Nicotinic control of axon excitability regulates thalamocortical transmission
Abstract
The thalamocortical pathway, a bundle of myelinated axons that arises from thalamic relay neurons, carries sensory information to the neocortex. Because axon excitation is an obligatory step in the relay of information from the thalamus to the cortex, it represents a potential point of control. We now show that, in adult mice, the activation of nicotinic acetylcholine receptors (nAChRs) in the initial portion of the auditory thalamocortical pathway modulates thalamocortical transmission of information by regulating axon excitability. Exogenous nicotine enhanced the probability and synchrony of evoked action potential discharges along thalamocortical axons in vitro, but had little effect on synaptic release mechanisms. In vivo, the blockade of nAChRs in the thalamocortical pathway reduced sound-evoked cortical responses, especially those evoked by sounds near the acoustic threshold. These data indicate that endogenous acetylcholine activates nAChRs in the thalamocortical pathway to lower the threshold for thalamocortical transmission and to increase the magnitude of sensory-evoked cortical responses. Our results show that a neurotransmitter can modulate sensory processing by regulating conduction along myelinated thalamocortical axons.
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Central cholinergic neurotransmission predominantly changes neuronal excitability, alters presynaptic release of neurotransmitters, and coordinates the firing of groups of neurons.
“Instead, central cholinergic neurotransmission predominantly changes neuronal excitability, alters presynaptic release of neurotransmitters, and coordinates the firing of groups of neurons (Kawai et al., 2007; Rice and Cragg, 2004; Wonnacott, 1997; Zhang and Sulzer, 2004).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Kawai et al., 2007
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“7f) were not effective in blocking TC LTP. Nicotinic receptors modulate excitability of thalamic projections to the ACx (Kawai et al., 2007), but these and previous data (Blundon et al., 2011) indicate that these receptors are not involved in mechanisms of TC LTP or TC LTD. EPSC60 was 187.3 33.1%…”
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“The effects of acetylcholine on pyramidal neurons have been investigated in great detail, and include direct depolarization and reduction of cortico-cortical input by muscarinic acetylcholine receptor activation, as well as enhancement of thalamo-cortical input via nicotinic receptors (McCormick & Prince, 1985; Gil et…”
BackgroundTraub, R. D., Middleton, S. J., Knöpfel, T., & Whittington, M. A. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06477.x · Cited by 64 · see citing works
“04 nA to each axonal compartment) in order to raise their excitability and spontaneous activity, as is likely to occur in nicotine (Kawai et al., 2007) or in low-calcium media.”
BackgroundInfluentialSynaptic mechanisms underlying cholinergic control of thalamic reticular nucleus neurons
Beierlein, M. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.277376 · Cited by 61 · see citing works
“Furthermore, slow changes in ACh levels might be involved in the activation of nAChRs expressed in TC axons (Kawai et al. 2007).”
BackgroundAddiction‐related neuroadaptations following chronic nicotine exposure
Wills, L., & Kenny, P. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15356 · Cited by 61 · see citing works
Do Nicotinic Receptors Modulate High-Order Cognitive Processing?
Koukouli, F., & Changeux, J. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.06.001 · Cited by 61 · see citing works
“An effect of nicotine and ACh on axon excitability was also described, indicating that nAChRs are probably located at nodes of Ranvier in particular along myelinated thalamocortical axons [114,115], revealing a nonsynaptic action of nicotinic agents.”
Sivarao, D. V., Frenkel, M. Y., Chen, P., Healy, F. L., Lodge, N. J., & Zaczek, R. C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.006 · Cited by 56 · see citing works
Neuromodulatory control of complex adaptive dynamics in the brain
Shine, J. M. (2023) · Interface Focus · doi:10.1098/rsfs.2022.0079 · Cited by 51 · see citing works
“There is evidence to suggest that the cholinergic system may favour feedforward modes of processing [84], either by exciting intra-telencephalic (IT) pyramidal cells [85] or by recruiting the parvalbumin-staining, fast-spiking GABAergic interneurons [86,87] that utilize feedforward inhibition [88,89] to facilitate hig…”
BackgroundKang, J. I., & Vaucher, E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005995 · Cited by 53 · see citing works
“These results have also been observed in sound-evoked cortical response in the auditory cortex [47].”
BackgroundPoorthuis, R. B., & Mansvelder, H. D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.003 · Cited by 48 · see citing works
“Pyramidal neurons in LV express a7 receptors and excitatory thalamocortical inputs to these neurons are strongly increased by activation of presynaptic, axonal b2-containing nAChRs, as in sensory cortical areas [120,121].”
