The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Regulation of in vivo TSH secretion by leptin
Abstract
Leptin, the product of the ob gene, is a hormone secreted by adipocytes that regulates food intake and energy expenditure. The hypothalamus-pituitary-thyroid axis is markedly influenced by the metabolic status, being suppressed during food deprivation. The aim of the present study was to assess whether leptin can act as a metabolic signal connecting the adipose tissue with the pituitary-thyroid axis. We studied the effect of leptin administration (10 microg, i.c.v.) on spontaneous TSH secretion and TSH responses to TRH in euthyroid and hypothyroid food-deprived rats. Spontaneous TSH secretion was assessed over 6 h with samples taken every 7 min. Administration of leptin to food-deprived euthyroid rats led to a reversal of the inhibitory effect exerted by fasting on spontaneous TSH secretion. This stimulatory effect of leptin on spontaneous TSH appears to be dependent on the thyroid status since it could not be observed in hypothyroid rats. This data suggests that blunted spontaneous TSH secretion in food-deprived rats is a functional and reversible state, and that the decreased leptin concentrations could be the primary event responsible for the suppression of the hypothalamic-pituitary-thyroid-axis in food-deprived rats.
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“It has previously been shown that leptin administration in rodents reverses the inhibitory effect of food deprivation on spontaneous pulsatile TSH secretion (40)”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [40]
Citations
Cites
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Cited by
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Thyroid Hormone Regulation of Metabolism
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Versini, M., Jeandel, P.-Y., Rosenthal, E., & Shoenfeld, Y. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.07.001 · Cited by 694
Thyroid dysfunction and diabetes mellitus: two closely associated disorders
Biondi, B., Kahaly, G. J., & Robertson, R. P. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00163 · Cited by 598
Metadata
- Authors
- Seoane, L. M., Carro, E., Tovar, S., Casanueva, F. F., & Dieguez, C.
- Affiliations
- Universidade de Santiago de Compostela (ES)
- Venue
- Regulatory Peptides
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 92
- Issue
- 1-3
- Pages
- 25-29
- ISSN
- 0167-0115 (ISSN-L)
- OpenAlex
- W2056871375
- Cited by
- 109
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Regulatory Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, thyroid-stimulating hormone, TSH secretion, hypothalamic-pituitary-thyroid axis, food deprivation, hypothyroidism, thyrotropin-releasing hormone, adipose tissue, energy metabolism
- MeSH terms
- Animals, Female, Food Deprivation, Thyrotropin, Thyrotropin-Releasing Hormone, Rats, Sprague-Dawley, Leptin, Rats
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