, G., & Milani, S. (2012) · Journal of Gastroenterology · doi:10.1007/s00535-012-0627-7 · Cited by 148

The homeostatic role of neuropeptide Yin immune function and its impact on mood and behaviour

Farzi, A., Reichmann, F., & Holzer, P. (2015) · Acta Physiologica · doi:10.1111/apha.12445 · Cited by 145

Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies

Darmani, N. A., Izzo, A. A., Degenhardt, B. F., Valenti, M., Scaglione, G., Capasso, R., Sorrentini, I., & Marzo, V. D. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.001 · Cited by 144

The Effect of Acute Psychologic Stress on Systemic and Rectal Mucosal Measures of Inflammation in Ulcerative Colitis

Mawdsley, J. E., Macey, M. G., Feakins, R. M., Langmead, L., & Rampton, D. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.017 · Cited by 143

Chronic Intermittent Psychosocial Stress (Social Defeat/Overcrowding) in Mice Increases the Severity of an Acute DSS-Induced Colitis and Impairs Regeneration

Reber, S. O., Obermeier, F., Straub, R. H., Falk, W., & Neumann, I. D. (2006) · Endocrinology · doi:10.1210/en.2006-0347 · Cited by 137

Relevance of Neuropeptide Y for the neuroimmune crosstalk

Bedoui, S., Kawamura, N., Straub, R. H., Pabst, R., Yamamura, T., & von Hörsten, S. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00424-1 · Cited by 134

Brain-immune interactions and disease susceptibility

Marques-Deak, A., Cizza, G., & Sternberg, E. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001643 · Cited by 134

Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease

Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124

Interaction of the endocrine system with inflammation: a function of energy and volume regulation

Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121

The Role of Psychological Stress in Inflammatory Bowel Disease

Mawdsley, J. E. D., & Rampton, D. S. (2006) · NeuroImmunoModulation · doi:10.1159/000104861 · Cited by 116

Stress and animal models of inflammatory bowel disease—An update on the role of the hypothalamo–pituitary–adrenal axis

Reber, S. O. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.014 · Cited by 116

Increase of sympathetic outflow measured by neuropeptide Y and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with systemic lupus erythematosus and rheumatoid arthritis: another example of uncoupling of response systems

Härle, P., Straub, R. H., Wiest, R., Mayer, A., Schölmerich, J., Atzeni, F., Carrabba, M., Cutolo, M., & Sarzi-Puttini, P. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.038059 · Cited by 114

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Li, Y., Zhu, W., Zuo, L., & Shen, B. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000791 · Cited by 111

The Endocannabinoid System and Physical Exercise

Matei, D., Trofin, D., Iordan, D. A., Onu, I., Condurache, I., Ionițe, C., & Buculei, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031989 · Cited by 130

The Brain-Gut Axis in Health and Disease

Omran, Y. A., & Aziz, Q. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_6 · Cited by 109

Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y

Painsipp, E., Herzog, H., Sperk, G., & Holzer, P. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01326.x · Cited by 93

Brain and Gut Interactions in Irritable Bowel Syndrome: New Paradigms and New Understandings

Coss‐Adame, E., & Rao, S. S. C. (2014) · Current Gastroenterology Reports · doi:10.1007/s11894-014-0379-z · Cited by 89

Role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases--the 10-year update.

Straub, R., Bijlsma, J., Masi, A., & Cutolo, M. (2013) · Seminars in Arthritis & Rheumatism · doi:10.1016/j.semarthrit.2013.04.008 · Cited by 83

Disruption of the blood–brain barrier during TNBS colitis

Natah, S. S., Mouihate, A., Pittman, Q. J., & Sharkey, K. A. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00654.x · Cited by 79

Neuroendocrine mechanisms of immune dysregulation: applications to allergy and asthma

Marshall, G. D. (2004) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61482-2 · Cited by 78

Review article: the role of the autonomic nervous system in the pathogenesis and therapy of IBD

Mogilevski, T., Burgell, R., Aziz, Q., & Gibson, P. R. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15433 · Cited by 77

Old Friends, immunoregulation, and stress resilience

Langgartner, D., Lowry, C. A., & Reber, S. O. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2228-7 · Cited by 76

Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1β/TNF

Haas, S., & Straub, R. H. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3852 · Cited by 71

