Isolation changes the incentive value of sucrose and social behaviour in juvenile and adult rats

Food reward: brain substrates of wanting and liking

Berridge, K. C. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00033-b · Cited by 1,901

Opiates and endogenous opioid peptides

Kelly, J. S., & Dingledine, R. J. (1977) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(77)90262-6 · Cited by 1,290

Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues

Tzschentke, T. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00060-4 · Cited by 1,280

Neurobehavioural mechanisms of reward and motivation

Robbins, T. W., & Everitt, B. J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80077-8 · Cited by 1,187

The ontogeny of behaviour in the albino rat

Bolles, R. C., & Woods, P. J. (1964) · Animal Behaviour · doi:10.1016/0003-3472(64)90062-4 · Cited by 570

The neurobiology of social play behavior in rats

Vanderschuren, L. J. M. J., Niesink, R. J. M., & Van Pee, J. M. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00020-6 · Cited by 559

The ontogeny of play in rats

Panksepp, J. (1981) · Developmental Psychobiology · doi:10.1002/dev.420140405 · Cited by 537

Animal Play

(1998) · Cambridge University Press eBooks · doi:10.1017/cbo9780511608575 · Cited by 477

Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat.

Pfaus, J. G., & Phillips, A. G. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.5.727 · Cited by 320

Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat

Pfaus, J. G., & Phillips, A. G. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.5.727 · Cited by 320

Space, time, and context drive anticipatory behavior: Considerations for understanding the behavior of animals in human care

Krebs, B. L., Chudeau, K. R., Eschmann, C. L., Tu, C. W., Pacheco, E., & Watters, J. V. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.972217 · Cited by 22

Abstinence environment contributes to age differences in reinstatement of cocaine seeking between adolescent and adult male rats

Li, C., & Frantz, K. J. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.003 · Cited by 15

Training dairy heifers with positive reinforcement: Effects on anticipatory behavior

Heinsius, J. L., Lomb, J., Lee, J. H. W., von Keyserlingk, M. A. G., & Weary, D. M. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23709 · Cited by 16

The Impact of Social Isolation and Environmental Deprivation on Blood Pressure and Depression-Like Behavior in Young Male and Female Mice

Challa, S. R., Fornal, C. A., Wang, B. C., Boyineni, J., DeVera, R. E., Unnam, P., Song, Y., Soares, M. B., Malchenko, S., Gyarmati, P., et al. (2023) · Chronic Stress · doi:10.1177/24705470231207010 · Cited by 16

“Live together, die alone”: The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress

Rivera, D. S., Lindsay, C. B., Oliva, C. A., Bozinovic, F., & Inestrosa, N. C. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100289 · Cited by 16

Effects of environmental manipulations on cocaine-vs-social choice in male and female rats

Marcus, M. M., Negus, S. S., & Banks, M. L. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173462 · Cited by 15

Environmental Enrichment During Adulthood Reduces Sucrose Binge-Like Intake in a High Drinking in the Dark Phenotype (HD) in C57BL/6J Mice

Rodríguez‐Ortega, E., Alcaráz-Iborra, M., de la Fuente, L., de Amo, E., & Cubero, I. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00027 · Cited by 13

The anxiogenic effects of adolescent psychological stress in male and female mice

Muñoz, P., & Franklin, T. B. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113963 · Cited by 13

Social Isolation during Peri-Adolescence or Adulthood: Effects on Sexual Motivation, Testosterone and Corticosterone Response under Conditions of Sexual Arousal in Male Rats

Amstislavskaya, T. G. (2013) · The Chinese Journal of Physiology · doi:10.4077/cjp.2013.baa074 · Cited by 12

Environmental Enrichment Modulates Drug Addiction and Binge-Like Consumption of Highly Rewarding Substances: A Role for Anxiety and Compulsivity Brain Systems?