BackgroundDopamine Modulates Ih in a Motor Axon
Ballo, A. W., Keene, J. C., Troy, P. J., Goeritz, M. L., Farzan Nadim, A., & Bucher, D. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0405-10.2010 · Cited by 49 · see citing works
“Among these are acetylcholine (Lang et al., 2003; Zhang et al., 2004; Kawai et al., 2007), GABA (Sakatani et al., 1991, 1993; Sun and Chiu, 1999; Verdier et al., 2003), and several amines (Meyrand et al., 1992; Mar and Drapeau, 1996; Bucher et al., 2003; Goaillard et al., 2004; Lang et al., 2006;…”
BackgroundCoppola, J. J., & Disney, A. A. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00008 · Cited by 48 · see citing works
“Nicotinic receptors expressed presynaptically by thalamic terminals are thought to increase the gain of incoming sensory data (Disney et al., 2007; Kawai et al., 2007).”
BackgroundNeuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia
Wecker, L., Engberg, M. E., Philpot, R. M., Lambert, C. S., Kang, C. W., Antilla, J. C., Bickford, P. C., Hudson, C. E., Zesiewicz, T. A., & Rowell, P. P. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.016 · Cited by 46 · see citing works
“Further, nicotine has been shown to regulate the activity of the central medial thalamus (Newman and Mair, 2007) and activate the thalamocortical pathway (Lambe et al., 2005; Kawai et al., 2007).”
BackgroundZolles, G., Wagner, E., Lampert, A., & Sutor, B. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn158 · Cited by 42 · see citing works
“2007), on axons of thalamocortical afferents (Kawai et al. 2007), and on pre-”
BackgroundCholinergic enhancement of functional networks in older adults with mild cognitive impairment
Pa, J., Berry, A. S., Compagnone, M., Boccanfuso, J. B., Greenhouse, I., Rubens, M. T., Johnson, J. K., & Gazzaley, A. H. (2013) · Annals of Neurology · doi:10.1002/ana.23874 · Cited by 45 · see citing works
Circuits for Modulation of Auditory Function
Schofield, B. R., & Hurley, L. M. (2018) · Springer handbook of auditory research · doi:10.1007/978-3-319-71798-2_9 · Cited by 45 · see citing works
Nicotinic Activation of Laterodorsal Tegmental Neurons: Implications for Addiction to Nicotine
Ishibashi, M., Leonard, C. S., & Kohlmeier, K. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.82 · Cited by 40 · see citing works
Complex Intrinsic Membrane Properties and Dopamine Shape Spiking Activity in a Motor Axon
Ballo, A. W., & Bucher, D. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0716-09.2009 · Cited by 39 · see citing works
“, 2003), and acetylcholine (Lang et al., 2003; Ding et al., 2004; Zhang et al., 2004; Kawai et al., 2007), and they affect both central and peripheral axons, in some cases even myelinated ones.”
BackgroundHeimfarth, L., Delgado, J., Mingori, M. R., Gelain, D. P., Moreira, J. C. F., & Pessoa‐Pureur, R. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2042-6 · Cited by 38 · see citing works
Bieszczad, K. M., Kant, R., Constantinescu, C. C., Pandey, S. K., Kawai, H. D., Metherate, R., Weinberger, N. M., & Mukherjee, J. (2011) · Synapse · doi:10.1002/syn.21530 · Cited by 35 · see citing works
“However, recent work suggests that activation of nAChRs in the auditory thalamocortical pathway enhances the excitability of myelinated thalamocortical axons (Kawai et al., 2007).”
Resting-state EEG, impulsiveness, and personality in daily and nondaily smokers
Rass, O., Ahn, W., & O’Donnell, B. F. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.05.007 · Cited by 34 · see citing works
Cox, B. C., Marritt, A. M., Perry, D. C., & Kellar, K. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05282.x · Cited by 35 · see citing works
“…to the optic nerve terminals in the SC and LGN, but instead might be on axons that project to the suprachiasmatic nucleus of the hypothalamus and/or the pretectal nucleus, or remain along the axons of the optic nerve, as was recently found in axons of the auditory system (Kawai et al. 2007).”
BackgroundLiang, K., Poytress, B. S., Weinberger, N. M., & Metherate, R. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.02.006 · Cited by 34 · see citing works
“, 2007) and thereby enhance cortical responses to CF stimuli (Kawai et al., 2007).”
Nicotinic filtering of sensory processing in auditory cortex
Metherate, R., Intskirveli, I., & Kawai, H. D. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00044 · Cited by 33 · see citing works
“, 2004) and it is consistent with the recent demonstration that nicotine enhances the excitability of myelinated auditory thalamocortical axons (Kawai et al., 2007).”
