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Cited by 167Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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Hypodopaminergic and hypernoradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder–the spontaneously hypertensive rat

Russell, Vivienne Ann·2002·Behavioural Brain Research
DOI 10.1016/s0166-4328(01)00425-9
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Abstract

Evidence supports dysfunction of dopaminergic and noradrenergic systems in patients with attention-deficit hyperactivity disorder (ADHD). Noradrenergic and dopaminergic systems exert distinct modulatory actions on the transfer of information through neural circuits that connect functionally distinct cortical areas with separate striatal regions and remain segregated in parallel striato-pallidal-thalamic and striato-substantia nigra pars reticulata-thalamic pathways. Prefrontal cortex performance is maximal at moderate stimulation of postsynaptic dopaminergic and noradrenergic receptors, and is reduced by either higher or lower levels of receptor stimulation. Spontaneously hypertensive rats (SHR) are generally considered to be a suitable genetic model for ADHD, since they display hyperactivity, impulsivity, poor stability of performance, impaired ability to withhold responses and poorly sustained attention, when compared with their normotensive Wistar-Kyoto (WKY) control rats. Evidence suggests that terminals of mesocortical, mesolimbic and nigrostriatal dopaminergic neurons of SHR release less dopamine in response to electrical stimulation and/or depolarization as a result of exposure to high extracellular K+ concentrations, than WKY. Vesicular storage of dopamine was suggested to be impaired in SHR, causing leakage of dopamine into the cytoplasm and increased d-amphetamine-induced transporter-mediated release. While electrically stimulated release of dopamine appears to be d…

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References 41 · Cited by 167

