Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age

van den Biggelaar, Anita H.J.; Gussekloo, Jacobijn; de Craen, Anton J.M.; Frölich, Marijke; Stek, Max L.; van der Mast, Roos C.; Westendorp, Rudi G.J.

doi:10.1016/j.exger.2007.01.011

Cited by 209Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age

van den Biggelaar, Anita H.J., Gussekloo, Jacobijn, de Craen, Anton J.M., Frölich, Marijke, Stek, Max L., van der Mast, Roos C., Westendorp, Rudi G.J.·2007·Experimental Gerontology

DOI 10.1016/j.exger.2007.01.011

Open this paper in CoChat — free account

Abstract

The association between inflammation and neuropsychiatric symptoms in old age is generally accepted but poorly understood. The purpose of this study was to examine whether inflammation precedes depressive symptoms and cognitive decline in old age, and to identify specific inflammatory pathways herein. We measured serum C-reactive protein (CRP) and lipopolysaccharide-induced production of Interleukin (IL)-1beta, IL-6, Tumor Necrosis Factor (TNF)-alpha, IL-1 receptor antagonist (ra), and IL-10 levels in 85-year-old participants free from neuropsychiatric symptoms at baseline (n=267). Participants were prospectively followed for depressive symptoms (Geriatric Depression Scale) and cognitive functioning (Mini Mental State Examination) from 85 to 90 years. Higher baseline CRP levels preceded accelerated increase in depressive symptoms (p<0.001). A higher production capacity of the pro-inflammatory cytokine IL-1beta preceded a greater increase of depressive symptoms (p=0.06), whereas that of its natural antagonist IL-1ra preceded a smaller increase of depressive symptoms (p=0.003). There was no relation of CRP, IL-1beta, and IL-1ra with cognitive decline. Our findings show that in old age inflammatory processes contribute to the development of depressive symptoms but not cognitive decline. A high innate IL-1ra to IL-1beta production capacity reflects a better ability to neutralize inflammation and may therefore protect against depressive symptoms.

Integrity signals

Registry

Crossref · 10.1016/j.exger.2007.01.011

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Increases in IL-6 and CRP prospectively predict the development of depressive symptoms.
“increases in IL-6 and CRP have been found to prospectively predict the development of depressive symptoms”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as van den Biggelaar et al., 2007
In a prospective study of 267 85-year-old subjects with no psychiatric history, elevated biomarkers of inflammation preceded the onset of depressed mood.
“a prospective study of 267 85-year-old subjects with no psychiatric history revealed that elevated biomarkers of inflammation preceded the onset of depressed mood in an aged population with no psychiatric history82.”
From From inflammation to sickness and depression: when the immune system subjugates the brain (2008) · cites this paper as [82]
Inflammatory markers predict increases in depressive symptoms in longitudinal studies.
“Markers of inflammation are elevated in depressed individuals (Dowlati et al., 2010; Haapakoski et al., 2015; Howren et al., 2009) and predict increases in depressive symptoms in longitudinal studies (Gimeno et al., 2009; Valkanova et al., 2013; van den Biggelaar et al., 2007; Wium-Andersen et al., 2013).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as van den Biggelaar et al., 2007

