Oxytocin mediates the inhibitory action of acute lithium on the morphine dependence in rats
Abstract
The role of central oxytocin in inhibitory action of lithium on the development of morphine dependence was behavioral investigated in rats. Acute lithium could enhance the morphine-induced analgesia in rats with or without chronic morphine treatment; this effect could be inhibited by intraventricular injection of oxytocin antagonist d (CH(2))(5)-Tyr (Me)-[Orn(8)]-Vasotocin (OVT). Lithium could attenuate naloxone-precipitated withdrawal signs in morphine dependent rats. The reduction of the expression of naloxone-precipitated withdrawal signs by lithium was reversed by ICV of OVT. The lithium significantly inhibited the conditioned place preference (CPP) induced by morphine, which inhibitory action of lithium could also reverse by ICV injection of OVT. These results suggested that lithium might inhibit the physical dependence on morphine as well as psychological dependence in rats, and that this inhibitory effect of lithium on the development of morphine dependence might be associated with oxytocin systems in the central nervous system.
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Preclinical studies in rats found that systemic injection of lithium leads to a significant elevation of peripheral oxytocin levels.
“As regard OT, preclinical studies in rats found that a systemic injection of lithium leads to a significant elevation of peripheral OT levels (Cui et al., 2001;You et al., 2001).”
From Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis (2016) · cites this paper as You et al., 2001
Early investigations provide some encouragement that oxytocin could prove a useful supplement to current treatment of both schizophrenia and drug addiction.
“Interestingly, early investigations provide some encouragement that oxytocin could prove a useful supplement to current treatment of both schizophrenia (Keri et al., 2008;Feifel et al., 2010) and drug addiction (You et al., 2001;Qi et al., 2009;Carson et al., 2010).”
From Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions (2013) · cites this paper as You et al., 2001
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- Authors
- You, Z. D., Li, J. H., Song, C. Y., Lu, C. L., & He, C.
- Affiliations
- Second Military Medical University (CN)
- Corresponding author
- You, Zhen Dong
- He, Cheng
- Venue
- Neuroscience Research
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 41
- Issue
- 2
- Pages
- 143-150
- ISSN
- 0168-0102 (ISSN-L)
- OpenAlex
- W2056918793
- Cited by
- 23
- References
- 45
- Citations by year
- 2020: 1 · 2017: 1 · 2016: 4 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Second Military Medical University
- National Key Research and Development Program of China
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, lithium, morphine dependence, opioid withdrawal, naloxone-precipitated withdrawal, conditioned place preference, morphine analgesia, arginine vasotocin, intraventricular injection, psychological dependence, physical dependence
- MeSH terms
- Analgesics, Opioid, Animals, Behavior, Animal, Conditioning, Psychological, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Interactions, Hypothalamo-Hypophyseal System, Hypothalamus, Anterior, Male, Morphine, Morphine Dependence, Naloxone, Narcotic Antagonists, Neurosecretion, Oxytocin, Pain Measurement, Substance Withdrawal Syndrome, Rats, Sprague-Dawley, Pain Threshold, Lithium Chloride, Antimanic Agents, Rats
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