Nicotine: from molecular mechanisms to behaviour

A psychomotor stimulant theory of addiction.

Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747 · see citing works

The psychology and neurobiology of addiction: an incentive–sensitization view

Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507 · see citing works

Addiction and the brain: The neurobiology of compulsion and its persistence

Hyman, S. E., & Malenka, R. C. (2001) · Nature reviews. Neuroscience · doi:10.1038/35094560 · Cited by 1,297 · see citing works

Putting a spin on the dorsal-ventral divide of the striatum

Voorn, P., Vanderschuren, L. J. M. J., Groenewegen, H. J., Robbins, T. W., & Pennartz, C. M. A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.006 · Cited by 1,188 · see citing works

Nucleus accumbens shell and core dopamine: differential role in behavior and addiction

Di Chiara, G. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00286-3 · Cited by 996 · see citing works

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

Corrigall, W. A., Franklin, K. B. J., Coen, K. M., & Clarke, P. B. S. (1992) · Psychopharmacology · doi:10.1007/bf02245149 · Cited by 829 · see citing works

Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area

Corrigall, W. A., Coen, K. M., & Adamson, K. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)90401-4 · Cited by 740 · see citing works

Long-term potentiation of excitatory inputs to brain reward areas by nicotine

Mansvelder, H. D., & McGehee, D. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00042-8 · Cited by 720 · see citing works

Neurotransmitter regulation of dopamine neurons in the ventral tegmental area

Kalivas, P. W. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90008-n · Cited by 704 · see citing works

Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas

Mansvelder, H. D., Keath, J. R., & McGehee, D. S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00625-6 · Cited by 701 · see citing works

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats

Imperato, A., Mulas, A., & Di Chiara, G. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90629-1 · Cited by 693 · see citing works

Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry

Gonon, F. G. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90307-7 · Cited by 676 · see citing works

Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei

Klink, R., d'Exaerde, A. D. K., Zoli, M., & Changeux, J.-P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01452.2001 · Cited by 674 · see citing works

Nicotinic acetylcholine receptors and the regulation of neuronal signalling

Dajas‐Bailador, F., & Wonnacott, S. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.04.006 · Cited by 618 · see citing works

Evidence that Tobacco Smoking Increases the Density of (−)‐[³H]Nicotine Binding Sites in Human Brain

Benwell, M. E. M., Balfour, D. J. K., & Anderson, J. M. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb10600.x · Cited by 551 · see citing works

Afferent connections of the laterodorsal and the pedunculopontine tegmental nuclei in the rat: A retro‐ and antero‐grade transport and immunohistochemical study

Semba, K., & Fibiger, H. C. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903230307 · Cited by 544 · see citing works

Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice

Champtiaux, N., Gotti, C., Cordero‐Erausquin, M., David, D. J. P., Przybylski, C., Léna, C., Clementi, F., Moretti, M., Rossi, F., Novère, N. G. L., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07820.2003 · Cited by 505 · see citing works

Differential control over cocaine-seeking behavior by nucleus accumbens core and shell

Ito, R., Robbins, T. W., & Everitt, B. J. (2004) · Nature Neuroscience · doi:10.1038/nn1217 · Cited by 501 · see citing works

Desensitization of neuronal nicotinic receptors

Quick, M. W., & Lester, R. A. J. (2002) · Journal of Neurobiology · doi:10.1002/neu.10109 · Cited by 456 · see citing works

The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour

Laviolette, S. R., & van der Kooy, D. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1298 · Cited by 452 · see citing works

Dissociation in Conditioned Dopamine Release in the Nucleus Accumbens Core and Shell in Response to Cocaine Cues and during Cocaine-Seeking Behavior in Rats

Ito, R., Dalley, J. W., Howes, S. R., Robbins, T. W., & Everitt, B. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07489.2000 · Cited by 441 · see citing works

The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity

Benwell, M. E. M., & Balfour, D. J. K. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09067.x · Cited by 426 · see citing works

Cue dependency of nicotine self-administration and smoking

Caggiula, A. R., Donny, E. C., White, A. R., Chaudhri, N., Booth, S., Gharib, M. A., Hoffman, A., Perkins, K. A., & Sved, A. F. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00676-1 · Cited by 425 · see citing works

The diversity of subunit composition in nAChRs: Evolutionary origins, physiologic and pharmacologic consequences

Le Novère, N., Corringer, P., & Changeux, J. (2002) · Journal of Neurobiology · doi:10.1002/neu.10153 · Cited by 411 · see citing works