Development and validation of a geriatric depression screening scale: a preliminary report
Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., & Leirer, V. O. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90033-4 · Cited by 15,025 · see citing works
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Move Over ANOVA: Progress in Analyzing Repeated-Measures Data andIts Reflection in Papers Published in the Archives of General Psychiatry
Gueorguieva, R., & Krystal, J. H. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.3.310 · Cited by 1,529 · see citing works
EFFECT OF HUMAN ERYTHROPOIETIN DERIVED FROM RECOMBINANT DNA ON THE ANAEMIA OF PATIENTS MAINTAINED BY CHRONIC HAEMODIALYSIS
Winearls, C., Pippard, M. J., Downing, M. R., Oliver, D., Reid, C. D. L., & Cotes, P. M. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92192-6 · Cited by 1,401 · see citing works
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147 · see citing works
Cytokine‐Induced Sickness Behavior: Mechanisms and Implications
Dantzer, R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05827.x · Cited by 808 · see citing works
Inflammatory markers and cognition in well-functioning African-American and white elders
Yaffe, K., Lindquist, K., Penninx, B. W., Simonsick, E. M., Pahor, M., Kritchevsky, S., Launer, L., Kuller, L., Rubin, S., & Harris, T. (2003) · Neurology · doi:10.1212/01.wnl.0000073620.42047.d7 · Cited by 706 · see citing works
Untitled work
(2000) · PubMed · Cited by 685 · see citing works
Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.
Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637 · see citing works
Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway
Li, Y., Liu, L., Barger, S. W., & Griffin, W. S. T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01605.2003 · Cited by 563 · see citing works
Interleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging
Weaver, J. D., Huang, M.-H., Albert, M., Harris, T., Rowe, J. W., & Seeman, T. E. (2002) · Neurology · doi:10.1212/wnl.59.3.371 · Cited by 536 · see citing works
Inflammatory markers and depressed mood in older persons: results from the health, aging and body composition study
Penninx, B. W. J. H., Kritchevsky, S. B., Yaffe, K. S., Newman, A. B., Simonsick, E. M., Rubin, S. M., Ferrucci, L., Harris, T. B., & Pahor, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01811-5 · Cited by 530 · see citing works
The Neuropsychiatric Effects of Treatment with Interleukin-2 and Lymphokine-Activated Killer Cells
Denicoff, K. D., RUBINOW, D. R., PAPA, M. Z., SIMPSON, C., SEIPP, C. A., LOTZE, M. T., Chang, A. E., ROSENSTEIN, D., & Rosenberg, S. A. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-2-293 · Cited by 456 · see citing works
The assessment of disability with the Groningen Activity Restriction Scale. Conceptual framework and psychometric properties
Kempen, G. I. J. M., Miedema, I., Ormel, J., & Molenaar, W. (1996) · Social Science & Medicine · doi:10.1016/s0277-9536(96)00057-3 · Cited by 393 · see citing works
Indicators of immune activation in major depression
Sluzewska, A., RYBAKOWSKI, J. K., Bosmans, E., Sobieska, M., Berghmans, R., Maes, M. H. J., & Wiktorowicz, K. (1996) · Psychiatry Research · doi:10.1016/s0165-1781(96)02783-7 · Cited by 384 · see citing works
Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.8.1189 · Cited by 364 · see citing works
Accuracy of the 15‐item geriatric depression scale (GDS‐15) in a community sample of the oldest old
de Craen, A. J. M., Heeren, T. J., & Gussekloo, J. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.773 · Cited by 364 · see citing works
Self-citation
Serum inflammatory proteins and cognitive decline in older persons
Dik, M. G., Jonker, C., Hack, C. E., Smit, J. H., Comijs, H. C., & Eikelenboom, P. (2005) · Neurology · doi:10.1212/01.wnl.0000158281.08946.68 · Cited by 338 · see citing works
Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease
Holmes, C. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.6.788 · Cited by 330 · see citing works
Mood and cognitive side effects of interferon-alpha therapy.
Valentine, A. D., Meyers, C. A., Kling, M. A., Richelson, E., & Hauser, P. (1998) · PubMed · Cited by 312 · see citing works
Cytokines, stress and depressive illness: Brain-immune interactions.
Anisman, H., & Merali, Z. (2003) · Annals of Medicine · doi:10.1080/07853890310004075 · Cited by 302 · see citing works
Cytokines: Powerful Regulators of Glial Cell Activation
John, G. R., Lee, S. C., & Brosnan, C. F. (2003) · The Neuroscientist · doi:10.1177/1073858402239587 · Cited by 299 · see citing works
Increase in Interleukin-1β in Late-Life Depression
Thomas, A. J., Davis, S., Morris, C., Jackson, E., Harrison, R., & O’Brien, J. T. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.1.175 · Cited by 291 · see citing works
Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice
Bluthé, R.-M., Layé, S., Michaud, B., Combe, C., Dantzer, R., & Parnet, P. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.01348.x · Cited by 283 · see citing works
INTERFERONS AS MEDIATORS OF PSYCHIATRIC MORBIDITY
Mcdonald, E. M., Mann, A. H., & Thomas, H. C. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91319-5 · Cited by 248 · see citing works
Cytokine Production and Serum Proteins in Depression
SEIDEL, A., AROLT, V., HUNSTIGER, M., RINK, L., BEHNISCH, A., & KIRCHNER, H. (1995) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1995.tb03604.x · Cited by 244 · see citing works
Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression
Layé, S., Gheusi, G., Cremona, S., Combe, C., Kelley, K. W., Dantzer, R., & Parnet, P. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.1.r93 · Cited by 243 · see citing works
Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming
