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Mechanisms of emotional arousal and lasting declarative memory.
Abstract
Neuroscience is witnessing growing interest in understanding brain mechanisms of memory formation for emotionally arousing events, a development closely related to renewed interest in the concept of memory consolidation. Extensive research in animals implicates stress hormones and the amygdaloid complex as key, interacting modulators of memory consolidation for emotional events. Considerable evidence suggests that the amygdala is not a site of long-term explicit or declarative memory storage, but serves to influence memory-storage processes in other brain regions, such as the hippocampus, striatum and neocortex. Human-subject studies confirm the prediction of animal work that the amygdala is involved with the formation of enhanced declarative memory for emotionally arousing events.
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“For example, emotionally salient events, which engage the arousal system, may facilitate the encoding and drive enhanced consolidation of the corresponding memory traces (e.g., refs. 30,31).”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [30]
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“This effect reflects the modulatory role of the amygdala on hippocampus based declarative and episodic memory [51].”
From Dose-dependent effects of endotoxin on neurobehavioral functions in humans (2011) · cites this paper as [51]
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Self-citation
Metadata
- Authors
- Cahill, L., & McGaugh, J. L.
- Affiliations
- University of California, Irvine (US)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 21
- Issue
- 7
- Pages
- 294-299
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2139502395
- Cited by
- 1,575
- References
- 80
- Citations by year
- 2026: 23 · 2025: 34 · 2024: 46 · 2023: 31 · 2022: 35 · 2021: 35 · 2020: 60 · 2019: 36 · 2018: 48 · 2017: 38 · 2016: 49 · 2015: 65 · 2014: 64 · 2013: 70 · 2012: 72
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- emotional arousal, declarative memory, memory consolidation, amygdala, stress hormones, hippocampus, emotional memory, striatum, neocortex
- MeSH terms
- Amygdala, Animals, Arousal, Corticosterone, Epinephrine, Humans, Learning, Memory, Memory, Short-Term, Mental Processes, Models, Neurological, Retention, Psychology, Stress, Physiological
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