BackgroundResultChristensen, M. H., Ishibashi, M., Nielsen, M. L., Leonard, C. S., & Kohlmeier, K. A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.010 · Cited by 32 · see citing works
“Nicotine did not significantly affect the firing threshold contrary to previous findings (Kawai et al., 2007).”
BackgroundResultEmergent pharmacology of conscious experience: new perspectives in substance addiction
Changeux, J., & Lou, H. C. (2011) · The FASEB Journal · doi:10.1096/fj.11-0702ufm · Cited by 30 · see citing works
“These observations thus make plausible a direct control of the GNW by nicotine at the white-matter level (66, 68, 106, 107).”
BackgroundSouffi, S., Nodal, F. R., Bajo, V. M., & Edeline, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.690223 · Cited by 30 · see citing works
Intskirveli, I., & Metherate, R. (2012) · Journal of Neurophysiology · doi:10.1152/jn.01129.2011 · Cited by 29 · see citing works
“Nicotinic enhancement of thalamocortical input likely involves enhanced excitability of myelinated thalamocortical axons (Kawai et al. 2007), which relay information about CF stimuli to A1.”
InfluentialPsychosis as a disorder of muscarinic signalling: psychopathology and pharmacology
McCutcheon, R. A., Weber, L. A. E., Nour, M. M., Cragg, S. J., & McGuire, P. K. (2024) · The Lancet Psychiatry · doi:10.1016/s2215-0366(24)00100-7 · Cited by 27 · see citing works
A brainstem-to-mediodorsal thalamic pathway mediates sound-induced arousal from slow-wave sleep
Shin, A., Park, S., Shin, W., Woo, J., Jeong, M., Kim, J.-J., & Kim, D. (2023) · Current Biology · doi:10.1016/j.cub.2023.01.033 · Cited by 27 · see citing works
“Previous research focused primarily on the role of the cholinergic pathways in thalamic regulation since cholinergic neurons in brainstem arousal centers closely mirror the sleep/wake cycle(22) and depolarize sensory thalamic neurons in vitro.(1,18,23) Moreover, ACh is a critical neuromodulator in different types of a…”
Broicher, T., Bidmon, H. J., Kamuf, B., Coulon, P., Gorji, A., Pape, H., Speckmann, E. ‐., & Budde, T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.10.025 · Cited by 28 · see citing works
Yang, D., Günter, R. H., Qi, G., Radnikow, G., & Feldmeyer, D. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz324 · Cited by 27 · see citing works
“onto L3, L4, and L5 neocortical neurons (Gil et al. 1997; Lambe et al. 2003; Kawai et al. 2007).”
BackgroundImpact of ageing on postsynaptic neuronal nicotinic neurotransmission in auditory thalamus
Sottile, S. Y., Ling, L. L., Cox, B. C., & Caspary, D. M. (2017) · The Journal of Physiology · doi:10.1113/jp274467 · Cited by 27 · see citing works
“nAChR activation can coordinate the response patterns of groups of individual neurons (Wonnacott, 1997; Kawai et al. 2007; Changeux, 2010).”
BackgroundEnhanced Sensory–Cognitive Processing by Activation of Nicotinic Acetylcholine Receptors
Gil, S. M., & Metherate, R. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty134 · Cited by 27 · see citing works
Câmara, D. F., Machado, M. L., Arantes, L. P., da Silva, T. C., da Silveira, T. L., Leal, J. G., Dornelles, L., Stefanello, S. T., & Soares, F. A. A. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.08.001 · Cited by 25 · see citing works
The Concept of Allosteric Interaction and Its Consequences for the Chemistry of the Brain
Changeux, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.x113.503375 · Cited by 25 · see citing works
“There is also electrophysiological evidence supporting a direct action of nicotine on axon conduction at the level of nAChRs present at the nodes of Ranvier (230) and at the white matter level (231).”
BackgroundHeightened Nicotinic Regulation of Auditory Cortex during Adolescence
Kawai, H. D., Kang, H.-A., & Metherate, R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1705-11.2011 · Cited by 25 · see citing works
“Receptors containing 4 2, but not 7, nAChR subunits mediate enhancement of 1 (Kawai et al., 2007) and 2 (moreover, sensitivity to DH E was qualitatively greater in females than in males) and CF-evoked activity (4).”