Identification of the Nicotinic Receptor Subtypes Expressed on Dopaminergic Terminals in the Rat Striatum

Zoli, M., Moretti, M., Zanardi, A., McIntosh, J. M., Clementi, F., & Gotti, C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-08785.2002 · Cited by 407 · see citing works

Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice

Salminen, O., Murphy, K. L., McIntosh, J. M., Drago, J., Marks, M. J., Collins, A. C., & Grady, S. R. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.6.1526 · Cited by 401 · see citing works

Effect of smoking history on [3H]nicotine binding in human postmortem brain

Breese, C. R., Marks, M. J., Logel, J., Adams, C. E., Sullivan, B., Collins, A. C., & Leonard, S. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36798-9 · Cited by 396 · see citing works

Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas

Wooltorton, J. R. A., Pidoplichko, V. I., Broide, R. S., & Dani, J. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03176.2003 · Cited by 363 · see citing works

Anatomical Substrates for Glutamate‐Dopamine Interactions

Sesack, S., Carr, D. B., Omelchenko, N., & Pinto, A. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.066 · Cited by 348 · see citing works

Ca2+ permeability of nicotinic acetylcholine receptors

Fucile, S. (2003) · Cell Calcium · doi:10.1016/j.ceca.2003.08.006 · Cited by 320 · see citing works

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca 2+ -binding sites

Novère, N. G. L., Grütter, T., & Changeux, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042699699 · Cited by 261 · see citing works

Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics

Picciotto, M. R., & Corrigall, W. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03338.2002 · Cited by 261 · see citing works

Regulation of Nicotinic Acetylcholine Receptor Numbers and Function by Chronic Nicotine Exposure

Gentry, C., & Lukas, R. (2002) · Current Drug Target -CNS & Neurological Disorders · doi:10.2174/1568007023339184 · Cited by 232 · see citing works

The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence

Balfour, D. J. K., Wright, A. E., Benwell, M. E. M., & Birrell, C. E. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00202-3 · Cited by 231 · see citing works

Dissociating nicotine and nonnicotine components of cigarette smoking

Rose, J. E., Behm, F. M., Westman, E. C., & Johnson, M. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00301-4 · Cited by 222 · see citing works

α-Bungarotoxin-Sensitive Nicotinic Receptors Indirectly Modulate [3H]Dopamine Release in Rat Striatal Slices via Glutamate Release

Kaiser, S., & Wonnacott, S. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.2.312 · Cited by 218 · see citing works

The β3 Nicotinic Receptor Subunit: A Component of α-Conotoxin MII-Binding Nicotinic Acetylcholine Receptors that Modulate Dopamine Release and Related Behaviors

Cui, C., Booker, T. K., Allen, R. S., Grady, S. R., Whiteaker, P., Marks, M. J., Salminen, O., Tritto, T., Butt, C. M., Allen, W. R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11045.2003 · Cited by 213 · see citing works

N-methyl-d-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens

Schilström, B., Nomikos, G. G., Nisell, M., Hertel, P., & Svensson, T. H. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00243-1 · Cited by 206 · see citing works

Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction

Pidoplichko, V. I., Noguchi, J., Areola, O. O., Liang, Y., Peterson, J., Zhang, T., & Dani, J. A. (2004) · Learning & Memory · doi:10.1101/lm.70004 · Cited by 196 · see citing works

Differential changes in accumbens shell and core dopamine in behavioral sensitization to nicotine

Cadoni, C., & Di Chiara, G. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00843-2 · Cited by 180 · see citing works

Presynaptic localisation of the nicotinic acetylcholine receptor β2 subunit immunoreactivity in rat nigrostriatal dopaminergic neurones

Jones, I. W., Bolam, J. P., & Wonnacott, S. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1345 · Cited by 167 · see citing works

Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy

Unwin, N. C. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01084-6 · Cited by 165 · see citing works

Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes

Schilström, B., Rawal, N., Mameli-Engvall, M., Nomikos, G. G., & Svensson, T. H. (2003) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003188 · Cited by 143 · see citing works

Acute and long-term changes in the mesolimbic dopamine pathway after systemic or local single nicotine injections

Ferrari, R., Le Novère, N., Picciotto, M. R., Changeux, J. P., & Zoli, M. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.02009.x · Cited by 132 · see citing works

Nicotinic Acetylcholine Receptors Interact with Dopamine in Induction of Striatal Long-Term Depression

Partridge, J. G., Apparsundaram, S., Gerhardt, G. A., Ronesi, J. A., & Lovinger, D. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02541.2002 · Cited by 128 · see citing works

Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists

Shoaib, M., Benwell, M. E. M., Akbar, M., Stolerman, I. P., & Balfour, D. J. K. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14854.x · Cited by 121 · see citing works

Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat

Sorenson, E. M., Shiroyama, T., & Kitai, S. T. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00064-5 · Cited by 107 · see citing works

Lesions of the Tegmental Pedunculopontine Nucleus Block the Rewarding Effects and Reveal the Aversive Effects of Nicotine in the Ventral Tegmental Area

Laviolette, S. R., Alexson, T. O., & van der Kooy, D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08653.2002 · Cited by 98 · see citing works

Assessment of nicotinic acetylcholine receptor subunit contributions to nicotine self-administration in mutant mice

Epping-Jordan, M. P., Picciotto, M. R., Changeux, J.-P., & Pich, E. M. (1999) · Psychopharmacology · doi:10.1007/s002130051135 · Cited by 86 · see citing works

An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine

Sallette, J., Bohler, S., Benoit, P., Soudant, M., Pons, S., Le Novère, N., Changeux, J.-P., & Corringer, P. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308260200 · Cited by 80 · see citing works

Pharmacologically induced cessation of burst activity in nigral dopamine neurons: Significance for the terminal dopamine efflux

Nissbrandt, H., Elverfors, A., & Engberg, G. (1994) · Synapse · doi:10.1002/syn.890170402 · Cited by 70 · see citing works

Short‐ and Long‐Term Modulation of Synaptic Inputs to Brain Reward Areas by Nicotine

Fagen, Z. M., Mansvelder, H. D., Keath, J. R., & McGehee, D. S. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.011 · Cited by 70 · see citing works

Evidence that mesoaccumbens dopamine and locomotor responses to nicotine in the rat are influenced by pretreatment dose and strain

Iyaniwura, T., Wright, A., & Balfour, D. (2001) · Psychopharmacology · doi:10.1007/s002130100852 · Cited by 57 · see citing works

Behavioural Pharmacology and Neurobiology of Nicotine Reward and Dependence

Chiara, G. D. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57079-7_24 · Cited by 43 · see citing works

Basic fibroblast growth factor (bFGF) acts on both neurons and glia to mediate the neurotrophic effects of astrocytes on LHRH neurons in culture

Gallo, F., Morale, M. C., Spina-Purrello, V., Tirolo, C., Testa, N., Farinella, Z., Avola, R., Beaudet, A., & Marchetti, B. (2000) · Synapse · doi:10.1002/(sici)1098-2396(20000615)36:4 · Cited by 39 · see citing works

The α 4 β 2 agonist SIB 1765F, but not the α 7 agonist AR-R 17779, cross-sensitises to the psychostimulant effects of nicotine

Grottick, A. J., Wyler, R., & Higgins, G. A. (2000) · Psychopharmacology · doi:10.1007/s002130000444 · Cited by 28 · see citing works

Postsynaptic α4β2 and α7 type nicotinic acetylcholine receptors contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons

Matsubayashi, H., Amano, T., Seki, T., Sasa, M., & Sakai, N. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.040 · Cited by 21 · see citing works

Untitled work

Hagihara (1999) · doi:10.1002/(sici)1096-9861(19990726)410:2

Untitled work

(2000) · doi:10.1002/1098-2396(20001215)38:4

The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse?

Pierce, R. C., & Kumaresan, V. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.016 · Cited by 913 · see citing works

Glutamatergic substrates of drug addiction and alcoholism

Gass, J. T., & Olive, M. F. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.039 · Cited by 485 · see citing works

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

Bastide, M. F., Meissner, W. G., Picconi, B., Fasano, S., Fernagut, P., Feyder, M. T., Francardo, V., Alcacer, C., Ding, Y., Brambilla, R., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.07.002 · Cited by 470 · see citing works

Nicotine addiction and comorbidity with alcohol abuse and mental illness

Dani, J. A., & Harris, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1580 · Cited by 382 · see citing works

Reward, addiction, withdrawal to nicotine

De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366 · see citing works

Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function

Goriounova, N. A., & Mansvelder, H. D. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012120 · Cited by 307 · see citing works

Distributed Network Actions by Nicotine Increase the Threshold for Spike-Timing-Dependent Plasticity in Prefrontal Cortex

Couey, J. J., Meredith, R. M., Spijker, S., Poorthuis, R. B., Smit, A. B., Brussaard, A. B., & Mansvelder, H. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.006 · Cited by 253 · see citing works

Prevention and treatment of drug addiction by environmental enrichment

Solinas, M., Thiriet, N., Chauvet, C., & Jaber, M. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.002 · Cited by 256 · see citing works

Why do patients with schizophrenia smoke?

