Cited by 360Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeuroscience and Neuropharmacology Research

Nicotinic receptors in the brain. Links between molecular biology and behavior

Open access
Picciotto, M·2000·Neuropsychopharmacology

Abstract

Molecular cloning has elucidated the sequence of a family of acetylcholine receptor subunits that are activated by nicotine. Subsequent studies on the localization of individual subunits and the physiological properties of nicotinic subunit combinations in vitro, have led to identification of subunit compositions of nicotinic receptors that may function in vivo, as the native receptor. A particular challenge for the field has been to use these molecular data to determine which individual nicotinic receptor subtype is responsible for mediating each of the behavioral effects of nicotine. Human and animal studies have shown that nicotine is reinforcing and likely responsible for the addictive properties of tobacco. In addition, nicotine has been shown to have effects on locomotion, cognition, affect, and pain sensitivity. Recent studies combining the techniques of molecular biology, pharmacology, electrophysiology, and behavioral analysis to analyze knock out mice that lack individual subunits of the nicotinic acetylcholine receptor, have helped identify the role of specific nicotinic subunits in some of these complex behaviors. These studies could ultimately be useful in designing specific nicotinic receptor agonists and antagonists that may have uses in the clinic.

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Crossref · 10.1016/s0893-133x(99)00146-3

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Authors
Picciotto, M.
Affiliations
Yale University (US)
Corresponding author
Picciotto, M
Venue
Neuropsychopharmacology
Published
2000-05
Volume
22
Issue
5
Pages
451-465
ISSN
0893-133X (ISSN-L)
OpenAlex
W2091673195
Cited by
354
References
165
Citations by year
2026: 5 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 10 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 9 · 2016: 16 · 2015: 14 · 2014: 13 · 2013: 15 · 2012: 10
FWCI
1.26
Type
journal article
Language
en
Open access
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
  • National Institutes of Health (DA10455)
  • National Institute on Drug Abuse (DA-00167, DA 10455, DA-07290, K12DA000167)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
nicotinic acetylcholine receptors, nicotinic receptor subunits, nicotine, nicotine dependence, tobacco, receptor knockout mice, locomotion, cognition, affect, pain sensitivity
MeSH terms
Animals, Behavior, Humans, Models, Neurological, Molecular Biology, Receptors, Nicotinic, Mice, Knockout, Mice

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