InfluentialSelf-citationHahn, C., Neuhaus, A. H., Pöğün, Ş., Dettling, M., Kotz, S. A., Hahn, E. W., Brüne, M., & Güntürkün, O. (2011) · Brain and Cognition · doi:10.1016/j.bandc.2011.03.015 · Cited by 25 · see citing works
“These receptors are abundant within the white matter of ascending auditory thalamocortical fibers, and their activation results in increased axonal excitability (Kawai et al., 2007).”
BackgroundA characterization of laminar architecture in mouse primary auditory cortex
Chang, M., & Kawai, H. D. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1744-8 · Cited by 25 · see citing works
Brown, K. L., Comalli, D. M., Biasi, M. D., & Woodruff-Pak, D. S. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00166 · Cited by 24 · see citing works
Muscarinic and Nicotinic Modulation of Thalamo-Prefrontal Cortex Synaptic Pasticity In Vivo
Bueno-Júnior, L. S., Lopes‐Aguiar, C., Ruggiero, R. N., Romcy-Pereira, R. N., & Leite, J. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047484 · Cited by 25 · see citing works
“Moreover, some reports have shown that presynaptic nicotinic receptors, mainly the low-affinity a7 and high-affinity a4b2 subtypes, can exert a calcium-dependent potentiation of the thalamocortical transmission [34,47,59,72,73], which could explain the net potentiating effects of PILO and NIC.”
Daulatzai, M. A. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9643-3 · Cited by 25 · see citing works
Guo, F., Intskirveli, I., Blake, D. T., & Metherate, R. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.01.006 · Cited by 22 · see citing works
“Specifically, pharmacological manipulations of the thalamus can reduce the amplitude of the layer 4 current sink (Kawai et al., 2007), or block modulation of the first 3–5 ms of the layer 4 current sink without affecting modulation of peak current sinks in layer 2/3 (Intskirveli & Metherate, 2012).”
BackgroundRole of β2-containing nicotinic acetylcholine receptors in auditory event-related potentials
Rudnick, N. D., Koehler, C., Picciotto, M. R., & Siegel, S. J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1358-6 · Cited by 22 · see citing works
“DHβE also impairs the thalamocortical transmission of auditory stimuli that gives rise to ERPs ( Kawai et al. 2007 ).”
BackgroundEndogenous Acetylcholine and Its Modulation of Cortical Microcircuits to Enhance Cognition
Venkatesan, S., Jeoung, H., Chen, T., Power, S. K., Liu, Y., & Lambe, E. K. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_138 · Cited by 21 · see citing works
Askew, C., Intskirveli, I., & Metherate, R. (2017) · eneuro · doi:10.1523/eneuro.0192-17.2017 · Cited by 18 · see citing works
Grupe, M., Grunnet, M., Laursen, B., & Bastlund, J. F. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.12.008 · Cited by 20 · see citing works
Invariant neural subspaces maintained by feedback modulation
Naumann, L., Keijser, J., & Sprekeler, H. (2022) · eLife · doi:10.7554/elife.76096 · Cited by 20 · see citing works
Cholinergic modulation of sensory perception and plasticity
Kunnath, A. J., Gifford, R. H., & Wallace, M. T. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105323 · Cited by 19 · see citing works
Cholinergic Mechanisms in Gastrointestinal Neoplasia
Moura, N. S., Schledwitz, A., Alizadeh, M. A., Kodan, A., Njei, L., & Raufman, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105316 · Cited by 19 · see citing works
Constantinou, S., & Fern, R. F. (2009) · Glia · doi:10.1002/glia.20839 · Cited by 18 · see citing works
“…(Zhang et al., 2004). nAChR activation can also modulate axonal excitability in mature myelinated axons of the thalamocortical pathway (Kawai et al., 2007). b-1 Adrenoreceptor activation increases the amplitude of submaximal compound action potentials in neonatal rat optic nerve in a…”
BackgroundMouse model predicts effects of smoking and varenicline on event-related potentials in humans
Rudnick, N. D., Strasser, A. A., Phillips, J. M., Jepson, C., Patterson, F., Frey, J. M., Turetsky, B. I., Lerman, C. E., & Siegel, S. J. (2010) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq049 · Cited by 17 · see citing works
“Consistent with this hypothesis, nicotine enhances action potential propagation and synaptic release in thalamocortical circuits via DHbEsensitive nAChRs (Kawai et al., 2007; Lambe, Picciotto, & Aghajanian, 2003).”
BackgroundChang, M., Suzuki, N., & Kawai, H. D. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24481 · Cited by 17 · see citing works
“To estimate the location of A1 for P5 through P60 without functional verification, we used a method previously found to identify A1 consistently (Cruikshank, Rose, & Metherate, 2002; Kawai et al., 2007).”