Rodríguez‐Ortega, E., & Cubero, I. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00295 · Cited by 14

Protective and therapeutic benefits of environmental enrichment on binge-like sucrose intake in C57BL/6J mice

Rodríguez‐Ortega, E., Alcaráz-Iborra, M., de la Fuente, L., & Cubero, I. (2019) · Appetite · doi:10.1016/j.appet.2019.03.033 · Cited by 14

Effects of pre-pubertal social experiences on the responsiveness of juvenile rats to predator odors

Siviy, S. M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.004 · Cited by 11

Ghrelin Induces Place Preference for Social Interaction in the Larger Peer of a Male Rat Pair

Schéle, E., Pfabigan, D. M., Simrén, J., Sailer, U., & Dickson, S. L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.01.027 · Cited by 10

Modulation of the pair housing induced feeding suppression

Lopak, V., & Eikelboom, R. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.009 · Cited by 10

Neurexin1α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia

Achterberg, E. J. M., Biemans, B., & Vanderschuren, L. J. M. J. (2025) · Psychopharmacology · doi:10.1007/s00213-024-06559-z · Cited by 9

Orexins/Hypocretins: Gatekeepers of Social Interaction and Motivation

Ouaidat, S., Amaral, I. M., Monteiro, D. G., Harati, H., Hofer, A., & Rawas, R. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052609 · Cited by 9

Opportunities for risk‐taking during play alters cognitive performance and prefrontal inhibitory signalling in rats of both sexes

Bijlsma, A., Birza, E. E., Pimentel, T. C., Maranus, J. P. M., van Gaans, M. J. J. M., Klooster, J. G. L. T., Baars, A. M., Achterberg, E. J. M., Lesscher, H. M. B., Wierenga, C. J., et al. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16313 · Cited by 11

How Postnatal Insults May Program Development: Studies in Animal Models

Dalmaz, C., Noschang, C. G., Krolow, R., Raineki, C., & Lucion, A. B. (2014) · Advances in neurobiology · doi:10.1007/978-1-4939-1372-5_7 · Cited by 9

Ameliorative effects of brief daily periods of social interaction on isolation-induced behavioral and hormonal alterations

Raz, S. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.03.009 · Cited by 9

Effects of adolescent social instability stress on social reward motivation and dopamine receptor expression in female and male rats

Leonetti, A. M., Sheehan, A. C., Murray, S. H., Burke, F. F., Fletcher, B. C. J., & McCormick, C. M. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115702 · Cited by 11

Anxiety does not contribute to social withdrawal in the subchronic phencyclidine rat model of schizophrenia

Seillier, A., & Giuffrida, A. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000325 · Cited by 8

Spatial discrimination reversal and incremental repeated acquisition in adolescent and adult BALB/c mice

Shen, A. N., Pope, D. A., Hutsell, B. A., & Newland, M. C. (2015) · Behavioural Processes · doi:10.1016/j.beproc.2015.06.005 · Cited by 7

Immediate early gene expression reveals interactions between social and nicotine rewards on brain activity in adolescent male rats

Bastle, R. M., Peartree, N. A., Goenaga, J. G., Hatch, K. N., Henricks, A. M., Scott, S. N., Hood, L. E., & Neisewander, J. L. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.024 · Cited by 7

Corticosterone disrupts spatial working memory during retention testing when highly taxed, which positively correlates with depressive-like behavior in middle-aged, ovariectomized female rats

Conrad, C. D., Peay, D. N., Acuña, A. M., Whittaker, K. E., & Donnay, M. E. (2024) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105600 · Cited by 6

A fast technique to induce and measure anticipatory behavior in bottlenose dolphins ( Tursiops truncatus )

Bigiani, S., & Pilenga, C. (2022) · Journal of Applied Animal Welfare Science · doi:10.1080/10888705.2022.2063019 · Cited by 6

Neuronal and psychological underpinnings of pathological gambling

Singer, B. F., Anselme, P., Robinson, M. J. F., & Vezina, P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00230 · Cited by 8

Effects of chlordiazepoxide on predator odor-induced reductions of playfulness in juvenile rats

Siviy, S. M., Steets, C. L., & DeBrouse, L. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.026 · Cited by 6

Effects of different opportunities for social interaction on the play fighting behavior in male and female golden hamsters (Mesocricetus auratus)

Vieira, M. L., Garcia, M. P., Rau, D. D. W., & Prado, A. B. (2005) · Developmental Psychobiology · doi:10.1002/dev.20101 · Cited by 6