Winterer, G. (2010) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283366643 · Cited by 238 · see citing works

Smoking, quitting, and psychiatric disease: A review

Aubin, H., Rollema, H., Svensson, T. H., & Winterer, G. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.007 · Cited by 231 · see citing works

Tobacco addiction

Hatsukami, D. K., Stead, L. F., & Gupta, P. C. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60871-5 · Cited by 227 · see citing works

Association of Low Striatal Dopamine D 2 Receptor Availability With Nicotine Dependence Similar to That Seen With Other Drugs of Abuse

Fehr, C., Yakushev, I. Y., Hohmann, N., Buchholz, H., Landvogt, C., Deckers, H., Eberhardt, A., Kläger, M., Smolka, M. N., Scheurich, A., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07020352 · Cited by 226 · see citing works

Smoking, nicotine and neuropsychiatric disorders

Döme, P., Lazáry, J., Kalapos, M. P., & Rihmer, Z. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.013 · Cited by 215 · see citing works

Nicotinic modulation of neuronal networks: from receptors to cognition

Mansvelder, H. D., van Aerde, K. I., Couey, J. J., & Brussaard, A. B. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0070-z · Cited by 201 · see citing works

Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure

Juarez, B., & Han, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.32 · Cited by 165 · see citing works

Nicotine and Parkinson's disease: implications for therapy

Quik, M., O'Leary, K., & Tanner, C. M. (2008) · Movement Disorders · doi:10.1002/mds.21900 · Cited by 154 · see citing works

Translational research in medication development for nicotine dependence

Lerman, C. E., LeSage, M. G., Perkins, K. A., O’Malley, S. S., Siegel, S. J., Benowitz, N. L., & Corrigall, W. A. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2361 · Cited by 149 · see citing works

Monoamine oxidase and tobacco dependence.

Lewis, A., Miller, J. H., & Lea, R. A. (2007) · Neurotoxicology · doi:10.1016/j.neuro.2006.05.019 · Cited by 153 · see citing works

Multiple roles for nicotine in Parkinson's disease

Quik, M., Huang, L. Z., Parameswaran, N., Bordia, T., Campos, C., & Perez, X. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.003 · Cited by 134 · see citing works

Nicotinic acetylcholine receptors and the ascending dopamine pathways

Livingstone, P. D., & Wonnacott, S. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.004 · Cited by 131 · see citing works

Chronic cigarette smoking and the microstructural integrity of white matter in healthy adults: a diffusion tensor imaging study

Paul, R., Grieve, S., Niaura, R., David, S., Laidlaw, D., Cohen, R., Sweet, L., Taylor, G., Clark, R., Pogun, S., et al. (2008) · Nicotine & Tobacco Research · doi:10.1080/14622200701767829 · Cited by 129 · see citing works

Striatal α6* Nicotinic Acetylcholine Receptors: Potential Targets for Parkinson’s Disease Therapy

Quik, M., & McIntosh, J. M. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.094375 · Cited by 127 · see citing works

Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits

Mansvelder, H. D., Mertz, M., & Role, L. W. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.01.007 · Cited by 126 · see citing works

Low dose nicotine treatment during early adolescence increases subsequent cocaine reward

McQuown, S. C., Belluzzi, J. D., & Leslie, F. M. (2007) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2006.10.012 · Cited by 117 · see citing works

The role of mesocorticolimbic dopamine in regulating interactions between drugs of abuse and social behavior

Young, K. A., Gobrogge, K. L., & Wang, Z. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.004 · Cited by 111 · see citing works

The Endogenous Cannabinoid System Modulates Nicotine Reward and Dependence

Merritt, L. L., Martin, B. R., Walters, C., Lichtman, A. H., & Damaj, M. I. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.138321 · Cited by 113 · see citing works

Molecular and Cellular Mechanisms of Action of Nicotine in the CNS

Barik, J., & Wonnacott, S. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-69248-5_7 · Cited by 108 · see citing works

Nicotinic actions on neuronal networks for cognition: General principles and long-term consequences

Poorthuis, R. B., Goriounova, N. A., Couey, J. J., & Mansvelder, H. D. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.031 · Cited by 102 · see citing works

Mitochondria as a possible target for nicotine action

Malińska, D., Wieckowski, M. R., Michalska, B., Drabik, K., Prill, M., Patalas‐Krawczyk, P., Walczak, J., Szymański, J., Mathis, C., van der Toorn, M., et al. (2019) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-019-09800-z · Cited by 103 · see citing works