Concepts of evolutionary medicine and energy regulation contribute to the etiology of systemic chronic inflammatory diseases

Straub, R. H. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.002 · Cited by 69

Chronic Subordinate Colony Housing Paradigm: A Mouse Model to Characterize the Consequences of Insufficient Glucocorticoid Signaling

Langgartner, D., Füchsl, A. M., Uschold‐Schmidt, N., Slattery, D. A., & Reber, S. O. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00018 · Cited by 73

Corticosteroid resistance in a subpopulation of multiple sclerosis patients as measured by ex vivo dexamethasone inhibition of LPS induced IL-6 production

DeRijk, R. H., Eskandari, F., & Sternberg, E. M. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.02.009 · Cited by 60

Role of the Brain-Gut Axis in the Pathophysiology of Crohn’s Disease

Stasi, C., & Orlandelli, E. (2008) · Digestive Diseases · doi:10.1159/000116774 · Cited by 57

Increased aggregation response of platelets in patients with inflammatory bowel disease

Andoh, A., Yoshida, T., Yagi, Y., Bamba, S., Hata, K., Tsujikawa, T., Kitoh, K., Sasaki, M., & Fujiyama, Y. (2006) · Journal of Gastroenterology · doi:10.1007/s00535-005-1721-x · Cited by 50

The role of the neuropeptide Y (NPY) family in the pathophysiology of inflammatory bowel disease (IBD)

El‐Salhy, M., & Hausken, T. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.09.005 · Cited by 55

During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH

Kizildere, S., Glück, T., Zietz, B., Schölmerich, J., & Straub, R. H. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480045 · Cited by 41

Unraveling the fatigue puzzle: insights into the pathogenesis and management of IBD-related fatigue including the role of the gut-brain axis

Truyens, M., Lernout, H., Vos, M. D., Laukens, D., & Lobatón, T. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1424926 · Cited by 42

Uncoupling of sympathetic nervous system and hypothalamic‐pituitary‐adrenal axis in cirrhosis

Wiest, R., Moleda, L., Zietz, B., Hellerbrand, C., Schölmerich, J., & Straub, R. H. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05456.x · Cited by 37

Neuroendocrine Dysregulation in Irritable Bowel Syndrome Patients: A Pilot Study

Stasi, C., Bellini, M., Gambaccini, D., Duranti, E., de Bortoli, N., Fani, B., Albano, E., Russo, S., Sudano, I., Laffi, G., et al. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16155 · Cited by 36

The link between negative affect, vagal tone, and visceral sensitivity in quiescent C rohn's disease

Rubio, A., Sonia Pellissier, A., Picot, A., Dantzer, C., & Bonaz, B. L. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12373 · Cited by 34

Altered sympathovagal balance and pain hypersensitivity in TNBS-induced colitis

Ciesielczyk, K., Furgała, A., Dobrek, Ł., Juszczak, K., & Thor, P. J. (2017) · Archives of Medical Science · doi:10.5114/aoms.2015.55147 · Cited by 32

Heart rate variability and inflammatory bowel disease in humans

Kim, K.-N., Yao, Y., & Ju, S.-Y. (2020) · Medicine · doi:10.1097/md.0000000000023430 · Cited by 37

Autonomic Dysfunction in Rheumatic Diseases

Straub, R. H., Baerwald, C., Wahle, M., & Jänig, W. (2005) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2004.09.002 · Cited by 29

Amelioration of dextran sulfate sodium-induced colitis by neuropeptide Y antisense oligodeoxynucleotide

Pang, X. H., Li, T. K., Xie, Q., He, F. Q., Cui, D. J., Chen, Y. Q., Huang, X. L., & Gan, H. T. (2010) · International Journal of Colorectal Disease · doi:10.1007/s00384-010-0964-z · Cited by 25

Psychoneuroimmunologic factors in inflammatory bowel disease

Mackner, L. M., Clough-Paabo, E., PAJER, K. A., Lourie, A., & Crandall, W. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21430 · Cited by 25

Effects of intestinal inflammation on specific subgroups of guinea-pig celiac ganglion neurons

Dong, X.-X., Thacker, M., Pontell, L. J., Furness, J. B., & Nurgali, K. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.08.045 · Cited by 24

Toward a better understanding of the central consequences of intestinal inflammation

