The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
New evidence for neurotransmitter influences on brain development
Abstract
The early appearance of monoamine systems in the developing mammalian CNS suggests that they play a role in neural development. We review data from two model systems that provide compelling new evidence of this role. In one model system-in utero exposure to cocaine-specific and robust alterations are seen in dopamine-rich areas of the cerebral cortex, such as the anterior cingulate cortex: D1 receptor-G protein coupling is greatly reduced, the GABAergic system is altered and pyramidal dendrites undergo excessive growth. In a second model system-a transgenic mouse line in which the gene that encodes monoamine oxidase A (MAOA) is disrupted, resulting in excessively high 5-HT levels-barrels fail to form in the developing somatosensory cortex. Both models reveal the effects of very early manipulation of monoamines on forebrain development, and the long-term anomalies that persist into adulthood.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Specific genes (e.g., 5-HTTLPR; (112, 113)) influencing neuromaturation have known associations with self-injurious behaviors (114, 115).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [113]
Citations
Cites
(2005) · Choice Reviews Online · doi:10.5860/choice.43-0626 · Cited by 4,726
Psychopharmacology: The third generation of progress
O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,020
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070
Psychopharmacology: The Third Generation of Progress.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-509_2 · Cited by 2,021
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
ANGEVINE, J. B., & SIDMAN, R. L. (1961) · Nature · doi:10.1038/192766b0 · Cited by 1,530
Neuronal migration, with special reference to developing human brain: a review
Sidman, R. L., & RAKIC, P. T. (1973) · Brain Research · doi:10.1016/0006-8993(73)90617-3 · Cited by 1,260
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
Lipsitt, L. P., & Rovee‐Collier, C. (1981) · Ablex Publishing Corp. eBooks · Cited by 1,146
Moore, R. Y., & Bloom, F. E. (1979) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.02.030179.000553 · Cited by 1,118
Research works printed but not linked: 13
- Olsen, 1995, Neurotoxicology, 16, 159
- Spear, 1995, Vol. 9, 55
- Seidler, 1992, J. Pharmacol. Exp. Ther., 263, 413
- Battaglia, 1995, NIDA Res. Monogr. Ser., 158, 115
- Lidow, 1994, Soc. Neurosci. Abstr., 20, 596
- Murphy, 1995, Lab. Anim. Sci., 45, 163
- Breslin, N.A. and Weinberger, D.R. (1991) in Fetal Neural Development and Adult Schizophrenia (Mednick, S.A. et al., eds), pp. pp. 199–215, Cambridge University Press
- Wang, 1997, Exp. Brain Res., 112, 359
- Murphy, E.H. et al. Exp. Brain Res. (in press)
- Wang, 1995, J. Pharmacol. Exp. Ther., 273, 492
- Grayson, 1941, Soc. Neurosci. Abstr., 22
- Wang, 1996, Brain Res., 715, 221, 10.1016/0006-8993(96)00012-1 · DOI
- Goldberg, 1989, Dev. Biol., 141, 438
Cited by
Sorted by citations
Trajectories of brain development: point of vulnerability or window of opportunity?
Andersen, S. L. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00005-8 · Cited by 1,503
The developmental role of serotonin: news from mouse molecular genetics
Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297
Is there more to gaba than synaptic inhibition?
Owens, D. F., & Kriegstein, A. R. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn919 · Cited by 1,172
Fetal Nicotine or Cocaine Exposure: Which One is Worse?
Slotkin, T. A. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37495-6 · Cited by 676
Prenatal Substance Abuse: Short- and Long-term Effects on the Exposed Fetus
Behnke, M., Smith, V. C., Behnke, M., Smith, V. C., Levy, S., Ammerman, S. D., Gonzalez, P. K., Ryan, S. A., Smith, V. C., Wunsch, M. J., et al. (2013) · PEDIATRICS · doi:10.1542/peds.2012-3931 · Cited by 603
Metadata
- Authors
- Levitt, P., Harvey, J. A., Friedman, E., Simansky, K., & Murphy, E. H.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 20
- Issue
- 6
- Pages
- 269-274
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2167345246
- Cited by
- 362
- References
- 86
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 11 · 2012: 11
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01da006871-04)
- National Institute on Drug Abuse (P01DA06871)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- monoaminergic systems, brain development, dopamine, dopamine D1 receptor, G protein coupling, GABAergic system, anterior cingulate cortex, monoamine oxidase A, serotonin, somatosensory cortex, transgenic mice, forebrain development, developmental neurotoxicity
- MeSH terms
- Animals, Brain, Cocaine, Female, Mice, Transgenic, Pregnancy, Prenatal Exposure Delayed Effects, Neurotransmitter Agents, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