Differential Regulation of α7 Nicotinic Receptor Gene (CHRNA7) Expression in Schizophrenic Smokers

Mexal, S., Berger, R., Logel, J., Ross, R. G., Freedman, R., & Leonard, S. S. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9233-4 · Cited by 100 · see citing works

Nigrostriatal Damage Preferentially Decreases a Subpopulation of α6β2* nAChRs in Mouse, Monkey, and Parkinson’s Disease Striatum

Bordia, T., Grady, S. R., McIntosh, J. M., & Quik, M. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.035998 · Cited by 97 · see citing works

Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women

Colilla, S., Lerman, C., Shields, P. G., Jepson, C., Rukstalis, M., Berlin, J., DeMichele, A., Bunin, G., Strom, B. L., & Rebbeck, T. R. (2005) · Pharmacogenetics and Genomics · doi:10.1097/01213011-200506000-00004 · Cited by 93 · see citing works

The Genetic Components of Alcohol and Nicotine Co-Addiction: From Genes to Behavior

Schlaepfer, I. R., Hoft, N. R., & Ehringer, M. A. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801020124 · Cited by 93 · see citing works

Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior

Kuzmin, A. V., Jerlhag, E., Liljequist, S., & Engel, J. A. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1375-5 · Cited by 89 · see citing works

Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype

Walsh, H., Govind, A. P., Mastro, R., Hoda, J. C., Bertrand, D., Vallejo, Y., & Green, W. N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m703432200 · Cited by 87 · see citing works

Orexin and leptin are associated with nicotine craving: A link between smoking, appetite and reward

von der Goltz, C., Koopmann, A., Dinter, C., Richter, A., Rockenbach, C., Grosshans, M., Nakovics, H., Wiedemann, K., Mann, K. F., Winterer, G., et al. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.005 · Cited by 86 · see citing works

Efficacy and Safety of Varenicline for Smoking Cessation

Hays, J. T., Ebbert, J. O., & Sood, A. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.01.017 · Cited by 84 · see citing works

Nicotine and endogenous opioids: neurochemical and pharmacological evidence

Hadjiconstantinou, M., & Neff, N. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.010 · Cited by 81 · see citing works

Differential nicotinic regulation of the nigrostriatal and mesolimbic dopaminergic pathways: Implications for drug development

Janhunen, S. K., & Ahtee, L. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.09.008 · Cited by 81 · see citing works

Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism

Dao, J. M., McQuown, S. C., Loughlin, S. E., Belluzzi, J. D., & Leslie, F. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.8 · Cited by 79 · see citing works

ATP and acetylcholine, equal brethren

Zimmermann, H. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.09.004 · Cited by 79 · see citing works

Effects of the nicotinic receptor partial agonists varenicline and cytisine on the discriminative stimulus effects of nicotine in rats

LeSage, M. G., Shelley, D., Ross, J. T., Carroll, F. I., & Corrigall, W. A. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.08.024 · Cited by 78 · see citing works

Long-term nicotine treatment differentially regulates striatal α6α4β2* and α6(nonα4)β2* nAChR expression and function

Perez, X. A., Bordia, T., McIntosh, J. M., Grady, S. R., & Quik, M. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.048843 · Cited by 77 · see citing works

Region-Specific Effects of Nicotine on Brain Activity: A Pharmacological MRI Study in the Drug-Naïve Rat

Gozzi, A., Schwarz, A. J., Reese, T., Bertani, S., Crestan, V., & Bifone, A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300955 · Cited by 77 · see citing works

Chronic Oral Nicotine Normalizes Dopaminergic Function and Synaptic Plasticity in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Primates

Quik, M., Chen, L., Parameswaran, N., Xie, X., Langston, J. W., & McCallum, S. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0215-06.2006 · Cited by 77 · see citing works

Rewarding and aversive effects of nicotine are segregated within the nucleus accumbens

Sellings, L. H. L., Baharnouri, G., McQuade, L. E., & Clarke, P. B. S. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06341.x · Cited by 76 · see citing works

First-Principles Calculation of pKafor Cocaine, Nicotine, Neurotransmitters, and Anilines in Aqueous Solution

Lu, H., Chen, X., & Zhan, C. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp072917r · Cited by 75 · see citing works

Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in rats

Liu, X., Palmatier, M. I., Caggiula, A. R., Donny, E. C., & Sved, A. F. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0863-3 · Cited by 72 · see citing works

