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Cited by 327

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Increased interleukin-6 expression by microglia from brain of aged mice

Ye, Shi-Ming, Johnson, Rodney W·1999·Journal of Neuroimmunology
DOI 10.1016/s0165-5728(98)00217-3
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Research works printed but not linked: 35

  1. Abe, 1991, Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex, Neurosci. Lett., 125, 172, 10.1016/0304-3940(91)90020-T · DOI
  2. Campbell, 1993, Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6, Proc. Natl. Acad. Sci. USA, 90, 10061, 10.1073/pnas.90.21.10061 · DOI · Paper page
  3. Chai, 1996, Subchronic glucocorticoid pretreatment reversibly attenuates IL-β induced fever in rats; IL-6 mRNA is elevated while IL-1 α and IL-1 β mRNAs are suppressed, in the CNS, Cytokine, 8, 227, 10.1006/cyto.1996.0032 · doi:10.1006/cyto.1996.0032
  4. Chomczynski, 1993, A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples, Biotechniques, 15, 532
  5. Daynes, 1993, Altered regulation of IL-6 production with normal aging, J. Immunol., 150, 5219, 10.4049/jimmunol.150.12.5219 · DOI · Paper page
  6. Finck, 1997, Central lipopolysaccharide elevates plasma IL-6 concentration by an α-adrenoreceptor-mediated mechanism, Am. J. Physiol., 272, R1880
  7. Frei, 1988, Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients, J. Exp. Med., 168, 449, 10.1084/jem.168.1.449 · DOI · Paper page
  8. Fujiwara, 1988, Brefeldin A cause disassembly of the Golgi complex and accumulation of secretory protein in the endoplasmic reticulum, J. Biol. Chem., 263, 18545, 10.1016/S0021-9258(19)81393-5 · DOI · Paper page
  9. Gadient, 1994, Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats, Neurosci. Lett., 182, 243, 10.1016/0304-3940(94)90807-9 · DOI
  10. Gallo, 1989, Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid, J. Neuroimmunol., 23, 109, 10.1016/0165-5728(89)90029-5 · DOI · Paper page
  11. Heyser, 1997, Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain, Proc. Natl. Acad. Sci. USA, 94, 1500, 10.1073/pnas.94.4.1500 · DOI · Paper page
  12. Hofman, 1989, Tumor necrosis factor identified in multiple sclerosis brain, J. Exp. Med., 170, 607, 10.1084/jem.170.2.607 · DOI · Paper page
  13. Holliday, 1995, Cerebellar granule neurons develop elevated calcium responses when treated with interleukin-6 in culture, Brain. Res., 673, 141, 10.1016/0006-8993(94)01417-G · DOI
  14. Houssiau, 1988, Elevated levels of the 26 K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system, Clin. Exp. Immunol., 71, 320
  15. Hull, 1996, The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease, Behav. Brain Res., 78, 37, 10.1016/0166-4328(95)00213-8 · DOI
  16. Irizarry, 1997, A β deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse, J. Neurosci., 17, 7053, 10.1523/JNEUROSCI.17-18-07053.1997 · DOI · Paper page
  17. Kishimoto, 1995, Interleukin-6 family of cytokines and gp130, Blood, 86, 1243, 10.1182/blood.V86.4.1243.bloodjournal8641243 · DOI · Paper page
  18. Lafortune, 1996, Expression of tumor necrosis factor-α (TNFα) and interleukin 6 (IL-6) mRNA in adult human astrocytes: comparison with adult microglia and fetal astrocytes, J. Neuropathol. Exp. Neurol., 55, 515, 10.1097/00005072-199605000-00003 · DOI
  19. Li, 1997, Interleukin-6 inhibits long-term potentiation in rat hippocampal slices, Brain Res., 748, 30, 10.1016/S0006-8993(96)01283-8 · DOI
  20. Mrak, 1997, Aging-associated changes in human brain, J. Neuropathol. Exp. Neurol., 56, 1269, 10.1097/00005072-199712000-00001 · DOI
  21. Perry, 1994, Biology of the mononuclear phagocyte system of the central nervous system and HIV infection, J. Leukocyte Biol., 56, 399, 10.1002/jlb.56.3.399 · DOI
  22. Perry, 1993, Altered antigen expression of microglia in the aged rodent CNS, Glia, 7, 60, 10.1002/glia.440070111 · DOI · Paper page
  23. Prechel, 1996, Increased interleukin-6 production by cerebral cortical tissue of adult vs. young mice, Mech. Ageing Dev., 92, 185, 10.1016/S0047-6374(96)01833-7 · DOI
  24. Qiu, 1995, Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons, J. Neurosci., 15, 6688, 10.1523/JNEUROSCI.15-10-06688.1995 · DOI
  25. Roberts, 1991, β A4 amyloid protein deposition in brain after head trauma, Lancet, 338, 1422, 10.1016/0140-6736(91)92724-G · DOI · Paper page
  26. Royston, 1992, Alzheimer's disease: pathology to potential treatments?, Trends. Pharmacol. Sci., 13, 131, 10.1016/0165-6147(92)90047-A · DOI
  27. Rozovsky, 1998, Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation, Neurobiol. Aging, 19, 97, 10.1016/S0197-4580(97)00169-3 · DOI · Paper page
  28. Sarder, 1996, Comparative effect of IL-2 and IL-6 on morphology of cultured hippocampal neurons from fetal rat brain, Brain. Res., 715, 9, 10.1016/0006-8993(95)01291-5 · doi:10.1016/0006-8993(95)01291-5
  29. SAS Institute, 1989. SAS/STAT User's Guide, Version 6, 4th edn., Vol. 2. SAS Institute, Cary, NC.
  30. Schöitz, 1992, Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain, Neurosci. Lett., 136, 189, 10.1016/0304-3940(92)90046-A · DOI
  31. Stanley, 1994, Glial cytokines as neuropathogenic factors in HIV infection: pathogenic similarities to Alzheimer's disease, J. Neurophathol. Exp. Neurol., 53, 231, 10.1097/00005072-199405000-00003 · DOI
  32. Walker, 1995, Complement and cytokine gene expression in cultured microglia derived from postmortem human brains, J. Neurosci. Res., 40, 478, 10.1002/jnr.490400407 · DOI
  33. Woodroofe, 1991, Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production, J. Neuroimmunol., 33, 227, 10.1016/0165-5728(91)90110-S · DOI · Paper page
  34. Yao, 1997, Induction of interleukin-1 β-converting enzyme (ICE) in murine microglia by lipopolysaccharide, Mol. Brain. Res., 51, 170, 10.1016/S0169-328X(97)00235-0 · DOI
  35. Young, 1995, Brain production of nitric oxide and transformation growth factor-β, Mech. Ageing Dev., 79, 115, 10.1016/0047-6374(94)01545-W · doi:10.1016/0047-6374(94)01545-w

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Metadata

Authors
Ye, S.-M., & Johnson, R. W.
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
1999-01
Volume
93
Issue
1-2
Pages
139-148
ISSN
0165-5728 (ISSN-L)
DOI
10.1016/s0165-5728(98)00217-3
OpenAlex
W2007197518
Cited by
327
References
4
FWCI
3.41
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Increased interleukin-6 expression by microglia from brain of aged mice. https://app.cochat.ai/papers/10.1016/s0165-5728(98)00217-3
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Ye, S.-M., & Johnson, R. W. (1999). Increased interleukin-6 expression by microglia from brain of aged mice. Journal of Neuroimmunology. https://doi.org/10.1016/s0165-5728(98)00217-3

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