van den Biggelaar, A. H. J., de Craen, A. J. M., Gussekloo, J., Huizinga, T. W. J., Heijmans, B. T., Frölich, M., Kirkwood, T. B. L., & Westendorp, R. G. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1162fje · Cited by 239 · see citing works
Self-citation
Temporal relation between depression and cognitive impairment in old age: prospective population based study
Vinkers, D. J., Gussekloo, J., Stek, M. L., Westendorp, R. G. J., & van der Mast, R. C. (2004) · BMJ · doi:10.1136/bmj.38216.604664.de · Cited by 231 · see citing works
Self-citation
Entry of Blood-Borne Cytokines into the Central Nervous System: Effects on Cognitive Processes
Banks, W. A., Farr, S. A., & Morley, J. E. (2002) · NeuroImmunoModulation · doi:10.1159/000071472 · Cited by 228 · see citing works
Inflammation markers in relation to cognition in a healthy aging population
Teunissen, C. E., van Boxtel, M. P. J., Bosma, H., Bosmans, E., Delanghe, J., Bruijn, C. D., Wauters, A., Maes, M. H. J., Jolles, J., Steinbusch, H. W. M., et al. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00398-3 · Cited by 220 · see citing works
Acute phase proteins in major depression
Berk, M., Wadee, A. A., Kuschke, R. H., & O’Neill-Kerr, A. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00139-6 · Cited by 215 · see citing works
Synergistic Effects of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α: Central Monoamine, Corticosterone, and Behavioral Variations
Brebner, K., Hayley, S., Zacharko, R., Merali, Z., & Anisman, H. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00166-9 · Cited by 214 · see citing works
Inflammatory Proteins and Depression in the Elderly
Tiemeier, H. W., Albert Hofman, D., van Tuijl, H. R., Kiliaan, A. J., Meijer, J., & Breteler, M. M. B. (2003) · Epidemiology · doi:10.1097/00001648-200301000-00025 · Cited by 205 · see citing works
A high response is not essential to prevent selection bias
Wiel, A. B. D., van Exel, E. R., de Craen, A. J. M., Gussekloo, J., Lagaay, A. M., Knook, D. L., & Westendorp, R. G. J. (2002) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00505-x · Cited by 203 · see citing works
Self-citation
Synergy between tumor necrosis factor α and interleukin-1 in the induction of sickness behavior in mice
Bluthé, R.-M., Pawlowski, M., Suárez, S., Parnet, P., Pittman, Q. J., Kelley, K. W., & Dantzer, R. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90009-4 · Cited by 203 · see citing works
Heritability estimates of innate immunity: an extended twin study
de Craen, A. J. M., Danielle Posthuma, B., Remarque, E. J., van den Biggelaar, A. H. J., Westendorp, R. G. J., & Boomsma, D. I. (2005) · Genes and Immunity · doi:10.1038/sj.gene.6364162 · Cited by 187 · see citing works
Self-citation
Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier
GUTIERREZ, E., Banks, W. A., & Kastin, A. J. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90005-1 · Cited by 176 · see citing works
Regulation of the Human Serotonin Transporter by Interleukin-1β
Ramamoorthy, S., Ramamoorthy, J. D., Prasad, P. D., Bhat, G. K., Mahesh, V. B., Leibach, F. H., & Ganapathy, V. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2659 · Cited by 156 · see citing works
Determination of tumour necrosis factor-α and interleukin-10 production in a whole blood stimulation system: assessment of laboratory error and individual variation
van der Linden, M. W., Huizinga, T. W. J., Stoeken, D.-J., Sturk, A., & Westendorp, R. G. J. (1998) · Journal of Immunological Methods · doi:10.1016/s0022-1759(98)00108-2 · Cited by 130 · see citing works
Self-citation
The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: effects of acute and chronic administration of the interleukin-1-receptor antagonist (IL-1ra)
Swiergiel, A. H., Smagin, G. N., Johnson, L. J., & Dunn, A. J. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01009-3 · Cited by 130 · see citing works
Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei
Nadjar, A., Bluthé, R.-M., May, M. J., Dantzer, R., & Parnet, P. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300755 · Cited by 120 · see citing works
The role of fever in appetite suppression after endotoxin administration
McCarthy, D. O., Kluger, M. J., & Vander, A. J. (1984) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/40.2.310 · Cited by 109 · see citing works
The 15‐item Geriatric Depression Scale (GDS‐15) detects changes in depressive symptoms after a major negative life event. The Leiden 85‐plus Study
Vinkers, D. J., Gussekloo, J., Stek, M. L., Westendorp, R. G. J., & van der Mast, R. C. (2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1043 · Cited by 108 · see citing works
Self-citation
Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age
Vinkers, D. J., Stek, M. L., van der Mast, R. C., de Craen, A. J. M., le Cessie, S., Jolles, J., Westendorp, R. G. J., & Gussekloo, J. (2005) · Neurology · doi:10.1212/01.wnl.0000167544.54228.95 · Cited by 105 · see citing works
Self-citation
The long‐term safety and tolerability of high‐dose interferon β‐1a in relapsing–remitting multiple sclerosis: 4‐year data from the PRISMS study
Gold, R., Rieckmann, P., Chang, P., et al. (2005) · European Journal of Neurology · doi:10.1111/j.1468-1331.2005.01083.x · Cited by 69 · see citing works
The EAE-associated behavioral syndrome II. Modulation by anti-inflammatory treatments
Pollak, Y. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00073-0 · Cited by 56 · see citing works
The Proinflammatory Cytokine, Interleukin-1α, Reduces Glucocorticoid Receptor Translocation and Function1
Pariante, C. M., Pearce, B. D., Pisell, T. L., Sanchez, C. I., Po, C., Su, C., & Miller, A. H. (1999) · Endocrinology · doi:10.1210/en.140.9.4359 · Cited by 40 · see citing works