Zebrafish for the Study of the Biological Effects of Nicotine

Klee, E. W., Ebbert, J. O., Schneider, H., Hurt, R. D., & Ekker, S. C. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr010 · Cited by 71 · see citing works

Morphine-induced place preference: Involvement of cholinergic receptors of the ventral tegmental area

Rezayof, A., Nazari-Serenjeh, F., Zarrindast, M., Sepehri, H., & Delphi, L. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.01.081 · Cited by 69 · see citing works

Mecamylamine Attenuates Cue-Induced Reinstatement of Nicotine-Seeking Behavior in Rats

Liu, X., Caggiula, A. R., Yee, S. K., Nobuta, H., Sved, A. F., Pechnick, R. N., & Poland, R. E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301129 · Cited by 69 · see citing works

Varenicline for smoking cessation: efficacy, safety, and treatment recommendations

Ebbert, J. O. (2010) · Patient Preference and Adherence · doi:10.2147/ppa.s10620 · Cited by 67 · see citing works

Subtype-selective nicotinic agonists enhance olfactory working memory in normal rats: A novel use of the odour span task

Rushforth, S. L., Allison, C., Wonnacott, S., & Shoaib, M. C. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.022 · Cited by 65 · see citing works

Nicotine exposure during adolescence alters the rules for prefrontal cortical synaptic plasticity during adulthood

Goriounova, N. A., & Mansvelder, H. D. (2012) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2012.00003 · Cited by 65 · see citing works

The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: A review

Crunelle, C. L., Miller, M. L., Booij, J., & van den Brink, W. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.11.001 · Cited by 63 · see citing works

Role for the nicotinic cholinergic system in movement disorders; therapeutic implications

Quik, M., Zhang, D., Perez, X. A., & Bordia, T. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.05.004 · Cited by 62 · see citing works

Gender differences in tobacco smoking dynamics and the neuropharmacological actions of nicotine

James, R. P. (2007) · Frontiers in bioscience · doi:10.2741/2696 · Cited by 62 · see citing works

Age dependent nicotinic influences over dopamine neuron synaptic plasticity

Placzek, A. N., Zhang, T. A., & Dani, J. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.014 · Cited by 61 · see citing works

Effects of varenicline and mecamylamine on the acquisition, expression, and reinstatement of nicotine-conditioned place preference by drug priming in rats

Biała, G., Staniak, N., & Budzyńska, B. (2010) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-010-0498-5 · Cited by 61 · see citing works

A translational pharmacology approach to understanding the predictive value of abuse potential assessments

Horton, D. B., Potter, D. M., & Mead, A. N. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283644d2e · Cited by 58 · see citing works

Pro-Cognitive and Antipsychotic Efficacy of the α7 Nicotinic Partial Agonist SSR180711 in Pharmacological and Neurodevelopmental Latent Inhibition Models of Schizophrenia

Barak, S., Arad, M., Levie, A. D., Black, M. D., Griebel, G., & Weiner, I. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.232 · Cited by 57 · see citing works

Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice

Besson, M., David, V., Baudonnat, M., Cazala, P., Guilloux, J., Repérant, C., Cloëz-Tayarani, I., Changeux, J., Gardier, A. M., & Granon, S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2422-1 · Cited by 57 · see citing works

Nicotine induces chromatin remodelling through decreases in the methyltransferases GLP, G9a, Setdb1 and levels of H3K9me2

Chase, K. A., & Sharma, R. P. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001101 · Cited by 53 · see citing works

Nicotine partially protects against paraquat‐induced nigrostriatal damage in mice; link to α6β2* nAChRs

Khwaja, M., McCormack, A., McIntosh, J. M., Di Monte, D. A., & Quik, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04177.x · Cited by 54 · see citing works

Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies

LeSage, M. G., Keyler, D. E., & Pentel, P. R. (2006) · The AAPS Journal · doi:10.1208/aapsj080108 · Cited by 54 · see citing works

Effects of stimulant drug use on the dopaminergic system: A systematic review and meta-analysis of in vivo neuroimaging studies

Proebstl, L., Kamp, F., Manz, K., Krause, D., Adorjan, K., Pogarell, O., Koller, G., Soyka, M., Falkai, P., & Kambeitz, J. (2019) · European psychiatry · doi:10.1016/j.eurpsy.2019.03.003 · Cited by 52 · see citing works

Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum

Isola, R., Zhang, H., Tejwani, G. A., Neff, N. H., & Hadjiconstantinou, M. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1315-4 · Cited by 51 · see citing works