Nyuyki, K. D., & Pittman, Q. J. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12935 · Cited by 26

Activated sympathetic nerve post stroke downregulates Toll-like receptor 5 and disrupts the gut mucosal barrier

Wang, H., Li, J., Wu, G., Lin, X., Chen, J., Liang, J., Zhang, J., Luo, X., Mao, H., Xie, J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101754 · Cited by 22

Disturbed in vitro adrenergic modulation of cytokine production in inflammatory bowel diseases in remission

Lucas, A., Cobelens, P. M., Kavelaars, A., Heijnen, C. J., Holtmann, G., Haag, S., Gerken, G., Langhorst, J., Dobos, G., Schedlowski, M., et al. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.09.011 · Cited by 22

Functional disruption of cortical cingulate activity attenuates visceral hypersensitivity and anxiety induced by acute experimental colitis

Brenner, L., Zerlin, L., & Tan, L. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-81256-x · Cited by 21

Cardiovascular and pupillary autonomic nervous dysfunction in patients with rheumatoid arthritis - a cross-sectional and longitudinal study.

Schwemmer, S., Beer, P., Schölmerich, J., Fleck, M., & Straub, R. H. (2006) · PubMed · Cited by 21

Depression has a Strong Relationship to Alterations in the Immune, Endocrine and Neural System

Hestad, K. A., Aukrust, P., Tønseth, S., & Reitan, S. K. (2009) · Current Psychiatry Reviews · doi:10.2174/157340009789542105 · Cited by 20

Nonpeptide Corticotropin-Releasing Hormone Receptor Type 1 Antagonists and Their Applications in Psychosomatic Disorders

Contoreggi, C. S., Rice, K. C., & Chrousos, G. P. (2004) · Neuroendocrinology · doi:10.1159/000081785 · Cited by 20

Predictive and potentially predictive factors in early arthritis: a multidisciplinary approach

Härle, P. (2005) · British journal of rheumatology · doi:10.1093/rheumatology/keh530 · Cited by 19

A method for describing and evaluating naturopathic whole practice.

Herman, P. M., Sherman, K. J., Erro, J. H., Cherkin, D. C., Milliman, B., & Adams, L. A. (2006) · PubMed · Cited by 16

Impact of comorbid psychiatric disorders on healthcare utilization in patients with inflammatory bowel disease: A nationally representative cohort study

Hill, E., Nguyen, N. H., Qian, A. S., Patel, S., Chen, P. L., Tse, C.-S., & Singh, S. (2022) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07505-9 · Cited by 15

Emerging Concepts for the Pathogenesis of Chronic Disabling Inflammatory Diseases: Neuroendocrine-immune Interactions and Evolutionary Biology

STRAUB, R. H., DEL REY, A., & BESEDOVSKY, H. O. (2007) · Psychoneuroimmunology · doi:10.1016/b978-012088576-3/50014-9 · Cited by 14

Systemic disease sequelae in chronic inflammatory diseases and chronic psychological stress: comparison and pathophysiological model

Straub, R. H. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12409 · Cited by 14

Effects of Some Kampo Medicines on Plasma Levels of Neuropeptide Y under Venipuncture Stress

Sato, Y., Katagiri, F., Itoh, H., & Takeyama, M. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.1757 · Cited by 14

Regulatory Role of the Pituitary-Adrenal Axis in Experimental Colitis: Effect of Adrenalectomy on the Clinical Course and the TH1/TH2 Immune Profile

Shibolet, O., Alper, R., Ilan, Y., & Weidenfeld, J. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000191610.97842.51 · Cited by 14

Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat

Kang, J. W., Kim, T. W., La, J., Sung, T. S., Kim, H. J., Kwon, Y., Kim, J. Y., & Yang, I. S. (2004) · Journal of Veterinary Science · doi:10.4142/jvs.2004.5.3.189 · Cited by 14

A bio-behavioral study of chronic idiopathic colitis in the rhesus macaque (Macaca mulatta)

Howell, S., White, D., Ingram, S., Jackson, R., Larin, J., Morales, P. R., García, A. P., Hicks, C., Hopper, K., & Wagner, J. (2012) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2012.01.003 · Cited by 13

Disease-specific alterations in central fear network engagement during acquisition and extinction of conditioned interoceptive fear in inflammatory bowel disease

