The EAE-associated behavioral syndrome II. Modulation by anti-inflammatory treatments
Abstract
EAE is associated with sickness behavior symptoms that are temporally correlated with inflammatory processes. To further elucidate the role of inflammatory mediators in the behavioral syndrome, EAE mice were injected daily with anti-inflammatory drugs, beginning at disease onset. Dexamethasone or interleukin-1 (IL-1) receptor antagonist or the prostaglandins synthesis inhibitor indomethacin attenuated the behavioral symptoms. Administration of the tumor necrosis-factor alpha (TNF-alpha) synthesis inhibitor pentoxifylline or targeted deletion of the type I TNF receptor had no behavioral effects whereas administration of pentoxifylline in IL-1ra-treated mice further reversed the behavioral depression. These findings demonstrate the critical involvement of pro-inflammatory cytokines and prostaglandins in the EAE-associated behavioral syndrome, and may have implications for understanding and treating the neuropsychiatric disturbances in multiple sclerosis (MS) patients.
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Multiple sclerosis can be modelled in rodents by experimental allergic encephalomyelitis (EAE), which is associated with clear signs of sickness and depression-like behaviour.
“This autoimmune neuroinflammatory disease can be modelled in rodents by a condition known as experimental allergic encephalomyelitis (EAE) that is associated with clear signs of sickness and depression-like behaviour88,89.”
From From inflammation to sickness and depression: when the immune system subjugates the brain (2008) · cites this paper as [89]
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- Authors
- Pollak, Y.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Pollak, Y
- ORCID
- Pollak, Y
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 137
- Issue
- 1-2
- Pages
- 100-108
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2013413557
- Cited by
- 56
- References
- 64
- Citations by year
- 2026: 3 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2016: 1 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 3
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hebrew University of Jerusalem
- Israel Science Foundation
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- experimental autoimmune encephalomyelitis, sickness behavior, depression-like behavior, anti-inflammatory therapy, dexamethasone, interleukin-1 receptor antagonist, indomethacin, prostaglandins, pentoxifylline, TNF-α, inflammatory cytokines, neuropsychiatric disorders, multiple sclerosis
- MeSH terms
- Animals, Anti-Inflammatory Agents, Behavior, Animal, Dexamethasone, Encephalomyelitis, Autoimmune, Experimental, Female, Lipopolysaccharides, Mice, Inbred C57BL, Mice, Transgenic, Pentoxifylline, Receptors, Interleukin-1, Mice
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