Comparison of frontostriatal circuits in adolescent nicotine addiction and internet gaming disorder

von Deneen, K. M., Hussain, H., Waheed, J., Xinwen, W., Yu, D., & Yuan, K. (2022) · Journal of Behavioral Addictions · doi:10.1556/2006.2021.00086 · Cited by 51 · see citing works

Prenatal nicotine exposure and development of nicotinic and fast amino acid-mediated neurotransmission in the control of breathing

Fregosi, R. F., & Pilarski, J. Q. (2008) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2008.05.008 · Cited by 48 · see citing works

Attenuation of nicotine-induced rewarding effects in A2A knockout mice

Castañé, A., Sòria, G., Ledent, C. A., Maldonado, R. J., & Valverde, O. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.05.005 · Cited by 51 · see citing works

The Molecular and Cellular Neurobiology of Nicotine Abuse in Schizophrenia

Mobascher, A., & Winterer, G. (2008) · Pharmacopsychiatry · doi:10.1055/s-2008-1081463 · Cited by 50 · see citing works

Nicotinic acetylcholine receptors controlling attention: Behavior, circuits and sensitivity to disruption by nicotine

Poorthuis, R. B., & Mansvelder, H. D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.003 · Cited by 48 · see citing works

Multiple CNS nicotinic receptors mediate l-dopa-induced dyskinesias: Studies with parkinsonian nicotinic receptor knockout mice

Quik, M., Campos, C., & Grady, S. R. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.06.027 · Cited by 49 · see citing works

Mechanism of acetylcholine-induced calcium signaling during neuronal differentiation of P19 embryonal carcinoma cells in vitro

Resende, R. R., Gomes, K. N., Adhikari, A., Britto, L. R. G., & Ulrich, H. (2007) · Cell Calcium · doi:10.1016/j.ceca.2007.04.007 · Cited by 49 · see citing works

Medial prefrontal cortical control of reward‐ and aversion‐based behavioral output: Bottom‐up modulation

Pastor, V. E., & Medina, J. H. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15168 · Cited by 48 · see citing works

Cholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia

Berman, J. A., Talmage, D. A., & Role, L. W. (2007) · International Review of Neurobiology · doi:10.1016/s0074-7742(06)78007-2 · Cited by 47 · see citing works

Modeling cholinergic aspects of schizophrenia: Focus on the antimuscarinic syndrome

Barak, S. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.006 · Cited by 46 · see citing works

Nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement

Morel, C., Montgomery, S. E., & Han, M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14160 · Cited by 45 · see citing works

Nicotine-mediated improvement in l-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal function

Quik, M., Mallela, A., Chin, M. C., McIntosh, J. M., Perez, X. A., & Bordia, T. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.09.006 · Cited by 45 · see citing works

The Role of CaMKII and ERK Signaling in Addiction

Jia, W., Kawahata, K., Cheng, A., & Fukunaga, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063189 · Cited by 45 · see citing works

Modeling Multiple Species of Nicotine and Deschloroepibatidine Interacting with α4β2 Nicotinic Acetylcholine Receptor: From Microscopic Binding to Phenomenological Binding Affinity

Huang, X., Zheng, F., Crooks, P. A., Dwoskin, L. P., & Zhan, C. (2005) · Journal of the American Chemical Society · doi:10.1021/ja052681+ · Cited by 44 · see citing works

Nicotinic Facilitation of Δ9-Tetrahydrocannabinol Discrimination Involves Endogenous Anandamide

Solinas, M., Scherma, M., Tanda, G., Wertheim, C. E., Fratta, W., & Goldberg, S. R. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.116830 · Cited by 44 · see citing works

Nicotinic cholinergic antagonists: A novel approach for the treatment of autism

Lippiello, P. M. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.11.015 · Cited by 43 · see citing works

Neuronal networks of nicotine addiction

Ortells, M. O., & Arias, H. R. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.08.019 · Cited by 44 · see citing works

Highly sensitive fluorescent probe for detection of alkaloids

Oliveri, I. P., & Bella, S. D. (2011) · Tetrahedron · doi:10.1016/j.tet.2011.09.100 · Cited by 42 · see citing works

Role of the cholinergic system in the pathology and treatment of schizophrenia

Scarr, E., & Dean, B. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.9.1.73 · Cited by 41 · see citing works

The Endocannabinoid System: A New Molecular Target for the Treatment of Tobacco Addiction

Scherma, M., Fadda, P., Foll, B. L., Forget, B., Fratta, W., Goldberg, S. R., & Tanda, G. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708786927859 · Cited by 42 · see citing works

Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats

Hayes, D. J., Mosher, T. M., & Greenshaw, A. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.08.034 · Cited by 41 · see citing works

Release‐enhancing pre‐synaptic muscarinic and nicotinic receptors co‐exist and interact on dopaminergic nerve endings of rat nucleus accumbens

Grilli, M., Patti, L., Robino, F., Zappettini, S., Raiteri, M., & Marchi, M. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05307.x · Cited by 40 · see citing works

Differential Regulation of Mesolimbic α3 /α6β2 and α4β2 Nicotinic Acetylcholine Receptor Sites and Function after Long-Term Oral Nicotine to Monkeys

McCallum, S. E., Parameswaran, N., Bordia, T., Fan, H., McIntosh, J. M., & Quik, M. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.104414 · Cited by 48 · see citing works

Association of CYP2A6*1B genetic variant with the amount of smoking in French adults from the Stanislas cohort

Gambier, N., Batt, A. G., Bastien, B., Pfister, M., Siest, G., & Visvikis‐Siest, S. (2005) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500314 · Cited by 40 · see citing works

Drug discrimination and neurochemical studies in α7 null mutant mice: tests for the role of nicotinic α7 receptors in dopamine release

Quarta, D., Naylor, C. G., Barik, J., Fernandes, C., Wonnacott, S., & Stolerman, I. P. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1281-x · Cited by 39 · see citing works

The effects of a novel nicotinic receptor antagonist N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on acute and repeated nicotine-induced increases in extracellular dopamine in rat nucleus accumbens

Rahman, S., Neugebauer‎, N. M., Zhang, Z., Crooks, P. A., Dwoskin, L. P., & Bardo, M. T. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.09.012 · Cited by 40 · see citing works

Age-dependent effects of low-dose nicotine treatment on cocaine-induced behavioral plasticity in rats

McQuown, S. C., Dao, J. M., Belluzzi, J. D., & Leslie, F. M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1642-0 · Cited by 39 · see citing works

Neurochemical pathways involved in the protective effects of nicotine and ethanol in preventing the development of Parkinson's disease: Potential targets for the development of new therapeutic agents

Ward, R. J., Lallemand, F., Witte, P. D., & Dexter, D. T. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.03.003 · Cited by 39 · see citing works

The role of fatty acid amide hydrolase inhibition in nicotine reward and dependence

Muldoon, P. P., Lichtman, A. H., Parsons, L. H., & Damaj, M. I. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.05.015 · Cited by 38 · see citing works

Ghrelin amplifies the nicotine-induced dopamine release in the rat striatum

Palotai, M., Bagosi, Z., Jászberényi, M., Csabafi, K., Dochnal, R., Manczinger, M., Telegdy, G., & Szabó, G. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.06.014 · Cited by 37 · see citing works

Development of Novel Pharmacotherapeutics for Tobacco Dependence: Progress and Future Directions

Harmey, D., Griffin, P. R., & Kenny, P. J. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts201 · Cited by 37 · see citing works

Comparison of the effects of bupropion and nicotine on locomotor activation and dopamine release in vivo

Sidhpura, N., Redfern, P. H., Rowley, H. L., Heal, D. J., & Wonnacott, S. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.025 · Cited by 37 · see citing works

Short-term benefit of smoking cessation along with glycopirronium on lung function and respiratory symptoms in mild COPD patients: a retrospective study

Pezzuto, A., Stellato, M., Catania, G., Mazzara, C., Tonini, S., Caricato, M., Crucitti, P., & Tonini, G. (2018) · Journal of Breath Research · doi:10.1088/1752-7163/aad0a8 · Cited by 37 · see citing works

Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics

Picciotto, M. R., & Corrigall, W. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03338.2002 · Cited by 261 · see citing works

The Neuronal Pathways Mediating the Behavioral and Addictive Properties of Nicotine

Balfour, D. J. K. (2009) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-540-69248-5_8 · Cited by 99 · see citing works

The Neurobiological Bases for the Pharmacotherapy of Nicotine Addiction

Matteo, V. D., Pierucci, M., Giovanni, G. D., Benigno, A., & Esposito, E. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780618920 · Cited by 60 · see citing works

Behavioural pharmacology of nicotine: multiple mechanisms

Stolerman, I. P. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01803.x · Cited by 36 · see citing works

Nicotine Addiction: From Molecules to Behavior

Picciotto, M. R. (1998) · The Neuroscientist · doi:10.1177/107385849800400610 · Cited by 1 · see citing works