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Cited by 254

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Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation

Rozovsky, I, Finch, C.E, Morgan, T.E·1998·Neurobiology of Aging
DOI 10.1016/s0197-4580(97)00169-3
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Research works printed but not linked: 52

  1. Akima, 1986, A study on the microvasculature of the cerebral cortex, Lab. Invest., 55, 482
  2. Beskow, 1971, Cerebral arterial deformities in relation to senile deterioration, Acta Psychiatr. Scand. Suppl., 221, 11
  3. Bouisson, 1975, Age related changes of the middle cerebral artery and a comparison with the radial and coronary artery, Angiology, 26, 257, 10.1177/000331977502600303 · doi:10.1177/000331977502600303
  4. Booth, 1991, Evidence for motility and pinocytosis in ramified microglia in tissue culture, Brain Res., 548, 163, 10.1016/0006-8993(91)91118-K · DOI
  5. Bronson, R. T. Rate of occurrence of lesions in 20 inbred and hybrid genotypes of rats sacrificed at 6 month intervals during the first years of life. In: Genetic Effects of Aging II. Harrison, D. E. (ed). Caldwell, NJ: Telford press; 1990:279–358.
  6. Coleman, 1987, Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease, Neurobiol. Aging, 8, 521, 10.1016/0197-4580(87)90127-8 · DOI · Paper page
  7. Coleman, 1990, The need for multiple time points in aging studies, Neurobiol. Aging, 11, 1, 10.1016/0197-4580(90)90055-5 · DOI
  8. Garcia-Segura, 1994, Gonadal hormone regulation of GFAP immunoreactivity and glial ultrastructure in the rat neuroendocrine hypothalamus, Glia, 10, 59, 10.1002/glia.440100108 · DOI
  9. Geinisman, 1995, Hippocampal markers of age-related memory dysfunction, Progr. Neurobiol., 45, 223, 10.1016/0301-0082(94)00047-L · DOI · Paper page
  10. Giulian, 1988, Interleukin-1 is an astroglial growth factor in the developing brain, J. Neurosci., 8, 709, 10.1523/JNEUROSCI.08-02-00709.1988 · DOI · Paper page
  11. Giulian, 1993, Brain glia release factors with opposing actions upon neuronal survival, J. Neuroscience, 13, 29, 10.1523/JNEUROSCI.13-01-00029.1993 · DOI · Paper page
  12. Gordon, 1991, Increased GFAP expression in the aged rat brain does not result from increased astrocyte density, Soc. Neurosci. Abstr., 17, 53
  13. Goss, 1990, GFAP RNA prevalence is increased in aging and in wasting mice, Exp. Neurol., 108, 266, 10.1016/0014-4886(90)90133-D · DOI
  14. Hansen, 1987, An immunocytochemical quantification of fibrous astrocytes in the aging human cerebral cortex, Neurobiol. Aging, 8, 1, 10.1016/0197-4580(87)90051-0 · DOI
  15. Hughes, 1987, A morphometric study of blood vessel, neuron and glial cell distribution in young and old rat, J. Neurol. Sci., 79, 101, 10.1016/0022-510X(87)90264-4 · DOI
  16. Kohama, 1995, Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice, Neurosci. Lett., 183, 164, 10.1016/0304-3940(94)11141-5 · DOI
  17. Korr, H. Proliferation of different cell types in the brain. In: Advances in Anatomy, Embryology and Cell Biology. Brodal, A.; Hild, W.; Limborgh, J.; Ortman, R.; Schiebler, T. H.; Tondury, G.; Wolff, E. (eds). New York: Springer; 1980, 61:5–16. · DOI
  18. Krekowski, 1996, Aging is associated with divergent effects on Nf-L and GFAP transcription in rat brain, Neurobiol. Aging, 17, 833, 10.1016/S0197-4580(96)00078-4 · DOI
  19. Krohn, 1995, Expression of vimentin increases in the hippocampus and cerebral cortex after entorhinal cortex lesioning and in response to transforming growth factor β1, J. Neuroimmunol., 56, 53, 10.1016/0165-5728(94)00133-9 · DOI
  20. Laping, 1994, Glial fibrillary acidic protein, Brain Pathol., 4, 259, 10.1111/j.1750-3639.1994.tb00841.x · DOI · Paper page
  21. Laping, 1994, Transforming growth factor-1 induces neuronal and astrocyte genes, Neuroscience, 58, 563, 10.1016/0306-4522(94)90081-7 · DOI
  22. Lindholm, 1992, Transforming growth factor β1 in the rat brain, Biol., 117, 395
  23. Lindsay, 1982, Astrocyte cultures from adult rat brain. Derivation, characterization and neurotrophic properties of pure astroglial cells from corpus callosum, Brain Res., 243, 329, 10.1016/0006-8993(82)90257-8 · DOI
  24. Lindsay, 1979, Early onset and topographical distribution of hypertrophied astrocytes in hippocampus of aging rats, J. Gerontol., 34, 661, 10.1093/geronj/34.5.661 · DOI
  25. Loughlin, 1993, Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta1, interleukin-4, noradrenaline and glucocorticoids, Immunology, 79, 125
  26. Major, 1997, Life-long dietary restriction attentuates age-related increases in hippocampal GFAP mRNA, Neurobiol. Aging, 18, 523, 10.1016/S0197-4580(97)00102-4 · DOI · Paper page
  27. Martin, 1983, Comparative rates of decline in the primary cloning efficiencies of smooth muscle cells from the aging thoracic aorta of two murine species of contrasting maximum life span potentials, Am. J. Pathol., 110, 236
  28. Martin, 1970, Replicative life-span of cultivated human cells, Lab. Invest., 23, 86