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Cardiac and autonomic function in patients with Crohn’s disease during remission

Zawadka‐Kunikowska, M., Słomko, J., Kłopocka, M., Liebert, A., Tafil‐Klawe, M., Klawe, J. J., Newton, J. L., & Zalewski, P. (2018) · Advances in Medical Sciences · doi:10.1016/j.advms.2018.04.009 · Cited by 11

Distinct Alterations in Central Pain Processing of Visceral and Somatic Pain in Quiescent Ulcerative Colitis Compared to Irritable Bowel Syndrome and Health

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Bottom-up and top-down signaling of IL-6 with and without habituation?

Straub, R. H. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.06.009 · Cited by 10

The origin of autoimmune diseases: is there a role for ancestral HLA-II haplotypes in immune hyperactivity

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A History of Psycho-Neuro-Endocrine Immune Interactions in Rheumatic Diseases

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Identification and comparison of microRNAs in pituitary gland during prenatal and postnatal stages of sheep by deep sequencing

Li, X., Li, C., Ni, W., Wang, D., Hou, X., Liu, Z., Cao, Y., Yao, Y., Zhang, X., & Hu, S. (2018) · Journal of Genetics · doi:10.1007/s12041-018-0991-z · Cited by 7

Stimulation of proinflammatory cytokines by volatile sulfur compounds in endodontically treated teeth

Lechner, J., & von Baehr, V. (2015) · International Journal of General Medicine · doi:10.2147/ijgm.s77693 · Cited by 7

A Study of Dizziness or Vertigo Cases Associated with Inflammatory Bowel Disease (Crohn’s Disease and Ulcerative Colitis) in a Vertigo Outpatient Clinic

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Myocardial IL-6 regulation by neurohormones—an in vitro superfusion study

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Stress and the Gastrointestinal System

Bonaz, B. L. (2016) · Springer eBooks · doi:10.1007/978-3-319-28609-9_7 · Cited by 6

Neuroendocrine-immune aspects of accelerated aging in rheumatoid arthritis

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Psychological Stress in Chronic Intestinal Diseases

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Mimicking disruption of brain-immune system-joint communication results in collagen type II-induced arthritis in non-susceptible PVG rats

Wolff, C., Straub, R. H., Hahnel, A., Randolf, A., Wildmann, J., Besedovsky, H. O., & del Rey, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.005 · Cited by 3

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NPY and Immune Functions: Implications for Health and Disease

Bedoui, S., Pabst, R., & von Hörsten, S. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18764-3_14 · Cited by 3

Chapter 27 Modulation of Hormone Axes by Anti-TNF Therapy

Atzeni, F., Sarzi‐Puttini, P., Cutolo, M., & Straub, R. H. (2008) · Technical report · doi:10.1016/s1571-5078(07)00227-9 · Cited by 3

Mon cerveau et mon intestin communiquent, parfois mal !

Bonaz, B. L., & Sonia Pellissier, A. (2013) · Pratique Neurologique - FMC · doi:10.1016/j.praneu.2013.10.004 · Cited by 3

Neuroendocrinology of Inflammatory Disorders

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Warum gibt es analoge Krankheitsmechanismen bei chronisch entzündlichen Krankheiten?

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An unusual finding in a patient with iron deficiency anaemia

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UHRF1 deficiency exacerbates intestinal inflammation by epigenetic modulation of NPY1R gene methylation

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Inflammatory Mediators Affect the Autonomic Nervous System

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Dysfunction of peripheral somatic and autonomic nervous system in patients with severe forms of Crohn’s disease on biological therapy with TNFα inhibitors–A single center study

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Pathogenesis and Neuroendocrine Immunology

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Gut Microbiota in Brain Development and Disorders of the CNS: Therapeutic Strategies Involving Dietary Modification, Pro- and Prebiotic Intervention, and Fecal Microbiota Transplantation (FMT) Therapy

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Psychological Stress: Something to Worry About?

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‘The emergence of neurotransmitters as immune modulators’: letter to Rafael Franco and colleagues

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Uncoupling between the vagal tone and HPA axis in patients with Crohn's disease or irritable bowel syndrome: Relation to stress and inflammation

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神经-内分泌-免疫网络与炎症性肠病

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