MethodJames, N. M., Gritton, H. J., Kopell, N., Sen, K., & Han, X. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.027 · Cited by 17 · see citing works
“on previous studies (Intskirveli and Metherate, 2012; Kawai et al., 2007), we expected that mecamylamine may attenuate the auditory evoked ERP at short time scales but we found no evidence of this during passive processing of sound.”
Troy, W. C. (2008) · SIAM Journal on Applied Dynamical Systems · doi:10.1137/070709888 · Cited by 17 · see citing works
Dopaminergic impact on local and global cortical circuit processing during learning
Happel, M. F. K. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.11.016 · Cited by 16 · see citing works
Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats
Chamoun, M., Sergeeva, E. G., Henrich‐Noack, P., Jia, S., Grigartzik, L., Ma, J., You, Q., Huppé‐Gourgues, F., Sabel, B. A., & Vaucher, E. (2017) · Neural Plasticity · doi:10.1155/2017/6928489 · Cited by 15 · see citing works
Cholinergic modulation of sensory processing in awake mouse cortex
Jiménez-Martín, J., Потапов, Д. О., Potapov, K., Knöpfel, T., & Empson, R. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-96696-8 · Cited by 15 · see citing works
Stanchev, D., & Sargent, P. B. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3400-11.2011 · Cited by 15 · see citing works
“…are often nonsynaptic (Fabian-Fine et al., 2001; Jones et al., 2001; Jones and Wonnacott, 2004), and activation of nAChRs by ACh modulates synaptic transmission or excitability (Mansvelder et al., 2002; Genzen and McGehee, 2003; Kawai et al., 2007; Wanaverbecq et al., 2007; Zhang and Berg, 2007).”
BackgroundMinces, V. H., Alexander, A. S., Datlow, M., Alfonso, S., & Chiba, A. A. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00016 · Cited by 14 · see citing works
“Still, this explanation is not entirely satisfactory given that other groups have shown a direct influence of acetylcholine on shaping sensory responses (Roberts et al., 2005; Disney et al., 2007; Kawai et al., 2007).”
BackgroundBueno-Júnior, L. S., Lopes‐Aguiar, C., Ruggiero, R. N., Romcy-Pereira, R. N., & Leite, J. P. (2012) · PLoS ONE · doi:10.1371/annotation/d2dbf233-db12-431f-b9b6-4bd31cbca23e · Cited by 14 · see citing works
Anderson, K., Hoffman, K. M., & Miwa, J. M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108071 · Cited by 13 · see citing works
“Central cholinergic neurotransmission can therefore alter neuronal excitability by changing the presynaptic release of neurotransmitters, depolarizing neurons on which they are expressed, inducing secondary messenger cascades, and/or coordinating the firing of groups of neurons (Rice and Cragg, 2004; Kawai et al., 200…”
BackgroundDeep Brain Stimulation Mechanisms in Parkinson's Disease: Immediate and Long-Term Effects.
Pei, H., Wu, Z., Ma, L., Wang, J., Li, J.-H., Geng, X., Zou, Y.-H., Zhang, M., Qi, R., & Yu, H.-L. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2306114 · Cited by 8 · see citing works
“The primary role of central cholinergic neurotransmission is to modulate the excitability of neurons, regulate the release of neurotransmitters presynaptic before synapse, and coordinate neuronal firing, akin to the process of neuromodulation [123,124].”
Background
- Authors
- Kawai, H., Lazar, R., & Metherate, R.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Metherate, Raju
- Venue
- Nature Neuroscience
- Published
- 2007-08-19
- Volume
- 10
- Issue
- 9
- Pages
- 1168-1175
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2159652741
- Cited by
- 171
- References
- 49
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 12 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 15 · 2012: 10
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA-12929, R01DA012929)
- National Institute on Deafness and Other Communication Disorders (R03DC008204, DC08204, DC 02967)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- nicotinic acetylcholine receptors, thalamocortical circuits, axon excitability, auditory thalamus, thalamocortical neurons, acetylcholine, myelinated axons, sensory processing
- MeSH terms
- Acoustic Stimulation, Action Potentials, Analysis of Variance, Animals, Axons, Cerebral Cortex, Dihydro-beta-Erythroidine, Dose-Response Relationship, Radiation, Electric Stimulation, Neural Pathways, Synaptic Transmission, Neurons, Nicotine, Reaction Time, Receptors, Nicotinic, Thalamus, Patch-Clamp Techniques, Nicotinic Agonists, Excitatory Postsynaptic Potentials, Mice, In Vitro Techniques
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