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  1. Alexander, 1986, Parallel organization of functionally segregated circuits linking basal ganglia and cortex, Ann. Rev. Neurosci., 9, 357, 10.1146/annurev.ne.09.030186.002041 · DOI · Paper page
  2. Arnsten, 1998, Catecholamine modulation of prefrontal cortical cognitive function, TICS, 2, 436
  3. Bull, 2000, Evaluation of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder: acquisition and performance of the DRL-60s test, Behav. Brain Res., 109, 27, 10.1016/S0166-4328(99)00156-4 · DOI · Paper page
  4. De Jong, 1995, The nigrostriatal dopamine system and the development of hypertension in the spontaneously hypertensive rat, Arch. Mal. Coeur. Vaiss., 88, 1193
  5. De Villiers, 1995, α2-Adrenoceptor mediated inhibition of [3H]dopamine release from nucleus accumbens slices and monoamine levels in a rat model for attention-deficit hyperactivity disorder, Neurochem. Res., 20, 427, 10.1007/BF00973098 · DOI
  6. Dougherty, 1999, DA transporter density in patients with attention deficit hyperactivity disorder, Lancet, 354, 2132, 10.1016/S0140-6736(99)04030-1 · DOI · Paper page
  7. Ernst, 1998, DOPA decarboxylase activity in attention deficit hyperactivity disorder adults. A [fluorine-18] fluorodopa positron emission tomographic study, J. Neurosci., 18, 5901, 10.1523/JNEUROSCI.18-15-05901.1998 · DOI · Paper page
  8. Himelstein, 2000, The neurobiology of attention-defict hyperactivity disorder, Front. Biosci., 5, D461, 10.2741/Himelste · DOI
  9. Kirouac, 1993, Up-regulation of dopamine receptors in the brain of the spontaneously hypertensive rat: an autoradiographic analysis, Neuroscience, 52, 135, 10.1016/0306-4522(93)90188-L · DOI
  10. Krause, 2000, Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography, Neurosci. Lett., 285, 107, 10.1016/S0304-3940(00)01040-5 · DOI · Paper page
  11. Linthorst, 1991, Effect of the dopamine D2 receptor agonist quinpirole on the in vivo release of dopamine in the caudate nucleus of hypertensive rats, Eur. J. Pharmacol., 201, 125, 10.1016/0014-2999(91)90335-N · DOI
  12. Linthorst, 1990, Electrically stimulated [3H]dopamine and [14C]acetylcholine release from nucleus caudatus slices: differences between spontaneously hypertensive rats and Wistar–Kyoto rats, Brain Res., 509, 266, 10.1016/0006-8993(90)90551-L · DOI
  13. Malone, 1994, Hemispheric processing and methylphenidate effects in attention-deficit hyperactivity disorder, J. Child. Neurol., 9, 181, 10.1177/088307389400900216 · DOI
  14. Maurice, 1999, Relationships bettween the prefrontal cortex and the basal ganglia in the rat: physiology of the cortico-nigral circuits, J. Neurosci., 19, 4674, 10.1523/JNEUROSCI.19-11-04674.1999 · DOI
  15. Mefford, 1989, A neuroanatomical and biochemical basis for attention-deficit disorder with hyperactivity in children; a defect in tonic adrenaline mediated inhibition of locus coeruleus stimulation, Med. Hypotheses, 29, 33, 10.1016/0306-9877(89)90164-3 · DOI
  16. Moll, 2000, Deficient intracortical inhibition in drug-naı̈ve children with attention-deficit hyperactivity disorder is enhanced by methylphenidate, Neurosci. Lett., 284, 121, 10.1016/S0304-3940(00)00980-0 · DOI
  17. Muly, 1998, D1 receptor in interneurons of macaque prefrontal cortex: distribution and subcellular localization, J. Neurosci., 18, 10553, 10.1523/JNEUROSCI.18-24-10553.1998 · DOI
  18. Myers, 1981, Changes in catecholamine neuronal uptake and receptor binding in the brains of spontaneously hypertensive rats (SHR), Brain Res., 220, 325, 10.1016/0006-8993(81)91221-X · DOI
  19. Palmer, 1999, Airpuff startle stress elicited fos expression in brain cardiovascular areas of young SHR and WKY rats, Clin. Exp. Hypertens., 21, 1061, 10.3109/10641969909052189 · DOI
  20. Richelson, 1984, Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: Most antidepressants selectively block norepinephrine uptake, Eur. J. Pharmacol., 104, 277, 10.1016/0014-2999(84)90403-5 · DOI
  21. Russell, 2000, The nucleus accumbens motor-limbic interface of the spontaneously hypertensive rat as studied in vitro by the superfusion slice technique, Neurosci. Biobehav. Rev., 24, 133, 10.1016/S0149-7634(99)00056-1 · DOI
  22. Russell VA, Allie S, Wiggins T. Increased noradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder—the spontaneously hypertensive rat. Behav. Brain Res. 2000;117:69–74. · DOI
  23. Russell, 1995, Altered dopaminergic function in the prefrontal cortex, nucleus accumbens and caudate–putamen of an animal model of attention-deficit hyperactivity disorder—the spontaneously hypertensive rat, Brain Res., 676, 343, 10.1016/0006-8993(95)00135-D · DOI · Paper page
  24. Russell, 1996, Impaired vesicular storage of dopamine in an animal model for attention-deficit hyperactivity disorder—the spontaneously hypertensive rat, Soc. Neurosci. Abstr., 22, 2082
  25. Russell, 1998, Differences between electrically-, ritalin- and d-amphetamine-stimulated release of [3H]dopamine from brain slices suggest impaired vesicular storage of dopamine in an animal model for attention-deficit hyperactivity disorder, Behav. Brain Res., 94, 163, 10.1016/S0166-4328(97)00177-0 · DOI
  26. Sagvolden, 2000, Behavioural validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD), Neurosci. Biobehav. Rev., 24, 31, 10.1016/S0149-7634(99)00058-5 · DOI · Paper page
  27. Sagvolden, 1992, Behavior of hypertensive and hyperactive rat strains: hyperactivity is not unitarily determined, Physiol. Behav., 52, 49, 10.1016/0031-9384(92)90432-2 · DOI
  28. Sagvolden, 1993, Frequent reward eliminates differences in activity between hyperkinetic rats and controls, Behav. Neural Biol., 59, 225, 10.1016/0163-1047(93)90986-R · DOI
  29. Sagvolden, 1992, The spontaneously hypertensive rat (SHR) as an animal model of childhood hyperactivity (ADHD): Changed reactivity to reinforcers and to psychomotor stimulants, Behav. Neural Biol., 58, 103, 10.1016/0163-1047(92)90315-U · DOI
  30. Sagvolden, 1993, Spontaneously hypertensive rats (SHR) as a putative animal model of childhood hyperkinesis: SHR behavior compared to four other rat strains, Physiol. Behav., 54, 1047, 10.1016/0031-9384(93)90323-8 · DOI · Paper page
  31. Sagvolden, 1998, Attention deficit/hyperactivity disorder—from brain dysfunctions to behaviour, Behav. Brain Res., 94, 1
  32. Solanto, 1998, Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration, Behav. Brain Res., 94, 127, 10.1016/S0166-4328(97)00175-7 · DOI · Paper page
  33. Swaab-Barneveld, 2000, Visual sustained attention in a child psychiatric population, J. Am. Acad. Child Adolesc. Psychiatry, 39, 651, 10.1097/00004583-200005000-00020 · DOI
  34. Teicher, 2000, Functional deficits in basal ganglia of children with attention-deficit hyperactivity disorder shown with functional magnetic resonance imaging relaxometry, Nat. Med., 6, 470, 10.1038/74737 · DOI
  35. Thierry, 1988, Influence of the mesocortical/prefrontal dopamine neurons on their target cells, Ann. New York Acad. Sci., 537, 101, 10.1111/j.1749-6632.1988.tb42099.x · DOI
  36. Tsuda, 1990, Norepinephrine release and neuropeptide Y in medulla oblongata of spontaneously hypertensive rats, Hypertension, 15, 784, 10.1161/01.HYP.15.6.784 · DOI
  37. Watanabe, 1997, Brain dopamine transporter in spontaneously hypertensive rats, J. Nucl. Med., 38, 470

Metadata

Authors
Russell, V. A.
Affiliations
University of Cape Town (ZA)
Corresponding author
Russell, Vivienne Ann
ORCID
Russell, Vivienne Ann
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2002-03
Volume
130
Issue
1-2
Pages
191-196
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/s0166-4328(01)00425-9
OpenAlex
W2009396930
Cited by
167
References
41
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 13 · 2014: 15 · 2013: 5 · 2012: 12
FWCI
7.04
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
attention deficit hyperactivity disorder, spontaneously hypertensive rats, prefrontal cortex, dopaminergic dysfunction, noradrenergic dysfunction, dopamine release, noradrenaline release, autoreceptors, hyperactivity, impulsivity, sustained attention
MeSH terms
Animals, Attention Deficit Disorder with Hyperactivity, Dopamine, Synaptic Transmission, Norepinephrine, Rats, Inbred SHR, Prefrontal Cortex, Rats

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