Channel noise in neurons
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The probabilistic gating of voltage-dependent ion channels is a source of electrical 'channel noise' in neurons. This noise has long been implicated in limiting the reliability (repeatability) of neuronal responses to repeated presentations of identical stimuli. More recently, it has been shown to increase the range of spiking behaviors exhibited in some neural populations. Channel numbers are tied to metabolic efficiency and the stability of resting potential, and channel noise might be exploited by future cochlear implants in order to improve the temporal representation of sound.
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In model cell types such as mammalian medial entorhinal cortex cells, modeled and experimental results match best for an average of 5 × 105 fast conductance Na+ and delayed rectifier K+ channels per neuron.
“In model cell types such as in mammalian medial enthorinal cortex cells, modeled and experimental results match best for an average of 5 × 105 fast conductance Na+ and delayed rectifier K+ channels per neuron [83].”
From An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields (2016) · cites this paper as [83]
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- Authors
- White, J. A., Rubinstein, J. T., & Kay, A. R.
- Affiliations
- Boston University (US)
- University of Iowa (US)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 23
- Issue
- 3
- Pages
- 131-137
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2149618862
- Cited by
- 673
- References
- 74
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 17 · 2023: 19 · 2022: 25 · 2021: 22 · 2020: 23 · 2019: 21 · 2018: 30 · 2017: 28 · 2016: 28 · 2015: 29 · 2014: 34 · 2013: 46 · 2012: 39
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Trends in Neurosciences (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › stochastic dynamics and bifurcation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- channel noise, voltage-gated ion channels, spiking behavior, cochlear implants
- MeSH terms
- Action Potentials, Animals, Axons, Cochlear Implants, Electric Stimulation, Humans, Ion Channels, Models, Neurological, Synaptic Transmission, Neurons, Stochastic Processes, Reproducibility of Results, Ion Channel Gating
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