Cited by 232Diabetes Management and ResearchDiabetes Management and EducationDiabetes Treatment and Management

Continuous glucose monitoring used to adjust diabetes therapy improves glycosylated hemoglobin: a pilot study

Bode, Bruce W., Gross, Todd M., Thornton, Kay R., Mastrototaro, John J.·1999·Diabetes Research and Clinical Practice

Abstract

A 5-week pilot study was conducted to determine if continuous glucose monitoring could be used to improve glycemic control. A total of nine subjects with type 1 diabetes and HbA1c values greater than 8.5% completed the study. Subjects wore a continuous glucose monitor for two 1-week periods during the study. After each sensor use, changes to diet, insulin dosage and self-monitored blood glucose (SMBG) schedule were made. HbA1c decreased from 9.9% (S.D. = 1.1%) at baseline to 8.8% (S.D. = 1.0%) 5 weeks after baseline (P = 0.0006), but daily insulin usage was unchanged over the same period of time (P = 0.428). The glucose sensors performed accurately, with a median correlation of 0.92 and a mean absolute difference of 19.1% (S.D. = 9.0%). The continuous glucose profiles allowed identification of glucose patterns and excursions that helped direct changes in therapy. These treatment changes would not have been made on the basis of meter data alone and were effective in improving glucose control. Additional studies are needed to validate these findings. This pilot study highlights the potential for continuous glucose monitoring to provide the valuable information necessary to make therapy adjustments that can dramatically improve patients' glycemic control and reduce the risk of long-term complications.

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Registry

Crossref · 10.1016/s0168-8227(99)00113-8

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5 of 5 references verified0 citation errors · 0 not checkable

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  • The continuous glucose monitoring system was validated against plasma glucose.

    “The Medtronic Guardian® REAL-Time has been validated against plasma glucose [49] and is widely used in clinical settings [50], [51].”
  • Standard communication protocols for electronic devices include Bluetooth classic, Zigbee, and Wi-Fi, but these protocols have not been designed to be power-efficient.

    “Standard communication protocols for electronic devices include Bluetooth classic,102 Zigbee,103 and Wi‐Fi.104 However, these protocols have not been designed to be power‐efficient.”

    From Wearables in Medicine (2018) · cites this paper as [103]

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Authors
Bode, B. W., Gross, T. M., Thornton, K. R., & Mastrototaro, J. J.
Affiliations
Atlanta Diabetes Associates (US)
Corresponding author
Bode, Bruce W.
Venue
Diabetes Research and Clinical Practice
Publisher
Elsevier BV
Published
1999-12
Volume
46
Issue
3
Pages
183-190
ISSN
0168-8227 (ISSN-L)
OpenAlex
W2103516801
Cited by
232
References
5
Citations by year
2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 6
FWCI
8.41
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Research and Clinical Practice (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
continuous glucose monitoring, type 1 diabetes, glycemic control, HbA1c, insulin dose adjustment, self-monitoring of blood glucose
MeSH terms
Adolescent, Adult, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Insulin, Male, Middle Aged, Monitoring, Physiologic, Pilot Projects, Therapy, Computer-Assisted, Treatment Outcome

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