  29. McCarthy, 1980, Preparation of astroglial and oligodendroglial cell cultures from rat cerebral tissue, J. Cell. Biol., 85, 890, 10.1083/jcb.85.3.890 · DOI · Paper page
  30. Morgan, 1993, TGF-β1 mRNA increases in macrophage/microglia cells of the hippocampus in response to deafferentation an kainic acid-induced neurodegeneration, Exp. Neurol., 120, 291, 10.1006/exnr.1993.1063 · DOI
  31. Morgan, 1995, Clusterin expression by astrocytes is influenced by TGF-β1 and heterotypic cell interactions, J. Neuroimmunol, 58, 101, 10.1016/0165-5728(94)00194-S · DOI
  32. Morgan, 1997, Age-related increases in the transcription of the astrocyte gene GFAP are attenuated by food restriction, Free Rad. Biol. Med., 23, 524, 10.1016/S0891-5849(97)00120-2 · DOI · Paper page
  33. Morganti-Kossman, 1992, Autocrine and paracrine regulation of astrocyte function by transforming growth factor-β, J. Neuroimmunol., 39, 163, 10.1016/0165-5728(92)90185-N · DOI
  34. Nichols, 1993, GFAP mRNA increases with age in rat and human brain, Neurobiol. Aging, 14, 421, 10.1016/0197-4580(93)90100-P · DOI · Paper page
  35. Pasinetti, 1993, Transforming growth factor β1 and fibronectin messenger RNA in rat brain, Neuroscience, 54, 893, 10.1016/0306-4522(93)90583-2 · DOI
  36. Perry, 1993, Altered antigen expression of microglia in the aged rodent CNS, Glia, 7, 60, 10.1002/glia.440070111 · DOI · Paper page
  37. Rozovsky, 1995, Transcriptional regulation of glial fibrillary acidic protein by corticosterone in rat astrocytes in vitro is influenced by the duration of time in culture and by astrocyte-neuron interactions, Endocrinology, 136, 2066, 10.1210/en.136.5.2066 · doi:10.1210/en.136.5.2066
  38. Saunders, 1971, X-ray microscopy and histochemistry of the human cerebral vessels, J. Neurosurg., 35, 128, 10.3171/jns.1971.35.2.0128 · DOI
  39. Schwartz, 1992, Preparation and characterization of type 1 astrocytes cultured from adult rat cortex, cerebellum, and striatum, Glia, 5, 75, 10.1002/glia.440050111 · DOI
  40. Singh, 1978, Glial cells from normal adult rat brain established in continuous culture, Brain Res., 155, 418, 10.1016/0006-8993(78)91041-7 · doi:10.1016/0006-8993(78)91041-7
  41. Sobin, 1992, Histochemical characterization of the aging microvasculature in the human and other mammalian and non-mammalian vertebrates by the periodic acid-Schiff reaction, Mech. Age. Devel., 63, 183, 10.1016/0047-6374(92)90064-K · DOI
  42. Spangler, 1994, Arteriolar tortuosity of the white matter in aging and hypertension. A microradiographic study, J. Neuropath. Exp. Neurol., 53, 22, 10.1097/00005072-199401000-00003 · DOI
  43. Streit, 1988, Functional plasticity of microglia, Glia, 1, 301, 10.1002/glia.440010502 · DOI · Paper page
  44. Stuehr, 1989, Nitric oxide—a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells, J. Exp. Med., 169, 1543, 10.1084/jem.169.5.1543 · DOI · Paper page
  45. Suzumura, 1993, Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro, J. Immunology, 151, 2150, 10.4049/jimmunol.151.4.2150 · DOI · Paper page
  46. Tan, 1997, Differential effect of age on transforming growth factor-β1 inhibition of prolactin gene expression versus secretion in rat anterior pituitary cells, Endocrinology, 138, 878, 10.1210/en.138.3.878 · doi:10.1210/en.138.3.878
  47. Van der Wal, 1993, Transforming growth factor-β1 is in plaques in Alzheimer and Down pathologies, NeuroReport, 4, 69, 10.1097/00001756-199301000-00018 · DOI
  48. Vernadakis, 1984, Glial cells dissociated from newborn and aged mouse brain, J. Neurosci. Res., 11, 253, 10.1002/jnr.490110305 · DOI
  49. Volicer, 1983, Beta-adrenergic receptor sensitivity in cultured vascular smooth muscle cells, Mech. Age. Devel., 21, 283, 10.1016/0047-6374(83)90047-7 · DOI
  50. Yoshida, 1996, Transcription supports age-related increase of GFAP gene expression in the male rat brain, Neurosci. Lett., 215, 107, 10.1016/0304-3940(96)12966-9 · DOI
  51. Young, 1995, Production of nitric oxide and transforming growth factor-β in developing and adult rat brain, Mech. Aging Devel., 79, 115, 10.1016/0047-6374(94)01545-W · doi:10.1016/0047-6374(94)01545-w
  52. Young-Chan, 1993, Autoregulation of transforming growth factor-β1 mRNA in the brain by intraventricular infusion in adult male rats, Soc. Neurosci. Abstr., 19, 1722

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Metadata

Authors
Rozovsky, I., Finch, C. E., & Morgan, T. E.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
1998-01
Volume
19
Issue
1
Pages
97-103
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/s0197-4580(97)00169-3
OpenAlex
W2034337512
Cited by
254
References
2
FWCI
4.64
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation. https://app.cochat.ai/papers/10.1016/s0197-4580(97)00169-3
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Rozovsky, I., Finch, C. E., & Morgan, T. E. (1998). Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation. Neurobiology of Aging. https://doi.org/10.1016/s0197-4580(97)00169-3

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