Flagged first, then by citations

Sorted by citations

From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works
From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · see citing works
CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies.
Valkanova, V., Ebmeier, K. P., & Allan, C. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.004 · Cited by 972 · see citing works
IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s Disease: Systematic Review and Meta-Analysis
Ng, A., Tam, W. W., Zhang, M. W., Ho, C. S., Husain, S. F., McIntyre, R. S., & Ho, R. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-30487-6 · Cited by 572 · see citing works
The role of inflammation and the gut microbiome in depression and anxiety
Peirce, J. M., & Alviña, K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24476 · Cited by 466 · see citing works
Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity
Minciullo, P. L., Catalano, A., Mandraffino, G., Casciaro, M., Crucitti, A., Maltese, G., Morabito, N., Lasco, A., Gangemi, S., & Basile, G. (2016) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0377-3 · Cited by 433 · see citing works
A prospective evaluation of the directionality of the depression–inflammation relationship
Stewart, J. C., Rand, K. L., Muldoon, M. F., & Kamarck, T. W. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.04.011 · Cited by 390 · see citing works
The longitudinal associations of inflammatory biomarkers and depression revisited: systematic review, meta-analysis, and meta-regression
Mac Giollabhui, N., Ng, T. H., Ellman, L. M., & Alloy, L. B. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00867-4 · Cited by 361 · see citing works
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Salamone, J. D., Yohn, S. E., López-Cruz, L., San Miguel, N., & Correa, M. (2016) · Brain · doi:10.1093/brain/aww050 · Cited by 350 · see citing works
Association of high-sensitivity C-reactive protein with de novo major depression
Pasco, J. A., Nicholson, G. C., Williams, L. J., Jacka, F. N., Henry, M. J., Kotowicz, M. A., Schneider, H. G., Leonard, B. E., & Berk, M. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.076430 · Cited by 321 · see citing works
Interleukin-1 Receptor Activation by Systemic Lipopolysaccharide Induces Behavioral Despair Linked to MAPK Regulation of CNS Serotonin Transporters
Zhu, C.-B., Lindler, K. M., Owens, A. W., Daws, L. C., Blakely, R. D., & Hewlett, W. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.116 · Cited by 317 · see citing works
Inflammation, Glutamate, and Glia in Depression:A Literature Review
McNally, L., Bhagwagar, Z., & Hannestad, J. (2008) · CNS Spectrums · doi:10.1017/s1092852900016734 · Cited by 289 · see citing works
The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253 · see citing works
Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity
Stuart, M. J., & Baune, B. T. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.001 · Cited by 257 · see citing works
Adult neurogenesis and neurodegenerative diseases: A systems biology perspective
Horgusluoglu, E., Nudelman, K., Nho, K., & Saykin, A. J. (2017) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32429 · Cited by 174 · see citing works
The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation.
Dooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176 · see citing works
Inflammation, Sanitation, and Consternation: Loss of Contact With Coevolved, Tolerogenic Microorganisms and the Pathophysiology and Treatment of Major Depression
Raison, C. L., Lowry, C. A., & Rook, G. A. W. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.161 · Cited by 169 · see citing works
Are there bi-directional associations between depressive symptoms and C-reactive protein in mid-life women?
Matthews, K. A., Schott, L. L., Bromberger, J. T., Cyranowski, J. M., Everson-Rose, S. A., & Sowers, M. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.08.005 · Cited by 132 · see citing works
Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms
Aschbacher, K., Epel, E., Wolkowitz, O. M., Prather, A. A., Puterman, E., & Dhabhar, F. S. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.10.010 · Cited by 112 · see citing works
Celecoxib or Naproxen treatment does not benefit depressive symptoms in persons age 70 and older: findings from a randomized controlled trial
Fields, C., Drye, L., Vaidya, V., & Lyketsos, C. (2012) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318227f4da · Cited by 96 · see citing works
C-reactive protein is elevated in atypical but not nonatypical depression: Data from the National Health and Nutrition Examination Survey (NHANES) 1999–2004