Effects of inescapable stress on responses to social incentive stimuli and modulation by escitalopram

Daniels, S., Lemaire, D., Lapointe, T., Limebeer, C. L., Parker, L. A., & Leri, F. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05940-6 · Cited by 5

Beyond the binary: Characterizing the relationships between sex and neuropeptide receptor binding density measures in the rat brain

Joel, D., Smith, C. J. W., & Veenema, A. H. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105471 · Cited by 5

Brief Introduction to Welfare Assessment: A ‘Toolbox’ of Techniques

Latham, N. (2010) · Wiley eBooks · doi:10.1002/9781444318777.ch6 · Cited by 5

Life-course effects of early life adversity exposure on eating behavior and metabolism

de Lima, R. M. S., Barth, B., Arcego, D. M., Krolow, R., Silveira, P. P., & Dalmaz, C. (2021) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2021.02.003 · Cited by 5

Noradrenergic modulation of play in Sprague-Dawley and F344 rats

Siviy, S. M., Martin, M. A., & Campbell, C. M. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06419-2 · Cited by 3

Juvenile stress as an animal model of childhood trauma

Richter‐Levin, G., & Jacobson‐Pick, S. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777042.012 · Cited by 3

A model to quantify the anticipatory response in cats

Tomi, G., Martorell, A., Torre, C., Compagnucci, M., & Manteca, X. (2011) · Animal Welfare · doi:10.1017/s0962728600002670 · Cited by 3

Juvenile play experience does not affect nicotine sensitization and voluntary consumption of nicotine in adult rats

Himmler, B. T., Nakahashi, A., Snow, E., McMickle, A., Muhammad, A., Biondolillo, K., Pellis, S. M., & Kolb, B. E. (2013) · Developmental Psychobiology · doi:10.1002/dev.21189 · Cited by 2

Emotions, Decision-Making, Conflict and Cooperation

Chatterji, M. K. (2016) · Emerald Group Publishing Limited eBooks · doi:10.1108/s1572-8323201725 · Cited by 2

Exploring the brain-behaviour interface: The role of juvenile play experiences

Himmler, B. T. (2015) · Open ULeth Scholarship (OPUS) (University of Lethbridge) · Cited by 2

The development of animal models for autism: A gene-environment approach

Ranger, P. (2016) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17019029.v1 · Cited by 2

Environmental Effects on Rat Ultrasonic Vocalizations and Brain Plasticity: Social Isolation and Environmental Enrichment

Seffer, D., Schwarting, R. K. W., & Wöhr, M. (2018) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-809600-0.00035-4 · Cited by 1

A free‐operant olfactory choice procedure to assess preference for social and nonsocial scents in female rats

Hinnenkamp, J. E., Dunthorn, A., Galizio, A., & Rogers, T. D. (2025) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.70030 · Cited by 1

Partner separation and sex contribute to anxiety-like behavior, but partner separation alone amplifies hippocampal inflammation following immune challenge

Chen, H., Weisenseel, Z., Stewart, S. M., Neigh, G. N., & Glasper, E. R. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106508 · Cited by 1

Chronic restraint stress increases social interaction in C57BL / 6J mice monitoring through MiceProfiler analysis

Zhao, W., Hu, Y., Sun, Q., Li, S., Gao, Z., Lin, M., Ding, Z., Sun, J., & Li, C. (2020) · The Anatomical Record · doi:10.1002/ar.24470 · Cited by 1

BEHAVIOURAL RESPONSES OF ARTIFICIALLY REARED RATS TO REWARD AND NOVELTY

Lomanowska, A. M. (2005) · UWSpace (University of Waterloo) · Cited by 1

Efeitos do isolamento social: sobre a persistência na procura em contextos associados ao álcool

Cortés‐Patiño, D. M. (2017) · doi:10.11606/t.47.2017.tde-24072017-184025 · Cited by 1

Social Play Behavior

Vanderschuren, L. J. M. J., & Achterberg, E. J. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00021-9 · Cited by 1

Unravelling the Role of the Dopamine D1 Receptor in Anhedonia, Asociality, and Avolition

Witt, K. (2023) · doi:10.26686/wgtn.24646128 · Cited by 1

The importance of reward-evaluating mechanisms for animal welfare

van der Harst, J. E., & Spruijt, B. M. (2009) · Utrecht University Repository (Utrecht University)

Social foraging in captive baboons: implications for enrichment

Jones, M. A. (2006) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)

Cross-talk between the Oxytocin and Vasopressin Systems in the Brian: Roles in Social Behavior

Song, Z. (2016) · Digital Archive @ GSU · doi:10.57709/7996120

Report of the 2009 RSPCA/UFAW Rodent Welfare Group meeting - focusing on fifty years of the Three Rs and welfare assessment.

Hawkins, P., Fry, D., Wells, S., Honess, P. E., Yeates, J. W., Farmer, A. M., Main, D., Osborne, N., Jennings, M., & Hubrecht, R. C. (2010)

Investigating anticipatory behaviours in lambs

Anderson, C. (2016) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))

Prosocial Influences on Nicotine Reinforcement, Reward, and Neural Signaling in Rodent Models

Peartree, N. A. (2015)

Patterns of Endocrine, Behavioural, and Neural Function Underlying Social Deficits after Social Instability Stress in Adolescent Rats

Hodges, T. E. (2018) · Brock University Digital Repository (Brock University)

Histaminergic neurotransmission as a gateway for the effects of the fat sensing molecule Oleoylethanolamide

Costa, A. (2020) · Premio Tesi dottorato/Premio Tesi di dottorato · doi:10.36253/978-88-6453-995-9

References

(2016) · Emerald Group Publishing Limited eBooks · doi:10.1108/s1572-832320160000025015

Empathy

Lahvis, G. P. (2018) · Springer eBooks · doi:10.1007/978-3-319-47829-6_1574-1

Empathy

Lahvis, G. P. (2022) · Springer eBooks · doi:10.1007/978-3-319-55065-7_1574

How social play experience shapes development of higher brain function

Bijlsma, A. (2023) · Utrecht University Repository (Utrecht University) · doi:10.33540/1927

Brief introduction to welfare assessment: a ‘toolbox’ of techniques

Lofgren, J. L. S. (2024) · Wiley eBooks · doi:10.1002/9781119555278.ch6

A review on the validity of animal models for neuropsychiatric disorders: an exploration of anhedonia

Witt, K. M., Harper, D. N., & Ellenbroek, B. A. (2025) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000816

Developing welfare parameters for bottlenose dolphins (Tursiops truncatus) under human care

Clegg, I. L. K. (2017) · theses.fr (ABES) · doi:10.70675/87e5fe82zcf54z4a8azacbezde447b9f4dc0

Multidimensional analysis of social withdrawal in the sub-chronic phencyclidine rat model for schizophrenia

Kalli, S., Davletova, A., Seillier, L., Kuchař, M., & Seillier, A. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07066-z

Single-housed, but not pair-housed, male and female rats demonstrate social conditioned place preference

Bensing, P. C., Bowers, C. P., Moosa, I., & Leong, K.-C. (2026) · Neuroscience Letters · doi:10.1016/j.neulet.2026.138731

Effects of adolescent social isolation on motivation for sucrose: Evidence from demand and choice procedures

Melo, E. F., de Medeiros, C. R. S., & Cortés‐Patiño, D. M. (2026) · Learning and Motivation · doi:10.1016/j.lmot.2026.102351

Incentive motivation and behavioral inhibition in socially-isolated rats

Morgan, M. J. (1975) · Physiology & Behavior · doi:10.1016/0031-9384(75)90205-x · Cited by 103

The effects of isolation-rearing on sucrose consumption in rats

HALL, F., HUMBY, T., WILKINSON, L., & ROBBINS, T. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00116-9 · Cited by 54

The effects of early social isolation on the motivation for social play in juvenile rats

Ikemoto, S., & Panksepp, J. (1992) · Developmental Psychobiology · doi:10.1002/dev.420250404 · Cited by 121

Social Behavior and Social Motivation in Adolescent Rats

Varlinskaya, E. I., Spear, L. P., & Spear, N. E. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00285-6 · Cited by 194