The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Regulation of in vivo TSH secretion by leptin
Abstract
Leptin, the product of the ob gene, is a hormone secreted by adipocytes that regulates food intake and energy expenditure. The hypothalamus-pituitary-thyroid axis is markedly influenced by the metabolic status, being suppressed during food deprivation. The aim of the present study was to assess whether leptin can act as a metabolic signal connecting the adipose tissue with the pituitary-thyroid axis. We studied the effect of leptin administration (10 microg, i.c.v.) on spontaneous TSH secretion and TSH responses to TRH in euthyroid and hypothyroid food-deprived rats. Spontaneous TSH secretion was assessed over 6 h with samples taken every 7 min. Administration of leptin to food-deprived euthyroid rats led to a reversal of the inhibitory effect exerted by fasting on spontaneous TSH secretion. This stimulatory effect of leptin on spontaneous TSH appears to be dependent on the thyroid status since it could not be observed in hypothyroid rats. This data suggests that blunted spontaneous TSH secretion in food-deprived rats is a functional and reversible state, and that the decreased leptin concentrations could be the primary event responsible for the suppression of the hypothalamic-pituitary-thyroid-axis in food-deprived rats.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It has previously been shown that leptin administration in rodents reverses the inhibitory effect of food deprivation on spontaneous pulsatile TSH secretion (40)”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [40]
Citations
Cites
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
Kalra, S. P., Dube, M. G., Pu, S., Xu, B., Horváth, T. L., & Kalra, P. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.1.0357 · Cited by 1,564
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
Kalra, S. P. (1999) · Endocrine Reviews · doi:10.1210/er.20.1.68 · Cited by 1,554
Identification of targets of leptin action in rat hypothalamus.
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,499
A leptin missense mutation associated with hypogonadism and morbid obesity
Strobel, A., Issad, T., Camoin, L., Ozata, M., & Strosberg, A. D. (1998) · Nature Genetics · doi:10.1038/ng0398-213 · Cited by 1,158
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
Håkansson, M., Brown, H., Ghilardi, N., Skoda, R. C., & Meister, B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00559.1998 · Cited by 741
Légrádi, G., Emerson, C. H., Ahima, R. S., Flier, J. S., & Lechan, R. M. (1997) · Endocrinology · doi:10.1210/en.138.6.2569 · Cited by 505
Neuroendocrine Regulation and Actions of Leptin
Casanueva, F. F., & Diéguez, C. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0187 · Cited by 385
Self-citation
Research works printed but not linked: 2
- Coya, 1997, Retinoic acid inhibits in vivo, Endocrinology, 138, 2203
- Legradi, 1998, Arcuate nucleus ablation prevents fasting-induced suppression of Pro-TRH mRNA in the hypothalamic paraventricular nucleus, Endocrinology, 139, 3262, 10.1210/en.139.7.3262 · DOI · Paper page
Cited by
Sorted by citations
Items 101–109 of 109
Zhang, L., Xu, S., Cheng, X. F., Zhu, Y. F., Cai, G., Wu, J., Gao, W., Bao, J., & Yu, H. (2025) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2024.0148 · Cited by 2
Time course of thyroxine on hypothalamic histamine in the rat
Tiligada, E., & Kakavas, S. (2006) · Inflammation Research · doi:10.1007/s00011-005-0029-x · Cited by 2
Ageing and the Endocrine Circadian System
Touitou, Y., & Haus, E. L. (2004) · Neuroimmune biology · doi:10.1016/s1567-7443(04)80013-9 · Cited by 1
Changes in thyroid volume and thyroid function in acromegaly after surgery in Chinese populationPreprint
Shao, Q., Li, J., Gao, L., Guo, X., Wang, Z., Deng, K., Lian, W., & Xing, B. (2019) · Research Square · doi:10.21203/rs.2.14190/v1 · Cited by 1
de López, G. M., López, Z., Bishop, W., Viana, M., & Hernández-Yánez, L. (2002) · Actualidad Contable FACES
1 Klinika Endokrynologii i Diabetologii Wieku Rozwojowego Akademii Medycznej w Poznaniu
Fichna, M., & Fichna, P. (2005)
Koenig, R. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4745-2.00020-1
Zhang, X., Jin, X., Han, Z., Jiang, M., & Shi, B. (2026) · Antioxidants · doi:10.3390/antiox15040476
Metadata
- Authors
- Seoane, L. M., Carro, E., Tovar, S., Casanueva, F. F., & Dieguez, C.
- Affiliations
- Universidade de Santiago de Compostela (ES)
- Venue
- Regulatory Peptides
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 92
- Issue
- 1-3
- Pages
- 25-29
- ISSN
- 0167-0115 (ISSN-L)
- OpenAlex
- W2056871375
- Cited by
- 109
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Regulatory Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, thyroid-stimulating hormone, TSH secretion, hypothalamic-pituitary-thyroid axis, food deprivation, hypothyroidism, thyrotropin-releasing hormone, adipose tissue, energy metabolism
- MeSH terms
- Animals, Female, Food Deprivation, Thyrotropin, Thyrotropin-Releasing Hormone, Rats, Sprague-Dawley, Leptin, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
