Cited by 258Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

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Nicotine as a modulator of behavior: beyond the inverted U

Picciotto, Marina R·2003·Trends in Pharmacological Sciences

DOI 10.1016/s0165-6147(03)00230-x

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Abstract

Nicotine is the crucial component in tobacco that underlies smoking behavior; however, the effects of nicotine can vary in both human and animal studies. Recent data from knockout mouse studies, neurotransmitter release studies and electrophysiological experiments support the hypothesis that conflicting behavioral effects elicited by nicotine can result from the activation of different subtypes of nicotinic acetylcholine receptors and the stimulation of antagonistic neuronal pathways. Thus, small differences in the activation state, connectivity or sensitivity of neuronal pathways among individuals might result in large differences in behavioral responses to nicotine. An understanding of the molecular and cellular processes that oppose nicotine reinforcement will be crucial for the development of new interventions to initiate smoking cessation or to prevent the transition from occasional smoking to dependence.

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Authors: Picciotto, M. R.
Affiliations: Yale University (US)
Corresponding author: Picciotto, Marina R
ORCID: Picciotto, Marina R
Venue: Trends in Pharmacological Sciences
Publisher: Elsevier BV
Published: 2003-09
Volume: 24
Issue: 9
Pages: 493-499
ISSN: 0165-6147 (ISSN-L)
DOI: 10.1016/s0165-6147(03)00230-x
OpenAlex: W2049324875
Cited by: 257
References: 79
Citations by year: 2026: 3 · 2025: 2 · 2024: 6 · 2023: 12 · 2022: 2 · 2021: 9 · 2020: 15 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 13 · 2013: 15 · 2012: 14
FWCI: 1.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Pharmacological Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (DA14241, DA 10455, DA84733, DA 00436)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nicotine, nicotinic acetylcholine receptors, receptor subtypes, nicotine reinforcement, smoking behavior, nicotine dependence, smoking cessation, neural pathways, knockout mice, neurotransmitter release, electrophysiology
MeSH terms: Animals, Behavior, Humans, Nicotine, Receptors, Nicotinic, Smoking, Nicotinic Agonists, Mice

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Nicotine as a modulator of behavior: beyond the inverted U

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