Cited by 101PI3K/AKT/mTOR signaling in cancerMicrobial Natural Products and BiosynthesisSignaling Pathways in Disease

Signal-transduction cascades as targets for therapeutic intervention by natural products

Cardenas, Maria Elena, Sanfridson, Annika, Cutler, N.Shane, Heitman, Joseph·1998·Trends in Biotechnology

Abstract

Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserved signal-transduction cascades. This article looks at the mechanisms of action of five natural products--the immunosuppressants cyclosporin A, FK506 and rapamycin, and the antiproliferative agents wortmannin and geldanamycin. These mechanisms reveal the importance of signal-transduction cascades as targets for therapeutic intervention and the enormous utility of studies of natural-product action in simple model genetic systems.

Integrity signals

Registry

Crossref · 10.1016/s0167-7799(98)01239-6

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Geldanamycin inhibits heat shock protein HSP90.

    “Geldanamycin is a natural fermentation product of the benzoquinone ansamycin and inhibits the heat shock protein HSP90 [220], as well show cytotoxic effect against HeLa cells [221].”

    From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [220]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Cardenas, M. E., Sanfridson, A., Cutler, N. S., & Heitman, J.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Heitman, Joseph
Venue
Trends in Biotechnology
Publisher
Elsevier BV
Published
1998-10
Volume
16
Issue
10
Pages
427-433
ISSN
0167-7799 (ISSN-L)
OpenAlex
W1968232511
Cited by
101
References
72
Citations by year
2023: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 7 · 2013: 3 · 2012: 1
FWCI
0.73
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ai041937-03, 5k01ca077075-04)
  • National Cancer Institute (KO1 CA77075)
  • National Institute of Allergy and Infectious Diseases (AI 39115, AI41937)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
signaling pathways, natural products, microbial secondary metabolites, cyclosporine, FK506, rapamycin, wortmannin, geldanamycin, immunosuppressants, antiproliferative agents, mechanism of action, target-based drug discovery
MeSH terms
Wortmannin, Androstadienes, Animals, Cell Cycle, Enzyme Inhibitors, Fungi, Humans, Immunosuppressive Agents, Quinones, Protein Biosynthesis, Signal Transduction, Benzoquinones, Tacrolimus, Cyclosporine, Apoptosis, HSP90 Heat-Shock Proteins, Calcineurin, Sirolimus, Lactams, Macrocyclic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review