The DOI matches its Crossref record; 77 of the 79 references it cites were found in a registry or an index.
Nicotine as a modulator of behavior: beyond the inverted U
Abstract
Nicotine is the crucial component in tobacco that underlies smoking behavior; however, the effects of nicotine can vary in both human and animal studies. Recent data from knockout mouse studies, neurotransmitter release studies and electrophysiological experiments support the hypothesis that conflicting behavioral effects elicited by nicotine can result from the activation of different subtypes of nicotinic acetylcholine receptors and the stimulation of antagonistic neuronal pathways. Thus, small differences in the activation state, connectivity or sensitivity of neuronal pathways among individuals might result in large differences in behavioral responses to nicotine. An understanding of the molecular and cellular processes that oppose nicotine reinforcement will be crucial for the development of new interventions to initiate smoking cessation or to prevent the transition from occasional smoking to dependence.
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In the citing paper
“The result of this circuit-level integration is that nicotine can modulate behavioral function bidirectionally, acting as a stimulant and increasing anxiety under some conditions and decreasing activity and anxiety in others (Picciotto 2003).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Picciotto 2003
In the citing paper
“nAChRs are expressed throughout the brain on both excitatory and inhibitory neurons, with the ability to increase inhibition of circuits when excitation is high and to increase excitation when circuits are less active (Picciotto 2003).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Picciotto 2003
In the citing paper
“Nicotine follows an inverted U-shaped dose-response curve [18, 60], and smokers titrate their nicotine intake to experience the rewarding while avoiding the aversive effects produced by high nicotine doses [61–64].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [60]
Citations
Cites
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Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320
Self-citationThe Health consequences of smoking: nicotine addiction: a report of the Surgeon General
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Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767
Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Mansvelder, H. D., & McGehee, D. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00042-8 · Cited by 720
Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
Mansvelder, H. D., Keath, J. R., & McGehee, D. S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00625-6 · Cited by 701
Klink, R., d'Exaerde, A. D. K., Zoli, M., & Changeux, J.-P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01452.2001 · Cited by 674
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Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum
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Nicotine maintains robust self-administration in rats on a limited-access schedule
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Cited by
Sorted by citations
Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404
Self-citationGuidelines on nicotine dose selection for in vivo research
Matta, S. G., Balfour, D. J., Benowitz, N. L., Boyd, R. T., Buccafusco, J. J., Caggiula, A. R., Craig, C. R., Collins, A. C., Damaj, M. I., Donny, E. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0441-0 · Cited by 824
Self-citationNeuronal nicotinic receptors: from structure to pathology
Gotti, C., & Clementi, F. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.006 · Cited by 970
Pierce, R. C., & Kumaresan, V. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.016 · Cited by 913
Anxiolytic effects of nicotine in zebrafish
Levin, E. D., Bencan, Z., & Cerutti, D. T. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.08.026 · Cited by 625
Metadata
- Authors
- Picciotto, M. R.
- Affiliations
- Yale University (US)
- Corresponding author
- Picciotto, Marina R
- ORCID
- Picciotto, Marina R
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 24
- Issue
- 9
- Pages
- 493-499
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2049324875
- Cited by
- 257
- References
- 79
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 12 · 2022: 2 · 2021: 9 · 2020: 15 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 13 · 2013: 15 · 2012: 14
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (DA14241, DA 10455, DA84733, DA 00436)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotine, nicotinic acetylcholine receptors, receptor subtypes, nicotine reinforcement, smoking behavior, nicotine dependence, smoking cessation, neural pathways, knockout mice, neurotransmitter release, electrophysiology
- MeSH terms
- Animals, Behavior, Humans, Nicotine, Receptors, Nicotinic, Smoking, Nicotinic Agonists, Mice
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