Hickman, R. J., Khambaty, T., & Stewart, J. C. (2014) · Journal of Behavioral Medicine · doi:10.1007/s10865-013-9510-0 · Cited by 90 · see citing works
Peripheral Inflammatory Parameters in Late-Life Depression: A Systematic Review
Martínez-Cengotitabengoa, M., Carrascón, L., O’Brien, J., Díaz-Gutiérrez, M.-J., Bermúdez-Ampudia, C., Sanada, K., Arrasate, M., & González-Pinto, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122022 · Cited by 85 · see citing works
The longitudinal associations between C‐reactive protein and depressive symptoms: evidence from the English Longitudinal Study of Ageing (ELSA)
Au, B., Smith, K. J., Gariépy, G., & Schmitz, N. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4250 · Cited by 79 · see citing works
Brain structures implicated in inflammation-associated depression
Harrison, N. A. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_30 · Cited by 74 · see citing works
The Role of Anxious Distress in Immune Dysregulation in Patients with Major Depressive Disorder
Gaspersz, R., Lamers, F., Wittenberg, G., Beekman, A. T. F., van Hemert, A. M., Schoevers, R. A., & Penninx, B. W. J. H. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0016-3 · Cited by 71 · see citing works
Interleukin-1 β-Targeted Treatment Strategies in Inflammatory Depression: Toward Personalized Care
Ellul, P., Boyer, L., Groc, L., Leboyer, M., & Fond, G. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12656 · Cited by 65 · see citing works
Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth
Tartter, M., Hammen, C., Bower, J. E., Brennan, P. A., & Cole, S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.01.003 · Cited by 66 · see citing works
Depression as sickness behavior? A test of the host defense hypothesis in a high pathogen population
Stieglitz, J., Trumble, B. C., Thompson, M. E., Blackwell, A. D., Kaplan, H., & Gurven, M. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.05.008 · Cited by 62 · see citing works
Increased Soluble TNF Receptor 2 in Antidepressant-Free Patients with Late-Life Depression
Diniz, B. S., Teixeira, A. L., Talib, L. L., Mendonça, V. A., Gattaz, W. F., & Forlenza, O. V. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.02.008 · Cited by 54 · see citing works
Chronic Systemic Inflammation Is Associated With Symptoms of Late-Life Depression: The ARIC Study
Sonsin-Diaz, N., Gottesman, R. F., Fracica, E., Walston, J., Windham, B. G., Knopman, D. S., & Walker, K. A. (2020) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.05.011 · Cited by 44 · see citing works
Depressive symptoms are associated with reduced neutrophil function in hip fracture patients
Duggal, N. A., Upton, J., Phillips, A. C., Hampson, P., & Lord, J. M. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.07.004 · Cited by 39 · see citing works
Mitochondria could be a potential key mediator linking the intestinal microbiota to depression
Chen, J., & Vitetta, L. (2020) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29311 · Cited by 36 · see citing works
Association between C reactive protein level and depressive symptoms in an elderly Korean population: Korean Social Life, Health and Aging Project
Song, B. M., Lee, J.-M., Choi, W., Youm, Y., Chu, S. H., Park, Y.-R., & Kim, H. C. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-006429 · Cited by 33 · see citing works
C-reactive protein and memory function suggest antagonistic pleiotropy in very old nondemented subjects
Silverman, J. M., Beeri, M. S., Schmeidler, J., Rosendorff, C., Angelo, G., Mavris, R. S., Grossman, H. T., Elder, G. A., Carrion-Baralt, J., & West, R. (2008) · Age and Ageing · doi:10.1093/ageing/afn278 · Cited by 31 · see citing works
Longitudinal Associations Between Serum Cytokine Levels and Dementia
Kim, J.-W., Stewart, R., Kang, H.-J., Bae, K.-Y., Kim, S.-W., Shin, I.-S., Yoon, J.-S., & Kim, J.-M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00606 · Cited by 29 · see citing works
No association between C-reactive protein and depressive symptoms among the middle-aged and elderly in China: Evidence from the China Health and Retirement Longitudinal Study
Zhang, L., Li, J.-L., Zhang, L.-L., Guo, L.-L., Li, H., & Li, D. (2018) · Medicine · doi:10.1097/md.0000000000012352 · Cited by 27 · see citing works
The relationships between high-sensitivity C-reactive protein and incident depressed mood among older adults
Luukinen, H., Jokelainen, J., & Hedberg, P. (2010) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365510903410548 · Cited by 25 · see citing works
Increased Serum Interleukin-9 and Interleukin-1β Are Associated with Depression in Type 2 Diabetes Patients
VARSHNEY, P., PARVEEN, R., KHAN, M. A., KOHLI, S., & AGARWAL, N. B. (2020) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20190177 · Cited by 19 · see citing works

Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration*
Meyer, N. J., Reilly, J. P., Anderson, B. J., Palakshappa, J. A., Jones, T. K., Dunn, T. G., Shashaty, M. G. S., Feng, R., Christie, J. D., & Opal, S. M. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002749 · Cited by 99 · see citing works
Studying the Pharmacokinetics of Interleukin-1RA Mutants
Khuzaima, I., Iftikhar, K., Tabarruk, U., et al. (2019) · BioScientific Review · doi:10.32350/bsr.0101.02 · Cited by 1 · see citing works
Activity of an Interleukin 1 Receptor Antagonist in Rabbit Models of Uveitis
Rosenbaum, J. T. (1992) · Archives of Ophthalmology · doi:10.1001/archopht.1992.01080160125049 · Cited by 58 · see citing works
Role of Interleukin-1/Interleukin-1 Receptor Antagonist Family of Cytokines in Long-Term Continuous Glucose Monitoring In Vivo
Klueh, U., Antar, O. S., Qiao, Y., & Kreutzer, D. L. (2013) · Journal of Diabetes Science and Technology · doi:10.1177/193229681300700614 · Cited by 10 · see citing works
Correlation between osteoarthritis and interleukin-1 receptor antagonist
Guang-yong, G. (2007) · Yixue yanjiusheng xuebao

Authors: van den Biggelaar, A. H. J., Gussekloo, J., de Craen, A. J. M., Frölich, M., Stek, M. L., van der Mast, R. C., & Westendorp, R. G. J.
Affiliations: Leiden University Medical Center (NL)
ORCID: Gussekloo, Jacobijn
Westendorp, Rudi G.J.
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2007-07
Volume: 42
Issue: 7
Pages: 693-701
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/j.exger.2007.01.011
OpenAlex: W2088634735
Cited by: 209
References: 48
Citations by year: 2026: 3 · 2025: 1 · 2024: 3 · 2023: 14 · 2022: 16 · 2021: 12 · 2020: 8 · 2019: 17 · 2018: 13 · 2017: 9 · 2016: 14 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 13
FWCI: 4.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Alzheimer Nederland
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: inflammation, IL-1 signaling, depressive symptoms, cognitive decline, C-reactive protein, IL-1β, interleukin-1 receptor antagonist, inflammatory cytokines, older adults, innate immune response, neuropsychiatric symptoms
MeSH terms: Activities of Daily Living, Aged, 80 and over, Aging, Cognition, Cognition Disorders, Depression, Female, Humans, Inflammation, Interviews as Topic, Male, Mental Status Schedule, Socioeconomic Factors, Stroke

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks