Cited by 109Regulation of Appetite and ObesityThyroid Disorders and TreatmentsHypothalamic control of reproductive hormones

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Regulation of in vivo TSH secretion by leptin

Seoane, Luisa M, Carro, Eva, Tovar, Sulay, Casanueva, Felipe F, Dieguez, Carlos·2000·Regulatory Peptides

DOI 10.1016/s0167-0115(00)00145-2

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Abstract

Leptin, the product of the ob gene, is a hormone secreted by adipocytes that regulates food intake and energy expenditure. The hypothalamus-pituitary-thyroid axis is markedly influenced by the metabolic status, being suppressed during food deprivation. The aim of the present study was to assess whether leptin can act as a metabolic signal connecting the adipose tissue with the pituitary-thyroid axis. We studied the effect of leptin administration (10 microg, i.c.v.) on spontaneous TSH secretion and TSH responses to TRH in euthyroid and hypothyroid food-deprived rats. Spontaneous TSH secretion was assessed over 6 h with samples taken every 7 min. Administration of leptin to food-deprived euthyroid rats led to a reversal of the inhibitory effect exerted by fasting on spontaneous TSH secretion. This stimulatory effect of leptin on spontaneous TSH appears to be dependent on the thyroid status since it could not be observed in hypothyroid rats. This data suggests that blunted spontaneous TSH secretion in food-deprived rats is a functional and reversible state, and that the decreased leptin concentrations could be the primary event responsible for the suppression of the hypothalamic-pituitary-thyroid-axis in food-deprived rats.

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Authors: Seoane, L. M., Carro, E., Tovar, S., Casanueva, F. F., & Dieguez, C.
Affiliations: Universidade de Santiago de Compostela (ES)
ORCID: Seoane, Luisa M
Carro, Eva
Tovar, Sulay
Casanueva, Felipe F
Venue: Regulatory Peptides
Publisher: Elsevier BV
Published: 2000-08
Volume: 92
Issue: 1-3
Pages: 25-29
ISSN: 0167-0115 (ISSN-L)
DOI: 10.1016/s0167-0115(00)00145-2
OpenAlex: W2056871375
Cited by: 109
References: 22
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 5
FWCI: 1.31
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Regulatory Peptides (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: leptin, thyroid-stimulating hormone, TSH secretion, hypothalamic-pituitary-thyroid axis, food deprivation, hypothyroidism, thyrotropin-releasing hormone, adipose tissue, energy metabolism
MeSH terms: Animals, Female, Food Deprivation, Thyrotropin, Thyrotropin-Releasing Hormone, Rats, Sprague-Dawley, Leptin, Rats

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Regulation of in vivo TSH secretion by leptin

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